Clinical trials: sponsored by Unity Health Toronto
Hemorrhagic Shock
Effect of Remote Ischemic Conditioning on Trauma Patients With Hemorrhagic Shock
The purpose of the study is to evaluate whether remote ischemic conditioning is a safe and effective intervention to prevent the development of inflammation and coagulopathy in trauma patients with hemorrhagic shock.
- Trial name
- NCT02071290
- Testing
- Pneumatic tourniquet
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Unity Health Toronto
Education
RCT of Intensive, Brief, and Control Indigenous Cultural Safety Training Interventions for Health Care Providers
Despite Canada's relative global affluence, striking Indigenous/non-Indigenous health disparities persist. Following the release of the Truth and Reconciliation Commission of Canada's Final Report, and the publication of the…
- Trial name
- NCT05890144
- Testing
- Big Canoe, Little Canoe, Control
- Where
- Canada
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Hyperglycemia in Critically Ill Patients
Comparison of 2 Methods to Achieve Tight Glucose Control in Cardiovascular ICU Patients
There is current evidence that maintaining ICU patient's blood sugar between 4.4-6.1 saves lives. However, this is difficult to do in the ICU and carries risks of lowering the blood sugar too much.
- Trial name
- NCT00636714
- Testing
- Nursing judgement, Nomogram
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Unity Health Toronto
Obscure Gastrointestinal Bleeding, Gastrointestinal Diseases
Assessing Depth of Small Bowel Insertion at Push Enteroscopy by Using Capsule Endoscopy
Bleeding from the gastrointestinal tract can originate from the small bowel. Typically, upper and lower endoscopies are unable to identify the site of bleeding and patients need to undergo special endoscopies with longer cameras…
- Conditions
- Obscure Gastrointestinal Bleeding, Gastrointestinal Diseases, Gastrointestinal Bleed, Angiodysplasia Intestine
- Trial name
- NCT05731388
- Testing
- Push enteroscopy
- Where
- Canada
- Volunteers
- 59 people
- Sponsor
- Unity Health Toronto
10-20mm Colorectal Polyp
Optimal Resection Technique for Medium-sized (10-20mm) Colorectal Polyps
This study will investigate which resection technique (Endoscopic Mucosal Resection (EMR), cold EMR, or underwater EMR) leads to lower recurrence rates and less adverse events in patients with colorectal polyps (10-20mm).
- Trial name
- NCT05849623
- Testing
- Endoscopic Mucosal Resection (EMR), Cold Endoscopic Mucosal Resection (C-EMR), Underwater Endoscopic Mucosal Resection (U-EMR)
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Clavicle Fracture
Surgically Treated Displaced Mid-diaphyseal Clavicle Fractures
This prospective, multi-centre study aims to determine clinical, radiographic, and patient-reported outcomes (PROMs) following surgical fixation of displaced mid-diaphyseal clavicle fractures and to compare implant removal rates…
- Trial name
- NCT05867355
- Testing
- surgical fixation
- Where
- Canada
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Knee Pain Chronic, Osteoarthritis
Cryoneurolysis for TKA - a Pilot Study
Total Knee Arthroplasty (TKA) is also known as a knee replacement. It is one of the most common orthopaedic (bone) surgeries performed and is usually very successful, but some people who have had a knee replacement feel pain that…
- Trial name
- NCT05286996
- Testing
- Iovera - Cryoneurolysis, Local anesthetic
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Unity Health Toronto
Endophthalmitis
Endophthalmitis Post Intravitreal Injections
Intravitreal injection (IVI) is an ophthalmological procedure used worldwide to treat ocular conditions. Its use has been steadily increasing for several years, because this method of drug delivery minimizes systemic exposure and…
- Trial name
- EPIIC (NCT04035369)
- Testing
- Tap and Inject (TAI), Pars Plana Vitrectomy (PPV)
- Where
- Canada
- Volunteers
- 310 people
- Sponsor
- Unity Health Toronto
COVID-19, COVID-19 Pneumonia
Self-proning and Repositioning in COVID-19 Outpatients at Risk of Complicated Illness
The rapid development of safe and effective COVID-19 treatment is a global health priority. Numerous studies evaluating therapies for this disease are currently underway, but the majority of these are in hospitalized patients…
- Conditions
- COVID-19, COVID-19 Pneumonia, Proning, Hospitalization
- Trial name
- NCT05518474
- Testing
- Self-proning
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- Unity Health Toronto
Asthma
The Electronic Asthma Management System
This study is an extension of a pilot study in which investigators developed and tested a computerized tool to help physicians to determine if their patients' asthma is well controlled, advise them on medication changes required…
- Trial name
- eAMS (NCT03193242)
- Testing
- Electronic Asthma Management System: eAMS
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Unity Health Toronto
Respiratory Distress Syndrome, TTN
Use of Gentle Synchronized Negative Pressure in Helping Babies Breathe
The NeoVest delivery device is a wearable vest/shell that surrounds the infant's abdomen. It was developed using serial body measurements of infants previously admitted to the St. Michael's Hospital NICU (REB #15-183).
- Conditions
- Respiratory Distress Syndrome, TTN, RDS of Prematurity, Respiratory Distress, Newborn
- Trial name
- Neovest (NCT03510169)
- Testing
- NeoVest
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Unity Health Toronto
Hepatopulmonary Syndrome
Supine Exercise in Hepatopulmonary Syndrome Patients With Orthodeoxia
Hepatopulmonary syndrome (HPS) is a rare condition that presents in about a quarter of patients with liver cirrhosis. In addition, a small subset of these HPS patients also have orthodeoxia, defined as a drop in oxygen levels…
- Trial name
- NCT04004104
- Testing
- Upright Exercise, Supine Exercise
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Unity Health Toronto
COVID-19 Experience
Data Collection on the Model Schools Pediatric Health Initiative at 5 SBHC Sites: COVID-19 Questionnaire
The Model School Pediatric Health Initiative arose out of concern about health access inequities and disparities among some of Toronto's most vulnerable children living in our inner-city neighborhoods.
- Trial name
- SBHC (NCT04534595)
- Testing
- COVID-19
- Where
- Canada
- Volunteers
- 851 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Evaluation of Preterm NAVA Catheter Placement
Positioning of EDI Catheter In Premature Infants
Nasogastric (NG) and orogastric (OG) feeding tubes have a high incidence of malpositioning, occurring in up to 59% of preterm infants (Lopes 2019).
- Trial name
- PIPI (NCT05107713)
- Where
- Canada
- Volunteers
- 65 people
- Sponsor
- Unity Health Toronto
Transfusion Reaction
Transfusion Associated Dyspnea Profiling
Transfusion reactions are defined as harms occurring during or after blood transfusion, with new heart/lung stress (eg. troubled breathing) regarded as cardiorespiratory transfusion reactions (CRTRs).
- Trial name
- TADPOL (NCT04267029)
- Testing
- TADPOL battery (deep clinicolaboratory profile)
- Where
- 4 sites in Canada
- Volunteers
- 151 people
- Sponsor
- Toronto Transfusion Medicine Collaborative
Apnea, Sleep Apnea Syndromes
Oropharyngeal Exercises and Post-Stroke Obstructive Sleep Apnea
This study evaluates the feasibility and effectiveness of an oropharyngeal exercise (O-PE) regimen in treating post-stroke obstructive sleep apnea, as an alternative therapy to continuous positive airway pressure (CPAP).
- Conditions
- Apnea, Sleep Apnea Syndromes, Sleep Apnea, Obstructive, Stroke
- Trial name
- NCT04212260
- Testing
- Oropharyngeal exercises
- Where
- Canada
- Volunteers
- 33 people
- Sponsor
- Sunnybrook Health Sciences Centre
Acute Respiratory Distress Syndrome
Continuous Negative Abdominal Pressure in ARDS (CNAP in ARDS)
The aim is to test a device for applying continuous negative abdominal pressure in patients with ARDS
- Trial name
- CNAP in ARDS (NCT03425318)
- Testing
- CNAP
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- The Hospital for Sick Children
Hypertension, Depression
Patient-Centred Innovations for Persons With Multimorbidity - Ontario
The aim of Patient-Centred Innovations for Persons With Multimorbidity (PACE in MM) study is to reorient the health care system from a single disease focus to a multimorbidity focus; centre on not only disease but also the…
- Conditions
- Hypertension, Depression, Anxiety, Musculoskeletal Pain
- Trial name
- PACEinMM-ON (NCT02742597)
- Testing
- TIP / IMPACT Plus Care Coordination
- Where
- 9 sites in Canada
- Volunteers
- 175 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Diabetes
Avoiding Diabetes After Pregnancy Trial in Moms
Mothers with previous gestational diabetes mellitus (GDM) represent a population at higher risk of future Type 2 diabetes mellitus (T2DM), which is preventable through lifestyle modification.
- Trial name
- ADAPT-M (NCT01918345)
- Testing
- Home-based Physical Activity Program with Health Coach, Home-based Low-GI Diet Program with Health Coach
- Where
- 5 sites in Canada
- Volunteers
- 345 people
- Sponsor
- Women's College Hospital
Major Depressive Disorder
Canadian Biomarker Integration Network for Depression (CAN-BIND) - Validation Study
This is a validation study that will replicate a completed study designed to assess biomarkers of treatment response to standard antidepressant treatment.
- Trial name
- NCT04162522
- Testing
- Escitalopram, Brexpiprazole
- Where
- 6 sites in Canada
- Volunteers
- 1 people
- Sponsor
- University Health Network, Toronto