Clinical trials: sponsored by University Hospital, Lille
Multiple Myeloma
Compare Lenalidomide and Subcutaneous Daratumumab vs Lenalidomide and Dexamethasone in Frail Subjects With Previously Untreated Multiple Myeloma Who Are Ineligible for High Dose Therapy
This is a Phase 3, randomized (study drug assigned by chance), open-label (participants and researchers are aware about the treatment, participants are receiving), active-controlled (study in which the experimental treatment or…
- Trial name
- IFM2017_03 (NCT03993912)
- Testing
- Daratumumab SC in combination with Lenalidomide, Lenalidomide PO (25mg), Dexamethasone PO (20mg): days 1, 8, 15, 22 of each 28-day cycle, until progression
- Where
- 23 sites in France
- Volunteers
- 294 people
- Sponsor
- University Hospital, Lille
Cardiogenic Shock, Extracorporeal Membrane Oxygenation
Individualized or Conventional Transfusion Strategies During Peripheral VA-ECMO
This multicenter randomized controlled trial compare two transfusion strategies of red blood cells transfusion in patients supported by veno-arterial extracorporeal membrane oxygenation for refractory cardiogenic shock.
- Conditions
- Cardiogenic Shock, Extracorporeal Membrane Oxygenation, Transfusion Related Complication, Anemia
- Trial name
- ICONE (NCT05699005)
- Testing
- Packed Red Blood Cells (PRBCs)
- Where
- 4 sites in France
- Volunteers
- 236 people
- Sponsor
- University Hospital, Lille
Intracranial Thrombosis
adaptatiVe Endovascular Strategy to the CloT MRI in Large Intracranial Vessel Occlusion
In the VECTOR trial, the aim is to analyze, in case of SVS+ occlusions, a first line Embotrap II added to CA combined strategy compare to CA alone strategy.
- Trial name
- VECTOR (NCT04139486)
- Testing
- combined EMBOTRAP II or III and Contact Aspiration, Contact Aspiration alone
- Where
- 23 sites in France
- Volunteers
- 526 people
- Sponsor
- Nantes University Hospital
Esophageal Cancer, Esophagectomy
PAravertebral CaTheter Versus Epidural Analgesia in Totally Minimally Invasive Esophagectomies
Esophageal cancer ranks as the seventh leading cause of cancer globally, with 604,100 new cases, and the sixth leading cause of cancer-related deaths worldwide.
- Conditions
- Esophageal Cancer, Esophagectomy, Multimodal Analgesia, Minimally Invasive Surgery
- Trial name
- PACEMIE (NCT07434739)
- Testing
- paravertebral catheter analgesia, Epidural group
- Where
- France
- Volunteers
- 506 people
- Sponsor
- University Hospital, Lille
Diet, Growth
The prEgnanCy and eArly Childhood nutrItion triaL (ECAIL)
The purpose of this study is to conduct a randomized controlled trial among 800 socially disadvantaged pregnant women and their families to test the effectiveness of a multi-component home visitation nutrition program, compared…
- Conditions
- Diet, Growth, Infant, Physical Activity
- Trial name
- ECAIL (NCT03003117)
- Testing
- Experimental: Intervention Program, Active comparator: Usual Care
- Where
- 2 sites in France
- Volunteers
- 607 people, healthy volunteers welcome
- Sponsor
- French Red Cross
Low Cardiac Output Syndrome Bypass Children
Performance of Carbon Dioxide (CO2)-Derived Parameters in Predicting Low Cardiac Output Syndrome
In congenital cardiac intensive care, low cardiac output syndrome (LCOS) after surgery is defined by a decrease in cardiac output due to cardiac dysfunction.
- Trial name
- GAP-CO2 (NCT07770386)
- Where
- France
- Volunteers
- 306 people
- Sponsor
- University Hospital, Lille
Intracerebral Haemorrhage, ICH
Characterization of Peri-Hemorrhagic Cerebral Edema Using Synthetic Sodium Imaging With 7-Tesla and 3-Tesla MRI
Intracerebral haemorrhage is the type of stroke with the highest mortality rate, estimated at 40% in the acute phase. Among survivors, half will experience functional disability.
- Trial name
- TIPITCH-7T (NCT07789990)
- Testing
- Sodium tissue concentration will be measured in perihematomal oedema
- Volunteers
- 48 people
- Sponsor
- University Hospital, Lille
Classic Congenital Adrenal Hyperplasia, 21-Hydroxylase Deficiency
Pediatric Congenital Adrenal Hyperplasia Management: Regret and Long-term Outcomes
Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is a chronic endocrine disorder, often diagnosed in the neonatal period. Severe forms may lead to genital virilization in afected girls and adrenal crises.
- Trial name
- CAH - REC (NCT07781267)
- Testing
- questionnaire
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Lille
Pneumonia, Ventilator-Associated, Pneumonia, Hospital-Acquired
Impact of a Strategy Based on Bacterial DNA Detection to Optimize Antibiotics in Immunocompromised Patients With Hospital-acquired Pneumonia Requiring Mechanical Ventilation
RESPIRE is a randomized, unblinded, controlled study to measure the impact of a strategy based on a PCR test on the adjustment of antimicrobial therapy in immunocompromised patients suspected with ventilator-associated or…
- Conditions
- Pneumonia, Ventilator-Associated, Pneumonia, Hospital-Acquired, Immunodeficiency
- Trial name
- RESPIRE (NCT05405491)
- Testing
- PCR based strategy, Standard care
- Where
- France
- Volunteers
- 31 people
- Sponsor
- University Hospital, Lille
Hepatocellular Carcinoma, Liver Transplant
PET TDM FDG-Choline as a Decision-making Tool for Routine Care on the Liver Transplant List for HCC
HCC is the most common malignant liver tumor for which liver transplantation is one of the pivotal curative treatments. The best possible selection of patients who are candidates for transplantation is essential in the current…
- Trial name
- TEP CARE (NCT04792801)
- Testing
- PET TDM FDG-Choline
- Where
- 2 sites in France
- Volunteers
- 108 people
- Sponsor
- University Hospital, Lille
Sarcopenia, Pancreatic Cancer
Preoperative Prehabilitation for Sarcopenic Patients Prior to Pancreatic Surgery for Cancer
Major digestive surgery is associated with a significant rate of postoperative complications. To improve postoperative outcome, efforts are focused on postoperative course leading to the concept of rehabilitation.
- Trial name
- PSOAS (NCT04469504)
- Testing
- Prehabilitation program, Oral Impact
- Where
- France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Lille
Giant Cell Arteritis
Giant Cell Arteritis: Comparison Between Two Standardized Corticosteroids Tapering
Corticosteroid therapy has always been the standard treatment for giant cell arteritis (GCA), with very good initial clinical efficacy but a high relapse rate when it declines.
- Trial name
- CORTODOSE (NCT04012905)
- Testing
- Corticosteroids for Systemic Use
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Caen
Subacute Stroke
The Multitasking Rehabilitation She Enhanced Walking Speed Compared to the Simple Post Stroke Rehabilitation Task (AVC)?
Stroke is the leading cause of severe disability in adults. The first cause of alterations in the quality of life and autonomy in these patients are disorders of walking and the balance.
- Trial name
- SYNCOMOT (NCT03009773)
- Testing
- rehabilitation multitasking walking., Traditional walking rehabilitation
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Stroke (CVA) or Transient Ischemic Attack, Stroke (CVA) or TIA
Trunk Impairment Scale - Adaptation and Validation in French
The objective of this project is to verify the validity and determine the clinimetric properties after translation and adaptation into French of the Trunk Impairment Scale (TIS), a scale for measuring trunk control and seated…
- Trial name
- KER-TIS fr (NCT07419087)
- Testing
- Evaluation by the TIS
- Where
- France
- Volunteers
- 67 people
- Sponsor
- Centre Mutualiste de Rééducation et de Réadaptation Fonctionnelles de Kerpape
Sickle Cell Disease
Prevalence of Problematic Use of Equimolar Mixture of Oxygen and Nitrous Oxide and Analgesics in the Sickle-cell Disease
The use of analgesics can lead to cases of drug abuse and dependence. It can also cause pseudo-addiction in patients suffering from pain.
- Trial name
- PHEDRE (NCT02580565)
- Testing
- telephone interview
- Where
- France
- Volunteers
- 1,004 people
- Sponsor
- Nantes University Hospital
Type 1 Diabetes (T1D), Islets of Langerhans Transplantation
Efficacy of Islet Re-transplantation After Failure of Beta-cell Replacement
Islet transplantation and pancreas transplantation are established therapeutic options for selected individuals with type 1 diabetes experiencing severe glycemic instability and recurrent hypoglycemia.
- Trial name
- MULT-ILOT (NCT07666789)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Montpellier
Autism Spectrum Disorder, Neurodevelopmental Disorders
Platform for the Prospective Mother-child Study of the Determinants of Neurodevelopmental Disorders
Neurodevelopmental disorders such as attention deficit disorder with or without hyperactivity, autism spectrum disorder, language and social communication disorder, motor coordination disorder, learning disorder (dyslexia…
- Trial name
- MARIANNE (NCT05681923)
- Testing
- Questionnaires, Biospecimen collection, Neurodevelopmental assessment visit
- Where
- France
- Volunteers
- 7,320 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Bone Neoplasm
Multicentric Bone Tumor Imaging Report and Data System
In this study a previously described structured multimodality image report system for the characterization of focal bone lesions is evaluated in a larger patient population.
- Trial name
- BTI-RADS M (NCT04884048)
- Testing
- Radiographs
- Where
- 9 sites in France
- Volunteers
- 1,100 people
- Sponsor
- Central Hospital, Nancy, France
Critical Illness, Anesthesia
Evaluation of Glycemic Variability (GLAIVE)
This study compared two methods of insulin infusion by syringe pumps to assess the impact of medical devices on the glycaemic variability in patients under IIT in ICU.
- Trial name
- GLAIVE (NCT02812927)
- Testing
- Edelvaiss Multiline-8, Standard infusion line
- Where
- France
- Volunteers
- 172 people
- Sponsor
- University Hospital, Lille
Hepatocellular Carcinoma, COVID-19
COVID-19 Infection in Patients With Hepatocellular Carcinoma
Since December 2019, a new disease named COVID-19 linked to a new coronavirus, SARS-CoV2 has emerged in China in the city of Wuhan, Hubei province, spreading very quickly to all 5 continents, and responsible for a pandemic.
- Trial name
- COVID19-CHIEF (NCT04367805)
- Testing
- nasopharyngeal Covid 19 RT-PCR
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens