Clinical trials: sponsored by University of Utah
Knee Osteoarthritis, Knee Osteoarthritis (Knee OA)
Genicular Artery Embolization for Reducing Pain in Medically Refractory Symptomatic Knee Osteoarthritis
Genicular Artery Embolization for Reducing Pain in Symptomatic Knee Osteoarthritis: A Pilot Randomized Sham-Controlled Study (SHAM-PAIN) is a NIH-NIAMS funded project designed to assess enrollment feasibility and detect any…
- Conditions
- Knee Osteoarthritis, Knee Osteoarthritis (Knee OA), Knee Osteoarthritis (OA)
- Trial name
- SHAM-PAIN (NCT06859164)
- Testing
- Genicular Artery Embolization, Lipiodol, Simple angiogram
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Utah
Skin Cancer Prevention, Sun Safety
Regional Efforts to Advance School-based Sun Safety Through Collaboration for Skin Health
This project will deliver a sun safety education presentation to high schools in the mountain west (e.g., Montana, Wyoming, and Idaho) who are at high melanoma risk.
- Trial name
- REACH West (NCT07904572)
- Testing
- REACH West
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- University of Utah
Chronic Pain
Mechanisms of CBD for Chronic Pain
This is a study designed to examine the neurochemical mechanisms associated with Cannabidiol (CBD) versus placebo for chronic non-cancer pain.
- Trial name
- NCT04044729
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Utah
HPV Vaccination, Uptake Vaccination
PREVENT HPV -Related Cancers Trial
This study will serve as one of the first to develop and test the effectiveness of strategies to promote HPV vaccination among diverse rural parents and caregivers of children ages 9-17 years in the Mountain West.
- Conditions
- HPV Vaccination, Uptake Vaccination, Series Completion
- Trial name
- NCT07217145
- Testing
- PREVENT
- Where
- United States
- Volunteers
- 1,455 people, healthy volunteers welcome
- Sponsor
- University of Utah
Congenital Diaphragmatic Hernia
De-implementing Inhaled Nitric Oxide for Congenital Diaphragmatic Hernia
The purpose of this study is to determine if de-implementation of inhaled nitric oxide (iNO) in the post-natal resuscitation/stabilization phase affects the composite outcome of extracorporeal life support (ECLS) use and/or…
- Trial name
- NCT05213676
- Testing
- Inhaled Nitric Oxide (iNO) use, De-implementation of Inhaled Nitric Oxide (iNO) use
- Where
- 19 sites in United States
- Volunteers
- 900 people
- Sponsor
- The University of Texas Health Science Center, Houston
Myelofibrosis
AlloHCT With PegINFa for Myelofibrosis
This is a single site, open-label, dose de-escalation, Phase 1 study of pegylated interferon alfa-2a administered after alloHCT in subjects with primary or secondary myelofibrosis.
- Trial name
- ATIOM (NCT05535764)
- Testing
- Pegylated interferon alpha2a
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Utah
Serious Games, Transition-age Youth
Aim 3: Pilot Study of a Serious Game to Promote Transition Readiness Skills
This study involves testing a new video game designed to support adolescents with congenital heart disease (CHD) in preparing to manage their health independently.
- Conditions
- Serious Games, Transition-age Youth, Transition to Adult Care, Congenital Heart Defect
- Trial name
- NCT07042334
- Testing
- Serious game for transition readiness
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Utah
Burnout, Secondary Trauma
PATH to Reducing Burnout Among Peers Who Deliver Overdose Prevention Services (R33 Phase Clinical Trial)
The investigators propose to test the effectiveness of PATH (Peer Advanced Training for total Health) as an educational workforce intervention for improving peer recovery support specialists' (PRSS) overdose prevention (OP)…
- Conditions
- Burnout, Secondary Trauma, Compassion Fatigue, Opioid Use Disorder
- Trial name
- NCT07886944
- Testing
- PATH (Peer Advanced Training for total Health)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Chestnut Health Systems
Herpes Simplex Oral
Efficacy and Safety of Acyclovir-penciclovir Cream Versus an Abreva in the Suppression of Herpes Simplex Virus Eruptions
This will be a randomized, efficacy assessor-blinded, parallel group, pilot study of up to 40 subjects with documented herpes labialis.
- Trial name
- NCT06558838
- Testing
- acyclovir-penciclovir cream, Abreva
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- University of Utah
Menopause, Vasomotor Symptoms (VMS)
Waning Moon: A Whole Person Health Intervention Designed by and for Urban Menopausal American Indian/Alaska Native Women
This study tests the feasibility and acceptability of Waning Moon, a culturally tailored menopause health intervention developed in partnership with the Urban Indian Center of Salt Lake (UICSL) for American Indian/Alaska Native…
- Conditions
- Menopause, Vasomotor Symptoms (VMS), Women's Health, Health Disparities
- Trial name
- NCT07713095
- Testing
- Waning Moon
- Volunteers
- 30 people
- Sponsor
- University of Utah
Erythrocytosis, Pulmonary Hypertension
Phase IIA Study of Belzutifan in EPAS1-, EGLN1-, or VHL-Mutant Erythrocytosis
Some people develop erythrocytosis, a condition characterized by having too many red blood cells, because of inherited changes (mutations) in genes such as EPAS1, EGLN1, or VHL.
- Conditions
- Erythrocytosis, Pulmonary Hypertension, Thrombosis
- Trial name
- NCT07895966
- Testing
- Belzutifan
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Utah
Primary Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis
Selinexor in Myelofibrosis Refractory or Intolerant to JAK1/2 Inhibitors
This is a phase II, open label, prospective, single-arm study evaluating the efficacy and safety of selinexor in patients with PMF or secondary MF (PPV-MF or PET-MF) who are refractory or intolerant to ruxolitinib and/or any…
- Conditions
- Primary Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis, Post-polycythemia Vera Myelofibrosis
- Trial name
- ESSENTIAL (NCT03627403)
- Testing
- Selinexor
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Utah
Chronic Myelomonocytic Leukemia (CMML)
Cobimetinib in Newly Diagnosed or HMA-treated CMML Patients With RAS Pathway Mutations
This is an open-label, nonrandomized phase 2 trial to assess the efficacy of cobimetinib in RAS pathway activated CMML. All eligible patients will be treated daily with cobimetinib in 28-day cycles.
- Trial name
- CONCERTO (NCT04409639)
- Testing
- Cobimetinib
- Where
- 3 sites in United States
- Volunteers
- 14 people
- Sponsor
- University of Utah
Colorectal Cancer
Social Media and Cancer Screening Information
NORC/AmeriSpeak will recruit participants who meet the study criteria and invite them to complete a 15-minute survey. Participants will be randomly assigned to one of five conditions, with approximately 400 people in each…
- Trial name
- NCT06712901
- Testing
- Median Ranked Cancer Screening Messaging, Overall Preferred Cancer Screening Messaging, Black American Preferred Cancer Screening Messaging
- Where
- United States
- Volunteers
- 2,030 people, healthy volunteers welcome
- Sponsor
- University of Utah
Anticoagulants, Drug Interactions
Shared Decision for Drug Interactions in Oral Anticoagulation
The purpose of this project is to implement and evaluate a shared-decision making (SDM) tool called DDInteract that was developed to support decision making for drug-drugs interactions while on oral anticoagulants.
- Trial name
- DDInteract (NCT06401863)
- Testing
- Shared Decision Making Tool
- Where
- 3 sites in United States
- Volunteers
- 610 people
- Sponsor
- University of Utah
Multiple Myeloma, Plasma Cell Leukemia
Use of Isatuximab, Dexamethasone and Lenalidomide in a Go-Slow Fashion for Ultra-Frail Patients With Multiple Myeloma
Historically, the frailest patients with multiple myeloma are under-represented in clinical trials, and have very high rates of treatment discontinuation, and early treatment mortality.
- Trial name
- UltraFrailMM (NCT06517017)
- Testing
- Isatuximab
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Utah
HIV Infections
Screen Smart: Using Digital Health to Improve HIV Screening and Prevention
The goal of this interrupted time series quasi-experimental design study is to implement universal opt- out HIV testing and linkage to HIV preventive care in 15-21 year old adolescents visiting the pediatric emergency department…
- Trial name
- Screen Smart (NCT06003192)
- Testing
- Universal Opt-out HIV Screening
- Where
- 4 sites in United States
- Volunteers
- 63,000 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Cardiac Arrest (CA)
Physiology-directed Epinephrine Dosing in Pediatric Cardiac Arrest
This is a prospective, observational, multi-center cohort study of pediatric cardiac arrests. The purpose of this study is to evaluate the physiologic response to epinephrine as an outcome discriminator in pediatric in-hospital…
- Trial name
- PEDICA (NCT07890610)
- Where
- 22 sites in United States
- Volunteers
- 1,620 people
- Sponsor
- Children's Hospital of Philadelphia
Stroke
A Novel Multimodal Approach to Promote Motor Recovery and Plasticity After Stroke
Upper extremity (UE) paresis or weakness is one of the most frequent impairments after stroke. Despite intense rehabilitation, motor and functional recovery of patients with severe hand impairments is poor.
- Trial name
- NCT07887880
- Testing
- tRNS (Transcranial Random Noise Stimulation), FES (Functional Electrical Stimulation)-assisted task-specific practice
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- University of Utah
Cardiac Arrest (CA)
Optimal Ventilation for Cardiac Arrest
Pediatric cardiac arrest is a life-threatening problem affecting >15,000 hospitalized children each year. Less than half of these children survive to hospital discharge, and neurologic morbidity is common among survivors.
- Trial name
- OPTI-VENT (NCT07114510)
- Testing
- OPTI-VENT Bundle, Transition, None - control
- Where
- 20 sites in United States
- Volunteers
- 1,530 people
- Sponsor
- Children's Hospital of Philadelphia
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