Find a clinical trial
Lynch Syndrome
Protocol for Non-invasive Gynaecological Surveillance in Lynch Syndrome
Lynch syndrome is the most common inherited condition that raises a person's risk of getting certain cancers. It happens because of changes in genes that normally fix damaged DNA.
- Trial name
- PREDI-ENDO (NCT07877779)
- Where
- United Kingdom
- Volunteers
- 1,450 people
- Sponsor
- University of Edinburgh
Myocardial Infarction, Myocardial Ischemia
Coronary Flow and Myocardial Viability: the FloVITA Study
Evaluation of fractional flow reserve (FFR) is a key method for assessing ischemia with a view to guiding revascularization strategy following acute coronary syndrome.
- Trial name
- FloVita (NCT04818918)
- Testing
- Absolute coronary flow measurement, Microvascular resistance measurement, Cardiac MRI
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Sarcopenia, Acute Stroke
Sarcopenia in Acute Ischemic Stroke
The objective of this observational study is to determine the prevalence of sarcopenia in patients aged 50 years and older with acute ischemic stroke, to characterize its trajectory during the acute phase using instrumental…
- Trial name
- NCT07764172
- Where
- Russia
- Volunteers
- 400 people
- Sponsor
- University Clinical Hospital na V.V.Vinogradov (branch of RUDN university na Patrice Lumumba)
Ischemic Stroke
Stroke-induced Myocardial Dysfunction: Role of GDF-15 (SMOG-15) Clinical Work Package
The aim of this study is to analyze the relationship between the blood biomarker GDF-15 and heart damage after stroke. It is being conducted in France, in the Neurology Department of the Dijon University Hospital (Burgundy).
- Trial name
- SMOG-15 (NCT05683873)
- Testing
- Electrocardiogram, transthoracic echocardiography, standard biology
- Where
- France
- Volunteers
- 130 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Breast Cancer
Factors Associated With Breast Cancer Risks and Outcomes
The purpose of this study is to learn more about risks and outcomes of breast cancer in people with different backgrounds. Tissue and blood will be collected from participants for research purposes.
- Trial name
- NCT07294703
- Testing
- Survey
- Where
- 7 sites in United States
- Volunteers
- 750 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Breast Cancer, Axillary Lymph Nodes Dissection
Audit of Targeted Sentinel Node Biopsy (TSNB) in Patients With Limited Nodal Disease Undergoing Primary Surgery
Axillary ultrasound scan (AUS) is routinely employed in the UK for preoperative axillary staging and can diagnose approximately 50 - 80% of node positive patients when combined with percutaneous needle biopsy techniques (either…
- Conditions
- Breast Cancer, Axillary Lymph Nodes Dissection, Axillary Metastases, Sentinel Lymph Node Biopsy (SLNB)
- Trial name
- NodeSMART (NCT07085442)
- Testing
- Targeted Sentinel Node Biopsy (TSNB)
- Where
- 14 sites in United Kingdom
- Volunteers
- 400 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Cancer, Type 2 Diabetes
QoLIDia: Quality of Life in Cancer Patients With Diabetes During Immunotherapy
The goal of this observational study is to see how type 2 diabetes affects quality of life in cancer patients receiving immunotherapy.
- Trial name
- QoLIDia (NCT07466212)
- Where
- 4 sites in Denmark
- Volunteers
- 920 people
- Sponsor
- Odense University Hospital
Diabetic Retinopathy (DR)
Preliminary Assessment of an Automated Tool for Diabetic Retinopathy Screening
This study is being done to evaluate the performance of a software that uses artificial intelligence to analyze photographs of the retina to help detect diabetic retinopathy.
- Trial name
- NCT07404657
- Testing
- automatic analysis of fundus images performed by the software tool based on artificial intelligence
- Where
- United States
- Volunteers
- 198 people
- Sponsor
- Centervue SpA
Neurofibromatosis 1, Neurofibromatosis 2
The NF Registry Sponsored by the Children's Tumor Foundation
The NF Registry is a database of patient-reported symptoms, treatments, and experiences with their neurofibromatosis disease. It is a contact registry to relay clinical trial opportunities to targeted patient subgroups, and to…
- Conditions
- Neurofibromatosis 1, Neurofibromatosis 2, Schwannomatosis, NF2-related Schwannomatosis
- Trial name
- NCT01885767
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- The Children's Tumor Foundation
MDD, Severe Depression
Sensation Seeking and TMS Response in TRD
his real-world observational study examines whether sensation-seeking personality traits influence the clinical response to transcranial magnetic stimulation (TMS) in patients with treatment-resistant depression (TRD).
- Conditions
- MDD, Severe Depression, Major Depressive Episode
- Trial name
- NCT07889739
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Technical University of Munich
Multiple Sclerosis
Mechanisms of Disease Severity in Multiple Sclerosis: an Integrative Multimodal Study
This study will identify a combination of disease severity markers (genetic, immunology, epigenetic, imaging) associated with disease severity and progression in a cohort of patients with multiple sclerosis.
- Trial name
- SEP-BIO-PROG (NCT03369106)
- Testing
- Composite severity score calculation
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Chronic Disease, Infectious Disorder
Biospecimen Analysis in Detecting Chemical Concentrations in Patients With Chronic or Infectious Diseases Receiving Meditations
This trial collects and analyzes sweat and saliva samples compared to blood in detecting chemical concentrations in the body in patients with chronic or infectious diseases receiving medications.
- Trial name
- NCT04160429
- Testing
- Biospecimen Collection, Medical Chart Review, Questionnaire Administration
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- City of Hope Medical Center
Breastfeeding Cessation
Experiences of Mothers Considering Breastfeeding Cessation: Decision-Making, Method Exploration, and Support Needs
This study aims to explore the experiences of mothers who are currently breastfeeding their children but are considering stopping breastfeeding.
- Trial name
- NCT07890142
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
B-Cell Non-Hodgkin Lymphoma (NHL)
Non-Interventional Study of Ranicabtagene Autoleucel Injection for Relapsed/Refractory B-cell Non-Hodgkin Lymphoma
Establishing real-world data of patients with relapsed/refractory B-cell non-Hodgkin lymphoma (r/r B-NHL) treated with Ranicabtagene Autoleucel Injection to evaluate its efficacy and safety.
- Trial name
- NCT07888530
- Testing
- Ranicabtagene Autoleucel Injection
- Volunteers
- 200 people
- Sponsor
- Hrain Biotechnology Co., Ltd.
Physical Therapy Evaluation
Analysis of a Stepped-Wedge Implementation of the PT-PENCIL Tool
Despite the need to evolve, the fact that physical therapists are a constrained resource prompts the need for care prioritization that is optimally targeted.
- Trial name
- PT-PENCIL Tool (NCT05964205)
- Testing
- Electronic clinical decision support tool
- Where
- United States
- Volunteers
- 9,704 people
- Sponsor
- Brittany Lapin
COVID-19
COVID-19 Immunity and Changes Over Time
The risk of household spread of SARS-CoV-2 hinges on both the transmission dynamics of the virus circulating in the community as well as the seroprotection pattern of constituent members, which can be attributed to vaccination…
- Trial name
- NCT05271669
- Where
- China
- Volunteers
- 1,350 people
- Sponsor
- Chinese University of Hong Kong
Pulmonary Hypertension, Pulmonary Arterial Hypertension
Artificial Intelligence-assisted Evaluation of Pulmonary HYpertension
Pulmonary hypertension represents a challenging and heterogeneous condition that is associated with high mortality and morbidity if left untreated.
- Trial name
- AIPHY (NCT05566002)
- Testing
- Right heart catheterization
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Chinese Pulmonary Vascular Disease Research Group
Radiation Treatment, Neurovascular Complications
Long-term Neurovascular Complications After Radiation Therapy in Head and Neck Cancer
Head and neck cancer is a group of cancers develop from the soft tissues, salivary gland, mucosa of the upper respiratory or digestive system covering the oral and nasal cavity.
- Trial name
- NCT06111430
- Where
- Taiwan
- Volunteers
- 800 people
- Sponsor
- Chang Gung Memorial Hospital
End-stage Liver Disease (ESLD), Acute Liver Failure
Establishing a Reference Framework for Outcomes After Machine-Preserved Liver Transplantation in Europe
Machine perfusion (MP) has become routine clinical practice in liver transplantation. However, as the field has matured, direct randomized comparisons between distinct MP modalities have become increasingly impractical, given…
- Conditions
- End-stage Liver Disease (ESLD), Acute Liver Failure, Liver Cirrhosis, Liver Transplantation
- Trial name
- REFRAME-MP (NCT07585890)
- Testing
- Endischemic hypothermic oxygenated machine perfusion (any device), Endischemic (back-to-base) normothermic machine perfusion (any device), Continuous (device-to-donor) normothermic machine perfusion (any device)
- Where
- 37 sites in Austria, Belgium and 8 more
- Volunteers
- 10,000 people
- Sponsor
- University Medical Center Groningen
Critical Illness
Multidimensional Dysfunction in Patients With Chronic Critical Illness in China
Over the past two decades, rapid advances in critical care medicine have markedly reduced short-term mortality among critically ill patients.
- Trial name
- NCT07585578
- Testing
- Data Collection and Assessment
- Where
- 4 sites in China
- Volunteers
- 888 people
- Sponsor
- Hongying Jiang, MD