Clinical trials: sponsored by Case Comprehensive Cancer Center
Gastrointestinal Cancer, Colon Cancer
EQUITY GI: A Prospective Study to Enhance Quality, Inclusivity, and Trial Participation in Black Patients With Gastrointestinal Cancer.
This research study is being conducted to improve the quality of care of participants who have a diagnosis of gastrointestinal cancer (anal, colon, rectal, esophageal, stomach, small bowel, appendix, pancreas, gall bladder…
- Conditions
- Gastrointestinal Cancer, Colon Cancer, Rectal Cancer, Anal Cancer
- Trial name
- NCT06263088
- Testing
- EQUITY GI
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Case Comprehensive Cancer Center
Prostate Cancer, Malignant Neoplasm of Prostate
MDRT in Prostate Cancer Treated With Long-term Androgen Deprivation Therapy in the STAMPEDE Trial (METANOVA)
The purpose of this study is to find out if giving radiation therapy (RT) to areas of metastatic prostate cancer at the time a participant is diagnosed will help control disease better than the usual treatment.
- Conditions
- Prostate Cancer, Malignant Neoplasm of Prostate, Secondary Malignant Neoplasm of Prostate
- Trial name
- NCT06150417
- Testing
- Androgen deprivation therapy (ADT), Androgen receptor signaling inhibitor (ARSI), Local Therapy: Radical Prostatectomy (RP) or Radiotherapy (RT)
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- Case Comprehensive Cancer Center
Colorectal Cancer, Liver Metastases
Histotripsy Plus Chemotherapy vs Chemotherapy Alone for Advanced Colorectal Liver Metastasis
The goal of this clinical trial is to learn if histotripsy plus chemotherapy works to treat unresectable, bilobar liver- confined colorectal cancer liver metastasis (CRLM).
- Conditions
- Colorectal Cancer, Liver Metastases, Liver Cancer
- Trial name
- NCT07044362
- Testing
- HistoSonics Edison® System, Chemotherapy
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Case Comprehensive Cancer Center
Cancer
Artificial Intelligence-Powered Support For Quality Of Life Improvement In Participants With Cancer
This research study is for people who are diagnosed with cancer and are receiving treatment for cancer who may benefit from psychotherapy.
- Trial name
- NCT07167056
- Testing
- Standard of Care Psychotherapy, WYSA App
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Case Comprehensive Cancer Center
Prostate Cancer, Prostatic Neoplasm
Investigation of Impact of AI on Prostate Cancer Workflow
This study will enroll participants who are undergoing an MRI before a prostate biopsy due to suspected prostate cancer. The purpose of this study is to see if the use of Artificial Intelligence (AI) helps detect lesions on an…
- Conditions
- Prostate Cancer, Prostatic Neoplasm, Cancer of the Prostate, Neoplasms, Prostate
- Trial name
- NCT07084779
- Testing
- AI
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Case Comprehensive Cancer Center
Glioblastoma, Venous Thromboembolism
Glioblastoma Remote Monitoring and Care - Research Protocol
The purpose of this research is to learn more about how what the Apple watch measures, in terms of walking data, heart rate, breathing rate, and sleep habits, relates to how participants feel.
- Conditions
- Glioblastoma, Venous Thromboembolism, Seizures
- Trial name
- NCT06129760
- Testing
- Apple Watch
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Case Comprehensive Cancer Center
Educational Intervention, Minorities
Patient Navigator PRE-ACT Educational Intervention to Promote Decision Making Among Minorities
This study focuses on psychosocial barriers at the patient level with the goal of promoting high quality decision making around clinical trials participation.
- Trial name
- NCT05701085
- Testing
- Educational Intervention
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Case Comprehensive Cancer Center
Glioblastoma Multiforme, Glioblastoma Multiforme, Adult
hSTAR GBM (Hematopoetic Stem Cell (HPC) Rescue for GBM)
This phase II trial studies the effect of P140K MGMT hematopoietic stem cells, O6-benzylguanine, temozolomide, and carmustine in treating participants with supratentorial glioblastoma or gliosarcoma who have recently had surgery…
- Conditions
- Glioblastoma Multiforme, Glioblastoma Multiforme, Adult, Supratentorial Glioblastoma, Supratentorial Gliosarcoma
- Trial name
- hSTAR GBM (NCT05052957)
- Testing
- P140K-MGMT, O6-benzylguanine, Photon Based Radiotherapy
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Leland Metheny
Acute Lymphocytic Leukemia
Inotuzumab Ozogamicin Post-Transplant For Acute Lymphocytic Leukemia
This study has two phases, Phase I and Phase II. The main goal of the Phase I portion of this research study is to see what doses post-transplant inotuzumab ozogamicin can safely be given to subjects without having too many side…
- Trial name
- NCT03104491
- Testing
- Inotuzumab Ozogamicin
- Where
- 7 sites in United States
- Volunteers
- 44 people
- Sponsor
- Leland Metheny
Acute Myelogenous Leukemia, Acute Lymphatic Leukemia
ABBA CORD: dCBT w/ Abatacept for aGVHD Prophylaxis
The goal of this clinical trial is to see if adding abatacept to tacrolimus and MMF prevents or reduces the chances of acute graft versus host disease which is a complication that can occur after transplant in participants with…
- Conditions
- Acute Myelogenous Leukemia, Acute Lymphatic Leukemia, Chronic Myelogenous Leukemia, Myelodysplastic Syndromes
- Trial name
- NCT06680661
- Testing
- Cyclophosphamide, Fludarabine, Thiotepa
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Leland Metheny
Non Hodgkin Lymphoma, B-cell Non Hodgkin Lymphoma
Rituximab (Rtx) + Tafasitamab in Combination With Allogeneic NK Cells for Treatment of Relapsed/Refractory (r/r) B-cell Non-Hodgkin Lymphoma (NHL)
This research study is for people who have relapsed or refractory B-cell non-Hodgkin's lymphoma (NHL) that has not responded to two or more lines of therapy.
- Conditions
- Non Hodgkin Lymphoma, B-cell Non Hodgkin Lymphoma, Diffuse Large B Cell Lymphoma, High-grade B-cell Lymphoma
- Trial name
- NCT07225439
- Testing
- Allogeneic NK cells, Rituximab, Tafasitamab
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Paolo Caimi, MD
Leptomeningeal Metastasis
Wearable-Triggered Digital Safety Net for Real-Time Monitoring & Intervention in Leptomeningeal Metastasis
This research study is for participants diagnosed with leptomeningeal metastasis disease (LMM), a condition where cancer has spread to the fluid and membranes surround the brain and spinal cord.
- Trial name
- NCT07704034
- Testing
- Calibration Phase, Stepped Wedge Intervention Phase
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Case Comprehensive Cancer Center
Breast Cancer, Breast Cancer Stage I
Herbs & Supplements in Breast Cancer Usage, Impact, and Personalized Approaches for Diverse Populations
This research study is enrolling participants diagnosed with breast cancer and receiving/received chemotherapy and/or endocrine therapy.
- Conditions
- Breast Cancer, Breast Cancer Stage I, Breast Cancer Stage II, Breast Cancer Stage III
- Trial name
- NCT06926530
- Testing
- No intervention
- Where
- 2 sites in United States
- Volunteers
- 240 people
- Sponsor
- Case Comprehensive Cancer Center
Marker; Structural
Fatty Acid Binding Proteins and Markers of Cellular Senescence in Cancer Survivors
The purpose of this research study is to investigate whether cancer survivors have higher levels of proteins called Fatty Acid Binding Proteins as well as 12 different markers of cellular senescence than people who have never had…
- Trial name
- NCT07114614
- Testing
- Specimen #1, Specimen #2
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Case Comprehensive Cancer Center
Brain Tumor
Multi-Parametric Quantitative MR Imaging in Evaluation of Brain Tumors
The purpose of the research study is to test new methods that could improve diagnosis and assessment of brain tumors. One of these methods is a new MR (magnetic resonance) imaging technique called magnetic resonance…
- Trial name
- NCT02956291
- Testing
- Magnetic Resonance Fingerprinting
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Case Comprehensive Cancer Center
Large B-cell Lymphoma, Central Nervous System Lymphoma
Golcadomide With Pemetrexed, Rituximab, and Dexamethasone for Relapsed and Refractory CNS Lymphomas
This research study is for people who have been diagnosed with large B-cell lymphoma of the central nervous system (CNS), which has either returned or is not responding to current treatment.
- Trial name
- NCT07608731
- Testing
- Golcadomide, Pemetrexed, Rituximab
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Allison Winter
Colorectal Cancer, Low Anterior Resection Syndrome
Transanal Irrigation for the Management of Early Low Anterior Resection Syndrome (LARS)
Transanal irrigation (TAI) has shown to improve fecal incontinence and increase quality of life in patients with low anterior resection syndrome (LARS).
- Trial name
- NCT07219745
- Testing
- Peristeen Plus Irrigation kit, LARS mobile application
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Case Comprehensive Cancer Center
Esophageal Adenocarcinoma, Esophageal Cancer
Liquid Nitrogen Spray Cryotherapy Prior to Neoadjuvant Systemic Therapy in Esophageal Adenocarcinoma
This research study is for people who have locally advanced esophageal adenocarcinoma and are expected to receive chemotherapy. The purpose of this study is to compare the effectiveness of Liquid Nitrogen Spray Cryotherapy (LNSC)…
- Trial name
- NCT07222657
- Testing
- Standard of care chemotherapy, LNSC
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Case Comprehensive Cancer Center
Nonmelanoma Skin Cancer, Basal Cell Carcinoma
Vitamin D Effects on Immune Microenvironment of Nonmelanoma Skin Cancer After Photodynamic Therapy (PDT)
This research study is for people who have been diagnosed with a nonmelanoma skin cancer (either basal cell carcinoma or squamous cell carcinoma) and are planning to receive either Mohs surgery or ED\&C (electrodessication \&…
- Conditions
- Nonmelanoma Skin Cancer, Basal Cell Carcinoma, Squamous Cell Carcinoma
- Trial name
- NCT07241585
- Testing
- Vitamin D (VitD), Photodynamic therapy (PDT), Mohs surgery or electrodessication & curettage (ED&C) (standard of care)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Case Comprehensive Cancer Center
Multiple Myeloma, Monoclonal Gammopathy of Undetermined Significance
Early Detection of Multiple Myeloma to Fight Cancer Disparities: A Screening and Patient Navigation Program
This project will pilot the expansion of the existing Taussig Outreach Program's community outreach and patient navigation model to study the multiple myeloma (MM) screening program.
- Conditions
- Multiple Myeloma, Monoclonal Gammopathy of Undetermined Significance, Smoldering Multiple Myeloma
- Trial name
- NCT05831358
- Testing
- Multiple Myeloma M-Protein Analysis, Multiple Myeloma Knowledge Questionnaires
- Where
- United States
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center