Clinical trials: sponsored by IRCCS Eugenio Medea
Autism Spectrum Disorder
Comutti - A Research Project Dedicated to Finding Smart Ways of Using Technology for a Better Tomorrow for Everyone, Everywhere.
According to World Health Organization, worldwide one in 160 children has an ASD. About around 25% to 30% of children are unable to use verbal language to communicate (non-verbal ASD) or are minimally verbal, i.e., use fewer than…
- Trial name
- COMUTTI (NCT05149144)
- Testing
- Clinical evaluation of participants by means of Autism Diagnostic Observation Schedule, audio signal dataset creation and validation; machine learning analysis, empirical evaluations
- Where
- Italy
- Volunteers
- 33 people
- Sponsor
- IRCCS Eugenio Medea
Neuromotor Impairments
Multicenter Study That Offers New Solutions for Paediatric Rehabilitation by Proposing a Rehabilitation Plan Based on Each Child's Needs Using New Technological and Robotic Devices, Combined Among Them.
The goal of this clinical trial is to demonstrate the efficacy of multi domain robotic and technological rehabilitation on everyday life and satisfaction in children with neuromotor conditions.
- Trial name
- MultiTECHChild (NCT06666829)
- Testing
- Multidomain intervention, Single domain intervention
- Where
- 6 sites in Italy
- Volunteers
- 194 people
- Sponsor
- IRCCS Fondazione Stella Maris
Hereditary Spastic Paraplegia
Robot-assisted Walking Treatment in Hereditary Spastic Paraplegia (HSP)
Patients will undergo a combined rehabilitation treatment consisting of 15 sessions on Lokomat and 15 sessions of physical therapy over three weeks for a total of 30 sessions. Two sessions/day for 5 days a week.
- Trial name
- NCT06728787
- Testing
- Robot-Assisted Gait Training
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS Eugenio Medea
Congenital Disorders
Congenital Disability and Rehabilitation: the TOPS Program
The study aims at evaluating the feasibility and the efficacy of the Teen On-line Problem Solving program (TOPS) in improving executive functioning and behavior problems in adolescents aged 11-19 years with congenital disability…
- Trial name
- TOPS (NCT04293705)
- Testing
- Teen On-line Problem Solving
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- IRCCS Eugenio Medea
Neurological Diseases or Conditions
Rehabilitation Through the Italian Version of the Teen Online Problem-Solving (TOPS) Program
The study aims at evaluating the feasibility and the efficacy of the Teen On-line Problem Solving program (TOPS) in improving executive functioning and behavior problems in adolescents with neurological condition aged 11-19…
- Trial name
- TOPS (NCT05169788)
- Testing
- Teen On-line Problem Solving
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- IRCCS Eugenio Medea
Cerebral Palsy
enGIneering For sporT for All
hemiplegia is a pathological condition that affects one side of the body which is associated with difficulty in maintaining an upright posture and walking and which is commonly compensated for by using orthoses (AFO).
- Trial name
- GIFT (NCT04794114)
- Testing
- experimental ankle foot orthosis, traditional ankle foot orthosis
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS Eugenio Medea
Cerebral Palsy
Cp eArly REhabilitation
The present study aims to investigate the efficacy of play-based rehabilitation delivered as usual care in children with cerebral palsy in a rehabilitation center offering both intensive and extensive care.
- Trial name
- iCARE (NCT06737471)
- Testing
- Intensive rehabilitation treatment, Extensive rehabilitation treatment
- Where
- 6 sites in Italy
- Volunteers
- 96 people
- Sponsor
- IRCCS Eugenio Medea
Epilepsies, Partial, Epilepsy Intractable
Contribution of Genetics, Non-invasive Methods and Neuropsychology in Focal Cryptogenic Epilepsies
Patients with cryptogenic focal epilepsy (unknown cause) represent about the 30% of the entire population of epilepsy patients. Among them, about 30% are drug-resistant.
- Trial name
- NCT05015868
- Testing
- Standard of care, Functional magnetic resonance imaging-Electroencephalogram combined analysis, High density- electroencephalogram or 7 Tesla magnetic resonance imaging
- Where
- Italy
- Volunteers
- 5 people
- Sponsor
- IRCCS Eugenio Medea
ADHD - Attention Deficit Disorder With Hyperactivity
Sustained Endogenous Attention Deficits in Attention Deficit Hyperactivity Disorder
Subjects with ADHD may exhibit deficits in sustained internal attention. The "Sustained-Paced Finger Tapping" test was recently developed and experimentally used in international literature to assess sustained internal attention…
- Trial name
- NCT06900400
- Testing
- Sustained-Paced Finger Tapping" (Petilli et al., 2018)
- Where
- 2 sites in Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
ADHD
Experimental Research on the Training of Executive Functions Through the APP "The Apollo & Rosetta Adventures" (E-FAR) in Children with ADHD (8-13 Yrs)
ADHD is one of the most prevalent neurodevelopmental disorders, with a strong impact on general functioning and in daily life. Executive Functions play an important role on this disorder, and numerous treatments have been…
- Trial name
- E-FAR (NCT06881719)
- Testing
- The Adventures of Apollo & Rosetta
- Where
- 2 sites in Italy
- Volunteers
- 35 people
- Sponsor
- University of Milano Bicocca
Movement Disorders, Treatment
High-tech Rehabilitation Impact on Muscle MRI
The use of high-tech techniques is becoming increasingly popular in the rehabilitation field, where the use of exoskeletons, robots, virtual reality, etc. allow for customized rehabilitation protocols.
- Trial name
- NCT06884956
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS Eugenio Medea
Autism Spectrum Disorder, Infant Development
Experimental Techniques for Early Identification of Autism
This project deals with essential challenges in the context of Autism Spectrum Disorder, benefiting from a longitudinal design in infancy and a cutting-edge electroencephalogram/eye-tracking integrated approach.
- Trial name
- NCT05712512
- Testing
- Neurodevelopmental assessment, Electrophysiological and eyetracking recordings
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Eugenio Medea
Neurodevelopmental Disorder (Diagnosis), Epilepsy
Characterization of Neurocognitive Profiles in Neurodevelopmental Disorders and Epilepsy: a Transdiagnostic Approach
Neurodevelopmental disorders (NDDs) are early-onset conditions affecting personal, social, and academic functioning, with high comorbidity rates and shared neurobiological traits.
- Trial name
- DIS-Neurodev (NCT06877260)
- Testing
- Computer based task with EEG
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Autism Spectrum Disorder, Early Intervention
Biomarkers Trajectories of Early Intervention in Siblings of Children with Autism Spectrum Disorder
This project deals with essential challenges in the context of Autism Spectrum Disorder benefiting from a prospective design in childhood, early intervention and a cutting-edge experimental techniques.
- Trial name
- NCT05614206
- Testing
- Behavioral intervention based on Applied Behavior Analysis principles
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Duchenne / Becker Muscular Dystrophy, Osteogenesis Imperfecta (OI)
Social Cognition in Dystrophinopathies and Neurodevelopmental Disorders
The primary aim of this observational study is to investigate specific aspects of social cognition in dystrophinopathies. Body awareness, interpersonal distance and emotional processing will be measured in a sample of patients…
- Conditions
- Duchenne / Becker Muscular Dystrophy, Osteogenesis Imperfecta (OI), Social Cognition
- Trial name
- NCT06874166
- Testing
- Electroencephalography (EEG), Social Cognition Tasks
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Neurodevelopmental Disorder (Diagnosis)
Expanding NGS Data with Optical Genome Mapping (OGM)
Over 50% of pediatric neurological and neurodevelopmental disorders lack a molecular diagnosis after standard DNA sequencing and molecular karyotyping.
- Trial name
- OGM (NCT06851377)
- Testing
- Optical Genome Mapping (OGM) and Whole Genome Sequencing (WGS), Trascriptome analysis
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS Eugenio Medea
Cerebral Palsy, Healthy Volunteers
Assessment of Navigation Abilities in Children With Cerebral Palsy and Their Peers
Spatial navigation skills are very important in everyday activities and quality of life but spatial navigation abilities are not part of the standard process of assessment and rehabilitation of patients.
- Trial name
- NCT06320106
- Testing
- Virtual Reality baseline assessment
- Where
- Italy
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Posterior Fossa Tumor
Intensive Physiotherapy in Children Affected by Posterior Fossa Tumors
The objective of the current study is to describe the effectiveness of conventional and intensive physiotherapeutic intervention in improving gross motor skills (i.e.
- Trial name
- NCT06832384
- Testing
- intensive physiotherapy
- Where
- 3 sites in Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS Eugenio Medea
Cerebral Palsy
Observational Study for the Epidemiology of Cerebral Palsy in Italy
BACKGROUND AND RATIONALE Cerebral Palsy (CP) is the leading cause of childhood disability, with an estimated prevalence of 2 to 2.5 per 1,000 births.
- Trial name
- DataNetCP (NCT06813586)
- Testing
- hospital-based registry
- Where
- 3 sites in Italy
- Volunteers
- 300 people
- Sponsor
- IRCCS Fondazione Stella Maris
Neurodevelopmental Disorders, Irritability
AP Metabolism Transcriptomics
It is known from the literature that treatment with antipsychotic drugs (AP) induces, even before changes in blood chemistry parameters, changes in gene transcription that are evident at the level of peripheral blood mononuclear…
- Trial name
- NCT06814314
- Testing
- Transcriptomic investigation
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Eugenio Medea