Clinical trials: sponsored by University Hospital, Angers
Postoperative Ileus
Study of the Efficience of Chewing-gum to Reduce the Duration of Postoperative Ileus
Postoperative ileus (POI) is a serious complication after surgery. While it complicates all type of surgery, it is more frequent after abdominal surgery (especially bowel or colorectal surgery).
- Trial name
- CHEWIP (NCT05296967)
- Testing
- chewing
- Where
- 6 sites in France
- Volunteers
- 128 people
- Sponsor
- University Hospital, Angers
Hepato Cellular Carcinoma (HCC), Intrahepatic Cholangiocarcinoma
Outpatient Versus Inpatient Care Pathway for Intra-arterial Treatment of Primary Liver Cancer (CHOC)
Randomized multicentre trial comparing two care organisations (ambulatory vs conventional inpatient) for patients undergoing transarterial chemoembolization (TACE) or radioembolization (TARE) for primary liver cancer (Hepato…
- Trial name
- CHOC (NCT06990659)
- Testing
- Ambulatory care, Conventional inpatient care
- Where
- 19 sites in France
- Volunteers
- 206 people
- Sponsor
- University Hospital, Angers
Acute Myeloid Leukemia (AML)
Study to Improve OS in 18 to 60 Year-old Patients, Comparing Daunorubicin Versus High Dose Idarubicin Induction Regimens, High Dose Versus Intermediate Dose Cytarabine Consolidation Regimens, and Standard Versus MMF Prophylaxis of GvHD in Allografted Patients in First CR
This open label, multicenter phase II/III study with multiple randomization phases at differents stages of AML treatment (induction, consolidation and HSCT where applicable) is designed to improve OS in younger (18 to 60…
- Trial name
- BIG-1 (NCT02416388)
- Testing
- Idarubicin, Daunorubicin, HD Cytarabine
- Where
- 56 sites in France
- Volunteers
- 3,100 people
- Sponsor
- University Hospital, Angers
Acute Heart Failure (AHF), Pulmonary Embolism (Diagnosis)
Pulmonary Embolism in Patients With Acute Heart Failure (PEHF Study)
This study focuses on two serious and common medical conditions: heart failure and pulmonary embolism (a blood clot in the lungs).
- Conditions
- Acute Heart Failure (AHF), Pulmonary Embolism (Diagnosis), Venous Thromboembolism
- Trial name
- PEHF (NCT07499661)
- Testing
- Systematic screening for pulmonary embolism in all patients using a guideline-recommended diagnostic algorithm
- Where
- 10 sites in France
- Volunteers
- 740 people
- Sponsor
- University Hospital, Angers
Pulmonary Embolism
Diagnostic Strategy for Suspected Pulmonary Embolism Based on 4PEPS
The increased use of diagnostic imaging and especially computed tomography pulmonary angiography in patients suspected of pulmonary embolism (PE) is an important point of concerns.
- Trial name
- SPEED&PEPS (NCT06015529)
- Testing
- 4PEPS strategy
- Where
- 23 sites in Belgium, France
- Volunteers
- 3,084 people
- Sponsor
- University Hospital, Angers
Low Back Pain
Effectiveness of Coordinated Care to Reduce the Prolonged Disability Risk Among Patients Suffering From Low Back Pain in Primary Care
Common low back pain affects about 23% of general population and can be associated with psychosocial difficulties and prolonged inability to work.
- Trial name
- COLOMB (NCT04826757)
- Testing
- Coordinated care
- Where
- 20 sites in France
- Volunteers
- 220 people
- Sponsor
- University Hospital, Angers
Cushing Syndrome, Fatty Liver Disease
NAC- NAFLD And Cushing
Cushing's Syndrome is a rare disease resulting from prolonged exposure to high levels of circulating cortisol. Clinical manifestations are variable but many patients present a metabolic syndrome (abdominal obesity, insulin…
- Trial name
- NAC (NCT05881005)
- Testing
- hepatic MRI
- Where
- 7 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Angers
Therapy, Pleural Infections
Comparison of Early Pleural Irrigation Strategy With Saline to the Standard of Care for the Management of Complicated Pleural Infections.
Intrapleural enzyme therapy (IET) is regarded by recent guidelines as a "rescue" therapy for managing complicated pleural infections; however, it is associated with significant side effects, including pleural bleeding, pain, and…
- Trial name
- EPISSOC (NCT07666464)
- Testing
- intrapleural irrigation, Standard care
- Where
- France
- Volunteers
- 244 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Non-alcoholic Fatty Liver Disease (NAFLD), Alcoholic Liver Disease (ALD)
Screening in Primary Care of Advanced Liver Fibrosis in NAFLD and/or Alcoholic Patients
The primary objective of the SOPRANO study is to compare two blood fibrosis tests, the eLIFT and the FibroMeter, for the screening of advanced liver fibrosis in patients with NAFLD and/or ALD from primary care centers.
- Conditions
- Non-alcoholic Fatty Liver Disease (NAFLD), Alcoholic Liver Disease (ALD), Liver Fibrosis
- Trial name
- SOPRANO (NCT05699018)
- Testing
- eLIFT
- Where
- 13 sites in France
- Volunteers
- 1,788 people
- Sponsor
- University Hospital, Angers
Barrett Esophagus, Dysplasia
A Study Comparing the Effectiveness of EndoRotor Versus Radiofrequency in Treating Barrett's Esophagus
Barrett Esophagus is a common pathology, with an estimated prevalence of 1.6% at risk of progression to precancerous mucosa (low to high grade dysplasia). The incidence of adenocarcinoma on BE is 0.5% per year.
- Trial name
- ENDOBARRETT (NCT04867590)
- Testing
- Endorotor, Radiofrequency
- Where
- 17 sites in France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Angers
Elderly Inpatients
Evaluation of a Prototype for an Innovative Room for the Elderly
The Groupement de Coopération Sanitaire des Hôpitaux Universitaires du Grand Ouest (GCS HUGO) (health cooperation group for university hospitals in the west of France), is proposing to improve the quality of geriatric care by…
- Trial name
- HOSPISENIOR (NCT06098534)
- Testing
- Hospi'Senior, Conventional room
- Where
- 5 sites in France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Angers
Patient With Indication for Major Abdominal Submesocolic, Parietal, Left Pancreatic or Liver Surger
Evaluation of the Value of Ultrasound Measurement of Stomach Diameter in Predicting Postoperative Nausea/Vomiting
The advent of enhanced rehabilitation after surgery has helped to reduce surgical stress, thereby improving postoperative outcomes by reducing the time it takes for patients to recover their transit and autonomy.
- Trial name
- EVOL2 (NCT07063069)
- Testing
- Abdominal ultrasound
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Angers
Rare Diseases, Genetic Disease
Functional Study to Indentify Genetic Etiology of Rare Diseases - ORIGIN
Next generation sequencing (NGS) allows some better diagnostic results, particularly, in the rare diseases field. At a twenty five percent rate, those exams highlight some variants which are not yet described in human pathology.
- Trial name
- ORIGIN (NCT05499091)
- Testing
- Skin biopsy, blood sample, urine sample
- Where
- France
- Volunteers
- 1,200 people
- Sponsor
- University Hospital, Angers
Hepatic Veno-Occlusive Disease, Nephroblastoma
Pharmacogenetic Study of Antimitotic Therapies Involved in Hepatic VOD in Children With Nephroblastoma or ALL
Hepatic veno-occlusive diseases (VOD) during cancer treatment in children are serious toxicities that have occurred with interruptions of chemotherapy and risk of relapse.
- Conditions
- Hepatic Veno-Occlusive Disease, Nephroblastoma, Acute Lymphoblastic Leukemia
- Trial name
- MVO (NCT04168788)
- Testing
- Blood test for genetic analysis
- Where
- 11 sites in France
- Volunteers
- 85 people
- Sponsor
- University Hospital, Angers
Neurodevelopmental Disorders and Developmental Abnormalities
Transcriptomic Approach for the Identification and Prioritization of Genome Variants in Neurodevelopmental Disorders With Malformation
Three million persons in France are impacted by rare diseases. Amid the 7000 different diseases which are identified today, neurodevelopmental disorders are the main symptoms found interesting 35 000 birth every years, according…
- Trial name
- ATOMICS (NCT06762678)
- Testing
- RNA sequencing and whole genome sequencing in a trio way
- Where
- 7 sites in France
- Volunteers
- 58 people
- Sponsor
- University Hospital, Angers
Acute Renal Failure
Measurement of Iohexol Plasma Clearance in Patients Leaving ICU After Acute Renal Failure
IOXSOR study's purpose to determine the frequency of non resolutive renal failure (estimated by the clearance of iohexol) at end of stay in ICU patients who have had acute renal failure episode.
- Trial name
- IOXSOR (NCT02961478)
- Testing
- IOHEXOL
- Where
- 11 sites in France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Angers
Cesarean Section; Dehiscence
The Impact of Cesarean Scar Defects on the Success of Assisted Human Reproduction
The prevalence of Caesarean sections continues to increase around the world. In France, the proportion of Caesarean sections has doubled from 11% in 1981 to 20,2% in 2016, bringing with it an increase in the risk of obstetrical…
- Trial name
- NICHE-ART (NCT04869007)
- Testing
- hysterosonography
- Where
- 5 sites in France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Angers
Time Between Hysterectomy and Resumption of Sexual Relations, Sexual Function
Impact of Time on Sexual Function (FSFI® Score) After Hysterectomy
In France, more than 62 000 hysterectomies are performed each year. Female sexual function is the result of multiple psychological, social and physiological factors.
- Trial name
- ISHYS (NCT05728281)
- Testing
- Recommended time after hysterectomy
- Where
- France
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Early Pregnancy Loss, Spontaneous Miscarriage
Interest of Simulation Training on the Announcement of Early Pregnancy Loss on the Psychological Impact of the Patients
Early pregnancy loss (or spontaneous miscarriage) is the loss of a pregnancy before 14 weeks of amenorrhea. Its incidence is estimated at between 10 and 15%, and increases with maternal age.
- Trial name
- MISC-TRAIN (NCT06647849)
- Testing
- centers whose interns receive simulation training in the announcement of early spontaneous miscarriage between the 2 inclusion phases, centers with standard in-house management of spontaneous miscarriage/pregnancy arrested in the emergency department
- Where
- 28 sites in France
- Volunteers
- 607 people
- Sponsor
- University Hospital, Angers
Venous Thromboembolism, Deep Vein Thrombosis
RIVAroxaban Versus Low-molecular Weight Heparin in Patients With Lower Limb Trauma Requiring Brace or CASTing
Lower limb trauma requiring immobilization is a very frequent condition that is associated with an increased risk of developing venous thromboembolism (VTE).
- Conditions
- Venous Thromboembolism, Deep Vein Thrombosis, Pulmonary Embolism, Lower Limb Trauma
- Trial name
- RIVACAST (NCT06195540)
- Testing
- Rivaroxaban 10 MG, Low Heparin Molecular Weight
- Where
- 37 sites in France
- Volunteers
- 1,424 people
- Sponsor
- University Hospital, Angers