Clinical trials: sponsored by University of Colorado, Denver
Amputation, Transfemoral Amputation
Transfemoral Osseointegrated Prosthesis Limb-Load Symmetry Training
This randomized controlled trial (n=25 enrolled, n=15 expected to complete) will 1) determine the feasibility of a 40-week limb-load biofeedback training intervention, 2) determine if there is an intervention signal of efficacy…
- Conditions
- Amputation, Transfemoral Amputation, Osseointegration
- Trial name
- TOPLOAD (NCT05695911)
- Testing
- Limb Load Biofeedback Training Intervention, Attention Control
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Colorado, Denver
Refractory Acute Myeloid Leukemia (AML), Relapsed Acute Myeloid Leukemia (AML)
CD64 CAR T Cell Therapy in Adults With Relapsed and/or Refractory AML
This is a Phase 1, open label, dose-escalation study to evaluate the safety, expansion, persistence, and preliminary clinical activity of lentivirally transduced autologous T cells expressing anti-CD64 chimeric antigen receptors…
- Conditions
- Refractory Acute Myeloid Leukemia (AML), Relapsed Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome, AML (Acute Myeloid Leukemia)
- Trial name
- NCT07347418
- Testing
- CD64 CAR T Cells
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Colorado, Denver
Elevated Caregiver Strain, Dementia Caregiver
Leveraging Interventions for Caregiver Growth, Health, Training, Empowerment and Navigation: Comparing Group Behavioral Interventions to Improve Dementia Caregiver Strain
The goal of this clinical trial is to compare two group-based interventions for caregivers of persons with memory loss (N=450) delivered via telehealth.
- Conditions
- Elevated Caregiver Strain, Dementia Caregiver, Caregiver Stress
- Trial name
- LIGHTEN (NCT07868588)
- Testing
- Caring Together, Savvy Caregiver
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- Massachusetts General Hospital
Pelvic Pain, Pelvic Floor Dysfunction
HOme PElvic Floor Improvement Trainer Trial
This study will gauge the efficacy of a home biofeedback treatment device for pelvic floor dysfunction/voiding dysfunction and pelvic pain.
- Conditions
- Pelvic Pain, Pelvic Floor Dysfunction, Voiding Dysfunction
- Trial name
- HoPe FIT (NCT06909539)
- Testing
- Home Pelvic Floor Trainer
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Colorado, Denver
Amputation, Transtibial Amputation - Unilateral
Influence of Prosthetic Foot Stiffness on Transtibial Osseointegrated Bone-Anchored Limb Outcomes
A clinical trial utilizing cross-over study design in which individuals with transtibial amputation using either a bone-anchored limb or standard socket prosthesis will perform activities of daily living with varying prosthetic…
- Conditions
- Amputation, Transtibial Amputation - Unilateral, Bone Anchored Devices, Osseointegration
- Trial name
- TBAL (NCT07263945)
- Testing
- As-prescribed prosthetic foot stiffness, A prosthetic foot that is two prosthetic foot stiffness categories stiffer than the stiffness of the as-prescribed prosthetic foot, A prosthetic foot that is two prosthetic foot stiffness categories softer than the stiffness of the as-prescribed prosthetic foot
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Colorado, Denver
Hydrogen Sulfide, Gastrointestinal Microbiome
Smart Underwear to Measure Diet-Induced Hydrogen Sulfide Production
The purpose of this study is to evaluate the ability of a wearable Smart Underwear prototype device to quantify diet-induced changes in gut microbial hydrogen sulfide (H₂S) production.
- Trial name
- NCT06802276
- Testing
- High Cysteine Diet, Low Cysteine Diet
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Parkinson Disease
Slow Wave Sleep as a Biomarker of Rehabilitation-induced Cognitive Improvement in PD
The purpose of this study is to investigate the effects of exercise rehabilitation on cognition and to evaluate slow wave sleep (SWS) as a biomarker and mediator of response to rehabilitation-induced improvement in cognitive…
- Trial name
- NCT04796506
- Testing
- Progressive Resistance Training (PRT), Delayed Exercise Training (DE), Endurance Training (ET)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Colorado, Denver
Cancer
Cancer Prevention for Young Rural Adults
Young adults aged 18-26 engage in a number of behaviors that increase their risk of developing cancer later in life including sedentary lifestyles, unhealthy eating, nicotine produce us, heavy drinking of alcohol, increased UV…
- Trial name
- NCT05618158
- Testing
- 4 Corners Rural Health Cancer Prevention
- Where
- 5 sites in United States
- Volunteers
- 1,796 people, healthy volunteers welcome
- Sponsor
- Klein Buendel, Inc.
Diabetes Mellitus, Diabetes Mellitus, Type 1
Day and Night Closed-loop in Young People With Type 1 Diabetes
The main study objective is to determine whether 24/7 automated closed-loop glucose control combined with low glucose feature will improve glucose control as measured by HbA1c.
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Glucose Metabolism Disorders, Endocrine System Diseases
- Trial name
- DAN05 (NCT02925299)
- Testing
- FlorenceM (US) and FlorenceX (UK), Insulin pump therapy
- Where
- 11 sites in United States, United Kingdom
- Volunteers
- 133 people
- Sponsor
- Jaeb Center for Health Research
Infertility, Obesity
Use of Pulsatile Intravenous FSH to Mitigate Reprometabolic Syndrome
Hypothesis: The investigators hypothesize that pulsatile FSH intravenous administration to women with obesity will correct the Reprometabolic Syndrome (RMS) luteal deficiency phenotype.
- Conditions
- Infertility, Obesity, Diminished Ovarian Reserve (DOR), Diminished Ovarian Reserve
- Trial name
- NCT06414096
- Testing
- Follicle Stimulating Hormone
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Critical Illness, Wounds and Injury
Strategy to Avoid Excessive Oxygen Using an Autonomous Oxygen Titration Intervention
This study is a multicenter randomized controlled trial to determine the effectiveness of a closed loop/autonomous oxygen titration system (O2matic PRO100) to maintain normoxemia (goal range SpO2 90-96%, target 93%) during the…
- Conditions
- Critical Illness, Wounds and Injury, Disease Attributes, Pathologic Processes
- Trial name
- SAVE-O2 AI (NCT06374225)
- Testing
- Automated Titration (O2matic)
- Where
- 4 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Colorado, Denver
Aging, Functional Recovery
Supplemental Mobility
This pilot study will evaluate the feasibility of a supplemental mobility intervention, the Safe Transfers And Mobility Program (STAMP).
- Conditions
- Aging, Functional Recovery, Skilled Nursing Facility, Medically Complex
- Trial name
- NCT07872384
- Testing
- High Intensity Rehabilitation, Safe Transfers and Mobility Program, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 192 people
- Sponsor
- University of Colorado, Denver
Down Syndrome, Autonomic Dysfunction
Exploring Sympathetic Nervous System Function in Individuals With Down Syndrome
Down syndrome (DS), the most common genetic cause of intellectual disability, is associated with widespread organ dysfunction, including abnormalities in the autonomic nervous system (ANS).
- Trial name
- DIVE (NCT07238465)
- Testing
- Cold Stress, Maximal Dynamic Exercise, Isometric Handgrip Exercise with Post-Exercise Muscle Ischemia
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Child Obesity
Community Active and Healthy Families Pragmatic Trial
This is a randomized pragmatic trial of the Community-AHF intervention to evaluate its effectiveness at decreasing body mass index in 5-12 year old children.
- Trial name
- NCT07868471
- Testing
- Community Active and Healthy Families Intensive Health Behavior and Lifestyle Treatment
- Volunteers
- 416 people
- Sponsor
- University of Colorado, Denver
Psychopathy
Effects of Transcranial Magnetic Stimulation on Social Cognition, Cognitive Processing, and Functional Brain Architecture
This clinical trial will examine whether transcranial magnetic stimulation (TMS), a noninvasive form of brain stimulation, can influence social cognition, cognitive processing, and brain function in adults with elevated…
- Trial name
- NCT07635940
- Testing
- continuous theta burst stimulation (cTBS), Intermittent theta burst stimulation (iTBS)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Colorado, Denver
Human Immunodeficiency Virus, Mental Disorder
Integrated Mental Health Care for Pregnant Women With HIV in Kenya: The Tunawiri Study
This study seeks to improve mental health, pregnancy, and HIV outcomes among pregnant and postpartum women living with HIV with common mental health disorders in Kenya.
- Trial name
- NCT06117163
- Testing
- Collaborative Care Model
- Where
- Kenya
- Volunteers
- 900 people
- Sponsor
- University of Colorado, Denver
Restless Leg Syndrome
Tolerability and Efficacy of CBD Extract for RLS Treatment
This study plans to learn more about the safety and tolerability of high Cannabidiol (CBD) cannabis extract (BRC-002) for use in Idiopathic Restless Legs Syndrome.
- Trial name
- NCT07224932
- Testing
- BRC-002, Placecbo
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Colorado, Denver
ARDS (Acute Respiratory Distress Syndrome), Acute Hypoxic Respiratory Failure
Precision Medicine Adaptive Network Platform Trial in Hypoxemic Acute Respiratory Failure
The goal of this trial is to accelerate the development of pharmacological therapies for critical illness by identifying biological sub phenotypes in patients with acute respiratory distress syndrome (ARDS).
- Trial name
- US-PANTHER (NCT07779642)
- Testing
- Simvastatin, Baricitinib
- Volunteers
- 300 people
- Sponsor
- University of Colorado, Denver
Overweight and Obesity
Neuronal and Behavioral Effects of an Implicit Priming Approach to Improve Eating Behaviors in Obesity
The purpose of this study is to determine how different behavioral interventions designed to alter food perceptions and behaviors affect brain responses to food, eating behaviors, and body weight.
- Trial name
- NCT05107908
- Testing
- Active Implicit Priming, Control Implicit Priming, Food Exposure Task
- Where
- United States
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Bone Marrow Transplant, Stem Cell Transplant
Shingrix In Recipients of Allogeneic Transplants
This research is designed to determine if the adjuvanted recombinant glycoprotein E (gE) herpes zoster (HZ) vaccine (Shingrix) has acceptable immunogenicity and safety in people who have undergone allogeneic stem cell transplant…
- Trial name
- Allo (NCT05775718)
- Testing
- Zoster Vaccine Recombinant
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of Colorado, Denver
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