Clinical trials: sponsored by University of Colorado, Denver
Parkinson's Disease (PD)
Investigating Basal Ganglia-Cortical Physiology During Sleep and Its Modulation by Adaptive Deep Brain Stimulation in Parkinson Disease
This is an interventional study of a cohort of patients with PD treated with DBS, and already utilizing adaptive DBS (dual threshold mode).
- Trial name
- NCT07808346
- Testing
- adaptive DBS (aDBS)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Colorado, Denver
Alcohol Withdrawal, Alcohol Abstinence
Intravenous Acetate as an Adjunctive Treatment for Alcohol Withdrawal in Hospitalized Patients
Alcohol withdrawal syndrome is a highly morbid condition affecting a substantial percentage of patients hospitalized who have alcohol use disorders, estimated at 5-6% of all hospitalized patients.
- Conditions
- Alcohol Withdrawal, Alcohol Abstinence, Alcohol Use Disorder
- Trial name
- NCT07810946
- Testing
- Sodium Acetate
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Colorado, Denver
Implantable Defibrillator User
TRAjectories and CLinical ExpeRiences of ICD Therapy Study
This is a prospective cohort study of older patients receiving implantable cardioverter-defibrillators. The purpose of the TRACER-ICD study is to conduct a prospective cohort investigation with the goal of 500 patients age >65…
- Trial name
- TRACER-ICD (NCT05116176)
- Testing
- Implantable cardioverter-defibrillators
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Beth Israel Deaconess Medical Center
Diabetes Mellitus, Type 1 Diabetes
Supporting Medtronic 780G Insulin Pump Adoption in Latino Patients: A Spanish - Language Training Initiative
This study plans to learn more about whether a support program delivered in Spanish or both English and Spanish for bilingual families helps Latino youth with Type 1 Diabetes (T1D) successfully use the Medtronic MiniMed 780G…
- Trial name
- APOYO780G (NCT07720388)
- Testing
- Culturally and linguistically tailored onboarding and support program, Medtronic MiniMed 780G Insulin Pump System
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Colorado, Denver
Circadian Rhythm Sleep Disorder of Shift Work Type, Metabolic Disease
Countermeasures to Circadian Misalignment
Insufficient sleep and circadian misalignment are independent risk factors for the development of obesity and diabetes, yet few strategies exist to counter metabolic impairments when these behaviors are unavoidable.
- Conditions
- Circadian Rhythm Sleep Disorder of Shift Work Type, Metabolic Disease, Insulin Sensitivity
- Trial name
- C2CM (NCT04966351)
- Testing
- Time-restricted feeding, Circadian Misalignment
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Video Laryngoscopy, Quality Improvement
OR Video-Laryngoscope Evaluations
The goal of this quality improvement protocol is to compare the evaluations between video laryngoscopes (VLs) available in the University of Colorado Health Hospital at Metro Denver operating rooms (ORs).
- Conditions
- Video Laryngoscopy, Quality Improvement, Operating Rooms, Comparative Effectiveness Study
- Trial name
- NCT07888946
- Testing
- AMBU Product, CMAC-Storz, Glidescope
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Colorado, Denver
Charcot-Marie-Tooth Disease, Type Ia (Disorder), HMSN
Genetics of Charcot Marie Tooth (CMT) - Modifiers of CMT1A, New Causes of CMT2
This project includes two projects. One is looking for new genes that cause Charcot Marie Tooth disease (CMT). The other is looking for genes that do not cause CMT, but may modify the symptoms a person has.
- Trial name
- INC-6602 (NCT01193088)
- Where
- 24 sites in United States, Australia and 4 more
- Volunteers
- 1,050 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Deterioration, Clinical
The Orientation Intervention to Rapid Response Teams (ORIENT-RRT) Study: A Quasi-Experimental Study
This study will measure knowledge, confidence, and nursing practice outcomes related to the effectiveness and feasibility of a 12-hour educational clinical intervention for NGNs during orientation.
- Trial name
- The ORIENT-RRT (NCT07897851)
- Testing
- Orientation day with rapid response nurse
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Colorado, Denver
Pain, Chronic, Back Pain
Acceptability and Efficacy of Pain Reprocessing Therapy in Racially/ Ethnically Diverse Adults With Chronic Back Pain
The goal of this clinical trial is to learn which treatment works better for adults with chronic pain. This study is comparing three treatments: Pain Reprocessing Therapy (PRT), Cognitive Behavioral Therapy (CBT), and usual care…
- Trial name
- NCT05820204
- Testing
- Pain reprocessing therapy (PRT), Cognitive Behavioral Therapy for Chronic Pain (CBT-CP), Usual care
- Where
- United States
- Volunteers
- 165 people
- Sponsor
- Weill Medical College of Cornell University
Communication Barriers
Examining the Impact of a Patient Communication Pathway in the Critical Care Setting on Patient Experience and Nursing Staff's Perceptions of Usability
The purpose of this study is to assess how an evidence-based communication protocol combined with Vidatalk can impact patient ICU experience and how usable this approach is perceived by nursing staff.
- Trial name
- NCT07897877
- Testing
- Evidence-based communication protocol associated low and high-tech communication approaches (i.e. Vidatalk)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Primary Care Patients, Primary Care Center
Testing the Impact of the MOHR Follow-up Support
This study will evaluate the impact of 3 different strategies to increase engagement of participants in My Own Health Report (MOHR) and health behavior change activities over time.
- Trial name
- NCT07569224
- Testing
- Providing reminder and resources via messages, Reminder and resources sent via navigation, Regular care
- Where
- 6 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Charcot Marie Tooth Disease
Natural History Evaluation of Charcot Marie Tooth Disease (CMT) Types CMT1B, CMT2A, CMT4A, CMT4C, and Others
This is an observational longitudinal study to determine the natural history and genotype-phenotype correlations of disease causing mutations in Charcot Marie Tooth disease (CMT) type 1B (CMT1B), 2A (CMT2A), 4A (CMT4A), and 4C…
- Trial name
- INC-6601 (NCT01193075)
- Where
- 24 sites in United States, Australia and 4 more
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Michael Shy
Prostate Cancer
Pragmatic Trial of Metformin for Glucose Intolerance or Increased BMI in Prostate Cancer Patients
Metformin is used widely in the treatment of type 2 diabetes. It has off-label indications for use in the prevention of diabetes and in hyperinsulinar obesity.
- Trial name
- PragMet (NCT05515978)
- Testing
- Metformin, Lifestyle Modification
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Colorado, Denver
Childhood Cancer, Survivorship
A Multilevel Intervention to Improve Adherence to Childhood Cancer Survivorship
More than 80% of childhood cancer survivors develop serious or life-threatening late effects after cancer therapy, but <20% receive recommended survivorship care offered at cancer center survivorship clinics.
- Conditions
- Childhood Cancer, Survivorship, Health Care Utilization, Health Knowledge, Attitudes, Practice
- Trial name
- BRIDGES (NCT05448560)
- Testing
- Multi-level Intervention of shared model of survivorship care, Comparison Group
- Where
- 4 sites in United States
- Volunteers
- 240 people
- Sponsor
- Georgetown University
Pleuropulmonary Blastoma, Sertoli-Leydig Cell Tumor
International PPB/DICER1 Registry
PPB has strong genetic implications, with a unique set of conditions in an individual or their family, occurring mostly in childhood and adolescence.
- Conditions
- Pleuropulmonary Blastoma, Sertoli-Leydig Cell Tumor, DICER1 Syndrome, Cystic Nephroma
- Trial name
- NCT03382158
- Where
- United States
- Volunteers
- 3,400 people, healthy volunteers welcome
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Periodontal Diseases
Addition of Dehydrated Human Amnion-Chorion Membrane During Scaling and Root Planing
Hypothesis: There will be an additional reduction of pocket depth and gain of clinical attachment when dehydrated human amnion-chorion membrane (dHACM) is placed into the periodontal disease defect after mechanical scaling and…
- Trial name
- NCT03836378
- Testing
- BioXclude™
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus
Multicenter Assessment of the Pancreas in Type 1 Diabetes
The overall goal of this research is to develop and validate standard operating procedures (SOP) to assess the human pancreas in individuals with type 1 diabetes (T1D) and other forms of diabetes using advanced, quantitative…
- Trial name
- MAP-T1D (NCT03585153)
- Testing
- Non-contrast magnetic resonance imaging
- Where
- 5 sites in United States, Australia
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Adenovirus, Primary Immune Deficiency Disorder
Adenovirus-specific Cytotoxic T-lymphocytes for Refractory Adenovirus Infection
Related donor Adenovirus (ADV) specific cytotoxic T cells (CTLs) manufactured with the Miltenyi CliniMACS Prodigy Cytokine Capture System will be administered intravenously in in children, adolescents and young adults with…
- Trial name
- NCT03266627
- Testing
- cytotoxic t-lymphocytes
- Where
- 10 sites in United States
- Volunteers
- 20 people
- Sponsor
- New York Medical College
Quadriplegia
Sensory Motor Transformations in Human Cortex
This research study is being conducted to develop a brain controlled medical device, called a brain-machine interface. The device will provide people with a spinal cord injury some ability to control an external device such as a…
- Trial name
- NCT01964261
- Testing
- Neural Prosthetic System 2 (NPS2)
- Where
- 4 sites in United States
- Volunteers
- 5 people
- Sponsor
- Richard A. Andersen, PhD
Breast Cancer Females, Newly Diagnosed Breast Cancer
Trial to Evaluate an Educational Video Series for Women in Breast Cancer Treatment
Approximately 200 English- or Spanish-speaking women newly diagnosed with stage I-III breast cancer will be randomized to either receive access to an online sexual health video series or receive usual care.
- Trial name
- NCT07434817
- Testing
- Sexual Health Educational Video Series, Standard Care (in control arm)
- Where
- 4 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Colorado, Denver
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