Clinical trials: sponsored by University of Nottingham
Tourette Syndrome, Chronic Tic Disorder
Median Nerve Stimulation for Tourette Syndrome and Chronic Tic Disorder
Tourette syndrome (TS) and chronic tic disorder (CTD) are neurodevelopmental disorders that impact approximately 1% of 5-18 year olds worldwide.
- Trial name
- NeSTS (NCT05269953)
- Testing
- Active stimulation
- Where
- United Kingdom
- Volunteers
- 135 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Cardio Vascular Disease, Dietary Change
Lifestyle Advice in CVD
Individuals living in the UK who are from ethnic minority communities have a higher risk of heart disease and strokes than white individuals. This risk arises from the social determinants of health.
- Conditions
- Cardio Vascular Disease, Dietary Change, Dietary Behaviors, Diet Habits
- Trial name
- NCT07672054
- Testing
- Experience of healthcare
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- University of Nottingham
Psychological Stress, Anxiety
Effects of L-Theanine and Hericium Erinaceus Gummies on Psychological, Cognitive, and Sleep Quality in University Students
The THEA-HEAL Trial is an 8-week randomized controlled study investigating the effects of a daily gummy supplement containing L-theanine and Hericium erinaceus (Lion's mane mushroom) extract on stress, anxiety, cognitive…
- Conditions
- Psychological Stress, Anxiety, Depression, Sleep Quality
- Trial name
- THEA-HEAL (NCT07665840)
- Testing
- gummy intervention
- Where
- Malaysia
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of Nottingham Malaysia
Ventilation, Mechanical, Ventilation-Associated Pneumonia
Surveillance of Neonatal Endotracheal Tube Colonisation
Babies in neonatal intensive care units (NICUs) sometimes need help breathing using a breathing tube (endotracheal tube, or ETT) connected to a breathing machine (ventilator).
- Trial name
- NETT (NCT07664449)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Overweight, Obesity
Glycaemic Response of Arabic Bread
Bread remains one of the most widely consumed staple foods worldwide, with wheat flour serving as its traditional foundation. However, the widespread dependence on refined wheat-based bread has paralleled the rising prevalence of…
- Conditions
- Overweight, Obesity, Glycaemic Response
- Trial name
- NCT07652320
- Testing
- Control Bread, Chickpea-Enriched Arabic Bread, Pea-Enriched Arabic Bread
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Surgery, Colorectal Cancer
Postoperative Electrical Muscle Stimulation Two
Undesirable loss of skeletal muscle mass (atrophy) is a common feature of many diseases as well as ageing, bed rest and physical inactivity.
- Conditions
- Surgery, Colorectal Cancer, Muscle Atrophy, Cancer Gi
- Trial name
- POEMS2 (NCT06964438)
- Testing
- Neuromuscular Electrical Stimulation, Protein supplement drink
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- University of Nottingham
Cardiac Surgery, Infection, Soft Tissue
Exploring if Patients Can Safely and Easily Swab Their Own Surgical Wounds at Home
The goal of this observational feasibility study is to learn if patients can safely, acceptably, and effectively collect their own wound swabs at home to detect clinically significant organisms in adults aged 18 and over who have…
- Conditions
- Cardiac Surgery, Infection, Soft Tissue, Wound Healing, Swabs
- Trial name
- TREASURE (NCT07200401)
- Testing
- Self-swabbing of surgical wound
- Where
- 2 sites in United Kingdom
- Volunteers
- 43 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Obesity
MRI Based Study to Assess Brain-gut Axis in Obesity
The mechanism of neural communication between the brain and gut in the regulation of food intake is complex and not fully understood.
- Trial name
- BGImaging (NCT05437653)
- Testing
- Nutritional Drink A, Nutritional Drink B
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Intrusive Memories of Traumatic Event(s)
A Brief Cognitive Task Intervention for NHS Staff Affected by COVID-19 Trauma (GAINS-2 Study)
Frontline healthcare staff are frequently exposed to traumatic events at work (e.g., witnessing patients die), amplified by the COVID-19 pandemic.
- Trial name
- GAINS-2 (NCT05616676)
- Testing
- Brief digital imagery-competing task, Brief digital music-listening task, Treatment As Usual
- Where
- United Kingdom
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- P1vital Products Limited
Cognitive Enhancement
Transcranial Focused Ultrasound Stimulation to Enhance Cognition in Healthy Participants
This study examines the impact of theta-burst transcranial focused ultrasound stimulation (tFUS) on cognitive performance in healthy participants, specifically focusing on both acute and post-stimulation effects on visual working…
- Trial name
- NCT06829368
- Testing
- Transcranial Focused Ultrasound Stimulation
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Frozen Shoulder
Exploring the Link Between Menopause, Glucose Control, and Frozen Shoulder in Women
Background Frozen shoulder (FS) is a common condition and affects how the shoulder moves, making it very stiff and sore. The shoulder joint becomes inflamed and tightened due to scarring in the joint called fibrosis.
- Trial name
- MENO-FROST (NCT07603089)
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Patient Safety
Clinical Experience of Maintaining Patient Safety in Hospital
The key purpose of the study is to establish what the barriers to preventing accidental falls in hospital are, what interventions are perceived to work best in preventing falls and what could help.
- Trial name
- CEMPSIH (NCT06738316)
- Testing
- Simulation
- Where
- 3 sites in United Kingdom
- Volunteers
- 53 people
- Sponsor
- University of Nottingham
Healthcare Access, Experience
Learning Differences in Medical Education
A learning difference or disability is a reduction in intellectual ability (GMC, 2024). It causes lifelong difficulty with everyday activities. Different individuals require different levels of support.
- Conditions
- Healthcare Access, Experience, Learning Disabilities
- Trial name
- NCT07585708
- Testing
- Experience of healthcare
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- University of Nottingham
Cellulitis of Leg
Cellulitis Optimal Antibiotic Treatment
To determine whether a short course of oral flucloxacillin (5 days) is non-inferior to a standard course (7 days) in terms of pain over days 6-14 (indicative of persistence or recurrence associated with the symptoms of most…
- Trial name
- COAT (NCT05584007)
- Testing
- Flucloxacillin Only Product in Oral Dose Form
- Where
- United Kingdom
- Volunteers
- 334 people
- Sponsor
- University of Southampton
Type 1 Diabetes Mellitis
Diathermy On Diabetes Glucose Monitoring Effectiveness
The goal of this observational study is to investigate if diathermy (a surgical tool that uses electrical energy to control bleeding) has any affect on the accuracy and functioning of continuous glucose monitoring systems in…
- Trial name
- DODGE (NCT07583238)
- Where
- United Kingdom
- Volunteers
- 126 people
- Sponsor
- University of Nottingham
Chronic Kidney Diseases
Application of Functional Renal MRI to Improve Assessment of Chronic Kidney Disease
Research question: Can multiparametric renal Magnetic Resonance Imaging (MRI) provide structural and functional assessment of the kidneys to deliver prognostic information and guide treatment options in chronic kidney disease…
- Trial name
- AFiRM (NCT04238299)
- Testing
- Multiparametric renal MRI
- Where
- United Kingdom
- Volunteers
- 486 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
X-linked Hypophosphatemia (XLH)
Effective Dosing of Burosumab in XLH
X-linked hypophosphataemia (XLH) is a rare, hereditary condition. The genetic defect leads to low blood phosphate levels and vitamin D suppression. Phosphate is required for strong bones and teeth and to store energy in cells.
- Trial name
- NCT07183579
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University of Nottingham
Metabolic Regulation
Bath Myorhythms Project
Human Physiology is coordinated by a circadian timing system that synchronises daily cycles of light-dark, wake- sleep, activity-rest and feeding-fasting.
- Trial name
- NCT06997315
- Testing
- Time of exercise, No exercise
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Bath
Major Depressive Disorder, Depression Moderate
Exercise Recovery From Persistent Depression: A Thematic Analysis
Depression is a leading cause of disability worldwide and poses a large economic burden in the UK. There is evidence that exercise is beneficial in the management of depression and NICE now recommends group exercise programs as a…
- Conditions
- Major Depressive Disorder, Depression Moderate, Depression Severe
- Trial name
- NCT05539495
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Nottingham
Traumatic Brain Injury
An Exploration of Sleep Disturbance and Outcomes in TBI (SLEEP-TBI)
This study aims to look at how sleep disturbance affects people who have had a traumatic brain injury. Sleep disturbance can include waking frequently in the night, difficulty falling asleep, excessive sleepiness or changes to…
- Trial name
- SLEEP-TBI (NCT07120373)
- Where
- United Kingdom
- Volunteers
- 180 people
- Sponsor
- University of Nottingham