Clinical trials: sponsored by Unity Health Toronto
Coronary Disease
A Study to Determine the Effect of Bi-Ventricular Pacing on Cardiac Hemodynamics After Coronary Artery Bypass Graft
The purpose of this study is to determine, using echocardiography, whether bi-ventricular pacing improves the contractile force by resynchronizing both ventricles, thereby improving and/or correcting the paradoxical septal…
- Trial name
- NCT00316368
- Testing
- Ethicon TPW32 60 cm (pacing wires x 2)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Unity Health Toronto
Stroke
Effectiveness of Virtual Reality Exercises in STroke Rehabilitation (EVREST)
This study is a pilot, randomized trial that will examine whether the Nintendo Wii virtual gaming system is safe and feasible for use in patients who have had a recent stroke.
- Trial name
- EVREST (NCT00692523)
- Testing
- Recreational therapy activities, Nintendo Wii
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
Cystic Fibrosis
Azithromycin in Patients With CF, Infected With Burkholderia Cepacia Complex
Pulmonary infection with Burkholderia cepacia complex (BCC) in patients with CF is often associated with a more rapid decline in lung function.
- Trial name
- NCT00298922
- Testing
- Azithromycin
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- Unity Health Toronto
Intubation
Comparison of Flex-It Stylet to Malleable Stylet for GlideScope Intubation: A Randomized Controlled Trial
Patients presenting for elective surgery requiring tracheal intubation will be randomized to one of two different ETT stylets. The primary outcome is time to intubation. The null hypothesis is that there will be no difference.
- Trial name
- NCT00771628
- Testing
- Flex-It Stylet, Standard malleable stylet
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Anemia, Peritoneal Dialysis
Oral Vitamin C for Correction of Anemia in Patients Receiving Peritoneal Dialysis
People with kidney failure are at risk for the development of anemia. Anemia is a decrease in the production of hemoglobin, a substance that carries oxygen in the blood.
- Trial name
- NCT00920413
- Testing
- Vitamin C
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- Unity Health Toronto
Respiration, Artificial, Respiratory Insufficiency
24-Hour NAVA Ventilation in Acute Respiratory Failure
Neurally Adjusted Ventilatory Assist (NAVA) is a new mode of mechanical ventilation that is controlled by the electrical activity of the diaphragm (EAdi).
- Trial name
- NCT00583037
- Testing
- Neurally Adjusted Ventilatory Assist (NAVA)
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Unity Health Toronto
Brain Injuries
Feasibility Trial of Traumatic Brain Injured Patients Randomized in the Prehospital Setting to Either Hypertonic Saline and Dextran Versus Normal Saline
This clinical trial will evaluate the ease of conducting a randomized trial on patients with severe head injury who are cared for by paramedics in the out of hospital setting.
- Trial name
- TOPHR HIT (NCT00878631)
- Testing
- hypertonic saline mixed with dextran, Normal Saline
- Where
- 2 sites in Canada
- Volunteers
- 113 people
- Sponsor
- Unity Health Toronto
Post Prandial Blood Glucose
The Effects of Salvia Hispanica-Enriched Foods on Glycemic and Insulinemic Responses and Subjective Satiety
Salvia hispanic (Salba) is postulated to increase satiety. This study determines the optimal amount of Salba as well as whether liquid or solid enriched products will produce maximum satiety.
- Trial name
- NCT00728065
- Testing
- White Bread, White bread with added 7.32g Salvia hispanica, White bread with added 15.58g Salvia hispanica
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Contrast Induced Nephropathy, Critically Ill
N-Acetylcysteine in Critically Ill Patients Undergoing Contrast Enhanced Computed Tomography
Critically ill patients frequently undergo contrast enhanced computed tomography (CT) to establish diagnoses and direct management. Contrast agents can disturb kidney function and result in kidney dysfunction.
- Trial name
- NCT00830193
- Testing
- N-acetylcysteine
- Where
- 2 sites in Canada
- Volunteers
- 45 people
- Sponsor
- Unity Health Toronto
Acute Respiratory Distress Syndrome
The Effect of High Frequency Oscillation on Biological Markers of Lung Injury
Although mechanical ventilation is life saving, it is associated with a number of severe complications collectively referred to as ventilator induced lung injury (VILI).
- Trial name
- NCT00673517
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Unity Health Toronto
Heart Arrest, Coma
Pilot Clinical Study of the LRS ThermoSuit™ System in Post Arrest Patients
The purpose of this study is to determine if the Life Recovery Systems Thermosuit(R) System is able to quickly and conveniently cool patients who are comatose after resuscitation from cardiac arrest.
- Trial name
- NCT00410969
- Testing
- ThermoSuit(R) System
- Where
- 2 sites in Canada
- Volunteers
- 27 people
- Sponsor
- Life Recovery Systems
Type 2 Diabetes
Blood Glucose Response to Highly Viscous Polysaccharide Enriched Biscuits in Healthy and Diabetic Subjects
Our objective was to test whether the highly viscous polysaccharide incorporated into the biscuit formulation would reduce the postprandial blood glucose response equally in healthy subjects and individuals with type 2 diabetes.
- Trial name
- NCT00728143
- Testing
- Highly viscous polysaccharide enriched biscuits
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Myocardial Ischemia
NOGA Angiogenesis Revascularization Therapy: Evaluation by RadioNuclide Imaging - The Northern Trial
To demonstrate the clinical efficacy and safety of vascular endothelial growth factor(VEGF165)when delivered by direct myocardial injection through the NOGA navigational catheter to improve myocardial perfusion in patients with…
- Trial name
- NCT00143585
- Where
- 7 sites in Canada
- Volunteers
- 120 people
- Sponsor
- Unity Health Toronto
Diabetes, Graft Rejection
Thymoglobulin in Calcineurin Inhibitor and Steroid Minimization Protocol
This study has been designed to test whether using Thymoglobulin with low dose Cyclosporine and early steroid dosage reduction will minimize both kidney rejection and the development of new onset diabetes mellitus after renal…
- Trial name
- NCT00706680
- Testing
- Thymoglobulin
- Where
- 3 sites in Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Retinal Vein Occlusion, Retinal Vein Thrombosis
Atorvastatin for the Treatment of Retinal Vein Occlusion
The ATORVO study is designed to determine whether atorvastatin (Lipitor) can improve vision, when compared to placebo
- Conditions
- Retinal Vein Occlusion, Retinal Vein Thrombosis, Central Retinal Vein Occlusion, Branch Retinal Vein Occlusion
- Trial name
- ATORVO (NCT00517257)
- Testing
- Atorvastatin
- Where
- Canada
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Infection, Sepsis
Bacterial Infection Diagnosis Using Blood DNA
Sepsis is a common cause of morbidity and death in intensive care units. Clinical and laboratory signs of systemic inflammation, including changes in body temperature, tachycardia, or leukocytosis, are neither sensitive nor…
- Trial name
- NCT00698919
- Testing
- Observational study
- Where
- 5 sites in France
- Volunteers
- 400 people
- Sponsor
- Delafontaine Hospital
Arthritis, Rheumatoid
Comparison of NeuFlex and Swanson Metacarpophalangeal Implants for Rheumatoid Arthritis
The main hypotheses for this study are as follows: 1. The use of NeuFlex implant results in flexion in the fourth and fifth MP joints that is at least 10 degrees greater than with teh use of the Swanson implant. 2.
- Trial name
- NCT00463424
- Testing
- NeuFlex metacarpophalangeal implant, Swanson metacarpophalangeal implant
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Unity Health Toronto
Arterial Hemostasis After Coronary Intervention
Arterial Closure Device Comparison Trial II - ACDC Trial II
PCI (coronary angioplasty) is a procedure performed through a catheter to open up blockages in the coronary arteries using balloons and stents for the treatment of angina or myocardial infarction.
- Trial name
- NCT00428155
- Testing
- closure device placement
- Where
- Canada
- Volunteers
- 448 people
- Sponsor
- Unity Health Toronto
Preventive Health Care
Improving Preventive Service Delivery at Adult Complete Health Check-Ups
To determine the effectiveness of a single checklist reminder form to improve the delivery of preventive health services at adult health check-ups in a family practice setting.
- Trial name
- NCT00316394
- Testing
- Preventive Care Checklist Form
- Where
- Canada
- Sponsor
- Unity Health Toronto
Type 2 Diabetes
Effect of Chia Seeds (Salvia Hispanica L.) on Glucose Control in Patients With Type 2 Diabetes
The purpose of this study is to determine whether the addition of Salvia hispanica L. Alba (Salba) to the conventional treatment for diabetes is associated with improvement in major and emerging cardiovascular risk factors in…
- Trial name
- NCT00362011
- Testing
- Salba diet
- Where
- Canada
- Sponsor
- Unity Health Toronto