Clinical trials: sponsored by UMC Utrecht
Virtual Reality Pain Distraction, Endocrinology
The Influence of Virtual Reality on Blood Parameters
The goal of this study is to learn what the impact of exposure to virtual reality content is on the levels of stress-related blood values in healthy volunteers.
- Conditions
- Virtual Reality Pain Distraction, Endocrinology, Haematology
- Trial name
- 8baan (NCT07042178)
- Testing
- Meditation video at the beach, Rollercoaster video
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Van Creveldkliniek
Osteo Arthritis Knee
Use of a Putty as Gap Filler in Open-wedge Osteotomy
Rationale: Realignment osteotomies around the knee are a proven surgical treatment for unicompartmental knee osteoarthritis and a malalignment. Osteotomies can be very painful in the early postoperative phase.
- Trial name
- AXOS (NCT05992038)
- Testing
- Osteotomy with putty, Conventional osteotomy
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- UMC Utrecht
Depressive Disorder, Major
Prospective Assessment of Cost-effectiveness and Side-effects of Depressive Patients Treated With ECT or TCA
Prospective observational cohort study to determine cost-effectiveness of ECT compared to medication in the treatment of major depressive disorder (MDD) in the Netherlands.
- Trial name
- PROSPECT (NCT05306184)
- Testing
- Electroconvulsive therapy (ECT)
- Where
- 2 sites in Netherlands
- Volunteers
- 220 people
- Sponsor
- Radboud University Medical Center
Out-of-Hospital Cardiac Arrest, Pulmonary Ventilation
CAvent-Ventilation During Advanced Cardiopulmonary Resuscitation in Out-of-hospital Cardiac Arrest- an Observational Study
The aim of this observational study is to investigate how ventilations is given during cardiopulmonary resuscitation (CPR) given by advanced life support providers (ALS).
- Trial name
- CAvent (NCT04237727)
- Testing
- Fluxmed GrH portable pneumotachograph
- Where
- 5 sites in Netherlands, Sweden
- Volunteers
- 241 people
- Sponsor
- Uppsala University
Adolescence Idiopathic Scoliosis
A Randomized Intra-Patient Controlled Trial of MagnetOs™ Putty vs Autograft in Instrumented Posterolateral Spinal Fusion in Idiopathic Scoliosis Patients
SUMMARY Rationale: Delayed union is a problem in adolescent idiopathic scoliosis (AIS) surgery, especially at the distal end of the construct.
- Trial name
- MAIS (NCT07512336)
- Testing
- MagnetOs putty 2.5cc, autograft
- Volunteers
- 140 people
- Sponsor
- UMC Utrecht
Liver Cancer (Locally Advanced or Metastatic), Liver Cancer Adult
Radioembolization With Intra-arterial Angiotensin II to Improve Tumor-absorbed Dose (RADIANT)
This clinical trial will test whether a short infusion of a drug called angiotensin II (AT-II) can make a liver cancer treatment work better.
- Trial name
- RADIANT (NCT07312292)
- Testing
- Angiotensin II (Giapreza®), Yttrium-90 radioembolization
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Niek Wijnen
Cartilage Damage
Comparing Clinical Outcomes of the One-step Cartilage Transplantation in Cartilage Defects of the Knee With Conservative Treatment
Articular cartilage defects in the knee have poor intrinsic healing capacity and may lead to functional disability and osteoarthritis.
- Trial name
- IMPACT2 (NCT04236739)
- Testing
- Instant MSC Product accompanying Autologous Chondron Transplantation
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- R.J.H. Custers
Infection, Bacterial, Infection Prevention
Optimising Kangaroo Care to Reduce Neonatal Severe Infection/Sepsis and Resistant Bacterial Colonisation Among High-risk Infants in NICU.
NeoDeco is a pragmatic, multicenter, parallel-group, cluster-randomised hybrid effectiveness-implementation trial designed to evaluate the impact of implementing optimised Kangaroo Care (KC) at the unit level compared to standard…
- Trial name
- NeoDeco (NCT05993442)
- Testing
- Optimised kangaroo care
- Where
- 24 sites in Greece, Italy and 3 more
- Volunteers
- 3,080 people
- Sponsor
- PENTA Foundation
Systemic Sclerosis, Systemic Scleroses, Diffuse
Upfront Autologous HSCT Versus Immunosuppression in Early Diffuse Cutaneous Systemic Sclerosis
HSCT has been implemented in (inter)national treatment guidelines for diffuse cutaneous systemic sclerosis (dcSSc) and is offered in clinical care and reimbursed by national health insurance in several European countries.
- Conditions
- Systemic Sclerosis, Systemic Scleroses, Diffuse, Scleroderma, Scleroderma, Diffuse
- Trial name
- UPSIDE (NCT04464434)
- Testing
- Upfront autologous HSCT
- Where
- 8 sites in Italy, Netherlands and 1 more
- Volunteers
- 60 people
- Sponsor
- UMC Utrecht
Coronary Artery Disease, Angina (Stable)
Coronary Sinus Reducer Therapy for Persisting Angina
Refractory angina due to advanced obstructive coronary artery disease (CAD) remains a major clinical problem with limited evidence-based treatment options.
- Trial name
- REDUCE ANGINA (NCT07485985)
- Testing
- Coronary sinus reducer
- Volunteers
- 25 people
- Sponsor
- UMC Utrecht
Ulcerative Colitis, Ulcerative Colitis Flare
Transfer of Feces in Ulcerative Colitis 2
The goal of this placebo-controlled randomised multicenter trial is to evaluate the efficacy and safety of anaerobic prepared donor fecal microbiota transplantation (FMT) compared to autologous FMT in patient with ulcerative…
- Conditions
- Ulcerative Colitis, Ulcerative Colitis Flare, Ulcerative Colitis Acute
- Trial name
- TURN2 (NCT05998213)
- Testing
- Fecal microbiota transplant
- Where
- Netherlands
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Bone Metastases
Prospective Evaluation of Interventional Studies on Bone Metastases - the PRESENT Cohort
Bone metastases are frequent distant manifestations of cancer, with pain as a common and devastating consequence. The primary treatment for painful bone metastases, external beam radiation therapy, is moderately effective: about…
- Trial name
- PRESENT (NCT02356497)
- Where
- Netherlands
- Volunteers
- 2,500 people
- Sponsor
- UMC Utrecht
Subarachnoid Hemorrhage, Spontaneous
Multicenter Registry of Patients With Subarachnoid Hemorrhage
The purpose of this registry is to collect detailed information on the characteristics, treatment, and outcomes of patients with a subarachnoid hemorrhage.
- Trial name
- MEASURE (NCT07482124)
- Testing
- None, observational study
- Where
- 9 sites in Netherlands
- Volunteers
- 1,000 people
- Sponsor
- UMC Utrecht
Margin Assessment, Breast Cancer
Spectral Cancer Tissue Recognition - I
This analytical performance study aims to validate the SPCTRone system for use in breast conserving surgery of breast cancer patients.
- Trial name
- SPCTR-I (NCT07459062)
- Where
- 2 sites in Netherlands
- Volunteers
- 100 people
- Sponsor
- SPCTR
Bone Metastases, Bone Neoplasm
Focused Ultrasound and RadioTHERapy for Noninvasive Palliative Pain Treatment in Patients With Bone Metastases
The FURTHER study aims to evaluate the effectiveness and cost-effectiveness of MR-HIFU (alone or in combination with EBRT) compared to EBRT alone, the standard-of-care, as a palliative treatment option to relieve CIBP.
- Conditions
- Bone Metastases, Bone Neoplasm, Bone Lesion, Bone Cancer
- Trial name
- FURTHER (NCT04307914)
- Testing
- External beam radiotherapy, MR-HIFU
- Where
- 6 sites in Finland, Germany and 2 more
- Volunteers
- 216 people
- Sponsor
- UMC Utrecht
Prostate Cancer
Utrecht Prostate Cohort for Cancer Treatment Intervention Studies and Long-term Evaluation
Rationale: Prostate cancer is the most common cancer in men worldwide. Survival rates are high due to the typically non-aggressive nature of disease and effective treatments.
- Trial name
- UPC (NCT04228211)
- Where
- 2 sites in Netherlands
- Volunteers
- 1,500 people
- Sponsor
- UMC Utrecht
Prostate Cancer, Erectile Dysfunction Following Radiation Therapy
EREctile Function Preservation for Prostate Cancer Radiation Therapy (ERECT)
Single-arm phase II trial of 70 men with low- or intermediate-risk prostate cancer receiving magnetic resonance guided adaptive radiotherapy (MRgRT) in 5 fractions of 7.25 Gy, additionally sparing the neurovascular bundles, the…
- Trial name
- ERECT (NCT04861194)
- Testing
- Neurovascular-sparing
- Where
- Netherlands
- Volunteers
- 70 people
- Sponsor
- UMC Utrecht
Oncology, Breast Cancer
The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study
The Multi-OutcoMe EvaluatioN of radiation Therapy Using the Unity MR-Linac Study (MOMENTUM) is a multi-institutional, international registry facilitating evidenced based implementation of the Unity MR-Linac technology and further…
- Conditions
- Oncology, Breast Cancer, Prostate Cancer, Gynecologic Cancer
- Trial name
- MOMENTUM (NCT04075305)
- Testing
- Radiation therapy
- Where
- 18 sites in United States, Australia and 7 more
- Volunteers
- 8,000 people
- Sponsor
- UMC Utrecht
Fahr Disease, Fahr Syndrome
Treatment of Ectopic Calcification in Fahr's Disease or Syndrome
Fahr's disease or syndrome are neurodegenerative diseases in which patients present with bilateral vessel associated calcifications in the basal ganglia.
- Conditions
- Fahr Disease, Fahr Syndrome, Primary Familial Brain Calcification
- Trial name
- CALCIFADE (NCT05662111)
- Testing
- Etidronate
- Where
- 2 sites in Netherlands, United Kingdom
- Volunteers
- 98 people
- Sponsor
- UMC Utrecht
Heart Failure
A Study on Remote Health Support for Patients With Heart Failure.
This multicenter prospective observational feasibility study evaluates the implementation of the RAPHAEL model, a remote monitoring palliative care approach for patients with heart failure.
- Trial name
- RAPHAEL (NCT07440472)
- Where
- 9 sites in Germany, Italy and 7 more
- Volunteers
- 90 people
- Sponsor
- Universitat Internacional de Catalunya