Clinical trials: sponsored by Ohio State University Comprehensive Cancer Center
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia
Geriatric Optimization Plan to Improve Survival in Older Adult Allogeneic Hematopoietic Cell Transplant Candidates, OTIS Study
This clinical trial tests whether a geriatric optimization plan (GO!) works to improve survival in patients over 60 with a hematologic malignancy or bone marrow failure syndrome eligible for allogeneic hematopoietic cell…
- Conditions
- Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Aplastic Anemia, Chronic Lymphocytic Leukemia
- Trial name
- NCT05972577
- Testing
- Health Promotion and Education, Medical Device Usage and Evaluation, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Cigarette Smoking-Related Carcinoma
A Comprehensive Evaluation of Tobacco-Flavored vs. Non-Tobacco Flavored E-cigarettes on Smoking Behavior
This clinical trial compares the use of tobacco flavored electronic cigarettes (ECs) vs. non-tobacco flavored ECs vs. nicotine replacement therapy (patches and lozenges) on smoking behavior in current cigarette smokers.
- Trial name
- NCT06260683
- Testing
- Nicotine Replacement, Questionnaire Administration, Vaping
- Where
- United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Early Stage Breast Carcinoma, Dyspnea
Inspiratory Muscle Training for Breast Cancer Patients on Chemotherapy
This clinical trial studies whether breathing exercises for the muscles that help with breathing air in, inspiratory muscle training (IMT), works to improve breathing muscle strength, shortness of breath, and physical activity…
- Trial name
- IMACT (NCT07386444)
- Testing
- Inspiratory muscle training
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Breast Cancer
Myeloid-Derived Suppressor Cell Function in Breast Cancer Patients
Myeloid-Derived Suppressor Cell Function in Breast Cancer Patients
- Trial name
- NCT04022616
- Testing
- Specimen collection
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
Ibrutinib as an Immune Modulating Agent for Patients With Asymptomatic, High-risk CLL/SLL Risk Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
This randomized phase II trial studies how well ibrutinib works when given together with vaccine therapies in treating patients without clinical signs or indications that raise the possibility of a particular disorder or…
- Trial name
- NCT02518555
- Testing
- Diphtheria Toxoid/Tetanus Toxoid/Acellular Pertussis Vaccine Adsorbed, Ibrutinib, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Jennifer Woyach
Cancer
Online Tai Chi Intervention to Promote Smoking Cessation Among Cancer Survivors
This clinical trial evaluates an online Tai Chi intervention to promote smoking cessation among cancer survivors. Tai chi is a practice that involves a series of slow gentle movements and physical postures, a meditative state of…
- Trial name
- NCT05941858
- Testing
- Smoking Cessation Intervention, Carbon Monoxide Measurement, Internet-Based Intervention
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Tobacco-Related Carcinoma
Nicotine and Tobacco Message Framing to Change Smoking Behavior in Diverse Groups of Young Adult Smokers
This clinical trial evaluates the effect of message framing on smoking behaviors among lesbian, gay, bisexual, transgender, queer (LGBTQ+) young adults who use nicotine and/or tobacco.
- Trial name
- NCT06644664
- Testing
- Health Education, Interview, Smoking Cessation Intervention
- Where
- United States
- Volunteers
- 292 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Recurrent Endometrial Serous Adenocarcinoma
Combination Niraparib and Dostarlimab Therapy for Recurrent or Persistent Uterine Serous Carcinoma
This phase II trial tests how well niraparib and dostarlimab work in treating patients with uterine serous carcinoma that has come back (after a period of improvement) (recurrent) and remains despite treatment (persistent).
- Trial name
- NCT05870761
- Testing
- Biospecimen Collection, Computed Tomography, Dostarlimab
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Casey Cosgrove
Behavior, Risk
Breast Cancer Study Tracking Risk Awareness of Alcohol Consumption and Improving Knowledge in Young Adult Women
This randomized trial aims to test the effects of co-created breast cancer counter marketing intervention messages for reducing alcohol consumption and impacting awareness and beliefs about the breast cancer risks from alcohol…
- Trial name
- B-Track (NCT07320664)
- Testing
- Alcohol and Breast Cancer Risk Messages, Skin Cancer Risk Messages
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
Adaptive De-intensified Radiotherapy Using Circulating Tumor DNA in HPV- Associated Oropharyngeal Cancer
This phase II trial studies how well using circulating tumor deoxyribonucleic acid (DNA) to guide lower dose radiation therapy works in treating patients with human papillomavirus infection (HPV)-associated oropharyngeal cancer.
- Conditions
- Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Oropharyngeal Squamous Cell Carcinoma
- Trial name
- NCT06323460
- Testing
- Biospecimen Collection, Carboplatin, Cisplatin
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Pancreatic Neoplasm
Evaluation of Endoscopic Ultrasound-Guided Radiofrequency Ablation for the Management of Pancreatic Tumors, ERASE Study
This clinical trial evaluates the safety and effectiveness of endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) for the management of patients with pancreatic tumors (including cysts) performed during recommended…
- Trial name
- ERASE (NCT05961982)
- Testing
- Chemical Ablation, Computed Tomography, Electronic Health Record Review
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Cigarette Smoking-Related Carcinoma
Impact of E-cigarette Use on the Body
This study examines how electronic (e)-cigarette use impacts the body, by studying both users and non-users of e-cigarettes. Early evidence indicates that e-cig users experience adverse health effects.
- Trial name
- NCT04972513
- Testing
- Biospecimen Collection, Nitric Oxide Breath Test, Oscillometry
- Where
- United States
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Plasma Cell Dyscrasias, Monoclonal Gammopathy of Undetermined Significance
Ohio State University Multiple Myeloma and Amyloidosis Data Registry and Sample Resource
The investigators are researching patients with diseases of their plasma cells in order to improve their quality and length of life.
- Conditions
- Plasma Cell Dyscrasias, Monoclonal Gammopathy of Undetermined Significance, AL Amyloidosis, Multiple Myeloma
- Trial name
- B-SCR-MM (NCT01408225)
- Testing
- tissue banking
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Cardiovascular Injury, Prostate Carcinoma
Cardiac MRI in Measuring the Impact of Anti-androgen Treatment on Cardiac Function in Patients With Prostate Cancer
Learning about the impact of anti-androgen treatment has on cardiac function in patients with prostate cancer may help plan treatment and help patients live more comfortably.
- Trial name
- NCT02722525
- Testing
- Magnetic Resonance Imaging, Exercise Intervention, Perfusion Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Advanced Breast Carcinoma, Anatomic Stage IV Breast Cancer AJCC v8
Living Well With Advanced Breast Cancer
This study evaluates the use of supportive care in patients with advanced breast cancer to better understand what has helped them, what has been hard, and what kind of help they still need.
- Conditions
- Advanced Breast Carcinoma, Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma
- Trial name
- NCT07227038
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIA Breast Cancer AJCC v8
Intensity Modulated Radiation Therapy or 3-Dimensional Conformal Radiation Therapy in Treating Patients With Lymph-Node Positive Breast Cancer
This phase II trial studies the shoulder morbidity in patients with lymph-node positive breast cancer receiving intensity modulated radiation therapy or 3-dimensional conformal radiation therapy.
- Conditions
- Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIA Breast Cancer AJCC v8, Anatomic Stage IIB Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8
- Trial name
- NCT03786354
- Testing
- 3-Dimensional Conformal Radiation Therapy, Intensity-Modulated Radiation Therapy
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Non-Muscle Invasive Bladder Carcinoma
Studying the Relationship of Patient Positioning and Intravesical Bacillus Calmette Guerin Dwell Time to Improve the Treatment of Non-muscle Invasive Bladder Cancer
This phase IV trial studies whether there is a relationship between how a patient is positioned while receiving bacillus Calmette Guerin (BCG) within the bladder (intravesical) and how long BCG stays in the bladder (dwell time)…
- Trial name
- NCT07474519
- Testing
- Accelerometry, BCG Solution, Electronic Health Record Review
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Cutaneous Melanoma, Merkel Cell Carcinoma
EMLA Topical Cream for Treatment of Pain in Patients Receiving Intra-Dermal Technetium 99 Injections for Lymphoscintigraphy for Skin Cancers
This phase II trial tests how well EMLA topical cream works in treating pain in patients with skin cancers receiving Technetium 99 injections for a lymphoscintigraphy mapping procedure.
- Conditions
- Cutaneous Melanoma, Merkel Cell Carcinoma, Skin Squamous Cell Carcinoma
- Trial name
- NCT06223659
- Testing
- Eutectic Mixture of Local Anesthetics, Questionnaire Administration
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8
Topical or Oral Minoxidil for the Treatment of Endocrine Therapy-Induced Alopecia in Patients With Stage I-IV Breast Cancer
This early phase I trial studies the possible benefits and/or side effects of topical or oral minoxidil in treating endocrine therapy-induced hair loss (alopecia) in patients with stage I-IV breast cancer.
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
- Trial name
- NCT05417308
- Testing
- Minoxidil, Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Prostate Adenocarcinoma, Stage IIB Prostate Cancer AJCC v8
Effects of Relugolix vs Leuprolide on Cardiac Function in Patients With Prostate Cancer
This phase II trial compares the effect of relugolix to leuprolide on cardiac function and performance in patients with prostate cancer.
- Conditions
- Prostate Adenocarcinoma, Stage IIB Prostate Cancer AJCC v8, Stage IIC Prostate Cancer AJCC v8
- Trial name
- NCT06330805
- Testing
- Biospecimen Collection, Contrast Agent, Leuprolide
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Ohio State University Comprehensive Cancer Center