Clinical trials: sponsored by Aarhus University Hospital
Myopia
Low-dose Atropine for the Prevention of Myopia Progression in Danish Children
Myopia (nearsightedness) is increasing in prevalence throughout the world. It is associated with a risk of potentially blinding complications such as retinal detachment and myopic maculopathy.
- Trial name
- APP (NCT03911271)
- Testing
- 0.1% atropine and 0.01% atropine, 0.01% atropine, 0.9% Sodium-chloride
- Where
- 3 sites in Denmark
- Volunteers
- 97 people
- Sponsor
- Line Kessel
Graves Ophthalmopathy
Glucocorticoids and Bone in Graves' Ophthalmopathy
Continuous use of systemic glucocorticoids decreases bone mineral density and increases fracture risk. Graves' orbitopathy is treated with weekly infusion of high-dose intravenous glucocorticoid.
- Trial name
- NCT03122847
- Testing
- Methylprednisolone
- Where
- 2 sites in Denmark
- Volunteers
- 39 people
- Sponsor
- Torben Harsløf
Stroke, Acute, Ischemic Stroke
Remote Ischemic Conditioning in Patients With Acute Stroke (RESIST)
Our primary aim is to investigate whether remote ischemic conditioning (RIC) as an adjunctive treatment can improve long-term recovery in acute stroke patients as an adjunct to standard treatment.
- Conditions
- Stroke, Acute, Ischemic Stroke, Hemorrhagic Stroke, Intracerebral Hemorrhage
- Trial name
- RESIST (NCT03481777)
- Testing
- Remote Ischemic Conditioning
- Where
- 4 sites in Denmark
- Volunteers
- 1,500 people
- Sponsor
- Grethe Andersen
Acute Lymphoblastic Leukemia
Asparaginase Encapsulated in Erythrocytes for Patients With ALL and Hypersensitivity to PEG-asparaginase
Pegylated-asparaginase (PEG-ASP) is an important part of the treatment of childhood acute lymphoblastic leukaemia (ALL). Unfortunately 13% of patients develops allergy and further treatment is impossible.
- Trial name
- NCT03267030
- Testing
- GRASPA
- Where
- 23 sites in Denmark, Estonia and 4 more
- Volunteers
- 55 people
- Sponsor
- Birgitte Klug Albertsen
Heart Arrest, Out-Of-Hospital
Calcium for Out-of-Hospital Cardiac Arrest
This is an investigator-initiated, multicenter, randomized, placebo-controlled, parallel group, double-blind, superiority trial of calcium during adult out-of-hospital cardiac arrest.
- Trial name
- COCA (NCT04153435)
- Testing
- Calcium Chloride, Sodium chloride 0.9%
- Where
- Denmark
- Volunteers
- 397 people
- Sponsor
- Lars Wiuff Andersen
Human Immunodeficiency Virus (HIV)
Romidepsin Plus 3BNC117 Phase 2a Study
The aim of this protocol is to evaluate the effects of romidepsin plus 3BNC117 or romidepsin alone on delaying or preventing viral rebound in ART-treated HIV-1-infected individuals during an analytical interruption of ART.
- Trial name
- ROADMAP (NCT02850016)
- Testing
- 3BNC117, Romidepsin
- Where
- 3 sites in United States, Denmark and 1 more
- Volunteers
- 48 people
- Sponsor
- Rockefeller University
Non-small Cell Lung Cancer
Navelbine And Radiotherapy in Locally Advanced Lung Cancer
This study is an open label randomized multi-centre phase II trial in patients with inoperable locally advanced stage IIB-IIIB Non Small Cell Lung Cancer who fulfils the general criteria for curatively intended irradiation.
- Trial name
- NARLAL (NCT00887783)
- Testing
- Navelbine, 66 Gy/33F, 60 Gy/30F
- Where
- 6 sites in Denmark
- Volunteers
- 117 people
- Sponsor
- Odense University Hospital
Heart Arrest
Vasopressin and Methylprednisolone for In-Hospital Cardiac Arrest
This is an investigator-initiated, multicenter, randomized, placebo-controlled, parallel group, double-blind, superiority trial of vasopressin and methylprednisolone during adult in-hospital cardiac arrest.
- Trial name
- VAM-IHCA (NCT03640949)
- Testing
- Vasopressin, Arginine, Methylprednisolone, NaCl
- Where
- 10 sites in Denmark
- Volunteers
- 501 people
- Sponsor
- Lars Wiuff Andersen
Infertility
Involuntary Childlessness and Stress Management
Many couples experience involuntary childlessness and seek treatment at fertility clinics. Going through treatment procedures can be very challenging, time consuming and emotionally demanding.
- Trial name
- NCT01187095
- Testing
- Expressive writing, Active ctrl
- Where
- Denmark
- Volunteers
- 298 people
- Sponsor
- University of Aarhus
Osteoporosis
Predictive Value of Bone Turnover Markers During Discontinuation With Alendronate
The study is a cohort study comprising 136 patients with osteoporosis stopping treatment with alendronate. The study will contribute with new knowledge about biochemical markers of bone turnover as predictors of bone loss after…
- Trial name
- PROSA (NCT03051620)
- Testing
- Discontinue alendronate
- Where
- Denmark
- Volunteers
- 142 people
- Sponsor
- Aarhus University Hospital
Osteoporosis
Treatment With Zoledronic Acid Subsequent to Denosumab in Osteoporosis
Denosumab is an antibody against receptor-activator of nuclear factor kappa-B ligand that prevents recruitment and differentiation of mature osteoclasts.
- Trial name
- ZOLARMAB (NCT03087851)
- Testing
- Zoledronic Acid
- Where
- Denmark
- Volunteers
- 61 people
- Sponsor
- Aarhus University Hospital
Non-small Cell Lung Cancer
Tarceva And Radiotherapy in Locally Advanced Lung Cancer Non-small Cell Lung Cancer
The trial is a phase II study of daily Tarceva combined with definitive radiotherapy in inoperable locally advanced non small cell lung cancer (stage IIB-IIIB).
- Trial name
- TARLAL (NCT00888511)
- Testing
- Tarceva, Radiotherapy
- Where
- 7 sites in Denmark
- Volunteers
- 15 people
- Sponsor
- Olfred Hansen
Epilepsy, Non-Epileptic Seizure
Validation of Criteria for Identification of Epileptiform Discharges in EEG Recordings of Patients With Epilepsy
Electroencephalography (EEG) records electric activity of the brain using electrodes placed on the scalp. EEG is an important tool in the diagnostic work-up of patients with epilepsy.
- Trial name
- CIED (NCT03533374)
- Testing
- Electroencephalogram (EEG) and visual evaluation
- Volunteers
- 100 people
- Sponsor
- Sándor Beniczky
Coronary Artery Disease
Diagnostic Accuracy of On-line Quantitative Flow Ratio (QFR). FAVOR II Europe-Japan
Quantitative Flow Ratio (QFR) is a novel method for evaluating the functional significance of coronary stenosis. QFR is assessed by calculation of the pressure in the vessel based on two angiographic projections.
- Trial name
- FAVOR II EJ (NCT02959814)
- Testing
- QFR (observational)
- Where
- 10 sites in Denmark, France and 5 more
- Volunteers
- 329 people
- Sponsor
- Aarhus University Hospital Skejby
Central Post Stroke Pain
Peripheral Sensory Input in Central Post Stroke Pain (CPSP)
Prospective, open-label study in 10 patients with Central Post Stroke Pain (CPSP). The study will evaluate the effects of peripheral nerve blockade on spontaneous pain and evoked thermal and mechanical responses in CPSP, and…
- Trial name
- NCT02148588
- Testing
- Ultrasound-guided peripheral nerve block with 2% lidocaine
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Washington University School of Medicine
Chronic Obstructive Pulmonary Disease (COPD)
Magnesium is Associated With QoL in COPD: A Cross-sectional Study
The aim of this study was to investigate the associations between serum concentrations of vitamin D, Magnesium and Calcium in Chronic obstructive pulmonary disease patients and the potential impact of these parameters on lung…
- Trial name
- NCT01564953
- Where
- Denmark
- Volunteers
- 143 people
- Sponsor
- University of Aarhus
Respiratory Disorders, Intensive Care, Neonatal
Timing of Planned Caesarean Section and Morbidity of the Newborn
The caesarean section rate is rising globally. About 10% of the newborns are submitted to a neonatal department after planned caesarean section, primarily with respiratory disorders.
- Trial name
- NCT00835003
- Testing
- Elective caesarean section
- Where
- 7 sites in Denmark
- Volunteers
- 1,273 people
- Sponsor
- Aarhus University Hospital
Postoperative Pain
Transversus Abdominis Plane Catheter: a Study of Method
Major abdominal surgery is associated with postoperative pain. Transversus Abdominis Plane(TAP) block has been shown to reduce pain and opioid-requirements after abdominal surgery.
- Trial name
- NCT01395043
- Testing
- Placing bilateral TAP-catheters preoperatively, Bupivacain 2.5 mg/ml with epinephrine bolus in TAP-catheters
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- Aalborg University Hospital
Maternal Obesity, Gestational Weight Gain
Lifestyle and Pregnancy: The Clinical Effect of Lifestyle Intervention During Pregnancy in Obese Women
Obesity is a serious and increasing health problem in the Western World with about one third of all pregnant women in Denmark being overweight. Among these are more than 11% severe obese.
- Conditions
- Maternal Obesity, Gestational Weight Gain, Obstetric Complications
- Trial name
- LiP (NCT00530439)
- Testing
- Lifestyle intervention, Control, Physical activity, dietetic counselling
- Where
- Denmark
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital