Clinical trials: sponsored by University of Minnesota
Obesity, Childhood
Lifestyle Counseling and Medication for Adolescent Weight Management
The prevalence of adolescent severe obesity is at an all-time high in the United States and the refractory nature of this disease has led to a serious and challenging conundrum in terms of how to provide effective, safe…
- Trial name
- QUEST (NCT04873245)
- Testing
- Intensive Behavioral Program, Semaglutide and Behavioral Program
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- University of Minnesota
Working Memory
Non-Invasive Brain Stimulation to Control Large-Scale Brain Networks
This project will assess the feasibility of traveling wave transcranial alternating current stimulation (tACS) to modify working memory performance and large-scale brain connectivity in surgical epilepsy patients.
- Trial name
- NCT04680481
- Testing
- Transcranial alternating current stimulation
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Minnesota
Child Development, Brain Development
Baby's First Years
Recent advances in developmental neuroscience suggest that experiences early in life can have profound and enduring influences on the developing brain.
- Conditions
- Child Development, Brain Development, Household and Family Processes
- Trial name
- BFY (NCT03593356)
- Testing
- Monthly cash gift payments of $333, Monthly cash gift payments of $20
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of California, Irvine
Smoking, Cigarette
Biomarkers of Exposure and Effect in Standardized Research E-cigarette (SREC) Users
This study is focused on characterizing the toxic and carcinogenic potential of the Standardized Research E-cigarette (SREC) developed by the National Institute on Drug Abuse.
- Trial name
- NCT04003805
- Testing
- Standardized Research E-cigarette (SREC)
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Healthy
State Dependence of Prefrontal Transcranial Magnetic Stimulation
The study will examine whether the benefits of brain stimulation on mental functioning can be enhanced if an individual is actively engaging the target brain networks while receiving brain stimulation.
- Trial name
- NCT05962385
- Testing
- Brain state while receiving TMS
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Kidney Transplant
Pilot Social Support Counseling Intervention for Kidney Transplant Candidates
Feasibility pilot social support counseling intervention for kidney transplant candidates
- Trial name
- NCT04363515
- Testing
- Social support network counseling intervention
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Allyson Hart
Metastatic Breast Cancer, Ovarian Cancer
Assessing the Time Demands of Cancer
A total of 80 individuals receiving treatment for metastatic breast or advanced stage ovarian cancer will be asked to complete a baseline survey and install the mobile app on their smartphone; carry the smartphone for 28…
- Trial name
- NCT05708703
- Where
- 2 sites in United States
- Volunteers
- 78 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
COVID-19
Strategies and Treatments for Respiratory Infections & Viral Emergencies (STRIVE): Shionogi Protease Inhibitor (Ensitrelvir)
Treatments are needed to improve outcomes among patients hospitalized for COVID-19, including direct-acting antiviral (DAA) agents to mitigate the pathology driven by ongoing viral replication.
- Trial name
- NCT05605093
- Testing
- Shionogi Protease Inhibitor (S-217622)
- Where
- 187 sites in United States, Argentina and 22 more
- Volunteers
- 602 people
- Sponsor
- University of Minnesota
Multiple Pulmonary Diseases
Uncuffed Endotracheal Tube vs. no Endotracheal Tube
This is a comparison of uncuffed endotracheal tube (UCETT) vs. no endotracheal tube (ETT) in endobronchial ultrasound-transbronchial needle aspiration (EBUS-TBNA) procedure under moderate sedation in terms of procedure tolerance…
- Trial name
- NCT06799455
- Testing
- Endotracheal tube
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Minnesota
Cystic Fibrosis-related Diabetes, Cystic Fibrosis
SGLT2 Inhibitor Therapy in Cystic Fibrosis-related Diabetes
This will be a placebo-controlled, randomized, double blind, crossover study with a 4 week wash out period. Collect pilot data on the safety, tolerability, and feasibility of empagliflozin therapy in overweight/obese patients…
- Trial name
- NCT06149793
- Testing
- Empagliflozin
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Minnesota
Stroke
Phase-dependent Evaluation of Motor Cortex Excitability With TMS in Stroke
The purpose of this study is to investigate the effects of transcranial magnetic stimulation (TMS) on motor cortex excitability in individuals who have suffered stroke and to study the influence of the phase of the oscillatory…
- Trial name
- NCT04968743
- Testing
- Transcranial magnetic stimulation (TMS)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Smoking
Feasibility of Conducting a Pilot Telehealth Study Assessing the Removal of Filter Ventilation on Smoking Behavior and Biomarkers in Menthol Smokers Switched to Non-menthol Cigarettes
This decentralized clinical trial assesses the feasibility of conducting a tobacco product evaluation study remotely via telehealth visits and mailed samples.
- Trial name
- NCT04514471
- Testing
- Minimally Ventilated non-menthol cigarettes, Ventilated non-menthol cigarettes
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Dandruff, Seborrheic Dermatitis
Cleansing Device for the Treatment of Scalp and Hair Conditions
The objective of this study is to evaluate an improvement of scalp health after the use of an investigational off-label WaterPik and brush device aimed to massage and cleanse the scalp.
- Conditions
- Dandruff, Seborrheic Dermatitis, Hair Loss
- Trial name
- NCT05319444
- Testing
- Off-brand Waterpik®
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Osteoporosis
Effects of Exoskeleton-Assisted Gait Training on Bone Health and Quality of Life
This is a randomized clinical trial to quantify the effects of exoskeleton-assisted gait on the musculoskeletal system and health-related quality of life.
- Trial name
- NCT02533713
- Testing
- Exoskeleton assisted gait training
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Craig Hospital
COVID-19
Strategies and Treatments for Respiratory Infections &Amp; Viral Emergencies (STRIVE): Immune Modulation Strategy Trial
COVID-19 can trigger a dysregulated immune response, and previous studies have shown that immune modulation can improve outcomes in hospitalized patients.
- Trial name
- NCT05822583
- Testing
- abatacept infusion
- Where
- 127 sites in United States, Australia and 17 more
- Volunteers
- 285 people
- Sponsor
- University of Minnesota
Obesity, Childhood
Pharmacokinetics and Pharmacodynamics of Topiramate for Weight Loss in Youth: PHARMATOP
Pediatric severe obesity is the fastest growing obesity category in the United States, and anti-obesity pharmacotherapies are promising adjuncts to lifestyle modification (LSM) for the treatment of this disease.
- Trial name
- PHARMATOP (NCT04986631)
- Testing
- Topiramate Tablets
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of Minnesota
End-stage Ankle Arthritis (ESAA), Osteoarthritis (OA)
Comparing Ankle Fusion to Ankle Replacement
End-stage ankle arthritis (ESAA) is a debilitating condition associated with severe pain, dysfunction, and reduced quality of life.
- Trial name
- NCT01620541
- Testing
- Ankle Arthrodesis, Ankle Arthroplasty
- Where
- 6 sites in United States
- Volunteers
- 517 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Working Memory
Traveling-wave Transcranial Electric Stimulation
This study will assess the impact of traveling wave transcranial alternating current stimulation (tACS) on working memory performance in adults.
- Trial name
- TravelingTES (NCT05399381)
- Testing
- Transcranial alternating current stimulation (tACS)
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Advanced Cancer
The PediQUEST Response Intervention Study
PediQUEST Response proposes a new system of care that expects to improve quality of life in children, adolescents, and young adults with advanced cancer and their parents.
- Trial name
- NCT03408314
- Testing
- PediQUEST Response, Usual Cancer Care
- Where
- 6 sites in United States
- Volunteers
- 194 people
- Sponsor
- Joanne Wolfe, MD, MPH
Spasmodic Dysphonia, Laryngeal Dystonia
Usability of Vibro-tactile Stimulation to Treat Spasmodic Dysphonia
The general aim of the study was to provide evidence for the usability and feasibility of applying vibro-tactile stimulation (VTS) at home as a non-invasive form of neuromodulation to improve speech in people with spasmodic…
- Trial name
- NCT06111027
- Testing
- Vibro-tactile stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Minnesota