Clinical trials: sponsored by Al-Azhar University
Malocclusions, Canine Retraction
Assessment of the Locally Administrated Vitamin D3 and Corticision Efficacy on Orthodontic Canine Retraction
To study the effect vitamin D effect on orthodontic tooth movement when used in combination with coticision technique, independent t test or an equivalent non-parametric test will be used for comparison.
- Trial name
- NCT07455656
- Testing
- patients will receive local application of vitamin D3 combined with corticision
- Where
- Egypt
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Low Back Pain
Acceptance and Commitment Therapy Plus Physiotherapy for Chronic Low Back Pain
This study is a randomized controlled trial (RCT) investigating whether adding Acceptance and Commitment Therapy (ACT) to standard physiotherapy provides greater benefits for adults with chronic low back pain than physiotherapy…
- Trial name
- NCT07766616
- Testing
- Acceptance and Commitment Therapy (ACT), Standard Physiotherapy Program
- Volunteers
- 64 people
- Sponsor
- Al-Azhar University
Dental Caries
Esthetic Evaluation of Onlay Restorations Constructed From Vita Ambria Glass Ceramics
There is limited data available on VITA AMBRIA glass ceramic , so this study is conducted to investigate the esthetic parameters of this new glass press system.
- Trial name
- NCT05437432
- Testing
- VITA AMBRIA, IPS e.max press
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
No Reflow Phenomenon, Reperfusion Injuries, Myocardial
Evaluating SGLT2 Inhibitors for the Reduction of No-Reflow Phenomenon in Patients Undergoing PCI
Study Background \& Purpose: The no-reflow phenomenon is a significant complication occurring in patients with acute myocardial infarction who undergo percutaneous coronary intervention (PCI).
- Conditions
- No Reflow Phenomenon, Reperfusion Injuries, Myocardial, Myocardial Infarction, STEMI - ST Elevation Myocardial Infarction
- Trial name
- NCT07898709
- Testing
- Empagliflozin (SGLT2i), dapagliflozin, Standard medical treatment
- Where
- 4 sites in Egypt
- Volunteers
- 100 people
- Sponsor
- Al-Azhar University
Previous Endodontic Treatment Failure and Radiographically Confirmed Periapical Radiolucency
Efficacy of 810 nm Diode Laser Disinfection on Inflammatory Cytokines and Postoperative Pain After Endodontic Retreatment
The main cause of endodontic disorders is microbial infection. From the infected pulp tissue, microorganisms can penetrate into the deeper layers of root dentine and propagate a periapical tissue through the apical foramen and…
- Trial name
- cytokines (NCT07141459)
- Testing
- 810 nm diode laser disinfection, Calcium Hydroxide Intracanal medication
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Periapical Diseases
Effect of Combined Root Canal Therapies in Mandibular Molars With Coexistent Mature and Immature Apices on the Healing Outcome
Recent advancements in dentistry are driven by the development of dental materials and therapies that support tissue regeneration, including the application of bioactive, biocompatible calcium silicate-based materials like…
- Trial name
- NCT07891611
- Testing
- Bioceramic apical plug, Regenerative endodontic procedure
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Al-Azhar University
Breast Cancer, Peripheral Neuropathy Due to Chemotherapy
Evaluation of the Effect of Amantadine in the Prevention of Paclitaxel-Induced Peripheral Neuropathy in Breast Cancer Patients
This randomized, controlled, open-label trial will evaluate the efficacy and safety of amantadine, an NMDA receptor antagonist with antioxidant and anti-inflammatory properties, in preventing paclitaxel-induced peripheral…
- Conditions
- Breast Cancer, Peripheral Neuropathy Due to Chemotherapy, VAS Score
- Trial name
- NCT07889115
- Testing
- Amantadine (oral)
- Volunteers
- 80 people
- Sponsor
- Al-Azhar University
Pregnancy at Increased Risk of Fetal Congenital Anomalies
Transabdominal Versus Transvaginal Ultrasound at 9-14 Weeks in High-Risk Pregnancies
This prospective observational comparative study aims to compare the visualization success rate (VSR) of transabdominal ultrasound (TAUS) and transvaginal ultrasound (TVUS) in high-risk singleton pregnancies between 9+0 to…
- Trial name
- NCT07883850
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Mohamed Mahrous Ahmed
Impact of ROM Exercises on Pain and Functional Ability in Patients With Second -Degree Burns
Impact of Range of Motion Exercises on Pain and Functional Ability
The goal of this quasi-experimental study is to evaluate the effect of range of motion (ROM) exercises on pain and functional ability among adult patients of both genders with second-degree burn injuries affecting the upper…
- Trial name
- ROM-SDB (NCT07883863)
- Testing
- Range of Motion exercises
- Volunteers
- 80 people
- Sponsor
- Al-Azhar University
Semen Analysis, Male Infertility
YO® Smartphone Home Sperm Test Versus Manual Semen Analysis in Egyptian Men
This study compares the YO® Home Sperm Test, a smartphone-based semen testing device, with conventional manual semen analysis performed according to the World Health Organization (WHO) 6th edition laboratory manual.
- Trial name
- NCT07880288
- Testing
- YO® Home Sperm Test, Manual Semen Analysis (WHO 6th Edition)
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Armed Forces College of Medicine, Cairo, Egypt
Sepsis, Septic Shock
Implementation of Timely Management of Sepsis and Septic Shock Protocol in the Emergency Department and Intensive Care Unit: A Quality Improvement Project at AFHJ
Study Title: Implementation of a Sepsis Management Protocol at Armed Forces Hospital Jazan (AFHJ). Purpose: The purpose of this quality improvement project is to determine if implementing a standardized, evidence-based "sepsis…
- Conditions
- Sepsis, Septic Shock, Systemic Inflammatory Response Syndrome (SIRS), Critical Illness
- Trial name
- NCT07460024
- Testing
- Adapted Surviving Sepsis Campaign (SSC) Protocol, Standard Clinical Care
- Where
- Saudi Arabia
- Volunteers
- 120 people
- Sponsor
- Al-Azhar University
Traumatic Peripheral Nerve Injury
Effect of Ultrasound Guided PRP Injection on Post Trumatic Peripheral Nerve Regeneration.
This study is a prospective non randomized controlled trial evaluating the effect of ultrasound-guided platelet-rich plasma (PRP) injections on peripheral nerve regeneration.
- Trial name
- NCT07879092
- Testing
- US guided PRP injection, Rehabilitation
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Seham A. Elazab
Hypotension, Spinal Anesthesia
Pupillary Light Reflex to Predict Post-Spinal Hypotension in Elective Cesarean Delivery
This prospective observational cohort study investigates whether pre-anesthetic pupillary light reflex (PLR) parameters can predict the risk of hypotension following spinal anesthesia in women undergoing elective cesarean…
- Conditions
- Hypotension, Spinal Anesthesia, Cesarean Delivery
- Trial name
- NCT07678723
- Testing
- Not applicable- observational study
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Reversal of Local Anesthesia in Children
Phentolamine Mesylate vs. Diode Laser for Anaesthesia Reversal
"Randomised three-arm trial comparing phentolamine mesylate (OraVerse), 650-nm diode laser and no intervention for accelerating reversal of soft-tissue anaesthesia after 4% articaine (1:100,000 epinephrine) buccal infiltration in…
- Trial name
- RCT (NCT05473858)
- Testing
- OraVerse Injectable Product, diode laser
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- sara nabil
Post-operative Pain, Periapical Inflammation
Modulation of Periapical Inflammation Following Nano-sized Intracanal Medication. A Randomized Controlled Clinical Trial
The main cause of endodontic disorders is microbial infection. From the infected pulp tissue, microorganisms can penetrate into the deeper layers of root dentine and propagate a periapical tissue through the apical foramen and…
- Trial name
- Nano-Chitosan (NCT07571837)
- Testing
- Nanochitosan paste, Nano-calcium hydroxide paste, Calcium hydroxide paste
- Where
- Egypt
- Volunteers
- 63 people
- Sponsor
- Al-Azhar University
Accelerate Tooth Movement
Impact of Various Acceleration Techniques on En-masse Retraction of Maxillary Anterior Teeth
Impact of Various Acceleration Techniques on En-masse Retraction of Maxillary Anterior Teeth: A Digital Software Evaluation (Comparative Clinical Study)
- Trial name
- LLLT- piezo (NCT07873853)
- Testing
- low level LAZER therapy., Retraction of Maxillary Anterior Teeth (en-mass) with conventional methods., Piezocision-assisted orthodontic retraction
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Polycystic Ovary Syndrome
Letrozole Versus Letrozole and Inositol
Polycystic ovary syndrome (PCOS) is one of the most common endocrine and metabolic disorders affecting women of reproductive age.
- Trial name
- NCT07873294
- Testing
- Letrozole tablets
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Al-Azhar University
Plane Warts
Efficacy of Ivermectin in the Treatment of Plane Warts
This study aims to evaluate the efficacy of ivermectin in the treatment of plane warts( flat warts). patients diagnosed with plane warts will be included to assess the clearance ratre of the lesions.
- Trial name
- NCT07710638
- Testing
- Ivermectin
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Al-Azhar University
Rheumatoid Arthritis (RA)
Evaluation of Dapagliflozin and Empagliflozin as Adjunctive Therapy to Methotrexate in Patients With Rheumatoid Arthritis
This study aims to evaluate the efficacy and safety of dapagliflozin and empagliflozin as adjunctive therapies to methotrexate in patients with rheumatoid arthritis who have active disease despite stable methotrexate treatment.
- Trial name
- NCT07864688
- Testing
- Dapagliflozin, Empagliflozin, Methotrexate
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Al-Azhar University
Congenital Lung Malformation
Early Outcomes of Thoracoscopic Anatomical Lesion Resection for Congenital Lung Malformations in Children: A Single-Center Experience in a Limited-Resource Country
This study aimed to evaluate the safety and efficacy of thoracoscopic resection for CLMs in pediatric patients.
- Trial name
- NCT07859774
- Volunteers
- 30 people
- Sponsor
- Al-Azhar University