Clinical trials: sponsored by Alexandria University
Oral Lichen Planus
Curcumin-mediated Photodynamic Therapy Versus Photobiomodulation in the Treatment of Oral Erosive Lichen Planus
Background: Oral Lichen Planus (OLP) is a chronic, T-cell-mediated inflammatory disease of the oral mucosa, with the erosive form causing painful ulcerations and erosions, significantly impacting the patient's quality of life and…
- Trial name
- NCT07910175
- Testing
- Nano- Curcumin-Mediated Photodynamic Therapy (PDT), Photobiomodulation Therapy (PBM)
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Alexandria University
Dental Implant Stability
Early Loading for Implants With Calcium Titanate Surface Technology in Posterior Mandibular Bone
Dental implants have revolutionized oral rehabilitation for partially edentulous patients. Recent advances in implant design and surface treatments have prompted the investigation of early loading methods, which aim to minimize…
- Trial name
- NCT07551128
- Testing
- Early implant loading, Delayed loading
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- Alexandria University
Infection, Surgical Site
Povidone-Iodine and Ozonated Distilled Water Irrigation in the Management of Maxillofacial Space Infections
Maxillofacial space infections are among the most common infections encountered in oral and maxillofacial surgery and may progress to severe, life-threatening complications if not properly managed, making their treatment a…
- Trial name
- NCT07904143
- Testing
- Incision and drainage + Povidone-iodine irrigation, Incision and drainage + ozonated distilled
- Where
- Egypt
- Volunteers
- 26 people
- Sponsor
- Alexandria University
Molar Hypomineralization
Intraosseus Injection Using Extra-short Needle Combined With Infiltration in Pediatric Patients With Molar Incisor Hypomineralization
Background: Effective pain control is crucial in managing pediatric dental patients. Molar-incisor hypomineralization (MIH), marked by enamel defects and dentin hypersensitivity, often hinders effective local anesthesia.
- Trial name
- NCT07239050
- Testing
- intraosseus anesthesia, Conventional nerve block
- Where
- Egypt
- Volunteers
- 26 people
- Sponsor
- Alexandria University
Therapeutic Communication
Culturally-Tailored AI Chatbot Simulation for Therapeutic Communication and Empathy in Psychiatric Nursing Students
Therapeutic communication and empathy are core competencies in psychiatric nursing, yet students often have limited opportunities to practise them safely with culturally realistic patients and families.
- Trial name
- AI-CHAT-PSY (NCT07905469)
- Testing
- Culturally-Tailored AI Chatbot Simulation, Instructor-Facilitated Peer Role-Play
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Badly Decayed Primary Molars, Preformed Pediatric Posterior Crowns
Evaluation of Bioflex and Zirconia Crowns Versus Stainless Steel Crowns on Primary Molars: Randomized Controlled Clinical Trial
The goal of this clinical trial is to evaluate the clinical effectiveness of bioflex crowns and zirconia crowns compared to stainless steel crowns when restoring primary molars 45 participant who their ages range between 6 and 8…
- Trial name
- NCT07156838
- Testing
- bioflex crown, zerconia crown, stainless steel crown
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Maternal Hypotension After Spinal Anesthesia
Comparison of Prophylactic Continuous Infusion of Norepinephrine, Ephedrine, and Their Combination for Prevention of Hypotension During Spinal Anaesthesia for Caesarean Delivery
Background Spinal anaesthesia is the preferred anaesthetic technique for most elective Caesarean deliveries; however, maternal hypotension following spinal anaesthesia remains very common and may be associated with maternal…
- Trial name
- NCT07899216
- Testing
- continuous infusion of noreadrenaline at a fixed rate of 30 ml/min of 4ug/ml, continious ephedrine infusion at a rate of 30 ml/min, Patients will receive a combined infusion of norepinephrine 2 µg/min and ephedrine 2 mg/min.
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Mental Illness Stigma, Psychiatric Nursing
AI Simulation to Reduce Stigma and Enhance Psychiatric Readiness in Nursing Students
Mental illness stigma among nursing students can undermine the quality of care that people with psychiatric conditions receive, and many students feel unprepared for psychiatric practice.
- Trial name
- AI-SIM-PSY (NCT07896538)
- Testing
- AI-Simulation Programme, Standard Psychiatric-Mental Health Nursing Curriculum
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Infraclavicular Vein Cannulation, Venous Cannulation
Right Versus Left Distal Axillary Vein Cannulation
Central venous cannulation is an essential procedure in the anaesthetic and critical care practice. Ultrasound has revolutionized the practice favoring the internal jugular cannulation to the other sites .Subcalvian vein…
- Trial name
- NCT06761326
- Testing
- Ultrasound guided right infraclavicular approach of subclavian vein cannulation, Ultrasound guided left infraclavicular approach of subclavian vein cannulation
- Where
- Egypt
- Volunteers
- 85 people
- Sponsor
- Alexandria University
Moral Injury
Mobile-Based Resilience Intervention for Moral Injury, Compassion Fatigue, and Distress in ICU Nurses
Critical care nurses are routinely exposed to high acuity, mortality, end-of-life decisions, and long rotating shifts, which can lead to moral injury, compassion fatigue (burnout and secondary traumatic stress), and psychological…
- Trial name
- ICU-RESILIENCE (NCT07896447)
- Testing
- Behavioral
- Where
- Egypt
- Volunteers
- 160 people
- Sponsor
- Alexandria University
Stage II and III Periodontitis
Effectiveness of Topical Fluoroquinolone Gel in Treating Stage II/III Periodontitis
The goal of this clinical trial is to investigate the effect of local application of levofloxacin gel on healing of periodontal pockets in patients with stage II/III periodontitis. The main questions it aims to answer are: 1.
- Trial name
- NCT07892261
- Testing
- Levofloxacin in-situ gel, Professional mechanical plaque removal
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Naira Mohammed
Hypoxic Ischemic Encephalopathy of Newborn, Neuro-protection
Levetiracetam as an Adjuvant Therapy to Hypothermia in Neonatal Asphyxia
Clinical evaluation of the possible neuroprotective effect of early prophylactic high dose of Levetiracetam as adjunctive therapy to WBC in neonates with HIE.
- Trial name
- NCT07897032
- Testing
- Levetiracetam, Therapeutic hypothermia (whole body cooling)
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Alexandria University
Preterm, Respiratory Distress Syndrome in Premature Infant
The Hemodynamic Impact of High-frequency Oscillatory Ventilation and Periodic Sighs in Preterm Infants
To evaluate the effectiveness of early lung recruitment using high-frequency oscillatory ventilation (HFOV) alone versus HFOV with superimposed sigh breaths in moderate-to-late preterm infants requiring invasive respiratory…
- Conditions
- Preterm, Respiratory Distress Syndrome in Premature Infant, Recruitment, Mechanical Ventilation
- Trial name
- NCT07896824
- Testing
- Superimposed sigh breaths, High frequency ventilation
- Volunteers
- 100 people
- Sponsor
- Alexandria University
Diabetic Macular Edema, Center-involved Diabetic Macular Edema
Randomized Clinical Trial to Evaluate the Effect of Dapagliflozin in Patients With Diabetic Macular Edema
The purpose of this clinical study is to explore the efficacy of dapagliflozin as an adjunct to intravitreal anti-vascular endothelial growth factor (anti-VEGF) for enhanced reduction of retinal thickness and vision improvement…
- Trial name
- DAPA-DME (NCT06845163)
- Testing
- Dapagliflozin, Anti-VEGF drug
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Alexandria University
Postoperative Delirium (POD) After Nephrectomy
A Prospective Comparative Clinical Trial of Postoperative Delirium Incidence in Open Versus Laparoscopic Nephrectomy
A prospective comparative clinical trial of postoperative delirium incidence in open versus laparoscopic nephrectomy
- Trial name
- NCT07892898
- Testing
- Open Nephrectomy, Laparoscopic Nephrectomy
- Where
- Egypt
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Renal Insufficiency, Chronic, Anxiety
AI-Guided Personalized Relaxation for Hemodialysis Patients
Patients undergoing maintenance hemodialysis frequently experience impaired health-related quality of life, anxiety, and difficulties in coping with the long-term demands of treatment.
- Conditions
- Renal Insufficiency, Chronic, Anxiety, Relaxation Therapy, Maintenance Hemodialysis
- Trial name
- NCT07522944
- Testing
- AI-Guided Relaxation Platform, Standard Hemodialysis Nursing Care
- Where
- Egypt
- Volunteers
- 128 people
- Sponsor
- Alexandria University
Dexmedetomidine, Emergence Agitation
Effect of Intranasal Dexmedetomidine on the Incidence of Emergence Agitation in Children Undergoing Strabismus Surgery
Dexmedetomidine is a selective a-2 adrenergic agonist that provides sedative and analgesic effects. Intranasal dexmedetomidine has a slower and gradual onset compared to intravenous injection , with low incidence of nasal…
- Trial name
- NCT07523438
- Testing
- high dex group, low dex group
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Alexandria University
Fasting Ramadan
Effect of Ramadan Fasting on Kidney Function and Proteinuria in Patients With Glomerulonephritis
This research aims to assess effects of ramadan fasting on kidney function and proteinuria in patients with glomerulonephritis.
- Trial name
- NCT06327009
- Testing
- fasting month of ramadan
- Where
- Egypt
- Volunteers
- 128 people
- Sponsor
- Alexandria University
Heart Failure
AI-Based Personalized Self-Management for Patients With Heart Failure
This study aims to evaluate the effectiveness of an AI-based personalized self-management intervention on self-care behaviors and health-related quality of life among patients with chronic heart failure.
- Trial name
- NCT07841665
- Testing
- Experimental: AI-Based Personalized Self-Management Intervention, Behavioral: AI-Based Personalized Self-Management Intervention
- Where
- 2 sites in Egypt
- Volunteers
- 150 people
- Sponsor
- Alexandria University
Cataract, Dexamethasone
Dexamethasone Versus Metoclopramide for Prophylaxis of Nausea and Vomiting After Cataract Surgery
Postoperative nausea and vomiting (PONV) is a common consequence of ambulatory surgery, affecting up to 80% of high-risk patients and 20-30% overall.
- Trial name
- NCT07086118
- Testing
- 0.9% normal saline, Metoclopramide 10mg, Dexamethasone
- Where
- Egypt
- Volunteers
- 210 people
- Sponsor
- Alexandria University