Clinical trials: sponsored by Assistance Publique - Hôpitaux de Paris
Pyelonephritis
Population Pharmacokinetics of Temocillin in Acute Enterobacterial Pyelonephritis in Children
Temocillin, a 6-alpha-methoxypenicillin derivative of ticarcillin, is a narrow-spectrum antibiotic, primarily restricted to Enterobacterales.
- Trial name
- TEMOKID-POP (NCT07070102)
- Testing
- blood samples
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Glucocorticoid-induced Adrenal Insufficiency
Post-corticosteroid Insufficiency: Search for a Threshold Value for Cortisol at 8 Hours, Prospective Study
Post-corticosteroid insufficiency is found in 40-60% of patients within 10 weeks following the cessation of prolonged corticosteroid therapy and in 20% of patients still after 1 year.
- Trial name
- SYNASTOPRO (NCT06208098)
- Testing
- Salivary cortisol dosage
- Where
- France
- Volunteers
- 170 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hearing Loss, Cochlear, Cytomegalovirus Congenital
Cytomegalovirus (CMV) Perilymphatic Fluid
In France, children cochlear implantation (CI) is performed 400 times per year. Causes of profound sensorineural hearing loss (SNHL) are represented by congenital malformation of the inner ear for 50 to 60%.
- Trial name
- CMVP (NCT04724265)
- Testing
- collection of sample of perilymphatic fluid during cochlear implantation
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Vestibular Dysfunction, Hearing Loss
Impact of Vestibular Function on Deaf Infants' Activities of Daily Living
This non-interventional study aims to assess the impact of vestibular impairments on the daily life activities of deaf children aged 0 to 2 years old.
- Conditions
- Vestibular Dysfunction, Hearing Loss, Motor Development
- Trial name
- IVANS (NCT06909266)
- Testing
- OT Hope 0 - 5 ans Therapeutic tool, Qualitative interviews with parents
- Where
- France
- Volunteers
- 105 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Foreign Body Ingestion
Foreign Body Ingestion During COVID-19 Lockdown
Ingestion of foreign bodies (FB) is one of the most observed domestic accidents and a frequent reason for consultation in pediatric emergency departments (PED).
- Trial name
- COCE (NCT05261074)
- Testing
- No intervention
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pediatric Acute Respiratory Failure
Regional Lung Ventilation During Prone Position in in Intubated Children
Mechanical ventilation can lead to pulmonary, diaphragmatic, and hemodynamic complications due to an increase in global and regional transpulmonary pressure.
- Trial name
- ChildProne-EIT (NCT07921745)
- Testing
- Thoracic electric impedance tomography to assed regional ventilation, Positive end-expiratory pressure (PEEP) trial titration, Collection of clinical Data
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Suicide Prevention
Mixed-method Evaluation of a Parental Psychoeducation Programme in a Suicide Risk Prevention Group
The number of emergency consultations for children and adolescents for suicidal ideation and suicide attempts has been rising steadily since 2010, and even more so since 2020.
- Trial name
- Pepps_Mix (NCT06576453)
- Testing
- Self-questionnaire WHOQOL-bref, Self-questionnaire Evaluation Inventory - Parent, quiz of knowledge
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Anomalies Chromosome
The Contribution of Optical Mapping to the Characterization of Chromosomal Rearrangements in Patients With Neurodevelopmental Disorders
In neurodevelomental disorders, duplications are genomic variations that are difficult to interpret because their orientation cannot be defined by conventional techniques (ACPA and FISH).
- Trial name
- Bionano (NCT07133789)
- Testing
- blood sampling of all patients and their parents
- Where
- France
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ondine Syndrome (Congenital Central Hypoventilation Syndrome)
Locus Coeruleus and CCHS (Congenital Central Hypoventilation Syndrome)
This study investigates whether cognitive dysfunction in young patients with congenital central hypoventilation syndrome (Ondine Syndrome) is related to the severity of the disease and dysfunction of the locus coeruleus (a…
- Trial name
- ONDINE-LC (NCT07081464)
- Testing
- MRI, EEG, Pupillometry
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Severe Asthma
Follow-up of Children With Severe Asthma at Adult Age
Most of clinical cohorts focused on the course of asthma over time and on the different phenotypes of asthma have investigated children and adults separately. The passage from childhood to adulthood is scarcely explored.
- Trial name
- S2AEA (NCT05032209)
- Testing
- follow-up of children with severe asthma in adulthood
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Rhumatoid Arthisis, Spondyloarthritis (SA)
Efficacy of a Self-Management Smartphone App to Improve Safety Skills in Patients With Inflammatory Arthritis
Rheumatoid arthritis (RA) and spondyloarthritis (SpA), including psoriatic arthritis (PsA), are chronic painful diseases that impair quality of life.
- Conditions
- Rhumatoid Arthisis, Spondyloarthritis (SA), Psoriatic Arthritis (PsA)
- Trial name
- RHUMATOSMART (NCT07460739)
- Testing
- SFR application
- Where
- France
- Volunteers
- 144 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Preterm Birth, Enterocolitis, Necrotizing
Study of the Influence of Intraperitoneal Insufflation of CO2 by Laparoscopy on the Short-term Evolution of Premature Infants With Ulcerative Necrotizing Enterocolitis
Ulcerative-necrotizing enterocolitis (ECUN) is an infectious and inflammatory disease of the digestive tract, which can lead to intestinal necrosis or perforation.
- Trial name
- NECO2 (NCT05882448)
- Testing
- laparotomy, Laparoscopy
- Where
- 2 sites in France
- Volunteers
- 54 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hidradenitis Suppurativa (HS)
Early Pathophysiology of Hidradenitis Suppurativa and Prediction of the Risk of Progression: a Prospective Cohort
Hidradenitis suppurativa (HS) is a chronic inflammatory disease affecting approximately 1% of the population. Most pathophysiological studies have focused on advanced forms (Hurley II-III), which obscures the initial mechanisms.
- Trial name
- Early-HS (NCT07920848)
- Testing
- Biological samples and questionnaires, Analysis of residual skin tissue
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Depressive Disorder, Major, Generalized Anxiety Disorder
Student Precarity and Psychiatry
Since the COVID-19 pandemic, mental health disorders have increased significantly, particularly among young people. In France, the proportion of young people aged 18 to 25 suffering from depression almost doubled between 2017 and…
- Conditions
- Depressive Disorder, Major, Generalized Anxiety Disorder, Suicidal Ideation, Loneliness
- Trial name
- PEPSY (NCT07618208)
- Testing
- Questionnaires
- Where
- France
- Volunteers
- 45,000 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Intensive Care Psychosis
Follow-up in Pediatric Intensive Care Unit
Background In developed countries, mortality rates in pediatric intensive care units (PICUs) are around 4% and thus, most children admitted to these units survive.
- Trial name
- APRELAREA (NCT06363344)
- Testing
- Questionnaires : PHQ-9 (Kroenke, 2001), the PSC (Sheldrick, 2012), the ASQ-SE (Squires, 2015), the PedsQL (Varni, 1999)
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Echocardiography in Intubated Children in Pediatric Intensive Care, Intubation Complication
Estimation of Central Venous Pressure by Echocardiography in Intubated Children in Pediatric Intensive Care
Central venous pressure (CVP) is a parameter used very regularly in pediatric resuscitation units. According to international recommendations, it should be measured during resuscitation of acute circulatory failure, severe head…
- Trial name
- PVCECHO (NCT05195424)
- Testing
- Estimation of central venous pressure by echocardiography in intubated children in pediatric intensive care
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Steroid-Dependent Nephrotic Syndrome, Steroid-Sensitive Nephrotic Syndrome
Efficacy and Safety of Obinutuzumab Versus Rituximab in Childhood Steroid Dependant and Frequent Relapsing Nephrotic Syndrome
B-cell depletion with rituximab induces sustained remission in children with Steroid-Dependent or Frequent Relapsing Nephrotic Syndrome (SD/FRNS).
- Trial name
- OBIRINS (NCT05786768)
- Testing
- single infusion of Rituximab, single infusion of Obinutuzumab
- Where
- France
- Volunteers
- 88 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Gastroesophageal Reflux
Jejunal Feeding Via Gastrojejunal Tube in Refractory Gastroesophageal Reflux
Gastroesophageal reflux disease (GERD) in children can be severe and lead to multiple complications, dizziness, esophagitis, respiratory failure or ENT infections.
- Trial name
- ReJej (NCT05278689)
- Testing
- No intervention
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Osteomyelitis
Acute Non-severe Osteomyelitis in Children - Outpatient Management Strategy With Oral Antibiotic Therapy Compared to a Standard Strategy With Conventional Hospitalization and Intravenous Antibiotic Therapy: a Randomized Open-label Non-inferiority Study With Bayesian and Medical-economic Analyses.
The incidence of bone and joint infections (BJI) in children (osteomyelitis, septic arthritis and spondylodiscitis) is 22 per 100,000 children in France.
- Trial name
- POOMA (NCT04554108)
- Testing
- therapeutic strategy
- Where
- France
- Volunteers
- 189 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pediatric Kidney Disease, Transplant;Failure,Kidney
Non-Invasive Monitoring of Pediatric Kidney Transplant Recipients and Immunosuppression Personalization: an Open-labeled Multicenter Randomized Controlled Study
Currently, the monitoring of children receiving a kidney transplantation includes surveillance biopsies to detect subclinical rejection and signs of toxicity of immunosuppressive drugs (tacrolimus).
- Trial name
- MONITOR (NCT06761482)
- Testing
- monitoring by dd-cfDNA, monitoring by T-Vis, monitoring by dd-cfDNA+ T-Vis
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.