Clinical trials: sponsored by Centre Hospitalier Universitaire de Nice
Trigeminal Neuralgia Treated by Radiosurgery
Impact of Individual Radiosensitivity on Late Toxicities of Radiosurgery in Essential Trigeminal Neuralgia
Trigeminal neuralgia is intense, electric-shock-like facial pain, most often triggered by touch, chewing or speech. It results from dysfunction of the trigeminal nerve, the 5th cranial nerve.
- Trial name
- TRITON (NCT06863324)
- Testing
- Radiation induced Lymphocyte Apoptosis diagnostic test
- Where
- 2 sites in France, Monaco
- Volunteers
- 74 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Community-acquired Pneumonia
Community-Acquired Pneumonia Diagnosis Using Lung Ultrasound in Emergency Room Adults
Community-Acquired Pneumonia (CAP) is a major problem in Emergency Department (ED). Diagnosis relies on combination of clinical symptoms and results of chest radiography (CR).
- Trial name
- CAPUERA (NCT04210102)
- Testing
- Lung Ultrasound (LUS), Chest radiography (CR)
- Where
- Monaco
- Volunteers
- 47 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Flu
Quantification of Viral Load in the Upper Respiratory Tract in Patients Treated With Olsetamivir for Influenza
Seasonal influenza is a frequent disorder with high impact on morbidity and mortality and significant burden on healthcare-related cost.
- Trial name
- VIRIDAE (NCT04515446)
- Testing
- Rapid test for diagnosis orientation, quantitative PCR
- Where
- Monaco
- Volunteers
- 18 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Stress
Perioperative Stress Management in Outpatient Surgery With L-tyrosine Supplementation (SPOT)
Patient undergoing surgery is exposed to many stressors: diachronic (gesture anticipation), synchronic (intraoperative aggression) and historical (subject's personality).
- Trial name
- SPOT (NCT05782829)
- Testing
- L-tyrosine supplementation
- Where
- Monaco
- Volunteers
- 88 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Virus-HIV
Polypharmacy on Healthy Aging in People Living With HIV Over the Age of 75
Since the advent of antiretroviral treatments, the life expectancy of people living with HIV (PLHIV) has increased significantly. In France, more than 30% of PLHIV are now over 50 years old.
- Trial name
- POLYVIH (NCT07388394)
- Testing
- interview with advanced practice nurse
- Where
- France
- Volunteers
- 136 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Diabetes Mellitus, Psychological Distress
Prevalence of Diabetes-related Distress Among Patients Living With Type 2 Diabetes in a University Hospital Center and Identification of Its Associated Factors.
Diabetes-related distress is a psychological construct associated with poorer glycaemic control in people living with diabetes. In France, few data are available on this topic and none focus specifically on adults with type 2…
- Trial name
- DIAMIND (NCT07392437)
- Testing
- Questionnaire and Physical Exam
- Where
- France
- Volunteers
- 290 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Alzheimer Disease, Myasthenia
Presence of Anti-RACH Antibodies and Neurocognitive Disorder in Myasthenic or Alzheimers's Patients.
The purpose of the study is to evaluate if there is a specific association between the presence of anti Rach antibodies in the CSF and the presence of a cogntive disorder in myasthenic patients.
- Trial name
- ARN-MA (NCT06523296)
- Testing
- Adults with Alzheimer's disease, Adults with Myasthenia, Healhty controls
- Where
- France
- Volunteers
- 1 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Hip Injuries
Psoas Tenotomy Under Ultrasound
The ilio-psoas conflict is a commonly accepted complication after total hip replacement, often linked to a mispositioning of the acetabular prosthetic component that conflicts with the ilio-psoas tendon.
- Trial name
- TEPSe (NCT06064136)
- Testing
- Psoas tenotomy under ultrasound
- Where
- France
- Volunteers
- 1 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Medical Imaging
Defining Dosimetric Reference Levels in Computed Tomography Spectral Scanning
Spectral computed tomography or dual-energy CT imaging can overcome the limitations of conventional CT in differentiating between two materials with equivalent total attenuation.
- Trial name
- NR Spectral (NCT07305103)
- Testing
- Spectral ComputedTomography
- Where
- France
- Volunteers
- 9,600 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Pelvic Organ Prolapse
AMBULAPSE STUDY Feasibility Study on Laparoscopic Double-mesh Sacrocolpopexy With or Without Robotic Assistance, in Female Patients Presenting With Symptomatic Pelvic Organ Prolapse, Based on an Outpatient Treatment Model.
Pelvic organ prolapse is an increasingly common functional disorder which affects approximately 30 to 40% of the female population, 12% of whom have a symptomatic form, with a psychological, physical and social impact.
- Trial name
- AMBULAPSE (NCT03764852)
- Testing
- outpatient laparoscopic
- Where
- 5 sites in France
- Volunteers
- 55 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Epidermolysis Bullosa Simplex, Ichthyosis
A 44-week Monocentric Open Study Assessing the Efficacy and Safety of Deucravacitinib in Adults With Inflammatory Genodermatoses
The goal of this clinical trial is to learn about deucravacitinib treatment in adults with inflammatory epidermal genodermatoses . The main question it aims to answer are: describe efficacity and safety of this treatment.
- Conditions
- Epidermolysis Bullosa Simplex, Ichthyosis, Genodermatosis, Inflammatory Congenital Ichthyoses
- Trial name
- GENEPID (NCT06136403)
- Testing
- deucravacitinib
- Where
- 2 sites in France
- Volunteers
- 8 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Infertility, Female, Pregnancy Related
Low TGF-β and Embryo Implantation in the Context of Assisted Reproductive Technology: Confirmation of a Biomarker Predictive of Success and Characterization of the Immune Microenvironment.
Infertility affects about one in seven couples in France. Beyond the medical and personal challenges, it has major societal implications.
- Trial name
- ImmuNoFertilit (NCT07859930)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Acid Sphingomyelinase Deficiency (ASMD), Niemann Pick Disease
National Multicentre Study of the Natural History of Acid Sphingo-myelinase Deficiency in Adults and Children
The goal of this study is to describe the natural history of ASMD in adult and paediatric patients with or without specific treatment in order to assess the impact of the disease on their daily lives and quality of life.
- Trial name
- FASMD (NCT06985212)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Wladimir MAUHIN, Dr
Parkinson Disease, Idiopathic
Video-oculography and Parkinson's Disease
This study aims to study, in patient with Parkinson's disease, mild to moderate stage (according to Movement Disorder Society Clinical Diagnostic Criteria for Parkinson's Disease, Postuma et al., 2015): the evolution of…
- Trial name
- NCT04731246
- Testing
- Video-oculography / Neuropsychological evaluations
- Where
- Monaco
- Volunteers
- 30 people
- Sponsor
- Association de Recherche Bibliographique pour les Neurosciences
Fragility Fractures of the Pelvis (FFP), Osteoporotic Fractures
Functional Outcomes in Older Adults With Fragility Fractures of the Pelvis: The FFP-France Study
Fragility fractures of the pelvis (FFP) are an increasingly common complication of osteoporosis in older adults and are associated with substantial morbidity, loss of independence, and mortality.
- Trial name
- NCT07871084
- Testing
- Observational Assessment of Fragility Fractures of the Pelvis
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Aging
Codesign, Physical Activity, and Seniors
The benefits of physical activity are well-established. However, adherence to and sustained participation remain limited. These difficulties are partly explained by a lack of consideration for individual differences and the…
- Trial name
- CAPS (NCT07582406)
- Testing
- Co-designed tailored physical activity program, Classical tailored physical activity program
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Craniofacial Fibrous Dysplasia
Morbidity in Adults With Craniofacial Fibrous Dysplasia: The CRANIO-DF Study
Fibrous dysplasia is a rare bone disorder in which normal bone is replaced by fibro-osseous tissue. Craniofacial involvement may be associated with substantial morbidity and complex multidisciplinary care.
- Trial name
- NCT07870616
- Testing
- No Intervention: Observational Cohort
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Pneumocystis Pneumonia, Pneumocystis Jirovecii Infection
CaspoNEB: Efficacy and Safety of Caspofungin Aerosols for the Curative Treatment of Pneumocystis Pneumonia
To assess the efficacy of administrating daily caspofungin aerosols versus placebo for seven days, in adjunction of conventional systemic antifungal therapy during curative treatment of Pneumocystis pneumonia, on the clinical…
- Conditions
- Pneumocystis Pneumonia, Pneumocystis Jirovecii Infection, Pneumocystis Infections
- Trial name
- CaspoNEB (NCT06892951)
- Testing
- Caspofungin Acetate 50 MG, Physiologic saline
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Tours
Disorder Related to Renal Transplantation, Diabetes
Prevention of Diabetes After Transplantation by Vildagliptin in the Early Post-transplant Period
Post-transplant diabetes affects 15 to 20% of renal transplant patients and contributes to increased morbidity and reduced survival of transplants and patients.
- Trial name
- PRODIG (NCT02849899)
- Testing
- Vildagliptin
- Where
- France
- Volunteers
- 47 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Aneurysm Abdominal, Peripheral Arterial Disease
Developing Trustworthy Artificial Intelligence (AI)-Driven Tools to Predict Vascular Disease Risk and Progression
The VASCULAID-RETRO study, within the broader VASCULAID project, aims to create artificial intelligence (AI) algorithms that can predict cardiovascular events and the progression of abdominal aortic aneurysm (AAA) and peripheral…
- Trial name
- VASCULAIDRETRO (NCT06206369)
- Testing
- No intervention, retrospective study
- Where
- 6 sites in Finland, Germany and 4 more
- Volunteers
- 11,000 people
- Sponsor
- Amsterdam UMC, location VUmc