Clinical trials: sponsored by Karolinska Institutet
Functional Hypothalamic Amenorrhea
Feasibility of a Digital Self-help Program for Functional Hypothalamic Amenorrhea (HEAL-FHA Pilot)
This study is a single-arm feasibility trial evaluating a 10-week web-based psychoeducational intervention for women with functional hypothalamic amenorrhea (FHA).
- Trial name
- HEAL FHA Pilot (NCT07589868)
- Testing
- 10-week web-based psychoeducational program
- Where
- 2 sites in Sweden
- Volunteers
- 15 people
- Sponsor
- Karolinska Institutet
Fibromyalgia
Objective Measurement of Pain Regulation in Individuals Who Have Received Internet-delivered Exposure-based Cognitive Behavior Therapy
Fibromyalgia: a common problem that requires treatment Fibromyalgia (FM) is a highly prevalent pain syndrome characterized by generalized pain and fatigue, often leading to extensive somatic and psychological distress.
- Trial name
- NCT07054333
- Testing
- Internet-delivered exposure-based cognitive behavior therapy
- Where
- 2 sites in Sweden
- Volunteers
- 50 people
- Sponsor
- Karolinska Institutet
Insomnia, Depression
Acute Psychological Sleep Stabilisation for Patients Hospitalised With Depression
Disturbed sleep occurs in almost all patients in psychiatric inpatient care, and although it is well known that comorbid sleep disorders in depression often persist after treatment of depression and also increase the risk of new…
- Trial name
- NCT06145555
- Testing
- Acute psychological sleep stabilization, Sleep hygiene education
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska Institutet
Depressive Symptoms, Anxiety Symptoms
Culturally Adapted i-CBT for Farsi/Dari Speaking Migrants
The aim of this randomized controlled trial (RCT) is to investigate the effectiveness of a culturally adapted internet-based cognitive behavioral therapy (i-CBT) intervention in reducing symptoms of common mental health issues…
- Conditions
- Depressive Symptoms, Anxiety Symptoms, Grief, Psychological Trauma
- Trial name
- i-CBT (NCT06828276)
- Testing
- Culturally adapted i-CBT
- Where
- Sweden
- Volunteers
- 93 people
- Sponsor
- Karolinska Institutet
Parenting Intervention, Anger
Digital Behavioral Parenting Programs With and Without Added Emotion Regulation Strategies to Manage Anger in Parenting
This pilot randomized controlled trial evaluates the feasibility, acceptability, and preliminary effects of two digital parenting interventions for parents experiencing difficulties with anger in parenting.
- Conditions
- Parenting Intervention, Anger, Emotion Regulation Difficulties, Parenting Behaviour
- Trial name
- NCT07795684
- Testing
- Online Behavioral Parent Training Program, Online Behavioral Parent Training + Emotion Regulation Program
- Where
- Sweden
- Volunteers
- 90 people
- Sponsor
- Karolinska Institutet
Heart Failure, Cardiovascular Risk Factors
Determining Efficacy of an Artificial Intelligence-based System for Heart Failure Detection Through Interpretation of Electrocardiograms (DECISION)
The DECISION trial aims to evaluate the efficacy of an artificial intelligence (AI)-powered system, Willem™, for improving the detection of heart failure (HF) in primary care settings by interpreting electrocardiograms (ECGs).
- Trial name
- DECISION (NCT07113223)
- Testing
- Willem™ platform ECG assessment
- Where
- 5 sites in Spain, Sweden
- Volunteers
- 1,968 people
- Sponsor
- Idoven 1903 S.L.
Obesity (BMI > 35)
Preserving Muscle Mass During Incretin-Induced Weight Loss
Treatment with incretin-based obesity medications leads to clinically meaningful weight loss and reduced cardiometabolic risk. However, the weight lost includes not only adipose tissue but also skeletal muscle, which may impair…
- Trial name
- INCRETraIN (NCT07761923)
- Testing
- Unilateral Resistance Training
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Karolinska Institutet
Alcohol Misuse
Adaptive Actions and Alcohol Use Outcomes During Internet-delivered Cognitive Behaviour Therapy
This observational study investigates an Internet-delivered Cognitive Behaviour Therapy (ICBT) intervention for alcohol misuse, called the Alcohol Change Course Enhanced (ACCE).
- Trial name
- NCT07021053
- Testing
- Alcohol Change Course Enhanced
- Where
- Canada
- Volunteers
- 165 people
- Sponsor
- University of Regina
Hypertension
Implementation of a Person-Centered and Integrated Care Pathway for Hypertension
The aim is to investigate whether information and educational initiatives on the Swedish national care pathway for hypertension, directed at primary care centers, lead to an increase in the proportion of patients achieving target…
- Trial name
- IMPLEMENT-HT (NCT07914283)
- Testing
- Educational intervention for doctors and nurses
- Volunteers
- 120,000 people
- Sponsor
- Region Stockholm
End Stage Renal Disease, Hemodialysis-Induced Symptom
Integrated Patient Care Intradialysis Programme in Hemodialysis Through a Virtual Health Platform
There is wide evidence regarding the weak points of end-stage Chronic kidney disease (CKD) patients in hemodialysis, and they include three intervention aspects: exercise, nutrition and psychological support.
- Conditions
- End Stage Renal Disease, Hemodialysis-Induced Symptom, Chronic Kidney Diseases
- Trial name
- GoodRENal (NCT04823286)
- Testing
- Virtual reality health platform during hemodialysis
- Where
- 8 sites in Belgium, Greece and 2 more
- Volunteers
- 41 people
- Sponsor
- Cardenal Herrera University
Digital Nerve Injury, Sensory Neurography
Sensory Neurography and S2PD After Digital Nerve Injury
The goal of this clinical comparative cross sectional study, is to investigate neurophysiological findings and S2PD (static two point discrimination test) measurements after digital nerve injury.
- Conditions
- Digital Nerve Injury, Sensory Neurography, S2PD
- Trial name
- NCT07904286
- Testing
- Sensory neurography, Static two point discrimination test, S2PD
- Where
- 2 sites in Sweden
- Volunteers
- 60 people
- Sponsor
- Cecilia Mellstrand Navarro
Pancreatic Cancer, Pancreatic Adenocarcinoma
Liquid Biopsy for ctDNA in Peritoneal Lavage and Blood in Pancreatic Cancer
Pancreatic cancer (PC) is a deadly disease and surgical resection of the tumor is the only hope of cure. Approximately 20-25% of the PC patients are candidates for intended curative resection, but despite microscopically radical…
- Trial name
- LIPAC (NCT05400681)
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Sonke Detlefsen
Cognitive Impairment, Dementia
Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability
This multi-center (6 sites: Helsinki, Kuopio, Oulu, Seinäjoki, Turku, Vantaa) intervention study aims to prevent cognitive impairment, dementia and disability in 60-77 year old persons at an increased dementia risk.
- Trial name
- FINGER (NCT01041989)
- Testing
- Nutritional guidance, Exercise, Cognitive training
- Where
- 5 sites in Finland
- Volunteers
- 1,260 people
- Sponsor
- University of Eastern Finland
Parkinson's Disease (PD), Multiple System Atrophy (MSA)
[18F]ACI-15916 PET in α-synucleinopathies
The goal of this clinical trial is to test whether we can reliably and safely measure the accumulation of pathological protein α-synuclein [involved in some diseases such as Parkinson's disease, Lewy body dementia and Multiple…
- Conditions
- Parkinson's Disease (PD), Multiple System Atrophy (MSA), Dementia With Lewy Bodies (DLB)
- Trial name
- NCT06891703
- Testing
- [18F]ACI-15916
- Where
- Sweden
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- AC Immune SA
Mental Disorder, Depression
Screening to Identify Parents in Need of Mental Health Support: A Feasibility Study in Child Welfare Services
The main aim of this study is to evaluate the feasibility, preliminary effects and experiences of the Collaboration-Screening-Referral approach (CSR / in Swedish: Samverkan-Screening-Hänvisning - SSH) when used with parents…
- Conditions
- Mental Disorder, Depression, Anxiety, Child Abuse
- Trial name
- NCT06600139
- Testing
- The Collaboration-Screening-Referral (SSH) model
- Where
- Sweden
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Self-harm Behavior, Eating Disorders
Evaluation of National Highly Specialized Care for Children and Adolescents With Severe Self-Harm or Eating Disorders
National Highly Specialized Care (NHV) is provided in Sweden to children and adolescents with severe and treatment-resistant self-harm or eating disorders when previous treatment has not led to sufficient improvement.
- Conditions
- Self-harm Behavior, Eating Disorders, Non-suicidal Self-injury (NSSI)
- Trial name
- NHV_CHILD (NCT07898059)
- Testing
- National Highly Specialized Care (NHV)
- Where
- 2 sites in Sweden
- Volunteers
- 120 people
- Sponsor
- Karolinska Institutet
Food Allergy, Oral Immunotherapy for Food Allergy
Slow Multiallergen Oral Immunotherapy in Young Children
The aim is to study whether a multiallergen oral immunotherapy (OIT) strategy with slow up-dosing and low treatment dose against food allergy in young children (0.5-3 years) is safe and effective, a method to cure food allergy…
- Trial name
- InFO (NCT06533462)
- Testing
- Multiallergen powder
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Karolinska Institutet
Lumbar Disc Herniation, Lumbar Radiculopathy
Selective Nerve Root Block Versus Sham to Reduce Surgery for Lumbar Disc Herniation
The SELDISC trial will investigate whether a selective nerve root block can reduce the need for surgery in adults with a herniated disc in the lower back.
- Conditions
- Lumbar Disc Herniation, Lumbar Radiculopathy, Lumbar Disc Herniation With Radiculopathy
- Trial name
- SELDISC (NCT07895589)
- Testing
- Selective Nerve Root Block
- Where
- 2 sites in Sweden
- Volunteers
- 262 people
- Sponsor
- Karolinska Institutet
Mental Illness, Depression
Identifying Parents in Child Welfare Services Who Need Mental Health Support: Depression and Anxiety Symptoms
The main aim of this study is to examine the occurrence of mental health symptoms among parents referred to the Swedish child welfare services for child maltreatment and other family related risks.
- Conditions
- Mental Illness, Depression, Anxiety
- Trial name
- NCT06572865
- Testing
- Screening for depression and anxiety
- Where
- Sweden
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Multiple Sclerosis (MS) - Relapsing-remitting
Tai Chi Training for Persons With Multiple Sclerosis.
Tai Chi combines strength and neuromuscular training with diaphragmatic breathing, attention, imagery and relaxation. After an initial learning period, participants can practise independently, potentially supporting self-efficacy…
- Trial name
- NCT07890974
- Testing
- Tai Chi training
- Where
- Sweden
- Volunteers
- 35 people
- Sponsor
- Karolinska Institutet
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