Clinical trials: sponsored by Kessler Foundation
Spinal Cord Injuries (SCI), Paraplegia and Tetraplegia
Self-balancing Personal Exoskeleton for SCI
This study aims to demonstrate the safety and effectiveness of the Eve personal exoskeleton in individuals with spinal cord injury (SCI).
- Trial name
- NCT06777576
- Testing
- Hands-free exoskeleton
- Where
- 2 sites in United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Wandercraft
Spinal Cord Injuries (SCI), Paraplegia and Tetraplegia
Self-balancing Personal Exoskeleton for SCI (Site 2)
This study aims to demonstrate the safety and effectiveness of the personal exoskeleton in individuals with spinal cord injury (SCI).
- Trial name
- NCT06814015
- Testing
- Hands-free exoskeleton
- Where
- 2 sites in United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Wandercraft
Spinal Cord Injury, Spasticity
Extracorporeal Shockwave Therapy as an Additional Treatment for Spasticity Secondary to Spinal Cord Injury
Spasticity is a common consequence of spinal cord injury and can have a profound impact on quality of life. The goal of this study is to learn if an intervention called focused extracorporeal shockwave therapy can enhance the…
- Trial name
- NCT07894991
- Testing
- Focused extracorporeal shockwave therapy, Botulinum toxin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Kessler Foundation
SCI - Spinal Cord Injury, Spasticity
Addressing Spasticity and Motor Function With Epidural Spinal Cord Stimulation
The purpose of this study is to investigate treating severe spasticity in persons with spinal cord injury by implanting a device in the body that delivers electrical stimulation around the spinal cord (spinal cord epidural…
- Trial name
- NCT07890558
- Testing
- Epidural implant stimulation device
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Kessler Foundation
Spinal Cord Injury, Spasticity
Shockwave for Elbow and Wrist Spasticity in People With Spinal Cord Injury
Approximately 305,000 people live with a spinal cord injury (SCI) in the United States. Sixty percent of these individuals have tetraplegia, which can cause significant dysfunction of the arms and hands.
- Conditions
- Spinal Cord Injury, Spasticity, Shockwave Therapy
- Trial name
- NCT07501429
- Testing
- Focused extracorporeal shockwave therapy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Kessler Foundation
Neck Pain
A Novel Device for Neck Pain in Active-duty Military Personnel With Forward Head Posture.
Neck pain is a common complaint among active duty military personnel, and can have tremendous impacts on quality of life and participation in duty-related activities.
- Trial name
- NCT05433025
- Testing
- Cervigard Neck Collar
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Kessler Foundation
Stroke, Stroke (CVA) or Transient Ischemic Attack
Neuromodulation-Enhanced Use of RObotic BALANCE Training to Improve Balance Function in Individuals With Stroke
Our proposed study, "NEUROBALANCE Stroke,"; aims to evaluate the effectiveness of a combined intervention involving robotic balance training and noninvasive brain stimulation in improving balance function and postural control in…
- Conditions
- Stroke, Stroke (CVA) or Transient Ischemic Attack, Stroke Ischemic, Stroke Gait Rehabilitation
- Trial name
- NEUROBALANCE (NCT07113041)
- Testing
- Combined (Robotic balance training and high-definition transcranial direct current stimulation), Standard of Care Balance Training
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Kessler Foundation
Upper Extremity Dysfunction, Traumatic Brain Injury
Targeted Noninvasive Brain Stimulation (T-NIBS) to Improve Hand Motor Functions in Acquired Brain Injury
Acquired Brain Injury (TBI) is a serious medical and health problem in the US. Individuals with an acquired brain injury due to stroke and Traumatic Brain Injury (TBI) commonly suffer from upper extremity physical impairments…
- Trial name
- NCT04057105
- Testing
- Active High-definition Transcranial Direct Current Stimulation (HD-tDCS), MusicGlove
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Kessler Foundation
Traumatic Brain Injury (TBI) Patients
Home-Based Walking for Thinking Skills in Persons With TBI
The purpose of this research study is to investigate the effects of a home-based 3-month long walking exercise program on cognitive (thinking) performance in persons with TBI.
- Trial name
- SWEAT-TBI (NCT07733284)
- Testing
- Walking
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Kessler Foundation
Traumatic Brain Injury, Mild Traumatic Brain Injury
Comparison of Two Group Wellness Interventions for Individuals With Neurologic Conditions and Their Support Persons
Approximately 5.3 million people live with a long-term disability resulting from a traumatic brain injury (TBI) and between 5-8% of those older than 60 suffer from Alzheimer's disease or other forms of dementia (ADRD).
- Conditions
- Traumatic Brain Injury, Mild Traumatic Brain Injury, Alzheimer's Disease, Brain Injury Traumatic Moderate
- Trial name
- NCT05048966
- Testing
- Group Wellness Class 1, Group Wellness Class 2
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- Kessler Foundation
Stoke
Treating New Learning and Memory Deficits Following Stroke
The purpose of this research study is to investigate the effectiveness of a memory enhancement technique in persons following stroke
- Trial name
- NCT07127367
- Testing
- Memory Training
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Kessler Foundation
Autism Spectrum Disorder
Feasibility and Safety of a Virtual-Reality Based Job Interview Training Tool in Teenagers With High-Functioning Autism
The current project involves the application of a VR job training software. We propose to use an interactive VR job interview practice system, Virtual Reality Job Interview Training (VR-JIT), in youths with ASD at the highschool…
- Trial name
- NCT04773548
- Testing
- VR-JIT
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Autism Spectrum Disorder
Evaluation and Refinement of KF-STRIDE Into the Interview!
Examine the acceptability, usability, feasibility, and initial efficacy of KF-STRIDE 3.0, the data from which will serve as a basis for a future fully powered RCT
- Trial name
- NCT07168941
- Testing
- KF-STRIDE
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Kessler Foundation
Stroke, Aphasia
Combined Exercise and Targeted Therapy for Post-Stroke Reading Deficits
The goal of the proposed project is to test the effectiveness of a novel hybrid approach to treatment of reading disorders after stroke, in which exercise training will be used in combination with a targeted reading treatment.
- Conditions
- Stroke, Aphasia, Reading Disorder
- Trial name
- NCT06213272
- Testing
- Phono-Motor Therapy, Aerobic Exercise Training (AET), Stretching
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Kessler Foundation
Traumatic Brain Injury
Improving Time-Based Prospective Memory in TBI
This research aims to test aspects of a computer-based cognitive rehabilitation program designed to improve thinking skills in individuals with traumatic brain injury (TBI).
- Trial name
- TBPM (NCT04065477)
- Testing
- computer-based cognitive rehabilitation (CBCR)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Kessler Foundation
Multiple Sclerosis, Relapsing-Remitting
Examining Effects of Tysabri on Cognitive Fatigue Using fMRI
The purpose of this research study is to investigate the effectiveness of Tysabri on cognitive fatigue in persons with Relapsing-Remitting Multiple Sclerosis (RRMS).
- Trial name
- NCT04565431
- Testing
- Tysabri
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Multiple Sclerosis, Relapsing-Remitting
Examining Effects of Ocrevus on Cognitive Fatigue Using fMRI
The purpose of this research study is to investigate the effectiveness of MS Disease modifying medications on cognitive fatigue in persons with relapsing remitting multiple sclerosis (RRMS).
- Trial name
- NCT04448977
- Testing
- Ocrevus
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Hypotension
Treatment of Orthostatic Hypotension in SCI
The purpose of this study is to identify the effects of non-pharmacological and pharmacological anti-hypotensive treatment interventions on orthostatic hemodynamic responses, symptoms of autonomic dysreflexia and orthostatic…
- Trial name
- SCI (NCT05839652)
- Testing
- Midodrine Hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Multiple Sclerosis
Acute Effects of Walking Exercise on Brain Functioning in Multiple Sclerosis
The project will involve a within-subjects, repeated-measures research design. Participants will initially be screened for relevant inclusion/exclusion criteria for maximizing safety of participating in an exercise study.
- Trial name
- PRIMERS (NCT06233370)
- Testing
- Moderate intensity walking exercise
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Kessler Foundation
Multiple Sclerosis, Relapsing-remitting Multiple Sclerosis
WEBCAMS: Walking Exercise for Brain and Cognition in Adults With Multiple Sclerosis
This study is a randomized controlled trial (RCT) that compares the effects of two different 12-month aerobic walking exercise programs on cognitive processing speed (CPS), brain MRI, and other functional outcomes in 32 adults…
- Trial name
- NCT05755061
- Testing
- GEMS Plus, GEMS
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Kessler Foundation