Clinical trials: sponsored by Penn State University
Facet Joint Pain
PNS vs RFA for Facet Joint Pain
Radiofrequency ablation of the medial nerve is the current surgical treatment for back pain originating from the facet joints in the spine. However, this procedure causes denervation of spinal muscles.
- Trial name
- NCT05952518
- Testing
- Sprint PNS system, Radiofrequency Ablation
- Where
- United States
- Sponsor
- Penn State University
Remote vs. In-Person, Remote Visits
Remote vs. In-Person Study Evaluation (RISE) Trials: RISE Above Smoking (Trial 1 of 3)
The study will employ a randomized, parallel-group design with two-stage randomization. After an initial brief screen for basic eligibility, participants will be randomized (within site) to either Remote (R) or In-Person (IP)…
- Conditions
- Remote vs. In-Person, Remote Visits, In-person Visits
- Trial name
- NCT06822049
- Testing
- Combination Nicotine Replacement Therapy (patch and lozenge)
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Alzheimer's Disease and Related Dementias, Alzheimer Disease and Related Dementias
SmartEnLite for Nursing Home Residents With Dementia
The goal of this clinical trial is to learn if the Smart Environmental Lighting (SmartEnLite) can help improve behaviors and sleep among residents with dementia in nursing homes.
- Trial name
- SmartEnLite (NCT07883291)
- Testing
- Smart Environmental Light (SmartEnLite)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Penn State University
Dietary Exposure
Tasting Plant Forward Meals
This study aims to examine how the amount of potato and form of potato within a meal impacts intake and acceptability of other non-starchy vegetables.
- Trial name
- NCT07202988
- Testing
- vegetable combination 1, vegetable combination 2, vegetable combination 3
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sara Maksi
Postpartum Physical Fitness and Functional Performance
Strong as a Mother
This study will evaluate Strong as a Mother, an existing community exercise program for women returning to exercise after childbirth.
- Trial name
- NCT07867275
- Testing
- Supervised Postpartum Functional Strength Training and Aerobic Conditioning
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Penn State University
Amyotrophic Lateral Sclerosis (ALS)
Do Video Recordings of Multidisciplinary Clinics Improve Quality of Life for People With ALS and Their Caregivers?
Amyotrophic lateral sclerosis (ALS) is a fatal, rare neurodegenerative disease affecting 30,000 people in the United States. The gold standard of care for people with ALS is multidisciplinary clinics (MDC).
- Trial name
- VITALS (NCT07454733)
- Testing
- Video recording, Notes Instruction
- Where
- 7 sites in United States
- Volunteers
- 800 people
- Sponsor
- Trustees of Dartmouth College
Shared Decision Making
PROMOTE: A Pilot and Feasibility Study
To assess the feasibility and acceptability of implementing and evaluating shared decision making (SDM) within a single opioid treatment program (OTP) using Implementation Facilitation (IF), and to obtain pilot data on key…
- Trial name
- PROMOTE (NCT07758439)
- Testing
- Implementation facilitation for shared decision making
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- University of Pittsburgh
Emotional Well-being, Psychological Stress
Feasibility of a Mind-Body Intervention for Optimism
This pilot study tests whether three brief mind-body activities can be delivered remotely to midlife adults, and whether they show early signs of improving cardiovascular health, emotional well-being, and stress.
- Conditions
- Emotional Well-being, Psychological Stress, Cardiovascular Risk
- Trial name
- NCT07862478
- Testing
- Emotional Well-Being Writing, Chair-Assisted Squats, Slow-Paced Breathing
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Penn State University
Diet Quality, Sleep
The Effects of an Evening Snack of Walnuts on Diet and Sleep Quality in Adolescents
The goal of this study is to examine whether an evening snack of 1 oz of walnuts consumed in place of usual evening snacks for 4 weeks has a beneficial effect on diet quality and sleep quality in adolescents age 13-17 years.
- Trial name
- NCT07862556
- Testing
- Walnuts, Control (usual diet)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Penn State University
Atrial Fibrillation
PaTH Clinical Data Research Network (CDRN) Atrial Fibrillation (AF) Clinician-Patient Partnership Cohort
The purpose of the PaTH Network AF Clinician-Patient Partnership Cohort is to use clinical data from electronic health records (EHR) and patient reported outcomes (PRO) to answer questions of clinical importance to patients…
- Trial name
- NCT02485288
- Where
- 4 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- University of Pittsburgh
GLP - 1
Exploring the Influence of Glucagon-like Peptide -1 (GLP-1) Medications on Food Cravings, Food Selection, and Food Intake Following Exposure to Food Advertisements
The purpose of this randomized control trial is to compare how food cravings, food selection, and food consumption change in response to frequent food advertisements compared to non-food advertisements in adults taking GLP-1…
- Trial name
- NCT07505134
- Testing
- Food advertisements, Tech advertisements
- Volunteers
- 50 people
- Sponsor
- Penn State University
Resectable Stage IIA to IIIB Non-small Cell Lung Cancer
An Open Label, Randomized Study of Neoadjuvant Nivolumab and Chemotherapy, With or Without Sub-ablative Stereotactic Body Radiation Therapy, for Resectable Stage IIA to IIIB Non-small Cell Lung Cancer
An open label, randomized study of neoadjuvant nivolumab and chemotherapy, with or without sub-ablative stereotactic body radiation therapy, for resectable stage IIA to IIIB non-small cell lung cancer
- Trial name
- NCT05500092
- Testing
- Nivolumab, (8gy x 3), Platinum Doublet
- Where
- 4 sites in United States
- Volunteers
- 17 people
- Sponsor
- Montefiore Medical Center
COVID-19 Vaccination
Influence of Vaccine Message Medium on Intentions to Vaccinate in College Students
The goal of this clinical trial is to understand the influence of vaccine message medium (e.g., text, photo, or video) on intentions to vaccinate in college students.
- Trial name
- NCT07861087
- Testing
- COVID-19 Video, COVID-19 Words, COVID-19 Poster
- Where
- United States
- Volunteers
- 1,064 people, healthy volunteers welcome
- Sponsor
- Penn State University
Dementia Caregiver
Machine Learning Enabled Management of Behavioural and Psychological Symptoms of Dementia Intervention for Dementia Caregivers
Develop and test a machine learning enabled management of behavioural and psychological symptoms of dementia intervention for dementia caregivers.
- Trial name
- NCT07444866
- Testing
- Active Control, Behavioral: Continue, Behavioral: Enhance human coaching
- Where
- Hong Kong
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Education University of Hong Kong
Cardiovascular (CV) Risk
Lions Hearts: A Community Approach to Multigenerational Cardiovascular Disease Risk
This pilot study evaluates the feasibility, acceptability, and preliminary effectiveness of Lion Hearts, a community-based, family-centered physical activity intervention designed to improve cardiovascular health among…
- Trial name
- NCT07147387
- Testing
- Lion Hearts Family-Based Physical Activity Program
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Penn State University
Prediabetes
Mediterranean Diet and Blood Sugar Study
The purpose of this research study is to determine if a healthy Mediterranean diet containing one medium potato/day has equivalent or non-different effects on risk factors for type 2 diabetes and heart disease compared to a…
- Trial name
- NCT07229781
- Testing
- Mediterranean-style diet with potatoes, Traditional-style Mediterranean diet
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Penn State University
Peripheral Artery Disease, Claudication, Intermittent
Passive Calf Stretching Therapy in Peripheral Artery Disease
The goal of this clinical trial is to assess the effects of passive calf muscle stretching in patients diagnosed with peripheral artery disease (PAD). The main question it aims to answer are: 1.
- Trial name
- NCT06041880
- Testing
- Passive calf muscle stretching device
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Penn State University
Menopause, Aging
Role of Menopause in Thermoregulation
The frequency and severity of heat waves has increased in the last decades. Older adults (over 65 years) have impaired responses to heat stress making them at increased risk for adverse events.
- Trial name
- NCT06798571
- Testing
- Elagolix Oral Tablet, Estradiol patch
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Penn State University
Physical Inactivity, Sedentary Lifestlye
Roybal Via Habit Formation
This pilot study will develop and evaluate ViaHabit, a personalized walking intervention designed to promote physical activity habit formation among sedentary midlife adults (ages 45-65).
- Trial name
- Via Habit (NCT07848178)
- Testing
- ViaHabit
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Louisiana State University and A&M College
Weight Gain Trajectory, BMI
Evaluating Care Integration Between Pediatric Primary Care Providers and WIC Nutritionists
This study looks at whether using secure digital systems to share information between pediatric health care providers (during regular well-child visits) and social care providers (during regular visits with WIC nutritionists) can…
- Conditions
- Weight Gain Trajectory, BMI, Responsive Parenting, Diet Quality
- Trial name
- WEE Baby (NCT07494097)
- Testing
- Data integration around responsive parenting, Standard Care (in control arm)
- Where
- United States
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Penn State University