Clinical trials: sponsored by Sheba Medical Center
Healthy Aging
ELITE: Deep Profiling and Algorithmic Polytherapy to Map Individual Response in Healthy Aging
ELITE, Evidence-Based Longevity Interventions and Targeted Engagement, was a randomized, open-label, two-active-arm Phase IIa pilot conducted at Sheba Medical Center in Ramat Gan, Israel.
- Trial name
- ELITE (NCT07871799)
- Testing
- AgeBiotics AB-01, AgeBiotics AB-02, Metformin
- Where
- Israel
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Psychosis, First Episode Psychosis
Stratification and Treatment in Early Psychosis Study - ENHANCE
The purpose of this study is: To investigate whether the response to antipsychotic treatment can be enhanced by adding cannabidiol (CBD) to the existing treatment, compared to placebo, in participants with a first episode of…
- Conditions
- Psychosis, First Episode Psychosis, Psychotic Disorders, Psychotic Episode
- Trial name
- STEP-ENHANCE (NCT06778564)
- Testing
- CBD 100 mg/mL Oral Solution
- Where
- 17 sites in Austria, Germany and 7 more
- Volunteers
- 250 people
- Sponsor
- University of Oxford
Treatment Resistant Psychosis, Psychosis
Stratification and Treatment in Early Psychosis Study -ASSIST
The purpose of this trial is: To investigate whether the response to clozapine treatment can be enhanced by adding cannabidiol (CBD), compared to placebo, in treatment resistant psychosis patients.
- Trial name
- STEP-ASSIST (NCT07326124)
- Testing
- CBD 100 mg/mL Oral Solution, Placeb
- Where
- 15 sites in Germany, Greece and 6 more
- Volunteers
- 250 people
- Sponsor
- University of Oxford
Cesarean Section Complications, Uterine Bleeding
Platelet Rich Plasma for Uterine Scar
When vessel wall injury occurs, platelets become activated, releasing more than 30 bioactive proteins, many of which have a fundamental role in hemostasis, inflammation and ultimate wound healing.
- Conditions
- Cesarean Section Complications, Uterine Bleeding, Pelvic Pain, Menstrual Irregularity
- Trial name
- AA-PRP (NCT05224726)
- Testing
- Platelet Rich Plasma
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Breast Cancer Stage IV, Oligometastatic Disease
Stereotactic Ablative Radiotherapy for OligoMetastatic Breast Cancer
TAORMINA is an international, multicentre, randomised phase 3 trial for patients with oligometastatic breast cancer (OMBC) that will be allocated to combined stereotactic ablative radiotherapy (SABR) + systemic therapy…
- Trial name
- TAORMINA (NCT05377047)
- Testing
- SABR
- Where
- 19 sites in Ireland, Israel and 4 more
- Volunteers
- 345 people
- Sponsor
- Vastra Gotaland Region
Diabetes Mellitus, Type 1 Diabetes, Mobile Health Platform
Feasibility and Effectiveness of Tele-diabetes Remote System on Glycemic Control and Quality of Life of Children and Youth With Type 1 Diabetes
The goal of this clinical trial is to examine the feasibility and effectiveness of a tele-diabetes remote monitoring system on managing type 1 diabetes (T1DM) among children and adolescents.
- Conditions
- Diabetes Mellitus, Type 1 Diabetes, Mobile Health Platform, Mobile Health Technology (mHealth), Mobile Health
- Trial name
- NCT07828106
- Testing
- Tele-diabetes Remote System
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
High-risk Pregnancy, Hospitalization
LLM-Generated Medical Summaries During Hospitalization to Improve Patient Activation in High-Risk Pregnancies
The goal of this clinical trial is to learn if AI-generated medical summaries help hospitalized pregnant participants better understand and actively participate in their own care.
- Conditions
- High-risk Pregnancy, Hospitalization, Patient Activation, Artificial Intelligence (AI)
- Trial name
- NCT07823517
- Testing
- LLM-Generated Medical Summaries
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Sheba Medical Center
Pancreatic Cancer, Pancreatic Diseases
A Study of Blood Based Biomarkers for Pancreas Adenocarcinoma
The purpose of this study is to develop a minimally invasive test to diagnose pancreatic cancer at early stages of disease and monitor response to treatment.
- Conditions
- Pancreatic Cancer, Pancreatic Diseases, Pancreatitis, Pancreatic Cyst
- Trial name
- NCT03334708
- Testing
- Blood Draw, Tumor Tissue Collection, Cyst Fluid
- Where
- 13 sites in United States, Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Scars, Scars Formation
The Study Examines the Efficacy of Treating Limb Scars Using a Combined Pressure Garment and Silicone Sheet Compared to Treatment With a Pressure Garment Alone. The Study Aims to Develop a Comprehensive Scar Assessment Framework, Integrating Objective and Subjective Tools to Evaluate Treatment
Rehabilitation of traumatic and surgical limb scars commonly includes the use of pressure garments to improve scar maturation. Silicone sheets are also widely used in scar management; however, the additional benefit of combining…
- Trial name
- NCT07744867
- Testing
- Pressure Garment and Silicone Sheet Therapy, Pressure Garment Therapy
- Volunteers
- 60 people
- Sponsor
- Sheba Medical Center
Retinitis Pigmentosa
9-cis Beta-Carotene-Rich Extract of Dunaliella Alga in Retinitis Pigmentosa Patients
The goal of this clinical trial is to learn if a natural supplement called 9-cis beta-carotene (derived from the Dunaliella alga) can improve vision and retinal function in adults with Retinitis Pigmentosa.
- Trial name
- NCT07509229
- Testing
- 9-cis beta-Carotene-rich extract of Dunaliella alga
- Where
- Israel
- Volunteers
- 41 people
- Sponsor
- Sheba Medical Center
Diabetes Mellitus, Type 1
Advanced Hybrid Closed Loop System (AHCL) in Older Patients With Type 1 Diabetes Mellitus
The trial is a randomized controlled, parallel group design study. Patients will be followed up during approximatively 12 months.
- Trial name
- NCT06236256
- Testing
- MiniMed™ 780G Advanced Hybrid Closed Loop (AHCL) system, MDI/CSII
- Where
- Israel
- Volunteers
- 42 people
- Sponsor
- Sheba Medical Center
Type 2 Diabetes Mellitus in Obese
Lifestyle Intervention to Reduce the Risk of Sarcopenia in Adults With Diabetes & Obesity Treated With Semaglutide
This study aims to test whether a multi-disciplinary intervention involving exercise and nutrition can slow down the decline in physical function, muscle strength and mass in older adults (aged 65 and above) with Type 2 diabetes…
- Trial name
- STAY-STRONG (NCT06497595)
- Testing
- Wegovy (2.4 Mg Dose) + exercise & nutrition, Wegovy (2.4 Mg Dose) + usual care
- Where
- 2 sites in Israel
- Volunteers
- 60 people
- Sponsor
- Sheba Medical Center
Irritable Bowel Syndrome (IBS)
IBS-Oriented CDED Versus Low FODMAP Diet for Irritable Bowel Syndrome
Background: Irritable Bowel Syndrome (IBS) affects approximately 4.1% of the global population and imposes a significant personal and healthcare burden.
- Trial name
- IBS-CDED (NCT07707635)
- Testing
- Modified Crohn's Disease Exclusion Diet (CDED), Low FODMAP Diet
- Volunteers
- 150 people
- Sponsor
- Ariel University
Lung Adenocarcinoma, Malignant Pleural Effusions (Mpe)
Ex Vivo Drug Response Profiling and Outcome Prediction in Lung Adenocarcinoma
This observational study evaluates if ex-vivo lung cancer drug sensitivity testing results correlate with the driver mutations found by genetic sequencing and if it can predict treatment response.
- Trial name
- NCT07636252
- Testing
- Non-Interventional Study
- Where
- Israel
- Volunteers
- 400 people
- Sponsor
- Sheba Medical Center
Obesity, Childhood
Evaluating a Telemedicine-based Intensive Treatment Program for Children and Adolescents With Obesity
The study objective is to evaluate whether a novel telemedicine-based intensive treatment program for children with obesity is superior to standard on-site care.
- Trial name
- NCT05700409
- Testing
- Intensive lifestyle consultations
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
Healthy Aging, Healthspan
Sheba Healthspan Research Population (SHARP) Trial - Sheba Longevity Center Diagnostic and Intervention Protocol to Lower Biological Age in Older Adults
Background: Population aging is accelerating rapidly in Israel and worldwide, necessitating adaptation of the healthcare system and considering new approaches that serve the needs of older adult populations.
- Conditions
- Healthy Aging, Healthspan, Biological Age, Intrinsic Capacity
- Trial name
- SHARP (NCT07596576)
- Testing
- healthspan personalized protocol, Control
- Where
- Israel
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Postpartum Hemorrhage, Twin Pregnancy
Carbetocin Uterotonic Treatment in Twin Pregnancies for Prevention of Postpartum Hemorrhage
The goal of this clinical trial is to learn if the drug carbetocin works better than standard care to prevent heavy bleeding after childbirth in people carrying twin pregnancies.
- Trial name
- CUTT-PPH (NCT07401524)
- Testing
- Carbetocin, Oxytocin
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Sheba Medical Center
Emergency Care, Telemedicine
Telemedicine-Based Emergency Physician Assessment Prior to ED Entry: A Randomized Controlled Trial
Background: Emergency department (ED) overcrowding is a growing challenge worldwide and is associated with prolonged length of stay (LOS), reduced patient satisfaction, and increased burden on healthcare systems.
- Conditions
- Emergency Care, Telemedicine, Emergency Department Crowding
- Trial name
- NCT07546071
- Testing
- Telemedicine-Based Remote Physician Assessment
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Sheba Medical Center
Sarcoma
Assessing Health-related Quality of Life in Sarcoma Patients
Although the clinical effectiveness of sarcoma treatment has improved, long-lasting and cumulative treatment side-effects may often detract from the overall marginal advantage.
- Trial name
- NCT04071704
- Where
- 3 sites in Germany, Jordan
- Volunteers
- 654 people
- Sponsor
- The Netherlands Cancer Institute
Lynch Syndrome
The Yield of Artificial Intelligence (GI Genius) in Lynch Syndrome - A Randomized Tandem-colonoscopy Trial
We aim to investigate the incremental detection rate of polyps using AI- assisted colonoscopy compared with high-definition white-light endoscopy (HD-WLE).
- Trial name
- NCT06654128
- Testing
- artificial intelligence
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center