Clinical trials: sponsored by Technical University of Munich
Heart Failure, Coronary Heart Disease (CHD)
Reliability of Multiple-Repetition-Maximum Tests in Patients With Cardiovascular Disease or Risk Factors
Exercise training is a cornerstone in the prevention and rehabilitation of cardiovascular disease. While research has primarily focused on endurance training, resistance training becomes more and more important.
- Conditions
- Heart Failure, Coronary Heart Disease (CHD), Atrial Fibrillation (AF), Diabetes Mellitus
- Trial name
- NCT06796582
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Technical University of Munich
Kidney Cancers, Prostate Cancer
Assessment of Intelligent Algorithms for Detection, Diagnosis and Risk Stratification of Tumors of the Kidney and Prostate
The COMFORT study will evaluate an artificial intelligence-based platform developed to support the clinical assessment of kidney and prostate cancer.
- Trial name
- COMFORT (NCT07888322)
- Testing
- Medical Reading, AI assisted Medical reading
- Where
- 6 sites in Germany, Greece and 2 more
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
MDD, Severe Depression
Sensation Seeking and TMS Response in TRD
his real-world observational study examines whether sensation-seeking personality traits influence the clinical response to transcranial magnetic stimulation (TMS) in patients with treatment-resistant depression (TRD).
- Conditions
- MDD, Severe Depression, Major Depressive Episode
- Trial name
- NCT07889739
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Technical University of Munich
Obesity (BMI>30)
Resistance Training to Prevent Muscle Loss During Treatment With Tirzepatide
Incretin-based pharmacotherapies induce significant weight loss and represent a paradigm shift in obesity treatment. However, particularly fast weight loss may be accompanied by a significant loss of muscle mass, which is…
- Trial name
- RESIST (NCT07777575)
- Testing
- Dual GIP/GLP-1 Receptor Agonist Tirzepatide, Resistance Training
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Technical University of Munich
Cancer, Shared Decision Making
Use of and Attitudes Towards Large Language Models for Health Information Among People With Cancer, the Public, and Health-care Professionals
This cross-sectional survey examined how people with cancer, the general public and health-care professionals use large language models (LLMs) such as ChatGPT for health information, what they expect from them, how comfortable…
- Conditions
- Cancer, Shared Decision Making, Artificial Intelligence
- Trial name
- NCT07526441
- Where
- Germany
- Volunteers
- 6,632 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Exercise Behavior, Multiple Myeloma
Exercise Phenotyping Prior to Chemotherapy in Newly Diagnosed Multiple Myeloma (MM-Exercise)
MM-Exercise is a prospective, single-centre, observational pilot study of patients with newly diagnosed multiple myeloma who have not yet started chemotherapy and whose resting echocardiogram is unremarkable or only mildly…
- Trial name
- MM-Exercise (NCT07851493)
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Technical University of Munich
Diabetes Mellitus, Type 2, Overweight and Obesity
Dietary Strategies for Remission of Type 2 Diabetes
In this project, the investigators will perform a multicenter randomised controlled trial to determine whether advice to consume a moderate, whole food-based low-carbohydrate high-fat (LCHF) ad libitum diet (CarbCount program)…
- Conditions
- Diabetes Mellitus, Type 2, Overweight and Obesity, Hypertension, Glucose Intolerance
- Trial name
- CARBCOUNT (NCT04943926)
- Testing
- Energy restricted diet, Low carbohydrate high fat diet
- Where
- Norway
- Volunteers
- 600 people
- Sponsor
- University of Bergen
Mental Health, Empathy
Strengthening Relationships and Mental Health Through a Couples-Based Economic Empowerment Intervention
This psychosocial sub-study is embedded within a larger cluster-randomised controlled trial titled Disentangling and Preventing Economic Violence against Women (ECOVI), conducted in rural and urban communities across Maharashtra…
- Conditions
- Mental Health, Empathy, Relation, Interpersonal
- Trial name
- NCT07108049
- Testing
- Let us Grow Together: Economic Wellbeing for Families
- Where
- 2 sites in India
- Volunteers
- 4,552 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Chronic Pancreatitis, Complication
The Natural History of Chronic Pancreatitis
Chronic pancreatitis (CP) is a disease characterized by inflammation and their replacement by fibrotic tissue. The destruction of pancreatic function and structure are the main complications.
- Conditions
- Chronic Pancreatitis, Complication, Risk Factors
- Trial name
- NCT03324698
- Where
- China
- Volunteers
- 4,000 people
- Sponsor
- Changhai Hospital
HFpEF - Heart Failure With Preserved Ejection Fraction, Atrial Fibrillation
AlEX-DHF: Ablation and Exercise in Diastolic Heart Failure
The investigators analyze the impact of exercise and ablation in patients with symptomatic short-persistent atrial fibrillation (Afib) and heart failure with preserved ejection fraction (HFpEF).
- Trial name
- AlEX-DHF (NCT06650995)
- Testing
- Exercise training
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Technical University of Munich
Idiopathic Parkinson´s Disease
Safety, Tolerability and Symptomatic Efficacy of the ROCK-Inhibitor Fasudil in Patients With Parkinson's Disease
The aim of this phase Ila trial is to provide evidence on safety, tolerability and symptomatic efficacy of the ROCK-inhibitor Fasudil in patients with early Parkinson's disease (PD).
- Trial name
- NCT05931575
- Testing
- Fasudil hydrochloride
- Where
- Germany
- Volunteers
- 81 people
- Sponsor
- Technical University of Munich
Pediatric Cancer Patients
Evaluation of an Exercise Intervention During Intensive Medical Treatment in Pediatric Oncology.
The BEPPO study is a Germany-wide clinical trial investigating whether a structured exercise program can improve physical and mental health in children and adolescents undergoing cancer treatment.
- Trial name
- BEPPO (NCT07647471)
- Testing
- Partially-standardised, supervised, continuity-of-care exercise intervention
- Where
- 13 sites in Germany
- Volunteers
- 346 people
- Sponsor
- Universität Duisburg-Essen
Corticobasal Syndrome (CBS)
PROFIL Study to Investigate the Effect of GPB on NfL Levels in Patients With Corticobasal Syndrome (CBS)
Corticobasal syndrome (CBS) is a rapidly progressive neurodegenerative disorder with an average survival time of about 6-8 years after the first clinical manifestation. No potent symptomatic treatment is currently available.
- Trial name
- PROFIL (NCT05983588)
- Testing
- RAVICTI 1.1 g/ml
- Where
- 2 sites in Germany
- Volunteers
- 32 people
- Sponsor
- Technical University of Munich
Abdominal Aortic Aneurysm, Endoleak
EndoVascular Aortic Repair With Sac Embolization for the Prevention of Type II Endoleaks (the EVAR-SE Study)
Beyond a certain threshold diameter, Abdominal aortic aneurysms (AAA) are treated by open surgical repair or, more often by endovascular aortic aneurysm repair (EVAR).
- Trial name
- EVAR-SE (NCT05665101)
- Testing
- Coil embolization of aneurysm sac
- Where
- Germany
- Volunteers
- 101 people
- Sponsor
- Univ.-Prof. Dr. Dr. med. Daniela Branzan
Cardiovascular Diseases, Pediatric Cancer
Cardiac Impairments Following Pediatric Cardiotoxic Anti-cancer Treatment
This study aims at investigating the feasibility of recruitment and application of a method regarding early detection of subclinical changes in cardiac health after completion of acute cancer treatment during childhood and…
- Trial name
- NCT05261256
- Testing
- Exercise stress echocardiography
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Childhood Cancer
ADLs at the End of Acute Treatment for Childhood Leukemia and Non-Hodgkin Lymphoma
Reduced activity levels and reduced muscular strength could severely impair the activities of daily living (ADLs) in pediatric leukemia and Non-Hodgkin lymphoma patients.
- Trial name
- NCT05235633
- Testing
- Assessment of the accomplishment regarding Activities of Daily Living at the end of acute treatment
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Technical University of Munich
Soft Tissue Sarcoma of the Lower Extremity, Bone Tumor of the Lower Extremity
Prehabilitation in Childhood Soft Tissue or Bone Sarcomas
This study aims to investigate the feasibility of a prehabilitative training intervention. The intervention includes specific strength and balance exercises during neoadjuvant chemotherapy with children and adolescents diagnosed…
- Conditions
- Soft Tissue Sarcoma of the Lower Extremity, Bone Tumor of the Lower Extremity, Childhood and Adolescent Cancer
- Trial name
- Prehab4Kids (NCT06743958)
- Testing
- Exercise intervention
- Where
- 2 sites in Germany
- Volunteers
- 16 people
- Sponsor
- Technical University of Munich
Soft Tissue Sarcoma of the Lower Extremity, Bone Sarcoma of the Lower Extremity
Functional and Structural Outcomes Following Childhood Bone or Soft Tissue Sarcomas of the Lower Extremity
Soft tissue and bone sarcomas of the lower extremity pose significant challenges for affected individuals, often associated with considerable burden.
- Conditions
- Soft Tissue Sarcoma of the Lower Extremity, Bone Sarcoma of the Lower Extremity, Childhood and Adolescent Cancer
- Trial name
- FOCUS (NCT06737172)
- Where
- 2 sites in Germany
- Volunteers
- 18 people
- Sponsor
- Technical University of Munich
Non-communicable Diseases (NCD), Neoplams
Health for Hungary (H4H) - Longitudinal Collection of Blood Samples and Corresponding Data
The Health for Hungary (H4H) study collects blood samples and corresponding health data to investigate healthy aging and health-to-disease transitions in middle-aged and elderly participants.
- Conditions
- Non-communicable Diseases (NCD), Neoplams, Cancer, Lung Cancer (NSCLC)
- Trial name
- H4H (NCT07743021)
- Where
- 33 sites in Hungary
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Center for Molecular Fingerprinting Research Nonprofit LLC
Norm, Social, Autonomy
Gender-Transformative Interventions and Normative Beliefs About Reproductive Decision-Making
The ECOVI trial is a two-arm cluster randomized controlled trial (cRCT) conducted in rural and urban communities across Maharashtra, Andhra Pradesh, and Rajasthan, India, and funded by the European Research Council (ERC).
- Conditions
- Norm, Social, Autonomy, Relation, Family
- Trial name
- Beyond (NCT07734961)
- Testing
- Let Us Grow Together: Economic Wellbeing for Families
- Where
- India
- Volunteers
- 2,276 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich