Clinical trials: sponsored by University Hospital, Antwerp
Gynaecological Cancers, Ovarian Cancer
Methylation Profiling in Self-samples for Identification of (Epi)Genetic Biomarkers for Gynecological Cancers
The goal of the MYSSELF study is to investigate which biological markers (i.e., (epi)genetic biomarkers) found in self-collected samples, such as first-void urine and vaginal samples, are linked to the presence of endometrial…
- Conditions
- Gynaecological Cancers, Ovarian Cancer, Endometrial Cancer, Vulvar Cancer
- Trial name
- MYSSELF (NCT07902375)
- Testing
- Colli-Pee 20 mL device with UCM, Evalyn Brush
- Where
- Belgium
- Volunteers
- 730 people
- Sponsor
- Universiteit Antwerpen
Acute Kidney Injury
Metabolic Complications Using a Low- Versus High Concentration Citrate Solution for Regional Anticoagulation in Continuous Kidney Replacement Therapy: A Pragmatic Randomized Trial.
This study is a pragmatic, randomized trial comparing two commercially available citrate solutions to determine their impact on metabolic complications in critically ill patients with acute kidney injury receiving continuous…
- Trial name
- LEON1 (NCT07751861)
- Testing
- low concentrated citrate solution (18 mmol/L), high concentrated citrate solution (136 mmol/L)
- Where
- Belgium
- Volunteers
- 176 people
- Sponsor
- University Hospital, Antwerp
Neutropenia, Febrile
Stopping Antibiotics After 3 Days for the Treatment of High-risk FEbrile Neutropenia
The goal of this clinical trial is to compare a short course of antibiotics in patients in whom no bacterial infection is found with the current "golden standard": long-term antibiotic treatment in adult hematology patients who…
- Trial name
- SAFE (NCT05926063)
- Testing
- Comparison short vs extended EBAT treatment group
- Where
- Belgium
- Volunteers
- 450 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Chronic Respiratory Diseases
Belgian Lung Function Study
Currently, it remains unclear how to manage serial lung function measurements in a clinical setting. The investigators aimed to tackle this problem by developing a machine learning (ML) model that can accurately predict…
- Trial name
- AIRCAST (NCT07419555)
- Where
- 5 sites in Belgium
- Volunteers
- 5,000 people
- Sponsor
- KU Leuven
Elective Surgery, Anxiety
Surgical COrncerns and Psychological Evaluation of Patients Undergoing Elective Surgery
This study wants to obtain more information regarding the patient's concerns since concerns of the patient about the procedure is found as a predictor for the development of chronic post-surgical pain.
- Conditions
- Elective Surgery, Anxiety, Chronic Post Surgical Pain
- Trial name
- SCOPE (NCT07158684)
- Testing
- Semi-structured interview
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- University Hospital, Antwerp
Type 1 Diabetes Mellitus, Obesity
The COCCOS Study: a Transition Program for Young Persons With Chronic Conditions
A study is undertaken to examine the feasibility of the newly developed transition program in adolescents with type 1 diabetes, asthma and obesity in a multicentric setting.
- Conditions
- Type 1 Diabetes Mellitus, Obesity, Asthma
- Trial name
- COCCOS (NCT07145671)
- Testing
- Transition program
- Where
- Belgium
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Tinnitus
The CATT Trial: Cost-effectiveness of a Smartphone Application for Tinnitus Treatment
The twofold aim of this single-blind two-arm 1:1 randomised control trial is to examine if the treatment effect and cost-effectiveness of a smartphone application, designed to increase therapy compliance and provide tinnitus…
- Trial name
- CATT (NCT05245318)
- Testing
- Standard Clinical care, Blended physiotherapy program
- Where
- Belgium
- Volunteers
- 241 people
- Sponsor
- Hasselt University
Well-being
Body Scan Meditations to Support Well-Being in Patients at Antwerp University Hospital.
INWARD is a pilot study designed to explore whether audio-guided body scan meditations can support well-being in adult patients receiving care in the haematology and oncology departments, including the day hospital, at Antwerp…
- Trial name
- INWARD (NCT07834021)
- Testing
- INWARD audio-guided body scan meditations
- Where
- Belgium
- Volunteers
- 29 people
- Sponsor
- Universiteit Antwerpen
Liver Transplant Failure, Prognostic Biomarkers
Serum GLYcomics to Predict Graft Loss and Mortality After Liver Transplantation
The first 12 months after liver transplantation (LT) are decisive in posttransplant outcome, as almost half of deaths and two thirds of graft loss requiring retransplant occur in the first year after LT.
- Trial name
- GLYGALT (NCT05866796)
- Testing
- GlycoTransplantTest
- Where
- Belgium
- Volunteers
- 600 people
- Sponsor
- University Hospital, Ghent
Musculoskeletal Infection, Chronic Rhinosinusitis (Diagnosis)
Establishing Personalized Phage Therapy and Its Comparative Cost in Difficult-to-treat Infections (EPHICACI)
EPHICACI is a multicenter, prospective study that continues and expands the monocentric PHAGEFORCE registry initiated at UZ Leuven.
- Conditions
- Musculoskeletal Infection, Chronic Rhinosinusitis (Diagnosis), Persistent Bacteremia, Pulmonary Infection
- Trial name
- EPHICACI (NCT06368388)
- Testing
- Prospective data collection phage therapy, Prospective data collection standard-of-care
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Acute Kidney Injury
A Study to Evaluate the Safety and Feasibility of Continuous Renal Replacement Therapy With Regional Citrate Anticoagulation in a Cohort Critical Ill Patients With Acute Kidney Injury and Presumed Absent Citrate Metabolism
Use of regional citrate anticoagulation in an at risk population with decreased citrate metabolism. This study assesses the feasibility and safety of regional citrate anticoagulation in this population.
- Trial name
- CAT-RISK (NCT07751874)
- Testing
- continuous renal replacement therapy with regional citrate anticoagulation
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- University Hospital, Antwerp
Stroke Gait Rehabilitation
Optimizing Gait Rehabilitation After Stroke
Following a cerebrovascular accident (CVA, also known as a stroke), hemiparesis occurs on the side opposite to the brain injury. This can lead to problems with walking and balance, as well as with arm movements whilst walking.
- Trial name
- NMC (NCT07798388)
- Testing
- VR-feedback application
- Where
- 3 sites in Belgium
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Pharmacokinetics, Amoxicillin-clavulanate
Antibiotic Dosing in Pediatric Intensive Care
Pharmacokinetics of antibiotics in critically ill neonates, infants and children
- Conditions
- Pharmacokinetics, Amoxicillin-clavulanate, Piperacillin-tazobactam, Vancomycin
- Trial name
- ADIC (NCT02456974)
- Testing
- blood sampling in patients receiving amoxicillin-clavulanate as part of routine clinical care, blood sampling in patients receiving piperacilline-tazobactam as part of routine clinical care., blood sampling in patients receiving vancomycin as part of routine clinical care.
- Where
- Belgium
- Volunteers
- 640 people
- Sponsor
- University Hospital, Ghent
Glucose Intolerance After a Recent History of Gestational Diabetes
Semaglutide for the Treatment of Glucose Intolerance in Women With Prior Gestational Diabetes
Gestational diabetes (GDM) is an important contributor to the increasing prevalence of type 2 diabetes (T2DM). Women with glucose intolerance in early postpartum are a particularly high-risk group with about 50% who will develop…
- Trial name
- SERENA (NCT05569772)
- Testing
- Semaglutide Pen Injector
- Where
- 13 sites in Belgium
- Volunteers
- 252 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Hospital Associated Disability, Immobility
Targeting Muscle Strength Loss Due to Hospitalization in Older Adults by Blood-flow Restriction Combined With an Electromyography-driven Serious Game.
This study investigates a new training method designed to help older adults preserve their muscle strength during hospitalization.
- Conditions
- Hospital Associated Disability, Immobility, Older Adults (65 Years and Older)
- Trial name
- GHOSTLY+ (NCT07294131)
- Testing
- Gamified isometric strength training with blood flow restriction, Standard Physiotherapy
- Where
- 3 sites in Belgium
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Corneal Edema, Corneal Endothelial Disorder
The Belgian Endothelial Surgical Transplant of the Cornea
This study is designed as a randomised multicentric parallel group pragmatic trial of Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) versus Descemet Membrane Endothelial Keratoplasty (DMEK) in corneal endothelial…
- Conditions
- Corneal Edema, Corneal Endothelial Disorder, Fuchs' Endothelial Dystrophy, Bullous Keratopathy
- Trial name
- BESTCornea (NCT05436665)
- Testing
- UT-DSAEK, DMEK
- Where
- 11 sites in Belgium
- Volunteers
- 220 people
- Sponsor
- University Hospital, Antwerp
Necrotizing Soft Tissue Infection
Adjunctive Hyperbaric Oxygen Treatment for Patients With Necrotizing Soft-Tissue Infection (HOT-NSTI Trial).
Necrotizing soft-tissue infection (NSTI) is a rare, severe, fast-progressing bacterial infection within the soft tissue compartment. The NSTI mortality rate remain high and largely unaltered in the last decades.
- Trial name
- HOT-NSTI (NCT07489274)
- Testing
- Hyperbaric oxygen treatment, Standard of Care (Investigator Choice)
- Where
- 2 sites in Belgium, Norway
- Volunteers
- 1,480 people
- Sponsor
- Ole Hyldegaard
Diabetes Mellitus Type 2, Impaired Balance in Elderly
Improvement Through Movement - Balance Control and Somatosensory Function in People With Diabetes Mellitus Type 2
This study focuses on improving balance control and somatosensory functions in individuals aged 60 years and older with diabetes mellitus tyoe 2 (DMT2).
- Conditions
- Diabetes Mellitus Type 2, Impaired Balance in Elderly, Somatosensory Disorders, Balance Control in Elderly
- Trial name
- NCT07786194
- Testing
- Balance control and exercise training, Relaxation and exercise training
- Where
- Belgium
- Volunteers
- 48 people
- Sponsor
- Universiteit Antwerpen
Functional Dyspepsia, Gastritis
The Prevalence and the Pathophysiological Role of Non-Helicobacter Pylori Helicobacter Spp. in Well-defined Gastric Diseases and (Pre-) Malignancies
The goal of this clinical trial is to discover the prevalence of NHPH bacteria (Non-Helicobacter pylori Helicobacter species) in patients with one of the following conditions: 1.
- Conditions
- Functional Dyspepsia, Gastritis, Gastritis Chronic, Gastric Cancer (GC)
- Trial name
- HELIS (NCT07770126)
- Where
- 3 sites in Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Vulvovaginal Candidiasis
DeVEnIR: Defining Vulvovaginal Candidiasis - Elements of Infection and Remedy
Female-specific health conditions are underrepresented in research. The taboo felt by women to talk about intimate wellbeing is fed by this gender gap in scientific knowledge.
- Trial name
- DeVEnIR (NCT06397248)
- Testing
- No intervention
- Where
- 3 sites in Belgium
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp