Clinical trials: sponsored by University Hospital, Brest
Chronic Respiratory Diseases
Interest of Cryotherapy in Reducing Pain During Radial Arterial Blood Sampling
Arterial puncture for blood gas analysis is a diagnostic procedure used to assess arterial blood gases and monitor a patient's oxygenation status.
- Trial name
- HOURRA (NCT07408011)
- Testing
- Apllication of medical device ice pack, Apllication of cream
- Where
- 2 sites in France
- Volunteers
- 258 people
- Sponsor
- University Hospital, Brest
Unilateral Cerebral Palsy
Evolution of Gait Parameters in Toddlers With Unilateral Cerebral Palsy
This study goal was to assess the evolution of spatio-temporal and kinematic gait parameters in toddlers with unilateral cerebral palsy (UCP) receiving standard rehabilitation during the first 18 months after gait acquisition and…
- Trial name
- NCT07906223
- Testing
- gait analysis
- Where
- Romania
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- National Clinical Center for Neuropsychomotor Recovery for Children Dr. Nicolae Robanescu
Mycobacterium; Xenopi, Lung Diseases
Amikacin Liposome Inhalation Suspension for Treatment of Mycobacterium Xenopi Pulmonary Infection
Treatment of Mycobacterium xenopi (MX) lung disease is not-well- tolerated and concerned a growing number of patients, especially with chronic pulmonary diseases or immunosuppression.
- Trial name
- AKAPI (NCT06585020)
- Testing
- Arikayce, standard treatment
- Where
- France
- Volunteers
- 190 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Healthy Subjects
Functional Regulation of Autoreactive Lymphocytes: Phenotypic and Transcriptomic Investigations in Healthy Subjects
The goal of this study is to study the autoreactive lymphocytes in healthy volunteers. More specifically, this research aims to identify what distinguishes the autoreactive lymphocytes found in healthy individuals from those…
- Trial name
- REFLEX (NCT07898826)
- Testing
- Blood sampling at D0, Blood sampling at D0, M12 and M24
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Cerebral Palsy (CP)
Effects and Feasibility of a HABIT-ILE and a Home Program on the Bimanual Performance of Children With Cerebral Palsy
This single arm double baseline study explored the efficacy and feasibility of the PARTNER program (30h HABIT-ILE + 10h home program) on the functional changes and families' resources of 14 children with unilateral CP aged 24 to…
- Trial name
- FACT (NCT07889622)
- Testing
- Behavioral
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Fondation Ildys
Stereotactic Body Radiotherapy, 68Ga-MAA
Functional Lung Avoidance Planning Guided by Lung Perfusion PET/CT Versus Anatomical Planning for Lung Stereotactic Body Radiotherapy
Stereotactic body radiotherapy (SBRT) has an increasing role in the treatment of both primary and secondary lung tumors. However, lung SBRT remains associated with significant radiation induced lung injury (RILI).
- Conditions
- Stereotactic Body Radiotherapy, 68Ga-MAA, Lung Cancer (Diagnosis)
- Trial name
- Pegasus 2 (NCT07289646)
- Testing
- Conventional anatomical planning radiotherapy, Functional Lung avoidance planning
- Where
- 2 sites in France
- Volunteers
- 418 people
- Sponsor
- University Hospital, Brest
Pneumocystis Pneumonia, Pneumocystis Jirovecii Infection
CaspoNEB: Efficacy and Safety of Caspofungin Aerosols for the Curative Treatment of Pneumocystis Pneumonia
To assess the efficacy of administrating daily caspofungin aerosols versus placebo for seven days, in adjunction of conventional systemic antifungal therapy during curative treatment of Pneumocystis pneumonia, on the clinical…
- Conditions
- Pneumocystis Pneumonia, Pneumocystis Jirovecii Infection, Pneumocystis Infections
- Trial name
- CaspoNEB (NCT06892951)
- Testing
- Caspofungin Acetate 50 MG, Physiologic saline
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Tours
Disorder Related to Renal Transplantation, Diabetes
Prevention of Diabetes After Transplantation by Vildagliptin in the Early Post-transplant Period
Post-transplant diabetes affects 15 to 20% of renal transplant patients and contributes to increased morbidity and reduced survival of transplants and patients.
- Trial name
- PRODIG (NCT02849899)
- Testing
- Vildagliptin
- Where
- France
- Volunteers
- 47 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Rheumatoid Arthritis (RA)
National Cohort of Subjects at Risk of Developing Rheumatoid Arthritis
PROMESS 1 is a multicenter cohort interventional study aiming at analyzing the factors associated with the risk of developing clinical arthritis among exposures or combinations of exposures in patients at risk of rheumatoid…
- Trial name
- PROMESS_1 (NCT06876064)
- Testing
- Blood test, Urine test, stool collection
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Addiction, Alcohol
Evaluation of the Implementation of a Parenting Program in Parents With Children Aged 4 to 12 Years and One Parent With an Alcohol Use Disorders
Alcohol use disorders are a major public health problem in Europe. The average prevalence of Alcohol Use Disorders (AUD) in the general population is 7.5%, although there are large variations between countries.
- Trial name
- APPROCHILD (NCT05490589)
- Testing
- EQUIPE Program
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Brest
Cancer
Understanding and Anticipating Therapeutic and ADverse Responses in Anti-cancer Immune Checkpoint Inhibition Towards a Better Therapeutic Management of Patients
The goal of this observational study is to explore the value of blood biomarkers for the purpose of predicting irAE development in cancer patients treated with immune checkpoint inihibitors (ICI) alone or in combination with…
- Trial name
- TADIG-P (NCT05973344)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Brest
Chronic Low Back Pain
Assessment of Pain Perception and the Impact of Central Sensitization on Biopsychosocial Manifestations During Physical Activity in Patients With Chronic Low Back Pain
The goal of this prospective observational study is to evaluate changes in cognitive and behavioural markers associated with central sensitisation between the start and end of an exercise retraining programme on an exercise bike…
- Trial name
- BASICS (NCT07818551)
- Testing
- Exercise rehabilitation on an ergocycle
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Brest
Uterine Anteflexion
Changes in the Angle of Uterine Flexion as the Bladder Fills
The goal of this clinical trial is to evaluate how bladder filling affects the uterine flexion angle in adult nulliparous women with a uterine flexion angle <90° when the bladder is empty.
- Trial name
- FLEXIMIX3 (NCT07803627)
- Testing
- Ultrasonography, Pelvic
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Polymyalgia Rheumatica (PMR)
Justification And Evaluation of Baricitinib Plus Corticosteroids Versus corticosteroiDs Alone in pOlymyalgia RhEumatica
Polymyalgia rheumatic (PMR) is an inflammatory rheumatic disease affecting the elderly. The diagnosis is based on established ACR/EULAR classification criteria.
- Trial name
- JADORE-BARI (NCT07279688)
- Testing
- Baricitinib 4 MG Oral Tablet, Baricitinib 2 MG Oral Tablet
- Where
- 23 sites in France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Brest
Attention Deficit Disorder With Hyperactivity (ADHD), Substance Use Disorder (SUD)
Unified Junction of Care, Integrated Treatments and Team Coordination for ADHD in Prison Settings With Substance Use Disorder
Substance use disorders (SUD) and attention deficit disorder with or without hyperactivity (ADHD) are frequently co-morbid, particularly among people under court supervision.
- Trial name
- JUSTICE-TDAH (NCT07487155)
- Testing
- Workshop
- Where
- France
- Volunteers
- 39 people
- Sponsor
- University Hospital, Brest
HIV Infections
Study Among People Living With HIV and Their Health Professionals of Associated Factors of Resilience to Self-stigma
This study is perform to study the effect of psychological and psychosocial factors associated with resilience to the self-stigmatization of people living with HIV
- Trial name
- RESILSTIGMA (NCT05149001)
- Where
- 43 sites in France, Guadeloupe and 1 more
- Volunteers
- 667 people
- Sponsor
- University Hospital, Clermont-Ferrand
Neuropathic Pain, Chronic Pain
Observational Study of the Use of 8% Capsaicin Patch in Children 0 to 18 Years Old
Patients aged less than 18-y with validated 8% capsaicin patch treatment in routine healthcare will be offered to participate the study. If they accept it as well as their parents, they will be included in the study .
- Trial name
- CAPSULE (NCT05299294)
- Testing
- Data collection
- Where
- 20 sites in France
- Volunteers
- 160 people
- Sponsor
- University Hospital, Brest
Head & Neck Squamous Cell Carcinoma
Diagnostic Performance Of 4D Dynamic LAFOV FDG-PET Acquisition for Differentiation of Residual Disease and Post-radiation Inflammation in Head Neck SCC Treated by Radiotherapy.
This multicenter prospective observational study will evaluate the value of dynamic FDG-PET LAFOV imaging during the initial therapeutic assessment of a head and neck cancer 3 months after completion of curative radiotherapy.
- Trial name
- POLARIS (NCT07417605)
- Where
- 3 sites in France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Brest
Healthy Subjects 14 to 18 Years Old
Shoulder Endurance Test: Normative Values in a Population of Female Handball Players Aged 14 to 18 in Intensive Training Structures.
57% of young female handball players experience shoulder pain. This pain is likely to affect training and performance, but most players continue to play despite it.
- Trial name
- SET-HANDBALL (NCT06754774)
- Testing
- Shoulder Endurance Test
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Temporomandibular Disorders (TMD)
Aerobic Physical Activity and Orofacial Myofascial Pain
Orofacial myofascial pain, most commonly represented by Temporomandibular Disorders (TMD) a significant public health, affecting approximately 12% to 14% of the general population.
- Trial name
- AERODOF (NCT07526688)
- Testing
- Temporal Summation of Pain and Questionnaire
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest