Clinical trials: sponsored by University Hospital, Toulouse
Subarachnoid Hemorrhage, Aneurysmal, Brain Ischemia
TicAgreLor Versus Placebo to Prevent Cerebral ISCHemia in anEuRysmal Low Grade SAH A Double Blinded Randomised Controlled Study
Among aneurysmal subarachnoid hemorrhage (aSAH) survivors, ischemic injuries such as peri procedural thromboembolic events (TEE) and delayed cerebral ischemia (DCI) represent the most important disabling complications.
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Brain Ischemia, Endovascular Procedure
- Trial name
- TALISCHER-SAH (NCT07821008)
- Testing
- Experimental group: ticagrelor
- Where
- 7 sites in France
- Volunteers
- 274 people
- Sponsor
- University Hospital, Toulouse
Superior Semicircular Canal Dehiscence
Functional Impact of Psychological Symptoms in Patients With Superior Semicircular Canal Dehiscence Syndrome (SSCD): a National Cross-sectional Study
Superior semicircular canal dehiscence syndrome (SSCD), also known as Minor syndrome, is a rare otoneurological condition characterized by auditory and vestibular symptoms.
- Trial name
- SDCS-PSY (NCT07922447)
- Volunteers
- 300 people
- Sponsor
- University Hospital, Toulouse
Older Adults (65 Years and Older), Polypharmacy (People Under Treatment With 5 or More Drugs)
Impact of Pharmacotherapy Optimization in Polymedicated Lebanese Older Adults in Primary Health Care Centers
Why are the researchers doing this study? Many older adults take five or more medicines every day. Some of these medicines may no longer help them. Some may even cause harm, such as falls, confusion or tiredness.
- Conditions
- Older Adults (65 Years and Older), Polypharmacy (People Under Treatment With 5 or More Drugs), Primary Health Care, Social Determinants of Health (SDOH)
- Trial name
- PHARMACT-PHC (NCT07866677)
- Testing
- Structured pharmacotherapy optimization, Usual Care
- Where
- Lebanon
- Volunteers
- 452 people
- Sponsor
- National Institute of Public Health, Clinical Epidemiology, and Toxicology-Lebanon (INSPECT-LB)
Post-Traumatic Stress Disorder, PTSD
Women Who Are Victims of Violence: Treatment of PTSD Through Reactivation of Traumatic Memories Using Propranolol
Post-traumatic stress disorder (PTSD) develops after life-threatening events, with domestic violence and sexual assault being major risk factors.
- Trial name
- VIOFEM (NCT07792122)
- Testing
- Propranolol, Psychotherapy
- Where
- 2 sites in France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Toulouse
Aphasia, Stroke
Effect of Anomia Rehabilitation Combined With Metacognitive Training in Patients With Chronic Vascular Aphasia
The postulate of this study is that rehabilitation combining linguistic and metacognitive training will result in a significant improvement in language performance correlated with changes in functional cerebral connectivity…
- Trial name
- METALEX (NCT06930131)
- Testing
- Semantic rehabilitation
- Where
- France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Toulouse
Mucositis Oral
Photobiomodulation Protocols in the Analgesia of Chemotherapy-induced Oral Mucositis in Children
Chemotherapy-induced oropharyngeal mucositis (OM) negatively impacts the quality of life of adult and pediatric patients by causing pain, dysphagia, dysgeusia and dysphonia.
- Trial name
- CURALASE01 (NCT04596410)
- Testing
- LLLT applied every other day, LLLT applied daily
- Where
- 16 sites in France
- Volunteers
- 87 people
- Sponsor
- University Hospital, Toulouse
Prostate Cancer - Recurrent, Prostate Cancer (Diagnosis)
Analysis of the Performance of PSMA Emission Tomography in Patients With Prostate Cancer Treated With HIFU
There would appear to be a strong interest in functional nuclear imaging for assessing the response to focal PaC treatment. Investigator team hypothesise that the diagnostic performance of PSMA PET is noninferior to that of MRI…
- Trial name
- ECETEP (NCT07766122)
- Testing
- Nuclear imaging (PSMA PET) with intravenous injection of a radiotracer one year after treatment (focal therapy)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Toulouse
Traumatic Brain Injury
Neurorehabilitation After Traumatic Brain Injury: Functional Magnetic Resonance Imaging Study
The current study aims to better understand cerebral plasticity mechanisms to optimize non-pharmacological rehabilitation approaches for patients with traumatic brain injury.
- Trial name
- RemCog-TC (NCT02698449)
- Testing
- transcranial direct current stimulation, Specific cognitive rehabilitation, Nonspecific cognitive rehabilitation
- Where
- France
- Volunteers
- 66 people
- Sponsor
- University Hospital, Toulouse
Dementia
Dementia in Long Term Care Facilities: Telemedicine for the Management of Neuropsychiatric Symptoms
Telemedicine may facilitate adequate treatment of Neuropsychiatric symptoms (NPS) by identifying underlying causes and tailoring a treatment plan (pharmacological or non-pharmacologic treatments including provision of staff…
- Trial name
- DETECT (NCT02472015)
- Testing
- telemedicine
- Where
- 2 sites in France
- Volunteers
- 143 people
- Sponsor
- University Hospital, Toulouse
Obstructive Sleep Apnea Syndrome
Predictive Factors for Occlusal Changes in Obstructive Sleep Apnea Treatment With Mandibular Advancement Appliance
This research addresses obstructive sleep apnea syndrome (OSAS), affecting 6-12% of French adults, often treated with mandibular advancement devices (MADs).
- Trial name
- APNEAMOUVE (NCT06576310)
- Testing
- Mandibular Advancement Device
- Where
- France
- Volunteers
- 118 people
- Sponsor
- University Hospital, Toulouse
Heart Failure, Cardiac Surgery
Discontinuation or Continuation of SGLT-2 Inhibitors Before Cardiac Surgery
SGLT-2 inhibitors are recommended treatments for managing heart failure patients. In cases of surgery, it is recommended to stop the treatment 3 days before surgery due to the risk of postoperative euglycemic diabetic…
- Trial name
- DISCO (NCT07766109)
- Testing
- treatment discontinuation, treatment continuation, ketone levels
- Where
- France
- Volunteers
- 434 people
- Sponsor
- University Hospital, Toulouse
Hematologic Neoplasms
Assistance Program for Outpatients Following an Allogeneic Hematopoietic Stem-cell Transplant
After the initial monitoring period during hospitalization and isolation, patients with recent transplants are regularly monitored in monthly consultations but are still fragile, immunosuppressed and undergoing many treatments.
- Trial name
- AMA-ALLO (NCT04323605)
- Testing
- Outpatient assistance program for transplant patients (AMA-ALLO) based on a "navigation" nurse
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Toulouse
Anorexia Nervosa
Speech Groups for Children Living With a Sibling Who Suffers From Anorexia Nervosa
Anorexia nervosa (AN) is a complex mental disease with a huge impact on the patient's siblings life and well-being. Based on literature, group interventions for siblings of children suffering from a chronic disease could provide…
- Trial name
- EMA-FRaM (NCT06528158)
- Testing
- sibling group
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Toulouse
Carotid Web
Familial Form of Carotid Web: a Doppler Ultrasound Study
There is no evidence of familial forms of carotid web. The aim of this study is to determine the prevalence of carotid web among relatives of patient with carotid web using carotid doppler ultrasound.
- Trial name
- Family-WEB (NCT06336083)
- Testing
- Doppler ultrasound
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Endometriosis, Infertility
Endometriosis Transcriptomic Cell Atlas
Endometriosis is an estrogen-dependent, chronic inflammatory gynecologic disease affecting women of reproductive age, with a therapeutic wandering of 6 to 10 years.
- Trial name
- EDISON (NCT06502548)
- Testing
- Endometriosis, Tubal ligation or Hysterectomy
- Where
- France
- Volunteers
- 92 people
- Sponsor
- University Hospital, Toulouse
Hypotension
Norepinephrine in the Management of General Anesthesia-Induced Arterial Hypotension in Chronic Heart Failure Patients
Arterial hypotension is a frequent complication of general anesthesia and a significant contributor to postoperative complications.
- Trial name
- NORAFLOW (NCT06350929)
- Testing
- Cardiac output monitoring by the Starling™ SV Sebac®
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Toulouse
Lung Cancer, Lung; Node
Molecular Analysis of Endoscopic Cytology Samples Supernatant in Pulmonary Nodules
Lung cancer screening is based on low dose CT scan (LDCT), a highly sensitive but poorly specific tool. Complementary specific approaches are thus strongly needed, among which cell-free DNA (cfDNA) genotyping has been proven…
- Trial name
- KOBE (NCT05306912)
- Testing
- Blood samples
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Toulouse
Pleural Effusion
Thoracic Ultrasound in the Treatment of Pleural Effusion
The main objective of the study is to assess the cost-effectiveness ratio of two management strategies of pleurisy in adults : a strategy by systematic thoracic ultrasound versus a strategy without thoracic ultrasound.
- Trial name
- ECHOPLEV (NCT02505763)
- Testing
- Strategy with thoracic ultrasound
- Where
- France
- Volunteers
- 127 people
- Sponsor
- University Hospital, Toulouse
Molar Incisor Hypomineralization
Computer-aided Design/Computer-aided Manufacturing for Mild to Moderate Molar Incisor Hypomineralization Treatment
Molar Incisor Hypomineralization (MIH) is a disease causing a structural defect in the enamel of permanent teeth. The treatment of these teeth consists of the removal of the affected part of the tooth and its reconstitution.
- Trial name
- MIhCFAO (NCT04922177)
- Testing
- Indirect ceramic restoration, Direct restoration
- Where
- France
- Volunteers
- 68 people
- Sponsor
- University Hospital, Toulouse
PARKINSON DISEASE (Disorder)
Effect of Botulinum Toxin on Resting Tremor of the Refractory Upper Limb in Parkinsonians
Tremor is one of the most common symptoms in Parkinson Disease (PD), affecting almost 60% of patients. There is currently no specific treatment for tremor in PD, and 30% of patients develop drug-resistant tremor, making its…
- Trial name
- TOX PARK (NCT07822893)
- Where
- 2 sites in France
- Volunteers
- 39 people
- Sponsor
- University Hospital, Toulouse