Clinical trials: sponsored by University of Southern Denmark
Knee Arthropathy
Motivational Feedback Following Total or Unicompartmental Knee Arthroplasty
The goal of this randomized controlled trial (RCT) nested in a prospective cohort study is to investigate whether physical activity (PA) following total knee arthroplasty (TKA) or unicompartmental knee arthroplasty (UKA) can be…
- Trial name
- KneeActivity (NCT06005623)
- Testing
- SENS Motion + Motivational Feedback
- Where
- 4 sites in Denmark
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Atrial Fibrillation (AF)
Cardiac Rehabilitation Needs Among Individuals With Atrial Fibrillation
The goal of this survey- and registry-based study is to learn about the cardiac rehabilitation needs of individuals with atrial fibrillation (AF). The main objectives of the study is to: 1.
- Trial name
- PRIME-AF (NCT06772207)
- Where
- Denmark
- Volunteers
- 30,882 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Atrial Fibrillation, Left Atrial Appendage Absent
Can Patients With Atrial Fibrillation Safely Discontinue Anticoagulant Therapy After Cardiac Surgery? (ATLAAC)
Left atrial appendage (LAA) closure has become a frequent addition to oral anticoagulation in patients with atrial fibrillation who undergo cardiac surgery.
- Conditions
- Atrial Fibrillation, Left Atrial Appendage Absent, Anticoagulant Adverse Reaction
- Trial name
- NCT06401616
- Testing
- OAC will be discontinued for the duration of the trial
- Where
- 6 sites in Denmark
- Volunteers
- 1,220 people
- Sponsor
- Odense University Hospital
Osteoporosis Secondary
Identifying Individuals at Risk of Glucocorticoid-Induced Impairment of Bone Disease
Previous studies have shown that there is a large inter-individual variability in the degree of bone loss during glucocorticoid treatment, and while some patients experience extensive bone loss other patients\' bone mass…
- Trial name
- RIGID (NCT06421597)
- Testing
- Prednisolone
- Where
- 2 sites in Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Quality of Life, Reduction, Harm
Medication Use and Quality of Life Among Older People
This project will provide new evidence on how to optimize medication use among older people with limited life expectancy. This will be done by testing whether a patient-centered deprescribing intervention, focused on aligning…
- Trial name
- NCT05123313
- Testing
- Deprescribing intervention
- Where
- Denmark
- Volunteers
- 191 people
- Sponsor
- Odense University Hospital
Device-detected Atrial Fibrillation, Subclinical Atrial Fibrillation
Blood Clotting Markers and Heart Ultrasound in People With Device-Detected Atrial Fibrillation
The purpose of this observational study is to investigate whether blood tests related to blood clotting are associated with established clinical stroke risk scores, the total amount of device-detected atrial fibrillation recorded…
- Conditions
- Device-detected Atrial Fibrillation, Subclinical Atrial Fibrillation, Atrial High Rate Episodes
- Trial name
- DDAF-HEV (NCT07713615)
- Where
- Denmark
- Volunteers
- 222 people
- Sponsor
- Andreas Sjøholm-Christensen
Colonrectal Cancer, Colonrectal Cancer (CRC)
Compassion-Based Rehabilitation Needs Assessment Following Colorectal Cancer Surgery
This randomized controlled trial evaluated the effect of a compassion-based intervention compared with standard procedure for rehabilitation needs assessment among patients undergoing surgery for colorectal cancer with curative…
- Trial name
- NCT07876388
- Testing
- Compassionate Access Targeted Therapy
- Where
- Denmark
- Volunteers
- 77 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Community Acquired Pneumonia (CAP)
Chest Radiography Versus Ultra-Low-Dose Chest Computed Tomography in Adults in the Emergency Department
Objective: To quantify and compare total staff person-time per imaging episode betweenconventional chest radiography (CXR) and ULDCT in adult emergency department patients in whom CAP is a differential diagnosis.
- Trial name
- TIME-CAP (NCT07870525)
- Testing
- ULDCT
- Where
- Denmark
- Volunteers
- 66 people
- Sponsor
- University of Southern Denmark
Mental Health, Social Interaction
PeerScreen Trial - Reducing Screen Media Use in Peer-groups of Young People
The purpose of the PeerScreen trial is to investigate whether reducing screen media use affects mental health, social interaction, sleep, physical activity, heart rate variability, and behavioral patterns in young people aged 13…
- Conditions
- Mental Health, Social Interaction, Sleep, Physical Activity
- Trial name
- NCT07531290
- Testing
- Screen media reduction
- Where
- Denmark
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Post Operative Pain, Knee Osteoarthritis
Cryoneurolysis Prior to Total Knee Arthroplasty
Knee osteoarthritis is a major issue worldwide with limited treatment options. Many patients receive knee joint replacement surgery which is considered effective and safe.
- Conditions
- Post Operative Pain, Knee Osteoarthritis, Opioid-Related Disorders
- Trial name
- NCT05840276
- Testing
- Cryoneurolysis
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Opioid Use, Unspecified, Pain, Postoperative
Influence of Nociception Level Monitor (NOL) Guided Analgesic Delivery on Robot-assisted Colorectal Surgery
Being relatively new, the NOL monitor may offer interesting observations in perioperative nociception levels and appropriate analgesic consumption in diverse surgeries, including robot-assisted surgery.
- Trial name
- NCT05662371
- Testing
- Nociception Level monitor (NOL), Standard care
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- University of Southern Denmark
Urinary Incontinence, Anal Incontinence
Pelvic Floor Muscle Training During Pregnancy
The project seeks to investigate effectiveness of PFMT during pregnancy.
- Conditions
- Urinary Incontinence, Anal Incontinence, Pelvic Organ Prolapse, Sexual Dysfunction
- Trial name
- NCT07104292
- Testing
- PFMT, Standard care
- Where
- Denmark
- Volunteers
- 804 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Rotator Cuff Tears, Rotator Cuff Injuries
Stem Cell Treatment for Regeneration of the Rotator Cuff (Lipo-Cuff Study)
Treatment of rotator cuff tears with micro-fragmented adipose tissue is a minimal-invasive procedure with the potential to shorten and ease recovery, accelerate return to daily activity and work of thus with a potential capacity…
- Conditions
- Rotator Cuff Tears, Rotator Cuff Injuries, Rotator Cuff Tear Arthropathy
- Trial name
- NCT06505135
- Testing
- Stem-cell treatment, Standard care
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- University of Southern Denmark
Posttraumatic Headache
Non-pharmacological Treatment of Patients at Risk of Developing Persistent Post-traumatic Headache: The PTHEENOT Study
The goal of this mixed method study is to test and evaluate the effect of an early interdisciplinary non-pharmacological treatment of patients at risk of developing persistent posttraumatic headache in order to prevent the…
- Trial name
- NCT06466499
- Testing
- The intervention group
- Where
- Denmark
- Volunteers
- 104 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Acute Low Back Pain, Chronic Low Back Pain (CLBP)
Exploring Multidimensional Trajectories in People With Low Back Pain
Low back pain (LBP) is a major health problem in Switzerland and worldwide. Globally, LBP remains the leading cause of years lived with disability and its incidence and associated socioeconomic consequences are predicted to…
- Trial name
- NCT07176845
- Testing
- Observational
- Where
- Switzerland
- Volunteers
- 600 people
- Sponsor
- Bern University of Applied Sciences
COPD, Breathlessness
Reducing Breathlessness With Dronabinol in COPD Patients
This clinical trial examines whether Dronabinol, which contains the synthetic psychoactive compound tetrahydrocannabinol (THC), can alleviate severe breathlessness in patients with severe and very severe chronic obstructive…
- Conditions
- COPD, Breathlessness, Cannabis
- Trial name
- BONG (NCT06473701)
- Testing
- Dronabinol 2.5mg Capsule
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Vejle Hospital
Atrial Fibrillation (AF), Obesity & Overweight
Danish Trial of Weight Loss to Reduce Atrial Fibrillation Progression
Obesity is an important risk factor for the development and progression of atrial fibrillation. Sustainable weight loss likely reduces the burden of atrial fibrillation, which has yet to be proven in adequately sized randomised…
- Trial name
- DANWRAP (NCT07816744)
- Testing
- Structured weight loss program including behavioral support and optional meal re-placement or pharmacotherapy with Glucagon-like peptide-1 receptor agonists (GLP1-RA), Standard Care (in control arm)
- Where
- 2 sites in Denmark
- Volunteers
- 480 people
- Sponsor
- Axel Brandes
Bone Disease, Metabolic, Diabetes Mellitus, Type 2
Glucose-dependent INsulinotropic Polypeptide: Effect on Bone Remodelling and Cell Activity (GINEBRA)
Glucose-dependent insulinotropic polypeptide (GIP) is released by the intestines in response to food intake and increases insulin secretion.
- Conditions
- Bone Disease, Metabolic, Diabetes Mellitus, Type 2, Obesity and Obesity-related Medical Conditions
- Trial name
- GINEBRA (NCT06790225)
- Testing
- Glucose-dependent Insulinotropic Polypeptide (GIP)
- Where
- Denmark
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Rotator Cuff Tears, Rotator Cuff Injuries
Repeated Injections of Adipose-derived Stem Cells in Rotator Cuff Tears
The aim of the project is to investigate whether repeated implantations of micro-fragmented adipose tissue (MFAT), into the shoulder muscle can improve the outcome of standard surgical treatment for rotator cuff tears (RCT).
- Conditions
- Rotator Cuff Tears, Rotator Cuff Injuries, Stem Cells
- Trial name
- NCT07592936
- Testing
- Adipose derived stem cell injection
- Volunteers
- 30 people
- Sponsor
- University of Southern Denmark
Stroke, Cerebrovascular Disorders
Video Call Assisted Assessment of Acute Stroke
This study aims to investigate whether a live stream video between the on-call neurologist and the emergency medical technicians can increase feasibility and performance of symptom-based prehospital stroke scales.
- Conditions
- Stroke, Cerebrovascular Disorders, Brain Diseases, Nervous System Diseases
- Trial name
- NCT06570681
- Testing
- Video call assisted assessment of acute stroke
- Where
- Denmark
- Volunteers
- 512 people
- Sponsor
- University of Southern Denmark