ExerciseNCT03995693
Fuel Selection During Eccentric Cycling With Glucose Ingestion
A study testing Solution ingestion, Constant load arm cranking and Expired gas sampling in people with Exercise and Damage Muscle, run by Université de Montréal at 1 site in Canada.
Trial summary
This study compares fuel selection during eccentric and concentric cycling, with (placebo) or without glucose ingestion during exercise. After a 2-week familiarization and habituation with the ergometers, subjects will complete four experimental conditions in a randomized order: concentric with placebo, eccentric with… Read more about this study
- Who is it for?
- Ages 18 to 45 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Exercise, Damage Muscle, Nutrition
- What is being tested?
- Solution ingestion, Constant load arm cranking and Expired gas sampling
- Type of treatment
- Pill or oral medicine, Surgery or procedure, Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 75 participants
- Where
- 1 siteCanada
- Study dates
- 1 Aug 2019to 1 Dec 2021
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 45 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Low alcohol consumption (<3 drinks/week)
- Non-smokers
- Not regularly taking medication for a known pathology
- Regularly practices endurance sports (cycling, running, etc.)
Who cannot join
- Intolerant to glucose (according to WHO standards)
- Musculoskeletal injury or illness affecting exercise performance
- Failure to respect protocol guidelines (diet, exercise prior to experimentation, etc.)
Trial locations and contacts
1 site in 1 country.
Canada1 site
Centre d'éducation physique et sportive de l'Université de Montréal (CEPSUM)
Montreal, Quebec, H3C 3J7
About this study
Official title: Fuel Selection During Eccentric Cycling: Comparison With Concentric Cycling and the Effect of Glucose Ingestion During Exercise
This study compares fuel selection during eccentric and concentric cycling, with (placebo) or without glucose ingestion during exercise. After a 2-week familiarization and habituation with the ergometers, subjects will complete four experimental conditions in a randomized order: concentric with placebo, eccentric with placebo, concentric with glucose, eccentric with glucose.
Read the detailed description
Cycling on a cycle ergometer typically requires repeated concentric muscle contractions to push on the pedals and produce mechanical work. An eccentric cycling ergometer has a motor that rotates the cranks with a predetermined torque, the cyclist needs to resist to the movement of the cranks. This leads to eccentric muscle contractions, the work is thus produced while the muscle is lengthening (negative work). This mode of exercise is known to produce a lower oxygen consumption (energy cost) for the same mechanical power output and also leads to muscle damage which can interfere with fuel selection.
- Conditions
- Exercise, Damage Muscle, Nutrition
- Being tested
- Solution ingestion, Constant load arm cranking, Expired gas sampling, Indirect respiratory calorimetry, Blood sampling
- Keywords
- eccentric exercise, 13C-glucose, exercise mode
- Medical subject headings
- Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Solution ingestionDietary supplement
Two ingestion modalities will be attributed (participant is blinded) in random order: a placebo and a glucose solution. The placebo contains water and a non-caloric sweetener (stevia) in order to reproduce the taste of the glucose solution. The glucose solution contains 6% glucose per volume, labelled with 13C. Both solutions will be administered in 8 doses: a bolus (333 mL) at rest, 30 minutes before the start of exercise, 167 mL immediately before exercise, 167 mL every 15 minutes during arm cranking, 125 mL immediately before concentric or eccentric pedalling and at 15 and 25 minutes of this last exercise period. In total, 1250 mL of solution will be administered during the experimental protocol.
Constant load arm crankingBehavioural
The participants will perform 45 minutes of arm cranking on a specialized ergometer at a power output corresponding to 30% of their concentric cycling VO2max, previously measured.
Expired gas samplingProcedure or surgery
Subjects will be asked, twice, to provide a forced expiration into a 10 mL plastic tube in order to collect a sample expired gases. This procedure will be done immediately before blood sampling and ingestion of the solution.
Indirect respiratory calorimetryProcedure or surgery
A mouthpiece and nose plug will be placed on the subject and expired gases will be analyzed by a metabolic cart during 3 minutes. This procedure will be done immediately before expired gas collection, blood sampling and ingestion of the solution.
Blood samplingProcedure or surgery
A catheter will be inserted in an antecubital vein and a saline solution will be continuously perfused to maintain vein open. 10 mL of blood will be collected immediately before ingesting the solution for a total of 80 mL.
Measure of maximal voluntary contraction force productionBehavioural
Maximal voluntary bilateral knee extensions (3 trials of 3-4 seconds each) will be performed on a chair equipped with force sensors to measure peak force production. These measurements will be done before the first ingestion, immediately before exercise, during the transition between arm cranking and concentric or eccentric cycling, and at the end of the exercise protocol.
Measure of muscle electrical activity (EMG)Diagnostic test
Surface electrodes will be placed on the biceps and quadriceps to measure EMG throughout the exercise protocol.
Measure of central and cutaneous temperaturesDiagnostic test
Wireless sensors will be placed on the skin of the arm, chest, back, abdomen, thigh and calf using adhesive tape. A wireless thermometric pill will be ingested the morning of the experiment. These will allow the measurement of skin and central temperatures throughout the exercise protocol.
Measure of perceived exertion, pain perception and affective responseDiagnostic test
100 points scales (CR100) will be used to measure perceived exertion and pain perception immediately before ingesting the gas sampling. At the same time, affective responses will be assessed using the "Feeling scale".
Measure of sweat and urine productionProcedure or surgery
Sweat production and sampling will be performed by measuring body weight before and after exercise, after voiding the bladder. Mass loss through the urine and gases will be accounted for in order to compute sweat production. A sweat sample will be collected using a cotton gauze placed into a plastic collector affixed in the upper back of the participants. A urine sample will be taken from the urine collected at the end of the exercise period. Urine and sweat volumes along with respective urea concentrations will be used to compute protein oxidation during exercise.
| Study group | Role | What they receive |
|---|---|---|
| Concentric cycling with placebo ingestion | Experimental | Participants will complete 45 minutes of arm cranking at an intensity corresponding to 30% of the concentric cycling VO2max, followed by 35 minutes of CONCENTRIC cycling on a recumbent ergometer at the same VO2. A PLACEBO solution (water with a non-caloric sweetener) will be ingested 30 min prior to starting exercise and every 15 min thereafter, until the exercise is completed. Indirect respiratory calorimetry, expired gas sampling, blood sampling will occur will be performed 4 minutes before each ingestion. Receives: Dietary Supplement: Solution ingestion; Behavioral: Constant load arm cranking; Procedure: Expired gas sampling; Procedure: Indirect respiratory calorimetry; Procedure: Blood sampling; Behavioral: Measure of maximal voluntary contraction force production; Diagnostic Test: Measure of muscle electrical activity (EMG); Diagnostic Test: Measure of central and cutaneous temperatures; Diagnostic Test: Measure of perceived exertion, pain perception and affective response; Procedure: Measure of sweat and urine production |
| Concentric cycling with glucose ingestion | Experimental | Participants will complete 45 minutes of arm cranking at an intensity corresponding to 30% of the concentric cycling VO2max, followed by 35 minutes of concentric cycling on a recumbent ergometer at the same VO2. A GLUCOSE solution (glucose with a trace amount of 13C) will be ingested 30 min prior to starting exercise and every 15 min thereafter, until the exercise is completed. Indirect respiratory calorimetry, expired gas sampling, blood sampling will occur will be performed 4 minutes before each ingestion. Receives: Dietary Supplement: Solution ingestion; Behavioral: Constant load arm cranking; Procedure: Expired gas sampling; Procedure: Indirect respiratory calorimetry; Procedure: Blood sampling; Behavioral: Measure of maximal voluntary contraction force production; Diagnostic Test: Measure of muscle electrical activity (EMG); Diagnostic Test: Measure of central and cutaneous temperatures; Diagnostic Test: Measure of perceived exertion, pain perception and affective response; Procedure: Measure of sweat and urine production |
| Eccentric cycling with placebo ingestion | Experimental | Participants will complete 45 minutes of arm cranking at an intensity corresponding to 30% of the concentric cycling VO2max, followed by 35 minutes of ECCENTRIC cycling on a recumbent ergometer at the same VO2. A PLACEBO solution (water with a non-caloric sweetener) will be ingested 30 min prior to starting exercise and every 15 min thereafter, until the exercise is completed. Indirect respiratory calorimetry, expired gas sampling, blood sampling will occur will be performed 4 minutes before each ingestion. Receives: Dietary Supplement: Solution ingestion; Behavioral: Constant load arm cranking; Procedure: Expired gas sampling; Procedure: Indirect respiratory calorimetry; Procedure: Blood sampling; Behavioral: Measure of maximal voluntary contraction force production; Diagnostic Test: Measure of muscle electrical activity (EMG); Diagnostic Test: Measure of central and cutaneous temperatures; Diagnostic Test: Measure of perceived exertion, pain perception and affective response; Procedure: Measure of sweat and urine production |
| Eccentric cycling with glucose ingestion | Experimental | Participants will complete 45 minutes of arm cranking at an intensity corresponding to 30% of the concentric cycling VO2max, followed by 35 minutes of ECCENTRIC cycling on a recumbent ergometer at the same VO2. A GLUCOSE solution (glucose with a trace amount of 13C) will be ingested 30 min prior to starting exercise and every 15 min thereafter, until the exercise is completed. Indirect respiratory calorimetry, expired gas sampling, blood sampling will occur will be performed 4 minutes before each ingestion. Receives: Dietary Supplement: Solution ingestion; Behavioral: Constant load arm cranking; Procedure: Expired gas sampling; Procedure: Indirect respiratory calorimetry; Procedure: Blood sampling; Behavioral: Measure of maximal voluntary contraction force production; Diagnostic Test: Measure of muscle electrical activity (EMG); Diagnostic Test: Measure of central and cutaneous temperatures; Diagnostic Test: Measure of perceived exertion, pain perception and affective response; Procedure: Measure of sweat and urine production |
What is being measured
The primary outcome is the main question the study is designed to answer.
Exogenous glucose oxidation
Measured by indirect respiratory calorimetry combined with tracer techniques.
Measured: Average over the 35 minutes of eccentric or concentric exercise
Maximal voluntary force production
Measured using isometric bilateral knee extensions
Measured: Change between baseline and end of exercise
Central and skin temperature
Measured using a thermometric pill and skin-surface electrodes
Measured: Average over the 35 minutes of eccentric or concentric exercise
Perceived exertion
Measured using a Category Ratio scale on 100 points (CR100), 0 signifies no exertion and 100 being maximal effort.
Measured: Average over the 35 minutes of eccentric or concentric exercise
Secondary outcomes (7)
Blood insulin concentration
Blood is sampled using a venous catheter over about 60 seconds. Following centrifugation to extract the plasma, a small sample is used to measure insulin concentration.
Measured: For 0 minutes corresponds to the beginning of exercise, at -31, -1, 14, 29, 44, 49, 59 and 69 minutes
Blood glucose concentration
Blood is sampled using a venous catheter over about 60 seconds. Following centrifugation to extract the plasma, a small sample is used to measure glucose concentration.
Measured: For 0 minutes corresponds to the beginning of exercise, at -31, -1, 14, 29, 44, 49, 59 and 69 minutes
Blood free-fatty acid concentration
Blood is sampled using a venous catheter over about 60 seconds. Following centrifugation to extract the plasma, a small sample is used to measure free-fatty acid concentration.
Measured: For 0 minutes corresponds to the beginning of exercise, at -31, -1, 14, 29, 44, 49, 59 and 69 minutes
Blood lactate concentration
Blood is sampled using a venous catheter over about 60 seconds. Following centrifugation to extract the plasma, a small sample is used to measure lactate concentration.
Measured: For 0 minutes corresponds to the beginning of exercise, at -31, -1, 14, 29, 44, 49, 59 and 69 minutes
Total carbohydrate, fat and protein oxidation
Measured by indirect respiratory calorimetry corrected for urea excretion in sweat and urine
Measured: Average over the 35 minutes of eccentric or concentric exercise
Pain perception: VAS
Visual analogue pain scale of 25 cm, relative distance converted to score on 100 points. Higher values correspond to greater pain sensation.
Measured: Average over the 35 minutes of eccentric or concentric exercise
Affective response
Feeling scale, ranging from -5 to +5, reporting the mood (Hardy \& Rejeski, 1989). -5 corresponds to very bad and +5 to very good.
Measured: Average over the 35 minutes of eccentric or concentric exercise
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Jun 2019
- Study start1 Aug 2019
- Primary completion1 Dec 2021
- Study completion1 Dec 2021
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for ExerciseStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Sequential
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 75 participants (actual)
Sponsor and investigators
- Lead sponsor
- Université de Montréal
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Jonathan Tremblay, Université de Montréal
- Investigators
- Jonathan Tremblay, PhD, Principal investigator, Université de Montréal
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03995693
- Sponsor's protocol ID
- eccentric-exogenous
- Status last verified
- May 2022
- First submitted
- 24 May 2019
- Last updated
- 17 May 2022
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 17 May 2022. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Fuel Selection During Eccentric Cycling: Comparison With Concentric Cycling and the Effect of Glucose Ingestion During Exercise
- ClinicalTrials.gov ID
- NCT03995693
- Acronym / sponsor ID
- eccentric-exogenous
- Conditions
- Exercise, Damage Muscle, Nutrition
- Keywords
- eccentric exercise, 13C-glucose, exercise mode
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 75 participants (actual)
- Lead sponsor
- Université de MontréalUniversity, hospital or other
- Study start
- 1 Aug 2019 (actual)
- Primary completion
- 1 Dec 2021 (actual)
- Study completion
- 1 Dec 2021 (actual)
- First posted
- 24 Jun 2019 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study compares fuel selection during eccentric and concentric cycling, with (placebo) or without glucose ingestion during exercise. After a 2-week familiarization and habituation with the ergometers, subjects will complete four experimental conditions in a randomized order: concentric with placebo, eccentric with placebo, concentric with glucose, eccentric with glucose.
Detailed description
Cycling on a cycle ergometer typically requires repeated concentric muscle contractions to push on the pedals and produce mechanical work. An eccentric cycling ergometer has a motor that rotates the cranks with a predetermined torque, the cyclist needs to resist to the movement of the cranks. This leads to eccentric muscle contractions, the work is thus produced while the muscle is lengthening (negative work). This mode of exercise is known to produce a lower oxygen consumption (energy cost) for the same mechanical power output and also leads to muscle damage which can interfere with fuel selection.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Sequential
- Masking
- Single blind (participant)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| Concentric cycling with placebo ingestion | Experimental | Dietary Supplement: Solution ingestion, Behavioral: Constant load arm cranking, Procedure: Expired gas sampling, Procedure: Indirect respiratory calorimetry, Procedure: Blood sampling, Behavioral: Measure of maximal voluntary contraction force production, Diagnostic Test: Measure of muscle electrical activity (EMG), Diagnostic Test: Measure of central and cutaneous temperatures, Diagnostic Test: Measure of perceived exertion, pain perception and affective response, Procedure: Measure of sweat and urine productionParticipants will complete 45 minutes of arm cranking at an intensity corresponding to 30% of the concentric cycling VO2max, followed by 35 minutes of CONCENTRIC cycling on a recumbent ergometer at the same VO2. A PLACEBO solution (water with a non-caloric sweetener) will be ingested 30 min prior to starting exercise and every 15 min thereafter, until the exercise is completed. Indirect respiratory calorimetry, expired gas sampling, blood sampling will occur will be performed 4 minutes before each ingestion. |
| Concentric cycling with glucose ingestion | Experimental | Dietary Supplement: Solution ingestion, Behavioral: Constant load arm cranking, Procedure: Expired gas sampling, Procedure: Indirect respiratory calorimetry, Procedure: Blood sampling, Behavioral: Measure of maximal voluntary contraction force production, Diagnostic Test: Measure of muscle electrical activity (EMG), Diagnostic Test: Measure of central and cutaneous temperatures, Diagnostic Test: Measure of perceived exertion, pain perception and affective response, Procedure: Measure of sweat and urine productionParticipants will complete 45 minutes of arm cranking at an intensity corresponding to 30% of the concentric cycling VO2max, followed by 35 minutes of concentric cycling on a recumbent ergometer at the same VO2. A GLUCOSE solution (glucose with a trace amount of 13C) will be ingested 30 min prior to starting exercise and every 15 min thereafter, until the exercise is completed. Indirect respiratory calorimetry, expired gas sampling, blood sampling will occur will be performed 4 minutes before each ingestion. |
| Eccentric cycling with placebo ingestion | Experimental | Dietary Supplement: Solution ingestion, Behavioral: Constant load arm cranking, Procedure: Expired gas sampling, Procedure: Indirect respiratory calorimetry, Procedure: Blood sampling, Behavioral: Measure of maximal voluntary contraction force production, Diagnostic Test: Measure of muscle electrical activity (EMG), Diagnostic Test: Measure of central and cutaneous temperatures, Diagnostic Test: Measure of perceived exertion, pain perception and affective response, Procedure: Measure of sweat and urine productionParticipants will complete 45 minutes of arm cranking at an intensity corresponding to 30% of the concentric cycling VO2max, followed by 35 minutes of ECCENTRIC cycling on a recumbent ergometer at the same VO2. A PLACEBO solution (water with a non-caloric sweetener) will be ingested 30 min prior to starting exercise and every 15 min thereafter, until the exercise is completed. Indirect respiratory calorimetry, expired gas sampling, blood sampling will occur will be performed 4 minutes before each ingestion. |
| Eccentric cycling with glucose ingestion | Experimental | Dietary Supplement: Solution ingestion, Behavioral: Constant load arm cranking, Procedure: Expired gas sampling, Procedure: Indirect respiratory calorimetry, Procedure: Blood sampling, Behavioral: Measure of maximal voluntary contraction force production, Diagnostic Test: Measure of muscle electrical activity (EMG), Diagnostic Test: Measure of central and cutaneous temperatures, Diagnostic Test: Measure of perceived exertion, pain perception and affective response, Procedure: Measure of sweat and urine productionParticipants will complete 45 minutes of arm cranking at an intensity corresponding to 30% of the concentric cycling VO2max, followed by 35 minutes of ECCENTRIC cycling on a recumbent ergometer at the same VO2. A GLUCOSE solution (glucose with a trace amount of 13C) will be ingested 30 min prior to starting exercise and every 15 min thereafter, until the exercise is completed. Indirect respiratory calorimetry, expired gas sampling, blood sampling will occur will be performed 4 minutes before each ingestion. |
Who may qualify
- Ages
- 18 to 45 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Low alcohol consumption (<3 drinks/week)
- Non-smokers
- Not regularly taking medication for a known pathology
- Regularly practices endurance sports (cycling, running, etc.)
Key exclusion criteria (3 listed)
- Intolerant to glucose (according to WHO standards)
- Musculoskeletal injury or illness affecting exercise performance
- Failure to respect protocol guidelines (diet, exercise prior to experimentation, etc.)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Solution ingestionTwo ingestion modalities will be attributed (participant is blinded) in random order: a placebo and a glucose solution. The placebo contains water and a non-caloric sweetener (stevia) in order to reproduce the taste of the glucose solution. The glucose solution contains 6% glucose per volume, labelled with 13C. Both solutions will be administered in 8 doses: a bolus (333 mL) at rest, 30 minutes before the start of exercise, 167 mL immediately before exercise, 167 mL every 15 minutes during arm cranking, 125 mL immediately before concentric or eccentric pedalling and at 15 and 25 minutes of this last exercise period. In total, 1250 mL of solution will be administered during the experimental protocol. | Dietary supplement | Concentric cycling with glucose ingestion, Concentric cycling with placebo ingestion, Eccentric cycling with glucose ingestion, Eccentric cycling with placebo ingestion |
| Constant load arm crankingThe participants will perform 45 minutes of arm cranking on a specialized ergometer at a power output corresponding to 30% of their concentric cycling VO2max, previously measured. | Behavioural | Concentric cycling with glucose ingestion, Concentric cycling with placebo ingestion, Eccentric cycling with glucose ingestion, Eccentric cycling with placebo ingestion |
| Expired gas samplingSubjects will be asked, twice, to provide a forced expiration into a 10 mL plastic tube in order to collect a sample expired gases. This procedure will be done immediately before blood sampling and ingestion of the solution. | Procedure or surgery | Concentric cycling with glucose ingestion, Concentric cycling with placebo ingestion, Eccentric cycling with glucose ingestion, Eccentric cycling with placebo ingestion |
| Indirect respiratory calorimetryA mouthpiece and nose plug will be placed on the subject and expired gases will be analyzed by a metabolic cart during 3 minutes. This procedure will be done immediately before expired gas collection, blood sampling and ingestion of the solution. | Procedure or surgery | Concentric cycling with glucose ingestion, Concentric cycling with placebo ingestion, Eccentric cycling with glucose ingestion, Eccentric cycling with placebo ingestion |
| Blood samplingA catheter will be inserted in an antecubital vein and a saline solution will be continuously perfused to maintain vein open. 10 mL of blood will be collected immediately before ingesting the solution for a total of 80 mL. | Procedure or surgery | Concentric cycling with glucose ingestion, Concentric cycling with placebo ingestion, Eccentric cycling with glucose ingestion, Eccentric cycling with placebo ingestion |
| Measure of maximal voluntary contraction force productionMaximal voluntary bilateral knee extensions (3 trials of 3-4 seconds each) will be performed on a chair equipped with force sensors to measure peak force production. These measurements will be done before the first ingestion, immediately before exercise, during the transition between arm cranking and concentric or eccentric cycling, and at the end of the exercise protocol. | Behavioural | Concentric cycling with glucose ingestion, Concentric cycling with placebo ingestion, Eccentric cycling with glucose ingestion, Eccentric cycling with placebo ingestion |
| Measure of muscle electrical activity (EMG)Surface electrodes will be placed on the biceps and quadriceps to measure EMG throughout the exercise protocol. | Diagnostic test | Concentric cycling with glucose ingestion, Concentric cycling with placebo ingestion, Eccentric cycling with glucose ingestion, Eccentric cycling with placebo ingestion |
| Measure of central and cutaneous temperaturesWireless sensors will be placed on the skin of the arm, chest, back, abdomen, thigh and calf using adhesive tape. A wireless thermometric pill will be ingested the morning of the experiment. These will allow the measurement of skin and central temperatures throughout the exercise protocol. | Diagnostic test | Concentric cycling with glucose ingestion, Concentric cycling with placebo ingestion, Eccentric cycling with glucose ingestion, Eccentric cycling with placebo ingestion |
| Measure of perceived exertion, pain perception and affective response100 points scales (CR100) will be used to measure perceived exertion and pain perception immediately before ingesting the gas sampling. At the same time, affective responses will be assessed using the "Feeling scale". | Diagnostic test | Concentric cycling with glucose ingestion, Concentric cycling with placebo ingestion, Eccentric cycling with glucose ingestion, Eccentric cycling with placebo ingestion |
| Measure of sweat and urine productionSweat production and sampling will be performed by measuring body weight before and after exercise, after voiding the bladder. Mass loss through the urine and gases will be accounted for in order to compute sweat production. A sweat sample will be collected using a cotton gauze placed into a plastic collector affixed in the upper back of the participants. A urine sample will be taken from the urine collected at the end of the exercise period. Urine and sweat volumes along with respective urea concentrations will be used to compute protein oxidation during exercise. | Procedure or surgery | Concentric cycling with glucose ingestion, Concentric cycling with placebo ingestion, Eccentric cycling with glucose ingestion, Eccentric cycling with placebo ingestion |
Primary outcome
Exogenous glucose oxidation
Time frame: Average over the 35 minutes of eccentric or concentric exercise
Measured by indirect respiratory calorimetry combined with tracer techniques.
Maximal voluntary force production
Time frame: Change between baseline and end of exercise
Measured using isometric bilateral knee extensions
Central and skin temperature
Time frame: Average over the 35 minutes of eccentric or concentric exercise
Measured using a thermometric pill and skin-surface electrodes
Perceived exertion
Time frame: Average over the 35 minutes of eccentric or concentric exercise
Measured using a Category Ratio scale on 100 points (CR100), 0 signifies no exertion and 100 being maximal effort.
7 secondary outcomes
Blood insulin concentration
Time frame: For 0 minutes corresponds to the beginning of exercise, at -31, -1, 14, 29, 44, 49, 59 and 69 minutes
Blood glucose concentration
Time frame: For 0 minutes corresponds to the beginning of exercise, at -31, -1, 14, 29, 44, 49, 59 and 69 minutes
Blood free-fatty acid concentration
Time frame: For 0 minutes corresponds to the beginning of exercise, at -31, -1, 14, 29, 44, 49, 59 and 69 minutes
Blood lactate concentration
Time frame: For 0 minutes corresponds to the beginning of exercise, at -31, -1, 14, 29, 44, 49, 59 and 69 minutes
Total carbohydrate, fat and protein oxidation
Time frame: Average over the 35 minutes of eccentric or concentric exercise
Pain perception: VAS
Time frame: Average over the 35 minutes of eccentric or concentric exercise
Affective response
Time frame: Average over the 35 minutes of eccentric or concentric exercise
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 May 2022.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Jonathan Tremblay, PhD principal investigator
Université de Montréal
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Solution ingestion, Constant load arm cranking and Expired gas sampling in people with Exercise and Damage Muscle, run by Université de Montréal at 1 site in Canada.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 17 May 2022. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Canada. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Exogenous glucose oxidation (time frame: Average over the 35 minutes of eccentric or concentric exercise). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 May 2022; AzTrials last refreshed its copy on 29 Oct 2026.