Exercise MetabolismNCT07360249
Glucose-fructose Ratio Pilot
A study testing Glucose and fructose (one-to-one) and Glucose and fructose (two-to-one) in people with Exercise Metabolism, run by University of Bath at 1 site in United Kingdom.
Trial summary
The aim of this pilot study is to estimate the effect size of changing the glucose-fructose ratio from 1:0.5 to 1:1 on exogenous carbohydrate oxidation rates during exercise, which can be used to power a future definitive study. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Exercise Metabolism
- What is being tested?
- Glucose and fructose (one-to-one) and Glucose and fructose (two-to-one)
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 11 participants
- Where
- 1 siteUnited Kingdom
- Study dates
- 14 Jan 2026to 10 Sep 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Age: 18 years and above;
- Performing endurance training for at least 5 hours per week
- Capable of three hours of continuous exercise
Who cannot join
- Glucose or lipid lowering, or weight loss medication
- Diagnosis of cardiovascular disease, renal failure, liver disease or type 2 diabetes
- Contraindications to exercise
- Pregnant or lactating
Trial locations and contacts
1 site in 1 country.
About this study
Official title: PILOT TEST OF GLUCOSE-FRUCTOSE RATIOS ON EXOGENOUS CARBOHYDRATE OXIDATION RATES DURING EXERCISE
The aim of this pilot study is to estimate the effect size of changing the glucose-fructose ratio from 1:0.5 to 1:1 on exogenous carbohydrate oxidation rates during exercise, which can be used to power a future definitive study.
- Conditions
- Exercise Metabolism
- Being tested
- Glucose and fructose (one-to-one), Glucose and fructose (two-to-one)
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Glucose and fructose (one-to-one)Other
Glucose and fructose ingested in solution in a one-to-one ratio (135 grams per hour for 3 hours during exercise)
Glucose and fructose (two-to-one)Other
Glucose and fructose ingested in solution in a two-to-one ratio (135 grams per hour for 3 hours during exercise)
| Study group | Role | What they receive |
|---|---|---|
| One to One ratio | Experimental | Glucose and fructose ingestion in a one-to-one ratio Receives: Other: Glucose and fructose (one-to-one) |
| Two to one ratio | Active comparator | Glucose and fructose ingestion in a two-to-one (1-to-0.5) ratio Receives: Other: Glucose and fructose (two-to-one) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Exogenous carbohydrate oxidation rate (g/h)
Total exogenous carbohydrate oxidation rate (g/h) over 120 minutes
Measured: 120 minutes
Secondary outcomes (8)
Peak exogenous carbohydrate oxidation rate (g/h)
Highest recorded exogenous carbohydrate oxidation rate (g/h)
Measured: 120 minutes
Whole-body carbohydrate oxidation rate (g/h)
Total whole-body carbohydrate oxidation rate (g/h)
Measured: 120 minutes
Endogenous carbohydrate oxidation rate (g/h)
Total endogenous carbohydrate oxidation rate (g/h)
Measured: 120 minutes
Whole-body fat oxidation rate (g/h)
Total whole-body fat oxidation rate (g/h)
Measured: 120 minutes
Blood lactate concentrations (mmol/L)
Mean blood lactate concentrations over 180 minutes
Measured: 120 mninutes
Blood glucose concentrations (mmol/L)
Mean blood glucose concentrations (mmol/L) over 180 minutes
Measured: 120 minutes
Ratings of gut comfort (arbitrary units)
Mean ratings of gut comfort (arbitrary units) over 180 minutes
Measured: 120 minutes
Ratings of perceived exertion (arbitrary units)
Mean ratings of perceived exertion (arbitrary units) over 180 minutes
Measured: 120 minutes
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Jan 2026
- Study start14 Jan 2026
- Primary completion10 Sep 2026
- Study completion10 Sep 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Exercise MetabolismStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 11 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Bath
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Javier Gonzalez, University of Bath
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07360249
- Sponsor's protocol ID
- 11030
- Status last verified
- Oct 2026
- First submitted
- 14 Jan 2026
- Last updated
- 26 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: Outcome measures in anonymised format.
Study at a glance
From the registry record, last updated by the sponsor on 26 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- PILOT TEST OF GLUCOSE-FRUCTOSE RATIOS ON EXOGENOUS CARBOHYDRATE OXIDATION RATES DURING EXERCISE
- ClinicalTrials.gov ID
- NCT07360249
- Acronym / sponsor ID
- 11030
- Conditions
- Exercise Metabolism
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 11 participants (actual)
- Lead sponsor
- University of BathUniversity, hospital or other
- Study start
- 14 Jan 2026 (actual)
- Primary completion
- 10 Sep 2026 (actual)
- Study completion
- 10 Sep 2026 (actual)
- First posted
- 22 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this pilot study is to estimate the effect size of changing the glucose-fructose ratio from 1:0.5 to 1:1 on exogenous carbohydrate oxidation rates during exercise, which can be used to power a future definitive study.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| One to One ratio | Experimental | Other: Glucose and fructose (one-to-one)Glucose and fructose ingestion in a one-to-one ratio |
| Two to one ratio | Active comparator | Other: Glucose and fructose (two-to-one)Glucose and fructose ingestion in a two-to-one (1-to-0.5) ratio |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Age: 18 years and above;
- Performing endurance training for at least 5 hours per week
- Capable of three hours of continuous exercise
Key exclusion criteria (4 listed)
- Glucose or lipid lowering, or weight loss medication
- Diagnosis of cardiovascular disease, renal failure, liver disease or type 2 diabetes
- Contraindications to exercise
- Pregnant or lactating
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Glucose and fructose (one-to-one)Glucose and fructose ingested in solution in a one-to-one ratio (135 grams per hour for 3 hours during exercise) | Other | One to One ratio |
| Glucose and fructose (two-to-one)Glucose and fructose ingested in solution in a two-to-one ratio (135 grams per hour for 3 hours during exercise) | Other | Two to one ratio |
Primary outcome
Exogenous carbohydrate oxidation rate (g/h)
Time frame: 120 minutes
Total exogenous carbohydrate oxidation rate (g/h) over 120 minutes
8 secondary outcomes
Peak exogenous carbohydrate oxidation rate (g/h)
Time frame: 120 minutes
Whole-body carbohydrate oxidation rate (g/h)
Time frame: 120 minutes
Endogenous carbohydrate oxidation rate (g/h)
Time frame: 120 minutes
Whole-body fat oxidation rate (g/h)
Time frame: 120 minutes
Blood lactate concentrations (mmol/L)
Time frame: 120 mninutes
Blood glucose concentrations (mmol/L)
Time frame: 120 minutes
Ratings of gut comfort (arbitrary units)
Time frame: 120 minutes
Ratings of perceived exertion (arbitrary units)
Time frame: 120 minutes
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 26 Oct 2026.
- Individual participant dataSharing planned: Yes. Outcome measures in anonymised format.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Glucose and fructose (one-to-one) and Glucose and fructose (two-to-one) in people with Exercise Metabolism, run by University of Bath at 1 site in United Kingdom.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 26 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United Kingdom. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Exogenous carbohydrate oxidation rate (g/h) (time frame: 120 minutes). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 Oct 2026.