Older Adults (60 - 85 Years Old)NCT07866807
Evaluation of Sarcopenia and Muscle Biomechanics in Older Adults After Lumbar Fusion Surgery
An observational study of Older Adults (60 - 85 Years Old) and Sarcopenia, run by Karamanoğlu Mehmetbey University at 1 site in Turkey (Türkiye).
Trial summary
Abstract Background: Lumbar fusion (LF) surgery successfully restores the mechanical stability of the spine; however, postoperative kinesiophobia and complications can trigger secondary sarcopenia. Read more about this study
- Who is it for?
- Ages 18 to 80 years
- Conditions the study is for
- Older Adults (60 - 85 Years Old), Sarcopenia, Lumbar Fusion Surgery
- How many people
- 51 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 5 Jan 2026to 1 Oct 2026
- How long will I take part?
- 1 Day
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 80 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: This single-center, prospective, comparative, cross-sectional study included 56 older patients with lumbar spinal stenosis. It comprised 31 patients with a history of lumbar fusion (LF) surgery and a control group of 25 patients undergoing conservative treatment, matched for age and body mass index.
Who may be able to join
- Age 18 years or older,
- History of chronic low back pain,
- History of multilevel LF surgery performed at least one month prior (to exclude the acute postoperative inflammatory phase).
- Age 18 years or older
- History of chronic low back pain.
Who cannot join
- Morbid obesity (BMI > 40 kg/m²)
- Systemic and metabolic diseases: Uncontrolled hypertension, diabetes mellitus, hyperlipidemia, and congestive heart failure.
- Neuromuscular and cognitive disorders: Central or peripheral neurological diseases affecting muscle tone or mobility (e.g., Parkinson's disease, hemiplegia, multiple sclerosis, and other neurodegenerative disorders),
- Nutritional and systemic factors: Conditions such as active malignancy, malabsorption syndromes, or clinical malnutrition that directly lead to systemic cachexia or loss of muscle mass, independent of postoperative immobility.
- Prolonged immobilization or strict bed rest lasting longer than one week (for reasons unrelated to the LF surgical protocol); visual, auditory, or literacy impairments that hinder the ability to complete performance tests (e.g., gait speed, chair-stand test) or clinical questionnaires.
- Pregnancy.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Evaluation of Sarcopenia and Muscle Biomechanics in Older Adults After Lumbar Fusion Surgery: A Cross-sectional Controlled Study Based on Ultrasound and Digital Myotonometry
Abstract Background: Lumbar fusion (LF) surgery successfully restores the mechanical stability of the spine; however, postoperative kinesiophobia and complications can trigger secondary sarcopenia. Conventional diagnostic algorithms focus on muscle mass and active strength, leading to the neglect of passive viscoelastic alterations in muscle tissue. This study aimed to investigate the prevalence of secondary sarcopenia and changes in in vivo muscle biomechanics in patients undergoing LF surgery, using ultrasonography and digital myotonometry methods.
Methods: This single-center, prospective, comparative, cross-sectional study included 56 older patients with lumbar spinal stenosis. It comprised 31 patients with a history of lumbar fusion (LF) surgery and a control group of 25 patients undergoing conservative treatment, matched for age and body mass index. Sarcopenia staging was performed using ISarcoPRM and EWGSOP2 diagnostic criteria. Appendicular muscle mass was measured via the ultrasound-based "Sonographic Thigh Adjustment Ratio" (STAR). The passive viscoelastic properties of the rectus femoris (RF), tibialis anterior, medial gastrocnemius, and lumbar extensor muscles were assessed using a handheld digital myotonometer.
Read the detailed description
This study is designed as a single-center, prospective, comparative cross-sectional investigation to evaluate the prevalence of secondary sarcopenia and alterations in passive muscle biomechanics among patients with a history of multilevel lumbar decompression and fusion (LF) surgery for lumbar spinal stenosis (LSS). To delineate long-term musculoskeletal adaptations associated with surgical intervention, findings are compared against an age- and body mass index (BMI)-matched control cohort of LSS patients managed exclusively with conservative therapy.
Following screening and enrollment at the outpatient Physical Medicine and Rehabilitation clinics, eligible participants undergo standardized evaluations in a temperature-controlled environment (22-24°C) after a 15-minute resting acclimatization period to ensure complete neuromuscular relaxation. Assessments follow a multi-step sequence:
Sarcopenia Screening and Functional Stratification: Initial risk screening is conducted using the validated SARC-F questionnaire. Isometric handgrip strength is assessed using a calibrated hydraulic hand dynamometer in accordance with American Society of Hand Therapists (ASHT) positioning. Dynamic lower-extremity physical performance is evaluated using the five-repetition chair stand test and the 4-meter usual gait speed test. Diagnostic categorization (probable, confirmed, and severe sarcopenia) is established based on the ISarcoPRM algorithm, supplemented by EWGSOP2 reference frameworks.
Ultrasonographic Muscle Architecture Assessment: High-resolution B-mode ultrasonography (Clarius L7 HD3 linear transducer) is utilized to evaluate muscle quantity and structural atrophy. Anterior thigh muscle thickness (rectus femoris and vastus intermedius) is measured at the midpoint between the anterior superior iliac spine (ASIS) and the superior patellar border to calculate the Sonographic Thigh Adjustment Ratio (STAR), normalizing muscle thickness to BMI. Lumbar multifidus muscle thickness is similarly quantified bilaterally at the L4-L5 intervertebral space in the prone position. All acoustic measurements employ abundant transmission gel to prevent soft-tissue compression artifacts.
In Vivo Passive Myotonometric Biomechanics: Non-invasive mechanical oscillation assessments are performed using a digital myotonometer (MyotonPRO) to record muscle tone (oscillation frequency, Hz), biomechanical stiffness (dynamic stiffness, N/m), and elasticity (logarithmic decrement). Standardized anatomical sites are tested bilaterally in a relaxed state:
Rectus Femoris: Midpoint between the ASIS and the superior patellar border (supine).
Tibialis Anterior: 12 cm distal to the lateral femoral condyle (supine).
Medial Gastrocnemius: 30 cm proximal to the posterior medial malleolus (prone).
Lumbar Extensors: 2 cm lateral to the L3-L4 intervertebral space (prone). Measurements are acquired in multi-scan mode applying consecutive mechanical impulses, and bilateral average parameters are computed for comparative biomechanical analysis.
- Medical subject headings
- Sarcopenia, Low Back Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Fusion Surgery Group | Patients who underwent multilevel lumbar fusion surgery at least 3 months ago | |
| Control Group | The group with chronic low back pain due to lumbar spinal stenosis |
What is being measured
The primary outcome is the main question the study is designed to answer.
Assessment of sarcopenia using the SARC-F test
The SARC-F is a validated self-report screening tool comprising five components: strength (lifting and carrying 10 pounds), assistance in walking across a room, rising from a chair, climbing a flight of 10 stairs, and frequency of falls in the past year. Each item is scored from 0 to 2 points, yielding a total score ranging from 0 to 10. A cutoff score of ≥4 was considered indicative of sarcopenia risk and predictive of impaired muscle function, prompting subsequent quantitative muscle strength and ultrasound assessments.
Measured: 02.02.2026-01.09.2026
Hand dynamometer for muscle strength performance
A Baseline® hydraulic hand dynamometer (90 kg capacity) was used to assess muscle strength in accordance with ISarcoPRM diagnostic criteria. According to the test procedure, three measurements of handgrip strength must be taken-with one-minute intervals between each-and the average value recorded. The measurement results are expressed in kilograms. ISarcoPRM recommends cut-off values of 32 kg for men and 19 kg for women regarding grip strength.
Measured: 02.02.2026-01.09.2026
The chair stand test
The chair stand test is a fundamental tool used to evaluate lower-extremity function and muscle strength in older adults and various patient populations. In this test, participants begin by sitting on a chair without armrests, with their arms crossed over their chests and their hip and knee joints flexed at 90°. Assessment commences after participants receive the "ready" and "start" commands. The researcher records the time required to complete five sit-to-stand cycles. The chair stand test is performed twice with a 1-2 minute rest interval, and the fastest time is used for evaluation. ISarcoPRM recommends a cutoff value of ≥12 seconds for the chair stand test .
Measured: 02.02.2026-01.09.2026
Calculating the Sonographic Thigh Adjustment Ratio (STAR).
Ultrasonographic evaluations will be performed using a high-resolution portable ultrasound system (Clarius L7 HD3, Clarius Mobile Health, Vancouver, Canada) equipped with a 4-13 MHz linear transducer. Measurements were performed with participants in a supine position, with knees in full extension and quadriceps muscles completely relaxed. The probe was placed transversely at the midpoint of the longitudinal line connecting the anterior superior iliac spine (ASIS) and the superior border of the patella. A generous amount of acoustic coupling gel was used to ensure optimal acoustic contact without applying excessive mechanical pressure to the underlying tissues. Anterior thigh muscle thickness was measured (in millimeters) as the vertical distance from the superficial fascia of the *rectus femoris* to the femoral periosteum, encompassing both the *rectus femoris* and *vastus intermedius* muscles. The STAR value was calculated by dividing the anterior thigh muscle thickness (mm) by the b
Measured: 02.02.2026-01.09.2026
The Thickness of the Multifidus muscle
The thickness of the multifidus muscle-one of the lumbar extensor muscles-was measured at the level of the L4-L5 intervertebral space. Measurements were taken three times at the L4-L5 spinal level while the participants were in the prone position, and the mean value was included in the analysis
Measured: 02.02.2026-01.09.2026
Muscle Myotonometer
The mechanical properties of gait-related muscles-specifically the rectus femoris (RF), tibialis anterior (TA), and gastrocnemius medialis (GM)-were assessed using a handheld myotonometer (MyotonPRO, Myoton AS, Tallinn, Estonia). Additionally, the biomechanical properties of the lumbar extensor muscles were evaluated using this method. All assessments were performed in a quiet examination room maintained at a constant temperature (22-24°C) following a 15-minute rest period intended to ensure complete physical relaxation and the absence of active voluntary muscle contraction. Measurements were taken bilaterally and evaluated by calculating the mean. This device non-invasively characterizes the biomechanical and viscoelastic properties of muscles
Measured: 02.02.2026-01.09.2026
Secondary outcomes (1)
Body Mass Index (BMI)
It is obtained by dividing the patient's weight (kg) by the square of their height (meters).
Measured: 02.02.2026-01.09.2026
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Oct 2026
- Study start5 Jan 2026
- Primary completion1 Sep 2026
- Study completion1 Oct 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (4)Papers the sponsor has linked to this study.
- Other trials for Older Adults (60 - 85 Years Old)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Prospective
- Enrolment
- 51 participants (actual)
- Target duration
- 1 Day
Sponsor and investigators
- Lead sponsor
- Karamanoğlu Mehmetbey University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Süleyman Gül, Karamanoğlu Mehmetbey University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07866807
- Sponsor's protocol ID
- E-70712088-050.04-303873
- Status last verified
- Oct 2026
- First submitted
- 30 Sep 2026
- Last updated
- 14 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided: patient privacy
Publications
Kara M, Kaymak B, Ata AM, Ozkal O, Kara O, Baki A, Sengul Aycicek G, Topuz S, Karahan S, Soylu AR, Cakir B, Halil M, Ozcakar L. STAR-Sonographic Thigh Adjustment Ratio: A Golden Formula for the Diagnosis of Sarcopenia. Am J Phys Med Rehabil. 2020 Oct;99(10):902-908. doi: 10.1097/PHM.0000000000001439.
PubMed 32941253Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyere O, Cederholm T, Cooper C, Landi F, Rolland Y, Sayer AA, Schneider SM, Sieber CC, Topinkova E, Vandewoude M, Visser M, Zamboni M; Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGSOP2. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019 Jan 1;48(1):16-31. doi: 10.1093/ageing/afy169.
PubMed 30312372Wang T, Jiang J, Li C, Xuan Q, Sun L, Xu G, Gu H, Gao H. Effects of internet-based cognitive behavioral therapy on kinesiophobia, exercise adherence, and back muscle function after lumbar fusion surgery. BMC Musculoskelet Disord. 2026 Mar 18;27(1):357. doi: 10.1186/s12891-026-09617-z.
PubMed 41845320Carreon LY, Glassman SD, Howard J. Fusion and nonsurgical treatment for symptomatic lumbar degenerative disease: a systematic review of Oswestry Disability Index and MOS Short Form-36 outcomes. Spine J. 2008 Sep-Oct;8(5):747-55. doi: 10.1016/j.spinee.2007.06.013. Epub 2007 Nov 26.
PubMed 18037354
Study at a glance
From the registry record, last updated by the sponsor on 14 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of Sarcopenia and Muscle Biomechanics in Older Adults After Lumbar Fusion Surgery: A Cross-sectional Controlled Study Based on Ultrasound and Digital Myotonometry
- ClinicalTrials.gov ID
- NCT07866807
- Acronym / sponsor ID
- E-70712088-050.04-303873
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 51 participants (actual)
- Lead sponsor
- Karamanoğlu Mehmetbey UniversityUniversity, hospital or other
- Study start
- 5 Jan 2026 (actual)
- Primary completion
- 1 Sep 2026 (actual)
- Study completion
- 1 Oct 2026 (actual)
- First posted
- 8 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Abstract Background: Lumbar fusion (LF) surgery successfully restores the mechanical stability of the spine; however, postoperative kinesiophobia and complications can trigger secondary sarcopenia. Conventional diagnostic algorithms focus on muscle mass and active strength, leading to the neglect of passive viscoelastic alterations in muscle tissue. This study aimed to investigate the prevalence of secondary sarcopenia and changes in in vivo muscle biomechanics in patients undergoing LF surgery, using ultrasonography and digital myotonometry methods.
Methods: This single-center, prospective, comparative, cross-sectional study included 56 older patients with lumbar spinal stenosis. It comprised 31 patients with a history of lumbar fusion (LF) surgery and a control group of 25 patients undergoing conservative treatment, matched for age and body mass index. Sarcopenia staging was performed using ISarcoPRM and EWGSOP2 diagnostic criteria. Appendicular muscle mass was measured via the ultrasound-based "Sonographic Thigh Adjustment Ratio" (STAR). The passive viscoelastic properties of the rectus femoris (RF), tibialis anterior, medial gastrocnemius, and lumbar extensor muscles were assessed using a handheld digital myotonometer.
Detailed description
This study is designed as a single-center, prospective, comparative cross-sectional investigation to evaluate the prevalence of secondary sarcopenia and alterations in passive muscle biomechanics among patients with a history of multilevel lumbar decompression and fusion (LF) surgery for lumbar spinal stenosis (LSS). To delineate long-term musculoskeletal adaptations associated with surgical intervention, findings are compared against an age- and body mass index (BMI)-matched control cohort of LSS patients managed exclusively with conservative therapy.
Following screening and enrollment at the outpatient Physical Medicine and Rehabilitation clinics, eligible participants undergo standardized evaluations in a temperature-controlled environment (22-24°C) after a 15-minute resting acclimatization period to ensure complete neuromuscular relaxation. Assessments follow a multi-step sequence:
Sarcopenia Screening and Functional Stratification: Initial risk screening is conducted using the validated SARC-F questionnaire. Isometric handgrip strength is assessed using a calibrated hydraulic hand dynamometer in accordance with American Society of Hand Therapists (ASHT) positioning. Dynamic lower-extremity physical performance is evaluated using the five-repetition chair stand test and the 4-meter usual gait speed test. Diagnostic categorization (probable, confirmed, and severe sarcopenia) is established based on the ISarcoPRM algorithm, supplemented by EWGSOP2 reference frameworks.
Ultrasonographic Muscle Architecture Assessment: High-resolution B-mode ultrasonography (Clarius L7 HD3 linear transducer) is utilized to evaluate muscle quantity and structural atrophy. Anterior thigh muscle thickness (rectus femoris and vastus intermedius) is measured at the midpoint between the anterior superior iliac spine (ASIS) and the superior patellar border to calculate the Sonographic Thigh Adjustment Ratio (STAR), normalizing muscle thickness to BMI. Lumbar multifidus muscle thickness is similarly quantified bilaterally at the L4-L5 intervertebral space in the prone position. All acoustic measurements employ abundant transmission gel to prevent soft-tissue compression artifacts.
In Vivo Passive Myotonometric Biomechanics: Non-invasive mechanical oscillation assessments are performed using a digital myotonometer (MyotonPRO) to record muscle tone (oscillation frequency, Hz), biomechanical stiffness (dynamic stiffness, N/m), and elasticity (logarithmic decrement). Standardized anatomical sites are tested bilaterally in a relaxed state:
Rectus Femoris: Midpoint between the ASIS and the superior patellar border (supine).
Tibialis Anterior: 12 cm distal to the lateral femoral condyle (supine).
Medial Gastrocnemius: 30 cm proximal to the posterior medial malleolus (prone).
Lumbar Extensors: 2 cm lateral to the L3-L4 intervertebral space (prone). Measurements are acquired in multi-scan mode applying consecutive mechanical impulses, and bilateral average parameters are computed for comparative biomechanical analysis.
Study design
- Observational model
- Case-control
- Time perspective
- Prospective
- Target follow-up
- 1 Day
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Fusion Surgery Group | – | –Patients who underwent multilevel lumbar fusion surgery at least 3 months ago |
| Control Group | – | –The group with chronic low back pain due to lumbar spinal stenosis |
Who may qualify
- Ages
- 18 to 80 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- This single-center, prospective, comparative, cross-sectional study included 56 older patients with lumbar spinal stenosis. It comprised 31 patients with a history of lumbar fusion (LF) surgery and a control group of 25 patients undergoing conservative treatment, matched for age and body mass index.
Key inclusion criteria (5 listed)
- Age 18 years or older,
- History of chronic low back pain,
- History of multilevel LF surgery performed at least one month prior (to exclude the acute postoperative inflammatory phase).
- Age 18 years or older
- History of chronic low back pain.
Key exclusion criteria (6 listed)
- Morbid obesity (BMI > 40 kg/m²)
- Systemic and metabolic diseases: Uncontrolled hypertension, diabetes mellitus, hyperlipidemia, and congestive heart failure.
- Neuromuscular and cognitive disorders: Central or peripheral neurological diseases affecting muscle tone or mobility (e.g., Parkinson's disease, hemiplegia, multiple sclerosis, and other neurodegenerative disorders),
- Nutritional and systemic factors: Conditions such as active malignancy, malabsorption syndromes, or clinical malnutrition that directly lead to systemic cachexia or loss of muscle mass, independent of postoperative immobility.
- Prolonged immobilization or strict bed rest lasting longer than one week (for reasons unrelated to the LF surgical protocol); visual, auditory, or literacy impairments that hinder the ability to complete performance tests (e.g., gait speed, chair-stand test) or clinical questionnaires.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Assessment of sarcopenia using the SARC-F test
Time frame: 02.02.2026-01.09.2026
The SARC-F is a validated self-report screening tool comprising five components: strength (lifting and carrying 10 pounds), assistance in walking across a room, rising from a chair, climbing a flight of 10 stairs, and frequency of falls in the past year. Each item is scored from 0 to 2 points, yielding a total score ranging from 0 to 10. A cutoff score of ≥4 was considered indicative of sarcopenia risk and predictive of impaired muscle function, prompting subsequent quantitative muscle strength and ultrasound assessments.
Hand dynamometer for muscle strength performance
Time frame: 02.02.2026-01.09.2026
A Baseline® hydraulic hand dynamometer (90 kg capacity) was used to assess muscle strength in accordance with ISarcoPRM diagnostic criteria. According to the test procedure, three measurements of handgrip strength must be taken-with one-minute intervals between each-and the average value recorded. The measurement results are expressed in kilograms. ISarcoPRM recommends cut-off values of 32 kg for men and 19 kg for women regarding grip strength.
The chair stand test
Time frame: 02.02.2026-01.09.2026
The chair stand test is a fundamental tool used to evaluate lower-extremity function and muscle strength in older adults and various patient populations. In this test, participants begin by sitting on a chair without armrests, with their arms crossed over their chests and their hip and knee joints flexed at 90°. Assessment commences after participants receive the "ready" and "start" commands. The researcher records the time required to complete five sit-to-stand cycles. The chair stand test is performed twice with a 1-2 minute rest interval, and the fastest time is used for evaluation. ISarcoPRM recommends a cutoff value of ≥12 seconds for the chair stand test .
Calculating the Sonographic Thigh Adjustment Ratio (STAR).
Time frame: 02.02.2026-01.09.2026
Ultrasonographic evaluations will be performed using a high-resolution portable ultrasound system (Clarius L7 HD3, Clarius Mobile Health, Vancouver, Canada) equipped with a 4-13 MHz linear transducer. Measurements were performed with participants in a supine position, with knees in full extension and quadriceps muscles completely relaxed. The probe was placed transversely at the midpoint of the longitudinal line connecting the anterior superior iliac spine (ASIS) and the superior border of the patella. A generous amount of acoustic coupling gel was used to ensure optimal acoustic contact without applying excessive mechanical pressure to the underlying tissues. Anterior thigh muscle thickness was measured (in millimeters) as the vertical distance from the superficial fascia of the *rectus femoris* to the femoral periosteum, encompassing both the *rectus femoris* and *vastus intermedius* muscles. The STAR value was calculated by dividing the anterior thigh muscle thickness (mm) by the b
The Thickness of the Multifidus muscle
Time frame: 02.02.2026-01.09.2026
The thickness of the multifidus muscle-one of the lumbar extensor muscles-was measured at the level of the L4-L5 intervertebral space. Measurements were taken three times at the L4-L5 spinal level while the participants were in the prone position, and the mean value was included in the analysis
Muscle Myotonometer
Time frame: 02.02.2026-01.09.2026
The mechanical properties of gait-related muscles-specifically the rectus femoris (RF), tibialis anterior (TA), and gastrocnemius medialis (GM)-were assessed using a handheld myotonometer (MyotonPRO, Myoton AS, Tallinn, Estonia). Additionally, the biomechanical properties of the lumbar extensor muscles were evaluated using this method. All assessments were performed in a quiet examination room maintained at a constant temperature (22-24°C) following a 15-minute rest period intended to ensure complete physical relaxation and the absence of active voluntary muscle contraction. Measurements were taken bilaterally and evaluated by calculating the mean. This device non-invasively characterizes the biomechanical and viscoelastic properties of muscles
1 secondary outcome
Body Mass Index (BMI)
Time frame: 02.02.2026-01.09.2026
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 14 Oct 2026.
- Results publication: PubMed 32941253Kara M, Kaymak B, Ata AM, Ozkal O, Kara O, Baki A, Sengul Aycicek G, Topuz S, Karahan S, Soylu AR, Cakir B, Halil M, Ozcakar L. STAR-Sonographic Thigh Adjustment Ratio: A Golden Formula for the Diagnosis of Sarcopenia. Am J Phys Med Rehabil. 2020 Oct;99(10):902-908. doi: 10.1097/PHM.0000000000001439.
- Results publication: PubMed 30312372Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyere O, Cederholm T, Cooper C, Landi F, Rolland Y, Sayer AA, Schneider SM, Sieber CC, Topinkova E, Vandewoude M, Visser M, Zamboni M; Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGSOP2. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019 Jan 1;48(1):16-31. doi: 10.1093/ageing/afy169.
- Results publication: PubMed 41845320Wang T, Jiang J, Li C, Xuan Q, Sun L, Xu G, Gu H, Gao H. Effects of internet-based cognitive behavioral therapy on kinesiophobia, exercise adherence, and back muscle function after lumbar fusion surgery. BMC Musculoskelet Disord. 2026 Mar 18;27(1):357. doi: 10.1186/s12891-026-09617-z.
- Results publication: PubMed 18037354Carreon LY, Glassman SD, Howard J. Fusion and nonsurgical treatment for symptomatic lumbar degenerative disease: a systematic review of Oswestry Disability Index and MOS Short Form-36 outcomes. Spine J. 2008 Sep-Oct;8(5):747-55. doi: 10.1016/j.spinee.2007.06.013. Epub 2007 Nov 26.
- Individual participant dataSharing planned: Undecided. patient privacy
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Older Adults (60 - 85 Years Old) and Sarcopenia, run by Karamanoğlu Mehmetbey University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 14 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Assessment of sarcopenia using the SARC-F test (time frame: 02.02.2026-01.09.2026). The study lists 6 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07866807, which also lists 4 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Oct 2026.