Clinical trials: ARDS, Human
Positive Expiratory Pressure, Acute Respiratory Distress Syndrome
Determination of the Best Positive End-expiratory Pressure (PEEP)
Determination of the best positive end-expiratory pressure (PEEP) based on oxygenation or driving pressure in patients with acute respiratory distress syndrome (ARDS) after cardiothoracic surgery The use of a positive…
- Trial name
- DROP (NCT03969407)
- Where
- France
- Volunteers
- 118 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
ARDS, Human, Covid19
Associations Between COVID-19 ARDS Treatment, Clinical Trajectories and Liberation From Mechanical Ventilator - an Analysis of the NorthCARDS Dataset
The mortality rates associated with COVID-19 related ARDS (COVIDARDS) have varied from observational reports from around the world.
- Trial name
- NorthCARDS (NCT04729075)
- Testing
- ARDS and COVID19 treatments
- Where
- United States
- Volunteers
- 1,800 people
- Sponsor
- Northwell Health
Acute Respiratory Distress Syndrome, COVID-19 Pneumonia
Recruitment Assessment in Patients With Acute Respiratory Distress Syndrome and Covid-19
Respiratory failure associated with Covid-19 can be expressed as acute respiratory distress syndrome (ARDS), which is an acute inflammatory lung injury,which generally requires the use of invasive mechanical ventilation (MV).
- Conditions
- Acute Respiratory Distress Syndrome, COVID-19 Pneumonia, Recruitment
- Trial name
- NCT05248243
- Testing
- Recruitment assessment
- Where
- Argentina
- Volunteers
- 41 people
- Sponsor
- Ramos Mejía Hospital
Pulmonary Contusion, Respiratory Failure
Relationship of Pulmonary Contusion to Pulmonary Inflammation and Incidence of Acute Respiratory Distress Syndrome
Pulmonary contusion (PC) is a significant problem after blunt trauma that may often lead to acute respiratory distress syndrome (ARDS) and in some patients, death.
- Conditions
- Pulmonary Contusion, Respiratory Failure, ARDS
- Trial name
- NCT02265198
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Wake Forest University Health Sciences
Child, Only, Infant, Newborn, Diseases
Capnography Monitoring in Ventilated Children
End-tidal CO2 measurements in children will be assessed for their accuracy with arterial CO2 measurements.
- Conditions
- Child, Only, Infant, Newborn, Diseases, Critical Illness, ARDS, Human
- Trial name
- NCT04354220
- Testing
- capnography monitoring, arterial blood gas
- Where
- Switzerland
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- Vincenzo Cannizzaro
Respiratory Distress Syndrome, Preterm Birth
Surfactant for Neonatal Respiratory Distress Syndrome(NRDS) and Neonatal Acute Respiratory Distress Syndrome(NARDS)
In preterm infants with neonatal respiratory distress syndrome (NRDS), exogenous pulmonary surfactant(PS) replacement therapy is one of the most important therapeutic breakthrough to reduce neonatal mortality.
- Conditions
- Respiratory Distress Syndrome, Preterm Birth, Acute Respiratory Distress Syndrome, Surfactant Dysfunction
- Trial name
- NCT04777760
- Testing
- one dose of surfactant replacement, two and more doses of surfactant replacement
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
ARDS (Acute Respiratory Distress Syndrome)
Comparative Analysis of Salivary and Bronchoalveolar Lavage IL-6 and TNF-α as Biomarkers in Pediatric Acute Respiratory Distress Syndrome
The aim of this study is to determine the degree of agreement in cytokines level measured through BAL and those measured through salivary glands excretion.
- Trial name
- NCT07380373
- Testing
- Bronchoscopy
- Where
- Egypt
- Volunteers
- 37 people
- Sponsor
- Ain Shams University
Acute Respiratory Distress Syndrome, Acute Lung Injury
Genetic Variability and Biomarkers in Children With Acute Lung Injury
Acute Lung Injury (ALI) and the more severe Acute Respiratory Distress Syndrome (ARDS) are a significant problem in Pediatric Intensive Care Units, affecting up to 16 of every 1000 children admitted to these units.
- Trial name
- BALI (NCT01048996)
- Where
- United States
- Sponsor
- Medical College of Wisconsin
Respiratory Distress Syndrome, Adult, Lung Diseases
Acute Respiratory Distress Syndrome Clinical Network (ARDSNet)
The purposes of this study are to assess rapidly innovative treatment methods in patients with adult respiratory distress syndrome (ARDS) as well as those at risk of developing ARDS and to create a network of interactive Critical…
- Trial name
- NCT00000579
- Testing
- Low Tidal Volume Ventilation, Positive End-Expiratory Pressure, Lysofylline
- Where
- 21 sites in United States, Canada
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Acute Lung Injury, Acute Respiratory Distress Syndrome
Epidemiology Research on Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) in Adult ICU in Shanghai
To survey the prevalence and the mortality of the Acute Lung Injury/ Acute Respiratory Distress Syndrome (ALI/ARDS) in 12 university hospital ICUs in Shanghai.
- Trial name
- NCT01186874
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Tongji University
Neonatal Acute Respiratory Distress Syndrome(ARDS)
Epidemiological Study of Neonatal Acute Respiratory Distress Syndrome (ARDS)
Neonatal acute respiratory distress syndrome(ARDS) is a rare but often severe respiratory disorder. The incidence remains unclear and mortality is about 30%-60%.
- Trial name
- NCT03311165
- Testing
- no intervention
- Where
- 2 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
ARDS, Human, Burns
Predictive Factors, Demographics and Mortality for ARDS in Burn Patients
This retrospective study characterizes the clinical course and identifies four independent predictors of Acute Respiratory Distress Syndrome (ARDS) after burn injury (post-burn ARDS; pbARDS).
- Conditions
- ARDS, Human, Burns, Lung Diseases
- Trial name
- NCT03807232
- Volunteers
- 400 people
- Sponsor
- University of Zurich
ARDS, NRDS
Acute Respiratory Distress Syndrome(ARDS) in Neonates
Acute respiratory distress syndrome in neonates has been defined in 2015. Earlier identification and successful intervention into the potential pregnancy associated risk factors for the conversion from NRDS to ARDS is one of the…
- Trial name
- NCT03227289
- Testing
- Stayed in NRDS, Converted to ARDS
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Acute Respiratory Distress Syndrome
EPVent 2- A Phase II Study of Mechanical Ventilation Directed by Transpulmonary Pressures
This phase II multi-centered, randomized controlled trial of mechanical ventilation directed by esophageal pressure measurement will test the primary hypothesis that using a strategy of maintaining a minimal but positive…
- Trial name
- EPVent2 (NCT01681225)
- Testing
- Esophageal-pressure guided mechanical ventilation, High PEEP mechanical ventilation
- Where
- 14 sites in United States, Canada
- Volunteers
- 202 people
- Sponsor
- Beth Israel Deaconess Medical Center
Acute Respiratory Distress Syndrome
Pediatric Acute Respiratory Distress Syndrome Ventilation Bundle
Mortality rates in children with pediatric acute respiratory distress syndrome (PARDS) are higher in Asia compared to other regions.
- Trial name
- NCT03504176
- Testing
- Ventilation bundle
- Where
- Singapore
- Volunteers
- 134 people
- Sponsor
- KK Women's and Children's Hospital
Acute Respiratory Distress Syndrome, Acute Lung Injury
Role and Molecular Mechanism of Farnesoid X Receptor(FXR) and RIPK3 in the Formation of Acute Respiratory Distress Syndrome in Neonates
In the clinical data, the changes of RIPK3 and FXR were monitored in the lung lavage fluid and blood from the patients. In vivo experiments to find high risk factors to induce AEC necrosis and further lead to ARDS evidence, can…
- Conditions
- Acute Respiratory Distress Syndrome, Acute Lung Injury, FXR, RIPK3
- Trial name
- NCT02598648
- Testing
- FXR, RIPK3
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Acute Respiratory Distress Syndrome
A Comparative Study of Glucocorticoids Efficacy in Acute Respiratory Distress Syndrome
The aim of the work is to compare the efficacy of equivalent doses of methylprednisolone, dexamethasone and hydrocortisone in patients with ARDS
- Trial name
- NCT06496997
- Testing
- Methylprednisolone, Dexamethasone, Hydrocortisone
- Where
- Egypt
- Volunteers
- 195 people
- Sponsor
- Fayoum University
Acute Respiratory Distress Syndrome (ARDS)
Dexamethasone Treatment for Sepsis-associated Acute Respiratory Distress Syndrome: a Multicenter, Randomised, Double-blinded, Controlled Trial
Acute respiratory distress syndrome (ARDS) is a major cause of acute hypoxemic respiratory failure in critically ill patients and is associated with substantial mortality.
- Trial name
- DEFEND (NCT07576660)
- Testing
- Dexamethasone
- Where
- 2 sites in China
- Volunteers
- 1,704 people
- Sponsor
- Southeast University, China
Acute Respiratory Distress Syndrome (ARDS)
The Oscillation for Acute Respiratory Distress Syndrome (ARDS) Treated Early (OSCILLATE) Trial
What is the effect of early high frequency oscillation (HFO) versus a lung-protective conventional ventilation (CV) strategy (using HFO only as rescue therapy), on all-cause hospital mortality among patients with severe early…
- Trial name
- OSCILLATE (NCT01506401)
- Testing
- SensorMedics 3100B High Frequency Oscillatory Ventilator, Lung Protective Ventilation
- Where
- 38 sites in United States, Canada and 3 more
- Volunteers
- 548 people
- Sponsor
- Canadian Critical Care Trials Group
Acute Respiratory Failure With Hypoxia
pRotective vEntilation With Veno-venouS Lung assisT in Respiratory Failure
This is a trial of a new way of treating patients with respiratory failure. The investigators propose to deliver a multi-centre clinical trial to determine whether veno-venous extracorporeal carbon dioxide removal (VV-ECCO2R) and…
- Trial name
- REST (NCT02654327)
- Testing
- VV-ECCO2R to enable lower tidal volume mechanical ventilation
- Where
- United Kingdom
- Volunteers
- 1,120 people
- Sponsor
- Belfast Health and Social Care Trust