Clinical trials: Brachytherapy
Prostate Cancer
Leuprolide, Bicalutamide, and Implant Radiation Therapy in Treating Patients With Locally Recurrent Prostate Cancer After External-Beam Radiation Therapy
RATIONALE: Androgens can cause the growth of prostate cancer cells. Antihormone therapy, such as leuprolide and bicalutamide, may lessen the amount of androgens made by the body.
- Trial name
- NCT00684905
- Testing
- bicalutamide, leuprolide acetate, adjuvant therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Malignant Tumors
Clinical Study of Pretreatment PET/CT Parameters for Predicting the Efficacy of 125I Seed Implantation in the Treatment of Malignant Tumors
This study aimed to determine if pre-treatment 18F-FDG PET/CT metabolic parameters could predict the effectiveness of 125I seed implantation for malignant tumors.
- Trial name
- NCT07208487
- Where
- China
- Volunteers
- 41 people
- Sponsor
- Jiangxi Provincial Cancer Hospital
Stage IIIA Cervical Cancer FIGO 2018, Stage IIIB Cervical Cancer FIGO 2018
Asian Gynecological Brachytherapy Registry in Cervical Cancer
Gynecological cancer poses as significant public health issue, especially in Asian countries, where it is a leading cause of cancer-related deaths among women.
- Conditions
- Stage IIIA Cervical Cancer FIGO 2018, Stage IIIB Cervical Cancer FIGO 2018, Stage IVA Cervical Cancer FIGO 2018, Stage IB Cervical Cancer FIGO 2018
- Trial name
- AGBR-FERN-Gyn (NCT07196033)
- Where
- 5 sites in India, Japan and 1 more
- Volunteers
- 1,000 people
- Sponsor
- Tata Memorial Hospital
Cervical Cancer
Hydrogel Spacer During Definitive Radiotherapy for Cervical Cancer
This prospective, single-center study will evaluate the feasibility, spatial stability, and dosimetric effects of an absorbable hydrogel spacer placed between the cervix/vagina and rectum before definitive radiotherapy for…
- Trial name
- Hydrogel-RT (NCT07904182)
- Testing
- Absorbable Hydrogel Spacer
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Prostate Cancer
Implant Radiation Therapy Using Radioactive Iodine in Treating Patients With Localized Prostate Cancer
RATIONALE: Implant radiation therapy delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue.
- Trial name
- J-POPS (NCT00534196)
- Testing
- Permanent iodine-125 (Brachytherapy)
- Where
- 31 sites in Japan
- Volunteers
- 6,927 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Breast Cancer
Pilot Study of Partial Breast Irradiation Utilizing Permanent Breast Seed Implant to Treat Breast Cancer
Background: Recent single arm studies have suggested that partial breast irradiation (PBI), delivered in a relatively short overall treatment time of a few days, may be an effective alternative to adjuvant whole breast…
- Trial name
- NCT01191164
- Testing
- Partial Breast Irradiation Utilizing Permanent Breast Seed Implant
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- British Columbia Cancer Agency
Prostate Cancer
Phase I Targeting Dominant Intraprostatic Lesion Using MR Spectroscopy and HDR Brachytherapy
This is a phase I study to evaluate the feasibility and safety of using MRI/MRS to identify the dominant intraprostatic lesion (DIL) and to selectively boost the lesion using inverse planned high dose rate (HDR) brachytherapy.
- Trial name
- NCT00807820
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of California, San Francisco
Cervical Cancer
Single Application Brachytherapy in Cervical Cancer
The purpose of the study is to evaluate safety and feasibility of single brachytherapy application with dose delivery in multiple fractions.
- Trial name
- NCT03110497
- Testing
- Single application multi-fraction brachytherapy
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Tata Memorial Hospital
Prostate Cancer
Improving Assessment (and Ultimately Outcomes) of Permanent Prostate Implant Therapy
Permanent prostate implants are a type of radiation therapy in which a high dose of radiation is delivered to cancerous tissue by many small radioactive "seeds".
- Trial name
- NCT00127816
- Testing
- Permanent prostate implant
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- AHS Cancer Control Alberta
Thyroid Neoplasms
Clinical Efficacy of 125I Seed Implantation in the Treatment of Refractory Differentiated Thyroid Cancer
A retrospective analysis was conducted on RAIR-DTC patients who underwent radioactive 125I seed implantation from January 2015 to February 2022 at Jiangxi Cancer Hospital. Prescription dose: 80~120 Gy.
- Trial name
- NCT06362772
- Testing
- Iodine-125 brachytherapy
- Volunteers
- 36 people
- Sponsor
- Jiangxi Provincial Cancer Hospital
NSCLC, Non Small Cell Lung Cancer
A Study of Cesium-131 Brachytherapy Following Sub-Lobar Resection for Early Stage Non Small Cell Lung Cancer
For patients diagnosed with early (Stage I) non-small cell lung cancer, a lobe of lung is usually removed at surgery to treat the cancer.
- Trial name
- NCT01237171
- Testing
- Cesium-131 Brachytherapy Seed
- Where
- United States
- Sponsor
- IsoRay Medical, Inc.
Prostate Adenocarcinoma, Stage I Prostate Cancer
High-Dose Brachytherapy in Treating Patients With Prostate Cancer
This trial studies the side effects and how well high-dose brachytherapy works in treating patients with prostate cancer that has not spread to other parts of the body.
- Conditions
- Prostate Adenocarcinoma, Stage I Prostate Cancer, Stage IIA Prostate Cancer, Stage IIB Prostate Cancer
- Trial name
- NCT02346253
- Testing
- Internal Radiation Therapy, Bicalutamide, Leuprolide Acetate
- Where
- United States
- Volunteers
- 146 people
- Sponsor
- Stanford University
Coronary In-stent Restenosis
Retrospective Long-term Safety and Efficacy Study of the Beta-Cath(TM) 3.5F System
The study will evaluate the long-term safety and efficacy of intravascular beta radiation therapy to treat coronary in-stent restenosis using the Beta-Cath(TM) 3.5F System; data will be collected retrospectively on patients…
- Trial name
- NCT00852176
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Best Vascular, Inc.
Osteosarcoma
Single High-dose Brachytherapy for Giant Osteosarcoma Masses
This study is a prospective, single-arm, phase II, single-center study. Patients with locally unresectable giant osteosarcoma masses who meet the criteria are enrolled in the experimental group, and all patients receive a single…
- Trial name
- NCT06524778
- Testing
- brachytherapy
- Volunteers
- 16 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Prostate Cancer
Intensity Modulated Versus Interstitial - Radiation Therapy
Purpose: The purpose of this trial is to compare two different treatment options for patients with low risk and low-tier intermediate risk prostate cancer.
- Trial name
- NCT00407875
- Testing
- Intensity Modulated External Beam Radiation Therapy
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- British Columbia Cancer Agency
Prostate Cancer
Brachytherapy in Treating Patients With Prostate Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Giving radiation therapy through seeds implanted into the prostate may kill more tumor cells.
- Trial name
- NCT00003312
- Testing
- iodine I 125
- Where
- 258 sites in United States, Canada
- Volunteers
- 95 people
- Sponsor
- Radiation Therapy Oncology Group
Keloid
Effect of Strontium-90 Brachytherapy Combined With Hyperthermia in the Treatment of Keloid
Keloid patients were randomized into the experimental and control groups. Experimental group: Strontium-90 (Sr-90) brachytherapy followed by hyperthermia. Control group: Sr-90 brachytherapy alone .
- Trial name
- NCT06431360
- Testing
- hyperthermia
- Where
- 2 sites in China
- Volunteers
- 80 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Prostate Cancer
Prospective Evaluation of Focal Brachytherapy Using Cesium-131 For Patients With Low Risk Prostate Cancer
The standard options for men with very low risk prostate cancer include active surveillance and the standard treatment options for low risk disease, i.e.
- Trial name
- NCT02290366
- Testing
- Focal prostate brachytherapy with Cesium-131
- Where
- United States
- Sponsor
- Ronald M. Benoit, MD
Cervical Cancer
ElectroMagnetic-guided Interstitial Catheter Navigation for Gynecological brachyTherapy
Phase I study evaluating the feasibility of using electromagnetic navigation (EMN) for the catheter implantation procedure required of cervical brachytherapy.
- Trial name
- E-MINT (NCT03781271)
- Testing
- Electromagnetic Navigation
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Sunnybrook Health Sciences Centre
Prostatic Neoplasms
HSV-tk + Valacyclovir Therapy in Combination With Brachytherapy for Recurrent Prostate Cancer
The purpose of this study is to conduct a Phase I - II clinical trial to extend preclinical studies involving in situ HSV-tk + Valacyclovir gene therapy in combination with brachytherapy for recurrent prostate cancer.
- Trial name
- NCT01913106
- Testing
- HSV-tk +Valacyclovir in Combination with Brachytherapy
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- The Methodist Hospital Research Institute