Clinical trials: Craniotomy
Pain, Postoperative, Children
Pre-emptive Scalp Infiltration With Dexamethasone Plus Ropivacaine for Post-Craniotomy Pain in Children
At present, pediatric postoperative analgesia has not been fully understood and controlled, particularly craniotomy surgery. On the one hand, professional evaluation of postoperative pain for young children is difficult; on the…
- Trial name
- NCT04051723
- Testing
- The dexamethasone plus ropivacaine, The ropivacaine
- Where
- 2 sites in China
- Volunteers
- 80 people
- Sponsor
- Beijing Tiantan Hospital
Craniotomy for Epilepsy and Malignant Tumor Removal
Brain-Shift Monitoring Using 3D Scanning
A prospective non-invasive data/image collection for evaluation of the performance of the Advanced Scanners 3D scanner during brain surgery.
- Trial name
- NCT05018338
- Testing
- Brain shift monitoring
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Advanced Scanners Inc.
Arterial Cannulation
Ultrasound Assisted Arterial Cannulation in Small Children
Arterial cannulation is a commonly performed invasive procedure in the operation room, the emergency department, and in the intensive care unit.
- Trial name
- NCT01742416
- Testing
- Ultrasound, Palpation Method
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- The Hospital for Sick Children
Craniotomy
Post Market Study of Tutopatch In Craniotomy
This is a post market prospective, multi-center study of up to 75 participants at approximately 8 clinical study sites. The objective of the study is to evaluate safety by assessing incidence of device and/or procedure related…
- Trial name
- NCT07118020
- Where
- 2 sites in Austria, Spain
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- RTI Surgical
Surgical Site Infection, Antibiotics Prophylaxis
Cefuroxime vs Ceftriaxone for SSI Prevention in Neurosurgery
BACKGROUND: Surgical site infection (SSI) is potentially catastrophic in neurosurgical procedures, causing poor in-hospital outcomes in more than half of those affected and significantly increased length of hospital stay.
- Trial name
- NCT05398081
- Testing
- Cefuroxime (Zinnat®), Ceftriaxone (Rocephin®)
- Where
- Nigeria
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Dr. Promise Tamunoipiriala Jaja
Craniotomy Surgery, Pediatric Patient Safety
The Effect Of Positive End-Expiratory Pressure on Optic Nerve Sheath Diameter In Pediatric Patients Undergoing Craniotomy in Supine Position
This study evaluated the effect of positive end-expiratory pressure (PEEP) on optic nerve sheath diameter (ONSD), an indicator of intracranial pressure, in pediatric patients undergoing craniotomy in the supine position.
- Conditions
- Craniotomy Surgery, Pediatric Patient Safety, Pediatric Patient, Positive End-expiratory Pressure (PEEP)
- Trial name
- NCT07370779
- Testing
- General Anesthesia, Anesthetic Agents, mechanical ventilation (MV)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Intracranial Aneurysm, Stent Embolisation
Treatment of Unruptured Intracranial Aneurysms in China
Un-ruptured intracranial aneurysm is a complex disease that seriously affects human life and health. At present, the treatment of intracranial aneurysm is divided into interventional treatment and craniotomy clipping, the two…
- Conditions
- Intracranial Aneurysm, Stent Embolisation, Craniotomy, Coil-assissted Embolisation
- Trial name
- NCT03133598
- Where
- China
- Volunteers
- 5,126 people
- Sponsor
- Zhujiang Hospital
Brain Injuries, Traumatic
Pre-hospital and Intra-hospital Temporal Delays in Patients Requiring Emergent Trauma Craniotomy
The investigators aim to retrospectively map the delays in the acute care of traumatic brain injury patients necessitating emergent craniotomies.
- Trial name
- NCT02803112
- Testing
- Emergent craniotomy for traumatic brain injury
- Volunteers
- 67 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Recurrent Malignant Glioma
Phase I/II Trial of Intracerebral IL13-PE38QQR Infusions in Pediatric Patients With Recurrent Malignant Glioma
IL13-PE38QQR is an oncology drug product consisting of IL13 (interleukin-13) and PE38QQR (a bacteria toxin). IL3-PE38QQR is a protein that exhibits cell killing activity against a variety of IL13-receptor positive tumor cell…
- Trial name
- NCT00378235
- Testing
- IL13-PE38QQR
- Where
- 10 sites in United States
- Sponsor
- INSYS Therapeutics Inc
Brain Tumor, Primary
Intra-operative Variation in Size of Brain Tumors After Craniotomy
We planned to evaluate the change in tumor dimensions of intraaxial parenchymal tumors after craniotomy by comparing the tumor size on intraoperative ultrasonography (IOUSG) with pre-operative CECT and CEMRI brain.
- Trial name
- NCT04365647
- Where
- India
- Volunteers
- 51 people
- Sponsor
- Sheri Kashmir Institute of Medical Sciences
Posterior Fossa Lesion
Comparison of Surgical Outcomes of Craniotomy and Craniectomy in Posterior Fossa Lesions
The purpose of this randomized controlled trial is to compare the surgical outcomes of craniotomy and craniectomy among patients with posterior fossa lesions.
- Trial name
- NCT06831695
- Testing
- Craniotomy, Craniectomy
- Volunteers
- 80 people
- Sponsor
- University of Health Sciences Lahore
Posterior Fossa Tumor
Ultrasound-guided Greater Occipital Nerve Block in Children Undergoing Posterior Fossa Craniotomy
Surgery within the posterior fossa is associated with the highest incidence and greatest severity of acute postoperative pain that may persist beyond the immediate postoperative period.
- Trial name
- NCT03762343
- Testing
- ultrasound guided Greater occipital nerve block, control group C
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Kasr El Aini Hospital
Glioblastoma, IDH-wildtype, Glioblastoma
The RECMAP-study: Resection With or Without Intraoperative Mapping for Recurrent Glioblastoma
Resection of glioblastoma in or near functional brain tissue is challenging because of the proximity of important structures to the tumor site.
- Conditions
- Glioblastoma, IDH-wildtype, Glioblastoma, Glioblastoma Multiforme of Brain, Astrocytoma, Malignant
- Trial name
- RECMAP (NCT06273176)
- Testing
- Awake mapping under local anesthesia, Asleep mapping under general anesthesia, Resection under general anesthesia without mapping
- Where
- 8 sites in United States, Belgium and 3 more
- Volunteers
- 225 people
- Sponsor
- Erasmus Medical Center
Brain Neoplasms
Dexmedetomidine and Intelligence Development in Pediatric Patients Undergoing Craniotomy
The purpose of this randomized, double-blind and placebo-controlled pilot study is to investigate whether dexmedetomidine when used as an adjuvant to general anesthesia can decrease the harmful effects of anesthesia and surgery…
- Trial name
- NCT02810899
- Testing
- dexmedetomidine, normal saline
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University First Hospital
Pain, Postoperative Children
Pre-emptive Infiltration of the Scalp with Diprospan Plus Ropivacaine for Pain After Craniotomy in Children
At present, pediatric postoperative analgesia has not been fully understood and controlled, particularly craniotomy surgery. On the one hand, professional evaluation of postoperative pain for young children is difficult; on the…
- Trial name
- NCT06321354
- Testing
- The diprospan plus ropivacaine group, The ropivacaine group
- Where
- 2 sites in China
- Volunteers
- 108 people
- Sponsor
- Beijing Tiantan Hospital
Post Craniotomy Surgery, Cancer
The Management of Postoperative Craniotomy Pain in Pediatric Patients
The purpose of this prospective, clinical observational trial is to assess the incidence of pain (and analgesia), methods of pain assessment (and by whom), prescribed analgesics, methods of analgesic delivery, and patient/parent…
- Conditions
- Post Craniotomy Surgery, Cancer, Epilepsy, Vascular Malformations
- Trial name
- NCT01576601
- Where
- 3 sites in United States
- Volunteers
- 81 people
- Sponsor
- Johns Hopkins University
Disruption or Dehiscence of Closure of Skull or Craniotomy
Incidence of Pain After Craniotomy in Children
The primary objective is to assess the incidence and severity of pain after major craniotomy in paediatric patients (from 1 month to 10 years of age).
- Trial name
- Brainpain (NCT01142830)
- Where
- 8 sites in Italy
- Volunteers
- 218 people
- Sponsor
- San Gerardo Hospital
Pterional Craniotomy
A Clinical Effectiveness Trial in Post-Operative Pterional Craniotomy Drain Placement
This is a clinical trial where patients who present to the neurosurgery service in need of a procedure that requires a pterional craniotomy will be screened, and if eligible, enrolled for the randomization in the placement of a…
- Trial name
- EPOP (NCT02792361)
- Testing
- Standard Suction Drain
- Volunteers
- 90 people
- Sponsor
- University of Arizona
Brain Tumors
Integrated Pulmonary Index and Opioid Based Patient Controlled Analgesia
An optimal analgesic therapy is very important for postoperative recovery. In recent years, several studies showed that the prevalence of the moderate to severe pain after craniotomy ranged from 69 to 87% of patients.
- Trial name
- NCT04313374
- Testing
- Morphine PCA 1 mg, Morphine PCA 0,5 mg
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Ruptured Intracranial Aneurysms, Unruptured Intracranial Aneurysms
Treatment of Ruptured Intracranial Aneurysms in China.
Ruptured intracranial aneurysms is currently a common disease that seriously affects human health and quality of life due to its high morbidity,high mortality and high disability.
- Conditions
- Ruptured Intracranial Aneurysms, Unruptured Intracranial Aneurysms, Stent-Assisted Coiling, Non-Stent-Assisted Coiling
- Trial name
- NCT03462433
- Where
- China
- Volunteers
- 1,384 people
- Sponsor
- Zhujiang Hospital