Clinical trials: Craniotomy
Postoperative Nausea and Vomiting
Scalp Blocks Effect on Postoperative Nausea & Vomiting After Craniotomy
In this study, the investigators hypothesize that preemptive scalp block in neurosurgical patients may decrease incidence of PONV after craniotomy through decreasing intraoperative inhalational agents' concentration and…
- Trial name
- NCT04240236
- Testing
- Scalp block, Control Group
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Posterior Fossa Lesion
Comparison of Surgical Outcomes of Craniotomy and Craniectomy in Posterior Fossa Lesions
The purpose of this randomized controlled trial is to compare the surgical outcomes of craniotomy and craniectomy among patients with posterior fossa lesions.
- Trial name
- NCT06831695
- Testing
- Craniotomy, Craniectomy
- Volunteers
- 80 people
- Sponsor
- University of Health Sciences Lahore
Anesthesia, Craniotomy
Anesthesiological Strategies in Elective Craniotomy
This protocol, NeuroMorfeo, aims to assess equivalence between volatile and intravenous anesthetics for neurosurgical procedures.
- Conditions
- Anesthesia, Craniotomy, Neurosurgery
- Trial name
- Neuromorfeo (NCT00741351)
- Testing
- Sevoflurane + Fentanyl, Sevoflurane + Remifentanyl, Propofol + Remifentanyl
- Where
- 15 sites in Italy
- Volunteers
- 411 people
- Sponsor
- Azienda Ospedaliera San Gerardo di Monza
Brain Tumor
Dexmedetomidine Versus Magnesium Sulphate in Patients Undergoing Craniotomy for Deeply Settled Intracranial Tumours
An intracranial tumor, is an abnormal mass of tissue in which cells grow and multiply uncontrollably, seemingly unchecked by the mechanisms that control normal cells.
- Trial name
- NCT05743725
- Testing
- Dexmedetomidine, Magnesium sulfate
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Assiut University
Brain Tumor, Craniotomy
Intraoperative Goal Directed Fluid Management in Supratentorial Brain Tumor Craniotomy
Pulse pressure variation (PPV) to standard fluid management (4ml/Kg/hr) in patients undergoing supratentorial mass excision. The investigators hypothesize that in these procedures, goal-directed fluid therapy (GDT) might improve…
- Trial name
- NCT03033706
- Testing
- Pulse pressure variation guided fluid therapy, Traditional fluid therapy, Brain tumor excision
- Where
- Egypt
- Volunteers
- 61 people
- Sponsor
- Cairo University
Awake Craniotomy for Brain Tumour Surgery
Patient-controlled Versus Anesthesiologist-controlled Propofol-remifentanil in Awake Craniotomy
Awake craniotomy for removal of brain tumour is performed because the tumour may be located close to areas of the brain that control specific functions such as movement or speech.
- Trial name
- NCT00992940
- Testing
- Patient-Controlled Sedation/Analgesia, Anesthetist-Controlled Sedation/Analgesia
- Where
- Canada
- Sponsor
- University Health Network, Toronto
Airway Stress Response
Dexmedetomidine vs Labetalol for Airway Stress in Hypertensive Craniotomy Patients
This randomized trial compares dexmedetomidine and labetalol in controlling airway and hemodynamic stress during extubation in hypertensive patients undergoing craniotomy.
- Trial name
- NCT07034898
- Testing
- Dexmedetomidine, Labetalol
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Supratentorial Tumors
The Therapeutic Time Window of Mannitol During Craniotomy for Optimal Brain Relaxation in Patients With Supratentorial Tumours
Although mannitol is used for brain relaxation during neurosurgery and in the treatment of raised intracranial pressure; there is not a consensus on its safe, effective dose and the duration of its administration.
- Trial name
- NCT03444519
- Testing
- Mannitol
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Huashan Hospital
Scalp Block
Effect of Scalp Block on Intraoperative Hemodynamics and Postoperative Pain in Craniotomy Patients"
The goal of this clinical trial is to learn if an ultrasound-guided scalp block can improve intraoperative hemodynamic stability and provide better postoperative pain relief in adult patients undergoing elective supratentorial…
- Trial name
- NCT07496632
- Testing
- Surgical site infiltration with plain bupivacaine, Scalp block with plain bupivacaine
- Where
- Bangladesh
- Volunteers
- 72 people
- Sponsor
- Bangladesh Medical University
Complications, Pulmonary
Laryngeal Mask Airway Facilitates a Safe and Smooth Emergence From Anesthesia in Patients Undergoing Craniotomy
Stabilizing hemodynamic and reducing pulmonary complications during extubation with switching endotracheal tube to laryngeal mask in craniotomies
- Trial name
- NCT05253404
- Testing
- Ambu® AuraOnce™ Disposable Laryngeal Mask
- Where
- Taiwan
- Volunteers
- 62 people
- Sponsor
- Chang Gung Memorial Hospital
Children With Craniosynostoses
Nautilus: Dynamic Craniotomy; New Surgical Technique and Preliminary Results
Being the craniostenoses sutural basically a disease, the fact that the brain being trapped in an enclosure that does not have complacency required to accompany their growth constitutes the challenge of treatment, which aims to…
- Trial name
- Nautilus (NCT01672619)
- Testing
- dynamic craniotomy
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Nucleo de Plastica Avancada
Cranioplasty, Craniotomy
Effectiveness of 3D Bone Matrix in Cranioplasty
The objective of this clinical trial is to evaluate the effectiveness of a 3D bone scaffold in relation to a scaffold formed by PCL + β-TCP (polycaprolactone and beta-tricalcium phosphate), compared to the use of PMMA (polymethyl…
- Conditions
- Cranioplasty, Craniotomy, Craniotomy Clipping, Craniotomy Surgery
- Trial name
- OSTEOPRINTCR (NCT06792864)
- Testing
- OsteoprintCR, SMAR SET GMV Endurance Gentamicin
- Where
- Chile
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Universidad Austral de Chile
Analgesia
Effects of SCALP Block on Postoperative Analgesia in Craniotomy Surgery
Patients undergoing craniotomy surgery often experience severe postoperative pain. This pain can affect the patient's hemodynamics, disrupt sleep patterns, and prolong hospital stays.
- Trial name
- NCT06588751
- Testing
- Scalp block
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Konya City Hospital
Postoperative Nausea and Vomiting
Aprepitant With Dexamethasone Versus Ondansetron With Dexamethasone for PONV Prophylaxis in Patients Having Craniotomy
We hypothesize that the combination of aprepitant with dexamethasone will provide significantly improved prophylaxis against Postoperative nausea and vomiting compared with the combination of ondansetron and dexamethasone, in…
- Trial name
- NCT00734929
- Testing
- Aprepitant + Dexamethasone, Ondansetron + Dexamethasone
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- Duke University
Melanoma, Brain Metastases
CNS and Extracranial Tumor Tissues, CSF, and Blood From Patients With Melanoma Brain Metastases
The purpose of this study is to collect and bank samples of blood and tissues (such as brain tissue or lymph nodes), as well as cerebrospinal fluid (CSF), which is the fluid that bathes and cushions the spinal cord.
- Trial name
- 13-052 (NCT02058953)
- Testing
- Craniotomy scheduled, Collection for non-craniotomy
- Where
- 3 sites in United States, Australia
- Volunteers
- 7 people
- Sponsor
- University of Pittsburgh
Pain
The Effect of Intravenous Acetaminophen on Post-Operative Pain After Craniotomy
The purpose of the study is to determine the efficacy of IV acetaminophen when administered to neurosurgical patients at the beginning and end of their surgery.
- Trial name
- NCT03445390
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Stanford University
Liposomal Bupivacaine, Microvascular Decompression
Effect of Local Infiltration of Liposomal Bupivacaine on Postoperative Analgesia in Patients With Craniotomy Microvascular Decompression
Background: Approximately 60-84% of patients undergoing craniotomy experience moderate to severe pain within 48 hours postoperatively, with posterior fossa craniotomy patients experiencing more severe pain.
- Trial name
- NCT07245290
- Testing
- liposomal bupivacaine local infiltration, normal operation
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Post Craniotomy Surgery, Cancer
The Management of Postoperative Craniotomy Pain in Pediatric Patients
The purpose of this prospective, clinical observational trial is to assess the incidence of pain (and analgesia), methods of pain assessment (and by whom), prescribed analgesics, methods of analgesic delivery, and patient/parent…
- Conditions
- Post Craniotomy Surgery, Cancer, Epilepsy, Vascular Malformations
- Trial name
- NCT01576601
- Where
- 3 sites in United States
- Volunteers
- 81 people
- Sponsor
- Johns Hopkins University
Osmotherapy, Intracranial Pressure
Comparison of 20% Mannitol and 3% Hypertonic Saline for Cerebral Relaxation During Elective Supratentorial Craniotomies
Mannitol 20% has long been used to treat elevated intracranial hypertension in trauma and intensive care settings. More recent data indicate that hypertonic saline may be as effective or more effective than mannitol for this…
- Trial name
- NCT01745081
- Testing
- 20% mannitol bolus administration, Hypertonic saline 3% bolus administration
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Université de Sherbrooke
Anesthesia
Total Intravenous Anesthesia in Patients Undergoing Craniotomy
Craniotomy presents true anesthetic challenges, mainly due to the need to optimize cerebral perfusion, facilitate brain relaxation, achieve rapid emergence for neurologic assessment, and minimize perioperative complications.
- Trial name
- NCT07105618
- Testing
- Dexmedetomidine, Fentanyl, Magnesium
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Zagazig University