Clinical trials: Dystonic Disorders
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Writer's Cramp, Dystonias
VTS Sensorimotor Neuromodulation in WC
Writer's cramps (WC) is a focal task-specific upper limb dystonia that significantly impairs handwriting and other manual skills, affecting functionality.
- Trial name
- VTS in WC (NCT07894198)
- Testing
- Vibro-tactile stimulation
- Volunteers
- 10 people
- Sponsor
- Ottawa Hospital Research Institute
Dystonia, Dystonia; Idiopathic
Dystonia Genotype-Phenotype Correlation
The purpose of this study is to (1) investigate the effect of known dystonia-causing mutations on brain structure and function, to (2) identify structural brain changes that differ between clinical phenotypes of dystonia, and to…
- Conditions
- Dystonia, Dystonia; Idiopathic, Dystonia, Primary, Dystonia, Secondary
- Trial name
- NCT03428009
- Testing
- Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Isolated/Primary Dystonia That Affects More Than One Region of the Body
An Observational Study of Individuals With Isolated Dystonia
This is an observational study in individuals with isolated (or primary) dystonia that involves more than one body region. The purpose of the study is to collect detailed information to help your physician and other researchers…
- Trial name
- NCT07111663
- Where
- 29 sites in United States
- Volunteers
- 200 people
- Sponsor
- Vima Therapeutics
Pediatric Disorder, Genetic Predisposition
Pharmacogenomic Contributions to Trihexyphenidyl Biotransformation and Response in Children With Dystonic Cerebral Palsy
This study looks at how a medicine called trihexyphenidyl works in children with dystonic cerebral palsy. The study aims to understand how trihexyphenidyl is broken down and used in the body of pediatric patients and whether this…
- Conditions
- Pediatric Disorder, Genetic Predisposition, Dystonia, Secondary, Dystonia
- Trial name
- TRIKE2 (NCT06554288)
- Testing
- Trihexyphenidyl
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's Mercy Hospital Kansas City
Cerebral Palsy, Dyskinetic, Secondary Dystonia
Focused Ultrasound Pallidotomy for Dyskinetic Cerebral Palsy in Pediatric and Young Adult Subjects
The primary objective of the proposed study is to evaluate the safety of ExAblate Transcranial MRgFUS as a tool for creating bilateral or unilateral lesions in the globus pallidus (GPi) in patients with treatment-refractory…
- Trial name
- NCT06036199
- Testing
- Focused Ultrasound Pallidotomy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Children's National Research Institute
Epilepsy in Children, Dyskinesias
A Retrospective Survey-based Multicenter Study to Delineate the Molecular and Phenotypic Spectrum of Epilepsy-dyskinesia Syndromes
The Epilepsy-Dyskinesia Study aims to advance the understanding of the clinical and molecular spectrum of epilepsy-dyskinesia syndromes, monogenic diseases that cause both movement disorders and epilepsy.
- Conditions
- Epilepsy in Children, Dyskinesias, Movement Disorders in Children, Neurologic Disorder
- Trial name
- NCT06585605
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Boston Children's Hospital
Movement Disorders, Parkinson Disease
Abbott DBS Post-Market Study of Outcomes for Indications Over Time
The purpose of this international study is to evaluate long-term safety and effectiveness of Abbott deep brain stimulation (DBS) systems for all indications, including Parkinson's disease, essential tremor or other disabling…
- Conditions
- Movement Disorders, Parkinson Disease, Essential Tremor, Tremor
- Trial name
- ADROIT (NCT04071847)
- Testing
- Deep Brain Stimulation (DBS)
- Where
- 48 sites in United States, Australia and 7 more
- Volunteers
- 1,000 people
- Sponsor
- Abbott Medical Devices
Dystonia, Primary
Agency in Dystonia
In this study, using computerized cognitive assessments combined with multi-modal neuroimaging approach investigators aim to address three specific questions on patients with cervical and myoclonus dystonia: (i) investigate…
- Trial name
- AGENT10 (NCT03351218)
- Testing
- Behavioral testing - computerized tasks
- Where
- France
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Epilepsy-Dyskinesia, Epilepsy
Registry and Natural History of Epilepsy-Dyskinesia Syndromes
The Registry and Natural History of Epilepsy-Dyskinesia Syndromes is focused on gathering longitudinal clinical data as well as biological samples (blood, urine, and/or skin/tissue) from male and female patients, of all ages, who…
- Conditions
- Epilepsy-Dyskinesia, Epilepsy, Dyskinesia, EDS
- Trial name
- NCT06967727
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- Boston Children's Hospital
Dystonia Disorder
İnvestigating Dysphagia in Pediatric Dystonia
Dystonia is a movement disorder involving involuntary, sustained, or intermittent muscle contractions that cause abnormal postures and repetitive movements, worsened by voluntary actions or stress.
- Trial name
- NCT06815757
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Gazi University
Secondary Dystonia, Cerebral Palsy, Mixed
The Effect of Dystonia Severity on Participation in Daily Living Activities and Caregivers in Children of Cerebral Palsy With Secondary Dystonia
Dystonia is the most common movement disorder in the pediatric population after spasticity. It can affect normal motor development and cause significant motor retardation.
- Trial name
- NCT06307561
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Acıbadem Atunizade Hospital
Dystonia, Dystonic Cerebral Palsy
Enhancing Sensorimotor Processing in Children With Dystonia
Dystonia is a severely disabling movement disorder with no cure, in which people suffer painful muscle spasms causing twisting movements and abnormal postures. There are many causes, including genetic conditions and brain injury.
- Conditions
- Dystonia, Dystonic Cerebral Palsy, Dystonia, Secondary, Dystonia, Primary
- Trial name
- NCT05612464
- Testing
- No intervention
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- King's College London
Cerebral Palsy, Excessive Crying
Excessive Crying in Children With Cerebral Palsy and Communication Deficits
Management of excessive crying in children with cerebral palsy and communication deficits [ECCCPCD] was guided by the associated clinical findings and investigations.
- Conditions
- Cerebral Palsy, Excessive Crying, Pain
- Trial name
- ECCCPCD (NCT04523935)
- Testing
- Baclofen, Diazepam, Clonazepam, Trihexyphenidyl, Tetrabenazine, Gabapentin, Topiramate, Lamotrigine, Amitriptyline.
- Volunteers
- 131 people
- Sponsor
- Sathbhavana Brain Clinic
Dystonia, Focal
Oral Zinc Supplementation to Enhance Botulinum Neurotoxin Response
Botulinum neurotoxin (BoNT) is injected into muscles for treatment of dystonia. BoNTs are zinc proteases, and their enzymatic effect is reduced in the setting of low zinc.
- Trial name
- NCT05095493
- Testing
- Zinc Acetate
- Volunteers
- 54 people
- Sponsor
- University of Texas Southwestern Medical Center
Primary Dystonia, Transcranial Magnetic Stimulation
Precision-targeted Transcranial Magnetic Stimulation in the Treatment of Primary Dystonia
In this scheme, TMS treatment of Primary dystonia is planned by precise magnetic resonance positioning.
- Trial name
- NCT04727177
- Testing
- Transcranial magnetic stimulation
- Where
- China
- Volunteers
- 1 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Primary Dystonia
Comparison of the Efficacy of Double Monopolar Versus Interleaving Stimulation Modes for Pallidal Deep Brain Stimulation
The aim of the study is to compare the efficacy and the safety profile of the newly introduced interleaving stimulation mode to those of the standard double monopolar stimulation mode during pallidal deep brain stimulation of…
- Trial name
- NCT01497639
- Testing
- Interleaving stimulation mode (Medtronic), Double monopolar stimulation mode (Medtronic)
- Where
- Hungary
- Volunteers
- 34 people
- Sponsor
- University of Pecs
Dystonia, Primary, Dysarthria
Study of Speech Disorders , Voice and Swallowing in Primary Dystonia Oromandibular
To better define the clinical characteristics of oromandibular dystonia, we aimed to study voice, speech and swallowing disorders in idiopathic oromandibular We planned to include consecutive patients followed in Lille Movement…
- Conditions
- Dystonia, Primary, Dysarthria, Dysphonia, Dysphagia
- Trial name
- DOM (NCT03380676)
- Where
- France
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Secondary Dystonia
Neuroablation Versus Neuromodulation Techniques for Treatment of Secondary Dystonia
The disability inflected by dystonia encouraged the development of many neurosurgical procedures. This is a prospective study included 120 patients suffering from intractable secondary dystonia.
- Trial name
- NCT03347240
- Testing
- Brain Lesioning, Combined anterior and posterior lumbosacral rhizotomy, Deep brain stimulation
- Volunteers
- 120 people
- Sponsor
- Ain Shams University
Primary Dystonia, Epilepsy
Assess Specific Kinds of Children Challenges for Neurologic Devices Study
The ASK CHILDREN study is intended to aid in future development of various neurologic devices (i.e. neuroprostheses). The ASK CHILDREN study seeks to use study information obtained to identify more efficient strategies in the…
- Conditions
- Primary Dystonia, Epilepsy, Hydrocephalus, Bladder Control
- Trial name
- NCT01191307
- Volunteers
- 16 people
- Sponsor
- Carlos Pena, PhD, MS