Clinical trials: Eye Manifestations
Low Vision, Both Eyes
Virtual Reality-Base Intelligent Orientation and Mobility Specialists Trial
The human subject research is a randomized, controlled training trial that tests the effectiveness of three Virtual Reality-based Intelligent Orientation and Mobility Specialists (VR-IOMSs) in teaching orientation and mobility…
- Trial name
- VR-IOMS (NCT04639531)
- Testing
- Orientation and Mobility Training with VR-IOMSs, Orientation and Mobility Training with COMS, No Orientation and Mobility Training
- Where
- 2 sites in United States
- Volunteers
- 117 people
- Sponsor
- University of Alabama at Birmingham
Amblyopia
Establishing New Treatment Approaches for Amblyopia: Perceptual Learning and Video Games
Amblyopia, a developmental abnormality that impairs spatial vision, is a major cause of vision loss, resulting in reduced visual acuity and reduced sensitivity to contrast.
- Trial name
- NCT05522972
- Testing
- Video Game Vision Training, Perceptual Learning, Occlusion Therapy
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Nova Southeastern University
Retinopathy of Prematurity, Retinal Detachment
Efficient Study of ACULAR in Inhibiting Proliferative Retinopathy in Prematurity
The purpose of this study is to test whether ACULAR, a nonsteroidal anti-inflammatory eye drop medication, can prevent the development of retinopathy of prematurity (ROP) and/ or decrease its severity.In this study ACULAR will be…
- Conditions
- Retinopathy of Prematurity, Retinal Detachment, Blindness
- Trial name
- ROP (NCT00634972)
- Testing
- ACULAR, REFRESH TEARS
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University of South Alabama
Behavioral Dynamics, Visual Impairment
Behavioral Dynamics Between Infants With Visual Loss and Healthy Controls
An individual senses the world and reflects feedbacks via independent behaviors. Such precise collaboration of the sensory and behavioral systems is fundamental to survival and evolution.
- Trial name
- NCT03431207
- Testing
- Standardized video recording for behaviors
- Where
- China
- Volunteers
- 4,196 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Neck Pain, Unilateral Blindness
Unilateral Blindness/ Unilateral Deafness-relation to Neck Pain
Neck pain is a common complaint in the general population affecting 10-15% of the general population. females more than men. Known risk factors are: Trauma, Repetitive lifting of heavy objects at work, driving vibrating vehicles…
- Conditions
- Neck Pain, Unilateral Blindness, Unilateral Deafness
- Trial name
- NCT00589407
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Hadassah Medical Organization
Cerebral Palsy
Effects of Associated Impairments on Activity and Participation in Children With Cerebral Palsy
This study will investigate the effects of associated impairments on the activity levels and social participation of school-aged children with Cerebral Palsy (aged 6-12) and their impact on their families' quality of life and…
- Trial name
- NCT06944171
- Where
- Turkey (Türkiye)
- Volunteers
- 107 people
- Sponsor
- Hacettepe University
Cerebral Palsy, Cortical Visual Impairment
Cortical Visual Impairment and Visual Attentiveness
This study will investigate the effect of enhanced visual and cross-modal environments upon the visual attentiveness of multiply handicapped children diagnosed with Cerebral Palsy (CP) and Cortical Visual Impairment (CVI).
- Trial name
- NCT00342108
- Testing
- cross-modal sensory stimulation
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Sheba Medical Center
Oral Proprioceptive Sensitivity and Upper Limb Kinesthetic Acuity
Oral Proprioceptive Sensitivity and Upper Limb Kinesthetic Acuity: A Pilot Study
The goal of this observational study is to investigate whether differences in oral proprioceptive sensitivity are associated with differences in kinesthetic acuity of the upper limbs in children.
- Trial name
- NCT07854314
- Testing
- Upper-Limb Kinesthetic Acuity Assessment, Effect of Auditory Stimulation on Visual Perception, Oral Proprioceptive Sensitivity Assessment
- Where
- Spain
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Sophie Román Richon
Amblyopia
NEIVATECH Virtual Reality-based System for Amblyopia
The NEIVATECH system has been designed to provide binocular vision training to 7-15 year old amblyopic children by discriminating Gabor patches presented with different contrast to each eye as a perceptual learning task.
- Trial name
- NEIVATECH (NCT04819386)
- Testing
- Active vision therapy sessions with the NEIVATECH Virtual Reality-based system
- Where
- 2 sites in Spain
- Volunteers
- 20 people
- Sponsor
- Increase-Tech
Apnea of Prematurity, Retinopathy of Prematurity
Use of Sucrose to Relieve Pain During Eye Exams in Infants
The purpose of this study is to see if an oral sucrose solution can comfort premature infants during their necessary eye exams. The investigators believe that the use of this solution prior to the eye exams will lead to a…
- Conditions
- Apnea of Prematurity, Retinopathy of Prematurity, Pain
- Trial name
- NCT00161694
- Testing
- sucrose solution
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Weill Medical College of Cornell University
Amblyopia, Amblyopia, Anisometropic
Stochastic Resonance Applied to Amblyopia Training and the Plasticity of Brain
The prevalence of Taiwan's population with amblyopia is 2-5%. Amblyopia affects the daily life and learning ability. The human visual system can be developed normally with exposure of clear images on the retina, which often drive…
- Trial name
- NCT04213066
- Testing
- Portable tablet
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
One Eye Blindness, Blind Left Eye
Multiplexing Prism Fitting for Field Expansion of Monocular Vision
The investigators are developing an assistive device, known as multiplexing prism that expands the field of view for individuals with acquired monocular vision (loss of an eye).
- Conditions
- One Eye Blindness, Blind Left Eye, Blind Right Eye
- Trial name
- NCT06027216
- Testing
- Multiplexing Prism
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Usher Syndrome
Clinical and Genetic Examination of Usher Syndrome Patients' Cohort in Europe
This study aims to characterize Usher patients in order to correlate this data with genetic information. Tasks: Standardization and improvement of Usher syndrome diagnosis: refine and elaborate special tests of visual and…
- Trial name
- EURUSH (NCT01954953)
- Where
- 6 sites in France, Germany and 2 more
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Visual Impairment, Cerebral Visual Impairment
VIPPSTAR-G1 Digital Early Intervention for Visual Impairment
Visual impairment in infancy is associated with significant risks for neurodevelopmental impairment. Early intervention based on enriched visual and multisensory experiences may promote neuroplasticity and improve developmental…
- Conditions
- Visual Impairment, Cerebral Visual Impairment, Neurodevelopmental Disorders, Prematurity
- Trial name
- VIPPSTAR-G1 (NCT07717671)
- Testing
- VIPPSTAR Digital Early Intervention, Standard Clinical Care
- Where
- 5 sites in Belgium, Italy and 1 more
- Volunteers
- 150 people
- Sponsor
- Università degli Studi di Brescia
Vision, Low
Project Magnify - A Comparison of Two Strategies to Improve Reading Ability
The purpose of Project Magnify is to determine which of the two current strategies (large print versus optical aids) for helping visually impaired students improve their reading abilities works better.
- Trial name
- NCT00366392
- Testing
- Optical Aids
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical University of South Carolina
Visual Perceptual Weakness (Disorder), Cerebral Visual Impairment
iVision - Development of a Game-based Therapy for Children With Cerebral Visual Impairment
The objective of the present study is to develop a therapeutic, adaptive, and enjoyable game that will be used by children with CVI between the mental age of 3 and 12 years.
- Trial name
- iVision (NCT04051983)
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Autoimmune Disease, Neurologic Autoimmune Disease
Autologous Stem Cell Transplant for Neurologic Autoimmune Diseases
This phase II trial studies the side effects and how well carmustine, etoposide, cytarabine and melphalan together with antithymocyte globulin before a stem cell transplant works in treating patients with autoimmune neurologic…
- Conditions
- Autoimmune Disease, Neurologic Autoimmune Disease, Autologous Transplant Autoimmune, Multiple Sclerosis Transplant
- Trial name
- NCT00716066
- Testing
- Anti-Thymocyte Globulin, Autologous Hematopoietic Stem Cell Transplantation, Carmustine
- Where
- 3 sites in United States
- Volunteers
- 53 people
- Sponsor
- Fred Hutchinson Cancer Center
Pupillary Constriction, Accomodation
Adjusted Study Protocol: Within-Subject Paired-Eye Design Comparing Pilocarpine 0.1%, Phentolamine 0.75%, and Combination Therapy for Cyclopentolate Reversal in Children
The study aims at reversing pupillary dilatation. and cycloplegia in children undergoing cycloplegic refraction for eyeglasses prescription and ocular examination.
- Trial name
- NCT07012512
- Testing
- Use of phentolamine eye drops to reverse cycloplegia, Pilocarpine 0.1%, Combination of pilocarpine 0.1% and phentolamine 0.75%
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Pain, Anxiety
Decreasing REcurrent Pain and Anxiety in Medical Procedures With a Pediatric Population: a Pilot Study
Children with injuries, including burns, experience severe pain intensity during medical procedures despite the increasing doses of analgesics.
- Conditions
- Pain, Anxiety, Burns, Child
- Trial name
- DREAM-P (NCT02977923)
- Testing
- VR distraction via Oculus Rift, Standard pharmacological treatment
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- St. Justine's Hospital
CBD Stone
Re-use of Ambu aScope During Exploration of the Common Bile Duct for Stones in Low-Resource Settings- a Retrospective Study
Various methods confirm stone clearance during surgical exploration of bile duct, but choledochoscopy is considered the most effective. However, choledochoscopes are expensive and often unavailable in low-resource settings.
- Trial name
- NCT07285447
- Testing
- Ambu aScope for visualization of biliary tree during exploration of CBD for stone
- Where
- Nepal
- Volunteers
- 75 people
- Sponsor
- B.P. Koirala Institute of Health Sciences