Clinical trials: First Trimester Pregnancy
Induced Abortion, First Trimester Abortion
Study of Clinic-based vs. Self-use of a Misoprostol-only Regimen for Induced Abortion
The goal of the study is to determine whether important clinical outcomes differ among women who access a misoprostol-only medication abortion regimen from a patent medicine vendor when compared with those who access it from a…
- Trial name
- NCT04242212
- Testing
- Misoprostol sourced from clinics, Misoprostol sourced from PMVs
- Where
- 3 sites in Nigeria
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Ipas
Contraception
Study of Immediate Start of Progestin Contraceptives in Medical Abortion
This study will compare immediate to post-abortion start of two progestin-based contraceptives (DMPA and etonorgestrel implants) among women having first trimester medical abortion who wish to use that method for post-abortion…
- Trial name
- Quickstart (NCT01902485)
- Testing
- Timing of Contraceptive Initiation in Medical Abortion
- Where
- 8 sites in United States, Mexico
- Volunteers
- 937 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
First Trimester Pregnancy, Fetal Heart Activity Absent
Markers of Oxidative Stress in a Early Week Miscarriage: Ischemia of Modified Albumin
The finding that ischemia-modified albumin (IMA) is increased in pre-eclamptic pregnancy suggests a role for IMA as a potential biomarker for abnormal placental development related to miscarriage.This study was undertaken to…
- Conditions
- First Trimester Pregnancy, Fetal Heart Activity Absent, Absence of Fetal Pole on Ultrasonographic Examination.
- Trial name
- IMA (NCT01988740)
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Fibroid, Miscarriage in First Trimester
Fibroids and the Risk of Miscarriage: a Prospective Observational Study in an Early Pregnancy Population
The aim of this observational study is to whether fibroids increase the risk of miscarriage in women in our early pregnancy population.
- Conditions
- Fibroid, Miscarriage in First Trimester, Miscarriage in Second Trimester
- Trial name
- FiRM (NCT06986616)
- Where
- United Kingdom
- Volunteers
- 436 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
Abortion in First Trimester, Pain, Procedural
Ketamine Versus Fentanyl for Surgical Abortions
Ketamine is commonly used for procedural sedation and analgesia. It is widely used for trauma cases in the emergency department and is considered a superior agent in the outpatient setting due to its lack of respiratory and…
- Conditions
- Abortion in First Trimester, Pain, Procedural, Opioid Use
- Trial name
- NCT04871425
- Testing
- Ketamine, Fentanyl
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Washington
Abortion, Therapeutic
A Randomized Study of Cervical Priming With Misoprostol Prior to Elective First Trimester Pregnancy Termination
The purpose of this study is to determine whether misoprostol administered prior to elective first trimester pregnancy has an effect on pain and ease of procedure and complications.
- Trial name
- NCT00310921
- Testing
- Misoprostol
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Pregnancy, Bacterial Vaginosis
Bacterial Vaginosis in Pregnancy: Detection by Weekly Vaginal pH Testing
Interventional study to assess the effect of early detection and treatment of bacterial vaginosis in pregnancy on preterm delivery rate.
- Conditions
- Pregnancy, Bacterial Vaginosis, Preterm Delivery
- Trial name
- NCT00799500
- Testing
- Screening
- Where
- Spain
- Volunteers
- 1,049 people, healthy volunteers welcome
- Sponsor
- Montse Palacio
Miscarriage
Serum Kisspeptin: a Predictive Marker of Miscarriage or Not?
This is a prospective observational study. Eligible women undergo ART treatment in our centre will be recruited for the study and each woman will only be included in the study once. Informed written consent will be obtained.
- Trial name
- NCT03940495
- Where
- China
- Volunteers
- 182 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Sickle Cell Disease, Pregnancy Related
LEARNER- Low dosE AspiRiN prEterm tRial (Angola)
This study is being conducted to evaluate the safety and effect of starting daily use of low dose (100 mg) aspirin in pregnant women with sickle cell disease, who are being followed in two county hospitals in Angola, in the first…
- Conditions
- Sickle Cell Disease, Pregnancy Related, Pregnancy Complications, Pre-Eclampsia
- Trial name
- LEARNER (NCT06417411)
- Testing
- Aspirin 100mg
- Where
- Angola
- Volunteers
- 450 people
- Sponsor
- Instituto Nacional de Investigacao em Saude, Angola
Contraception
A Comparison of Continuation Rates for Three Hormonal Contraceptive Methods
This study will assess the continuation rates among women using oral contraceptive pills, Depo-Provera and Ortho Evra following a first trimester abortion.
- Trial name
- NCT00253019
- Where
- United States
- Volunteers
- 321 people, healthy volunteers welcome
- Sponsor
- Emory University
Screening for Hyperglycemia in First Trimester in High and Low Risk Pregnancy
Screening For First Trimester's Hyperglycemia in High and Low Risk Pregnancy
Glucose intolerance is the commonest medical disorder complicating pregnancy. Hyperglycemia increases the risk of delivering a large for gestational age newborn (LGA) and related complications such as operative delivery, birth…
- Trial name
- NCT06064552
- Testing
- blood sugar
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Incomplete Abortion, Intrauterine Contraception
Ideal Timing of Intrauterine Contraception Insertion After Medical Management of First Trimester Incomplete Abortion
Background: Unintended pregnancies continue to cause a public health threat in Low and Middle Income countries yet with restrictive abortion laws.
- Conditions
- Incomplete Abortion, Intrauterine Contraception, Misoprostol
- Trial name
- PAIC (NCT05343546)
- Testing
- Use of either copper T380A or Levonorgestrel LNG 52 IUS after medical management of first trimester incomplete abortion
- Where
- Uganda
- Volunteers
- 2,076 people
- Sponsor
- Makerere University
Preeclampsia
A Study to Evaluate the Use of Placenta Protein 13 (PP13) in the First Trimester of Pregnancy as a Diagnostic Aiding Tool in the Assessment of the Risk for Developing Preeclampsia in Women With Low and Unknown Risk
The purpose of this study is to evaluate whether it is possible to detect changes in the concentration of PP13 in the blood of pregnant women who may go on to develop the complication of preeclampsia later on in the pregnancy…
- Trial name
- NCT00572793
- Where
- United States
- Volunteers
- 431 people, healthy volunteers welcome
- Sponsor
- Carl Weiner, MD
Fetus Disorder
AutoFUSE or First-Trimester Ultrasound Scan
The goal of this clinical trial is to validate the clinical application capabilities of AutoFUSE. The main questions it aims to answer are: Does AutoFUSE reduce the time required to obtain standard planes in first-trimester…
- Trial name
- NCT07601191
- Testing
- AutoFUSE system, Traditional ultrasound scan
- Where
- 3 sites in China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Retained Products of Conception Post Abortion
Oral Contraceptive Pills Versus Expectant Management for Retained Pregnancy Products
We speculate that the use of combined oral contraceptives may be a possible solution to promote the management of retained pregnancy products versus expectant management.
- Trial name
- NCT03230825
- Testing
- Oral contraceptive, Expectant management
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Miscarriage in First Trimester
Machine Learning Miscarriage Management Clinical Decision Support Tool Study
Machine learning used to develop an algorithm to determine chance of success with expectant or medical management for an individual patient.
- Trial name
- MLMM (NCT06384144)
- Testing
- Expectant Management of First Trimester Miscarriage, Medical Management of First Trimester Miscarriage
- Where
- United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Iron Deficiency (Without Anemia), Pregnancy
Iron Parameters in Non-anemic First Trimester Gravidas
The purpose of the study is to see the percentage of non-anemic, first trimester gravidas presenting to their obstetricians, who are iron deficient.
- Trial name
- NCT03670537
- Testing
- Iron parameters
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Auerbach Hematology Oncology Associates P C
Zika Virus Infection
Sensorimotor Outcomes of Children Exposed to Foetal Zika Virus Infection
Introduction: It is estimated that more than one million Brazilians were infected by zika virus in the last two years. Brazilian researchers first noted the virus's potential association with microcephaly.
- Trial name
- NCT03679728
- Testing
- First trimester, Second trimester
- Where
- Brazil
- Volunteers
- 31 people
- Sponsor
- University of Sao Paulo
Abortion Early
Dry vs Wet Misoprostol for Cervical Dilation in First Trimester Abortion
This study aims to verify whether the moisture of 400 µg of misoprostol pre uterine evacuation increases the dilatation of uterine cervix compared to dry misoprostol
- Trial name
- MisoWet (NCT02522078)
- Testing
- dry misoprostol, wet misoprostol
- Where
- Brazil
- Volunteers
- 46 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Pain
Buffered Lidocaine in Paracervical Blocks
For pain relief during a first trimester surgical aspiration, most providers use the paracervical block, either alone or in combination with other pain control techniques.
- Trial name
- NCT03107754
- Testing
- Lidocaine, Lidocaine-Sodium Bicarbonate
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- University of Hawaii