Clinical trials: Head and Neck
Oral Cancer, Oral Squamous Cell Carcinoma
Salivary Expression of SOX7 in Oral Squamous Cell Carcinoma: Diagnostic Accuracy Study
The study will include patients with oral cancer and healthy controls of both sexes. Subjects having any systemic diseases or other types of cancer will be excluded.
- Trial name
- NCT06031337
- Testing
- ELISA
- Where
- Egypt
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Thyroid Cancer
Hereditary Risk Factors for Thyroid Cancer
Thyroid cancers can occur sporadically, but can also be found as tumors that cluster in families with other cancers or genetic syndromes.
- Trial name
- NCT02747888
- Testing
- •Referral to Genetic Counselor, if indicated
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Venous Malformation
Efficacy and Safety Analysis of Polylauric Alcohol More Stable Foam Versus Ordinary Foam in the Treatment of Head and Neck Venous Malformations
The aim of this study is to explore the efficacy and safety of poly -LRB-cinnamyl alcohol) foam in the treatment of venous malformations of head and neck through a prospective randomized clinical trial, this trial may provide…
- Trial name
- NCT07066527
- Testing
- The addition of sodium hyaluronate to poly (cinnamyl alcohol-RRB- produces a more stable foam
- Where
- China
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Qilu Hospital of Shandong University
Facial Neoplasms
A Comparison of Accuracy Between Different Facial Scanning Techniques
Conventional alginate impressions are still a burden to both the patient and the operator especially in extraoral maxillofacial rehabilitations cases.
- Trial name
- NCT07557212
- Testing
- portable scanning, stationery scanning, mobile app scanning
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Esophageal Neoplasms
Irreversible Electroporation(IRE) For Unresectable Esophageal Neoplasms
The purpose of this study is to evaluate the safety and efficacy of irreversible electroporation (IRE) for unresectable Esophageal Neoplasms.
- Trial name
- IRE (NCT02430701)
- Testing
- Irreversible electroporation (IRE), NanoKnife
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fuda Cancer Hospital, Guangzhou
Premalignant Lesion, Oral Cancer
Diagnostic Accuracy of Mobile Phone Imaging Compared to Conventional Clinical Examination for Oral Cancer Screening
The aim of study is to evaluate the sensitivity and specificity of using mobile phone photographs versus conventional clinical examination as a screening tool for early detection of oral cancer.
- Trial name
- NCT06060288
- Testing
- Diagnosis by mobile phone imaging
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Cairo University
Lung Cancer, Breast Cancer
Plasma Metabolic Biomarkers for Multi-Cancer Diagnosis
The aim of this observational study is to comprehensively analyze the metabolites in plasma samples from multi-cancer patients using advanced mass spectrometry detection technology, in conjunction with metabolomics approaches.
- Conditions
- Lung Cancer, Breast Cancer, Colorectal Cancer, Thyroid Cancer
- Trial name
- NCT06363123
- Where
- 4 sites in China
- Volunteers
- 2,700 people, healthy volunteers welcome
- Sponsor
- Beijing Friendship Hospital
Migraine, Tension Type Headache
Effectiveness of a Cognitive and Physical Intervention to Reduce Head and Muscle Pain in a Large Population
This study is an interventional trial to evaluate the effectiveness of a cognitive and physical program (Intervention), in reducing the frequency of head and neck pain in the population of an extensive territory of Italy.
- Conditions
- Migraine, Tension Type Headache, Cervical Pain
- Trial name
- NCT01050972
- Testing
- Behavioral: Cognitive, Relaxation, Exercise Therapy
- Where
- Italy
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Oral Cavity Carcinoma
Behavior Changing Intervention for Smokeless Tobacco and Betel Quid Use in Adolescents
Smokeless tobacco (SLT) is a known risk factor for Oral, Pharyngeal and Esophageal carcinoma. Three-quarters global SLT consumption is among the South Asian Population.
- Trial name
- NCT03488095
- Testing
- BCI for SLT and BQ Use in Adolescents: A CRT
- Where
- Pakistan
- Volunteers
- 2,200 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Concussion
Primary Prevention of Concussion in Youth Ice Hockey Players
1. Background and Rationale: Little is currently known about intrinsic risk factors for sport-related concussion in youth ice hockey players.
- Trial name
- NCT03360786
- Testing
- Specific intervention, Control intervention
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sport Injury Prevention Research Centre
Forward Head Posture
Effect of Interactive Virtual Reality Device on Cervical Proprioception and Range of Motion in Forward Head Posture
Forward head posture (FHP) is one of the most common postural deformities, which affects 66% of the patient population and this study will be designed to investigate the effect of interactive virtual reality device on cervical…
- Trial name
- NCT05579613
- Testing
- Interactive virtual reality device
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Oral Squamous Cell Carcinoma, Oral Epithelial Dysplasia
Comparison of Morphometric Assessment Using Methyl Green Pyronin and AgNOR Staining of Oral Squamous Cell Carcinoma
Oral cancer represents the sixth most common cancer worldwide whilst in Pakistan it ranks the second most common cancer in either gender.
- Trial name
- OSCC (NCT01987934)
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Academy of Interdisciplinary Dental Education and Research
Otorhinolaryngologic Disease, Otorhinolaryngologic Neoplasm
Ultrasound Evaluation of Tongue Movements in Speech and Swallowing
This study will assess the use of ultrasound-a test that uses sound waves to produce images-as a diagnostic tool for evaluating speech and swallowing.
- Conditions
- Otorhinolaryngologic Disease, Otorhinolaryngologic Neoplasm, Pharyngeal Neoplasm, Polymyositis
- Trial name
- NCT00001167
- Where
- United States
- Volunteers
- 570 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Head and Neck Cancer
Continuous Local-anesthetic Wound Infusion for Neck Dissection
The goal of this study is to assess the efficacy of continuous local anesthetic wound infusion to improve quality of recovery following ablative surgery and neck dissection.
- Trial name
- CLAWED (NCT06201039)
- Testing
- 0.5% Lidocaine Hydrochloride, 0.9% Normal Saline
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Oral Cavity Squamous Cell Carcinoma, Saliva Altered
Salivary Ap4A, SCCA, TROP2 in Oral Cancer Patients
According to the World Health Organization, oral cancer (OC) is the eighth most common cancer in the world with a five year survival rate of 50%.
- Conditions
- Oral Cavity Squamous Cell Carcinoma, Saliva Altered, Precancerous Lesions
- Trial name
- OCSALTM (NCT03529604)
- Testing
- Saliva sampling, ELISA, HPLC
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Zagreb
Breast Carcinoma, Caregiver
Provider Training in Increasing Patient Tobacco Cessation Counseling and Referrals for Patients With Cancer Undergoing Radiation Therapy
This pilot clinical trial studies how well provider training works in increasing patient tobacco cessation counseling and referrals for patients with cancer undergoing radiation therapy.
- Conditions
- Breast Carcinoma, Caregiver, Head and Neck Carcinoma, Lung Carcinoma
- Trial name
- NCT03135782
- Testing
- Communication Skills Training, Medical Chart Review, Questionnaire Administration
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- OHSU Knight Cancer Institute
Achalasia Cardia, Esophageal Cancer (EsC)
INCIDENCE, PREVALENCE AND OVERALL RISK OF ESOPHAGEAL CANCER IN ACHALASIA: A PROPENSITY-MATCHED POPULATION-BASED STUDY FROM A LARGE MULTICENTER DATABASE
Esophageal Achalasia has been investigated as a potential risk factor for esophageal cancer (EC). Longstanding disease, repeated treatment, age and male sex seem the most relevant risk factors, but no clear effect size estimation…
- Trial name
- RECAP (NCT07022886)
- Testing
- achalasia treatments
- Where
- Italy
- Volunteers
- 47,000 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Papillary Thyroid Cancer
The Role of Central Neck Dissection in Stage N0 Papillary Thyroid Carcinoma
The benefits of prophylactic central neck dissection (pCND) remain controversial in clinically node-negative (cN0) papillary thyroid carcinoma (PTC).
- Trial name
- pCND (NCT04076514)
- Testing
- central neck dissection
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Assiut University
Sport-related Concussion
Effect of Neck Training on Outcomes Related to Sport-Related Concussion
Sport-related concussion (SRC) is a significant concern in soccer. This pilot quasi-experimental trial aims to investigate the efficacy and acceptability of an evidence-based neck resistance exercise program in female soccer…
- Trial name
- NCT06774976
- Testing
- 8-week Evidence-Based Neck Resistance Training Program
- Where
- Sweden
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Lund University
Potentially Malignant Lesions, Oral Lichen Planus
Diagnostic Accuracy of lncRNA DQ786243 and miRNA146a in Saliva of Oral Potentially Malignant Lesions
The aim of this study is to evaluate salivary expression of lncRNA DQ786243 as a potential marker for diagnosis of oral potentially malignant lesions compared to normal controls and its effect on salivary expression of miRNA146a.
- Conditions
- Potentially Malignant Lesions, Oral Lichen Planus, Leukoplakia, Oral
- Trial name
- NCT05730855
- Testing
- Real-time Polymerase Chain Reaction technique
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Fayoum University