Clinical trials: Internal Medicine
Diffuse Intrinsic Pontine Glioma
Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication
Diffuse Intrinsic Pontine Gliomas (DIPG) appear almost exclusively in children and adolescents, representing 15 to 20% of posterior fossa tumours.
- Trial name
- BIOMEDE (NCT02233049)
- Testing
- Erlotinib, Everolimus, Dasatinib
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Fatigue, Sleep Deprivation
Effect and Utilization of Protected Time Among Interns on Extended Duty-Hour Call Shifts
This study will test the feasibility and effectiveness of protected time for physicians in training during 30 hour shifts in a medical intensive care unit. The primary outcome will be fatigue.
- Conditions
- Fatigue, Sleep Deprivation, Depression
- Trial name
- NCT00983008
- Testing
- Protected time and Dedicated time
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Providence Health & Services
Idiopathic Thrombocytopenic Purpura
Study of a New Medication for Childhood Chronic Immune Thrombocytopenia (ITP), a Blood Disorder of Low Platelet Counts That Can Lead to Bruising Easily, Bleeding Gums, and/or Bleeding Inside the Body.
The purpose of this study is to investigate the efficacy, safety and tolerability of eltrombopag in children with previously treated chronic immune thrombocytopenia who are between 1 and 17 years of age. This is a 2 part study.
- Trial name
- PETIT2 (NCT01520909)
- Testing
- Eltrombopag
- Where
- 51 sites in United States, Argentina and 11 more
- Volunteers
- 92 people
- Sponsor
- GlaxoSmithKline
Disease, Delivery of Healthcare
Interprofessional Collaborative Communication in Acute Care Hospital Teams
Collaborative practice may improve patient outcomes in specific disease conditions and health care settings. The SCRIPT Programme is an intervention to implement informal, but structured, communication etiquette between members…
- Trial name
- SCRIPT (NCT00466297)
- Testing
- Face-to-face communication interactions
- Where
- 2 sites in Canada
- Volunteers
- 1,000 people
- Sponsor
- Sunnybrook Health Sciences Centre
Allergic Rhinitis, Sleep Disorder
Establishing the Collaborative Care Model for Pediatric Allergic Rhinitis With Sleep Disorder
The purpose of study is to compared the impact of the integrative care clinic to ordinary western medicine among patients of moderate persistent allergic rhinitis combined with sleep disorder and establishing the collaborative…
- Trial name
- NCT05031793
- Testing
- TCM, Western medicine
- Where
- Taiwan
- Volunteers
- 35 people
- Sponsor
- China Medical University Hospital
Acute Bronchiolitis, Viral Bronchiolitis
Internal Jugular Vein Respiratory Variability as a Marker of Disease Severity in Infant Bronchiolitis
This prospective observational cohort study evaluates whether respiratory-cycle variation in internal jugular vein (IJV) diameter, measured by point-of-care ultrasound, correlates with clinical disease severity in infants 1-23…
- Conditions
- Acute Bronchiolitis, Viral Bronchiolitis, Respiratory Syncytial Virus Infections
- Trial name
- IJV-BRONCH (NCT07778225)
- Testing
- Point-of-Care Ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Eskisehir Osmangazi University
Recurrent Tonsillitis, Obstructive Sleep Apnea
Post-operative Pain Control After Pediatric Adenotonsillectomy
Adenotonsillectomy is one of the most common surgical procedures performed in the pediatric population in the United States. It is generally a well-tolerated procedure with post-operative bleeding risk ranging from 3-5% in…
- Conditions
- Recurrent Tonsillitis, Obstructive Sleep Apnea, Sleep Disordered Breathing, Adverse Reaction to Drug
- Trial name
- NCT02296840
- Testing
- Ibuprofen, Hydrocodone-Acetaminophen
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Emory University
Sleep Initiation and Maintenance Disorders
Lendormin D® Tablet (Drug Use Result Survey)
Study to investigate the safety and the efficacy in patients with insomnia, receiving Lendormin D tablet under condition of normal clinical practice.
- Trial name
- NCT02224014
- Testing
- Lendormin D tablets
- Volunteers
- 485 people
- Sponsor
- Boehringer Ingelheim
Substance Use, Stress
Automating Peer Learning to Reduce Alcohol Use and Related Deviant Behavior in Secondary School
Deviant peer affiliation is one of the most important predictors of alcohol use in adolescence. These affiliations arise when socially marginalized youth self-aggregate and reinforce alcohol use and other deviant activity (i.e.…
- Conditions
- Substance Use, Stress, Relation, Interpersonal, Bullying
- Trial name
- PeerLearning (NCT04478240)
- Testing
- PeerLearning.net
- Where
- United States
- Volunteers
- 924 people, healthy volunteers welcome
- Sponsor
- Oregon Research Behavioral Intervention Strategies, Inc.
Depression, Anxiety
Online Mental Health Interventions for Children and Adolescents (OMHICA)
Mental health has become an increasing concern, especially among children and adolescents in schools. However, not all individuals in mental suboptimal states require pharmacological treatment.
- Conditions
- Depression, Anxiety, Stress, Insomnia
- Trial name
- NCT06238869
- Testing
- Computerized Cognitive Behavioral Therapy, Music Therapy, Health education
- Where
- China
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- Jiangsu Province Nanjing Brain Hospital
Neuroblastoma, Diffuse Intrinsic Pontine Glioma
PEACH TRIAL- Precision Medicine and Adoptive Cellular Therapy
A Phase I open-label, multicenter study, to evaluate the safety, feasibility, and maximum tolerated dose (MTD) of treating children with newly diagnosed DIPG or recurrent neuroblastoma with molecular targeted therapy in…
- Trial name
- PEACH (NCT04837547)
- Testing
- Tumor-specific ex vivo expanded autologous lymphocyte transfer (TTRNA-xALT)
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- University of Florida
Obstructive Sleep Apnea
Dexmedetomidine Versus Propofol Sedation for Drug-Induced Sleep Endoscopy in Pediatric Obstructive Sleep Apnea
This research study is designed to learn, first, whether two anesthetics have different effects on collapse seen within the upper airway during sleep endoscopy.
- Trial name
- NCT05303987
- Testing
- Propofol sedation, Dexmedetomidine sedation
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Erin Kirkham
Narcolepsy, Idiopathic Hypersomnia
Anesthetic Management of Patients With Chronic Sleep Disorders
The aim of this study is to describe and compare the anaesthesia history and possible problems encountered in 3 groups of patients with 3 chronic sleep diseases: narcolepsy, idiopathic hypersomnia, and restless legs syndrome…
- Conditions
- Narcolepsy, Idiopathic Hypersomnia, Restless Legs Syndrome
- Trial name
- ANEST-SLEEP (NCT04827329)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 700 people
- Sponsor
- University Hospital, Montpellier
Malignant Glioma
A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)
This phase I/II trial tests the safety, side effects, and best dose of selinexor given in combination with standard radiation therapy in treating children and young adults with newly diagnosed diffuse intrinsic pontine glioma…
- Trial name
- NCT05099003
- Testing
- Biopsy Procedure, Magnetic Resonance Imaging, Radiation Therapy
- Where
- 129 sites in United States, Australia and 2 more
- Volunteers
- 132 people
- Sponsor
- National Cancer Institute (NCI)
Sleep Apnea
Hepatic Drug Biotransformation in Children With Obstructive Sleep Apnea
The purpose of this research study is to determine the effect of chronic nighttime low oxygen saturations on selected body systems (liver) that break down drugs in children with obstructive sleep apnea syndrome (OSAS).
- Trial name
- NCT00310323
- Testing
- Dextromethorphan, Caffeine
- Where
- 2 sites in United States
- Volunteers
- 69 people
- Sponsor
- Virginia Commonwealth University
Insomnia
Pharmacokinetic and Safety of Ramelteon Between Adolescents With Insomnia and Healthy Adults
The purpose of this study is to determine the pharmacokinetic profile, safety, and tolerability of ramelteon in adolescents with insomnia, children with Attention Deficit Hyperactivity Disorder (ADHD) associated with insomnia and…
- Trial name
- NCT00914862
- Testing
- Ramelteon
- Where
- 2 sites in United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Takeda
Anesthesia, General Anesthesia
Efficacy of Opioid-free Anesthesia in Reducing Postoperative Respiratory Depression in Children Undergoing Tonsillectomy
The objective of this trial is to determine whether an opioid-free general anesthetic (OFA) technique utilizing ketamine, dexmedetomidine, lidocaine, and gabapentin can help reduce postoperative respiratory depression in the…
- Conditions
- Anesthesia, General Anesthesia, Analgesics, Opioid, Postoperative Complications
- Trial name
- NCT02987985
- Testing
- Acetaminophen, gabapentin, Acetaminophen, Ketamine , Lidocaine , Dexmedetomidine
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Saskatchewan
Insomnia
Ramelteon 8 mg Tablets Specified Drug-use Survey: <Long-term Survey on Insomnia Accompanied by Difficulty Falling Asleep> - Transitional Survey From the Preceding Drug-use Survey -
The purpose of this survey is to examine the safety and efficacy of long-term use of ramelteon tablets (Rozerem 8 mg Tablets) in participants with difficulty falling asleep associated with insomnia in daily medical practice.
- Trial name
- NCT02153086
- Testing
- Ramelteon
- Where
- 2 sites in Japan
- Volunteers
- 236 people
- Sponsor
- Takeda
Restless Legs Syndrome
Specified Drug Use-Results Survey of Regnite
This study is to investigate the long-term safety and efficacy and the information on the proper use of Regnite® under conditions of daily clinical use.
- Trial name
- NCT01887613
- Testing
- Regnite
- Where
- 7 sites in Japan
- Volunteers
- 1,597 people
- Sponsor
- Astellas Pharma Inc