Clinical trials: Low-level Light Therapy
Molar-Incisor Hypomineralization (MIH)
Nano Silver Fluoride and Photobiomodulation Therapy for Hypersensitivity and Pain in MIH-Affected Molars
Molar-incisor hypomineralization (MIH) is a developmental condition affecting primarily the first permanent molars and may be associated with post-eruptive enamel breakdown, hypersensitivity, and difficulties in achieving…
- Trial name
- NCT07826130
- Testing
- Nano Silver Fluoride, Photobiomodulation Therapy, Pre-appointment analgesics
- Volunteers
- 45 people
- Sponsor
- Ain Shams University
Myopia, Amblyopia
Myopia Control With Three Lever Irradiance of PBM Therapy in Children and Adults
Photobiomodulation therapy, that is, Low-level red-light technology provides a new and innovative myopia control approach. This strategy enables relatively high energies of light to be delivered at much shorter durations of…
- Conditions
- Myopia, Amblyopia, Refractive Error - Myopia Axial, Ametropia
- Trial name
- MCPT (NCT05957458)
- Testing
- Airdoc device of red light for Myopia
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Beijing Airdoc Technology Co., Ltd.
Myopia
Repeatability of AO-SLO (Mona IIa) Technology and Cone Cell Density of Individuals Use Repeated Low-level Red-light Therapy
To explore the repeatability of AO-SLO (Mona IIa) technology and the difference of cone cell density between individuals who used or not used repeated low-intensity red light treatment
- Trial name
- AO-SLO (NCT07160036)
- Testing
- RLRL(Model RS-200-2A, Eyerising; Suzhou Xuanjia Optoelectronic Technology Co., Ltd., Suzhou, China))
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Ruihua Wei
Childhood-onset Systemic Lupus Erythematosus, Lupus Nephritis (LN)
Childhood-onset Lupus Nephritis Initial Glucocorticoid-dose Harmonization Trial (LIGHT Trial)
Childhood-onset systemic lupus erythematosus (cSLE) is a severe chronic autoimmune disease with a high burden of major-organ involvement.
- Trial name
- LIGHT (NCT07719140)
- Testing
- High-dose prednisone, Low-dose prednisone
- Where
- 8 sites in China
- Volunteers
- 198 people
- Sponsor
- Peking Union Medical College Hospital
Graft-Versus-Host Disease, GVHD
A Study of Photobiomodulation (PBM) Therapy in People With Oral Graft-Versus-Host Disease (GVHD) After Stem Cell Transplant
The purpose of this study is to find out whether photobiomodulation/PBM therapy using the Thor LX2.3 therapy system is a safe and effective treatment for oral Graft-Versus-Host Disease/GVHD.
- Conditions
- Graft-Versus-Host Disease, GVHD, Undefined
- Trial name
- NCT05675930
- Testing
- Photobiomodulation Therapy
- Where
- 9 sites in United States
- Volunteers
- 44 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Myopia, Myopia Progressing
BRIGHT-LIGHT: Studying Red Light Therapy for Severe Short-Sightedness or Short-Sightedness That Worsens Despite Standard Treatment
Some children's short-sightedness (myopia) continues to worsen despite treatments such as atropine eye drops, myopia-control spectacles or contact lenses.
- Conditions
- Myopia, Myopia Progressing, Myopia Progression, Light
- Trial name
- BRIGHT LIGHT (NCT07923019)
- Testing
- Repeated low-level red-light (RLRL) therapy, Continued existing myopia treatment strategy
- Where
- 2 sites in Singapore
- Volunteers
- 40 people
- Sponsor
- Singapore National Eye Centre
Myopia, Astigmatism
The EYERISING Study
The purpose of this clinical trial is to see if and how well Repeated Low-Level Red Light (RLRL) therapy works to control myopia over 12 months.
- Conditions
- Myopia, Astigmatism, Anisometropia
- Trial name
- NCT07909720
- Testing
- Repeated Low-Level Red Light (RLRL) therapy
- Where
- 2 sites in United States, Nepal
- Volunteers
- 333 people
- Sponsor
- University of Wisconsin, Madison
Intraventricular Hemorrhage of Prematurity, Hydrocephalus
Light Therapy Device for Neonatal Intraventricular Hemorrhage Grade 3 and 4
The primary purpose of this study is to serve as a pilot study of the EFIL device treatment feasibility of IVH grades 3,4 to guide development of a larger trial.
- Trial name
- EFIL (NCT06797219)
- Testing
- Low Level Laser Therapy for Intraventricular Hemorrhage of Prematurity
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Rutgers, The State University of New Jersey
Gastrostomy Complications
LASER THERAPY IN GASTRIC STOMA INJURIES OF CHILDREN AND ADOLESCENTS
Compare the healing time of lesions in the mucosa of the gastric stoma of children and adolescents using laser therapy versus conventional treatment with protective barrier powder.
- Trial name
- NCT04863196
- Testing
- Laser therapy Treatment Group, Barrier Dust Treatment Group
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- University of Sao Paulo General Hospital
Red Laser Light-Induced Retinopathy of Both Eyes (Diagnosis)
Fundus Effects of Repeated Low-Level Red-Light Therapy in Chinese Myopic Minors: A Randomized Controlled Clinical Trial
1. Research Objective: The primary objective is to investigate the short-term effects of repetitive low-intensity red light therapy on the fundus of the eyes of underage individuals with myopia. 2.
- Trial name
- NCT06034912
- Testing
- Low-Intensity Red Light Therapy
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Metatarsal Stress Fracture, Stress Fracture of Tibia
Photobiomodulation Therapy for the Treatment of Lower Extremity Stress Fractures in a Military Training Setting
The goal of this clinical trial is to compare photobiomodulation therapy (PBMT) in addition to standard of care in the treatment of tibial and metatarsal bone stress injuries in a military training setting.
- Trial name
- PM12 (NCT05843864)
- Testing
- Photobiomodulation Therapy with Standard Physical Therapy
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- Brooke Army Medical Center
Photobiomodulation Therapy
Reversal of Anaesthesia with Diode Laser
Background: After local anesthesia, which is frequently used in pediatric dentistry, long-term soft tissue numbness can cause various problems.
- Trial name
- NCT06841120
- Testing
- Actual laser application
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University
Menopause, Urinary Incontinence
Evaluation of the Safety and Performance of the MILTA GYNECO Vaginal Probe in Postmenopausal Women With Vaginal Atrophy
Vulvovaginal atrophy is common after menopause, with a significant negative effect on quality of life. Large cohort studies have reported the prevalence of vaginal dryness to be between 27% and 55% and dyspareunia between 32% and…
- Conditions
- Menopause, Urinary Incontinence, Atrophic Vaginitis
- Trial name
- SIVAM (NCT05058313)
- Testing
- Photobiomodulation
- Where
- 3 sites in France
- Volunteers
- 25 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Myopia, Refractive Errors
Efficacy of Repeated Low-Level Red-Light Therapy in Myopia Control
The purpose of this study is to determine if repeated low-level red-light therapy can slow myopia progression in Chinese schoolchildren.
- Conditions
- Myopia, Refractive Errors, Eye Diseases
- Trial name
- NCT04073238
- Testing
- Low-level Red-light Therapy
- Where
- 4 sites in China
- Volunteers
- 264 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Malnutrition, Child
Use of Low-level Laser Therapy on Children Aged One to Five Years With Energy-protein Malnutrition
Malnutrition is a clinical-social disease caused by multiple prenatal, intrauterine and postnatal factors as well as social, political and cultural determinants (distal causes).
- Trial name
- NCT03355313
- Testing
- Low level Light therapy
- Where
- 2 sites in Brazil
- Volunteers
- 50 people
- Sponsor
- University of Nove de Julho
Autism, Attention Deficit Hyperactivity Disorder
Transcranial Photobiomodulation Therapy for the Treatment of Autistic Traits in Children and Adolescents With ADHD
An open label trial to assess the safety and efficacy of transcranial photobiomodulation (tPBM) in improving autistic traits in ADHD youth.
- Trial name
- NCT04569058
- Testing
- Transcranial Photobiomodulation
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Massachusetts General Hospital
Oropharyngeal Mucositis, Myeloablative Hematopoietic Cell Transplantation
Feasibility Study of Low Level Light Therapy for Prevention of Oropharyngeal Mucositis in Pediatric Transplants Patients
Oral mucositis (OM) is a painful and potentially debilitating acute toxicity that frequently affects children undergoing hematopoietic cell transplantation (HCT).
- Conditions
- Oropharyngeal Mucositis, Myeloablative Hematopoietic Cell Transplantation, Low Level Light Therapy
- Trial name
- NCT02119897
- Testing
- Low Level Light Therapy
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- Dana-Farber Cancer Institute
Progressive Myopia, Pediatric Myopia
Efficacy of Different Interventions for Progressive Myopia After Orthokeratology Lens Wear
Myopia has emerged as a significant concern impacting the visual health of children and adolescents on a global scale. According to research conducted by Holden BA et al., it is projected that by the year 2050, the worldwide…
- Conditions
- Progressive Myopia, Pediatric Myopia, Orthokeratology-related Myopia Progression
- Trial name
- NCT07494799
- Testing
- OK Lens Continuation Group, OK Lens + 0.01% Atropine Group, OK Lens with Reduced Optical Zone Group
- Volunteers
- 3,890 people
- Sponsor
- Tianjin Medical University Eye Hospital
Autistic Disorder
An Evaluation of Low Level Laser Light Therapy for Autistic Disorder 2
The purpose of this study is to determine whether the Erchonia HLS Laser is effective in the treatment of irritability associated with autistic disorder in children and adolescents aged five (5) to twelve (12) years.
- Trial name
- NCT04895605
- Testing
- Erchonia HLS Laser
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Erchonia Corporation
Myopia, Progressive, Refractive Errors
Repeated Low-Level Red-Light Therapy and Orthokeratology in Fast-progressing Myopia Control
The purpose of this multicenter randomized clinical trial is to evaluate the adjunctive effect of repeated low-level red-light therapy (RLRL) and orthokeratology (ortho-k) on myopia control in ortho-k non-responders who have…
- Conditions
- Myopia, Progressive, Refractive Errors, Eye Diseases
- Trial name
- NCT04722874
- Testing
- Ortho-k lenses, RLRL
- Where
- 3 sites in China
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University