Clinical trials: Modification
Obesity, Obesity, Childhood
A Novel Obesity Prevention Program for High-Risk Infants in Primary Care
The goal of this clinical trial is to test a responsive parenting obesity prevention program with infants and caregivers of color (e.g., non-White; Hispanic/Latinx) and/or who are economically marginalized (i.e., publicly…
- Conditions
- Obesity, Obesity, Childhood, Weight Gain, Weight Gain Trajectory
- Trial name
- THRIVE (NCT06028113)
- Testing
- THRIVE 2.0
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Obesity and Overweight, Obese Adolescents
Mitigation of Cardiovascular Disease Risks in Children With Extreme Obesity
The goal of this clinical trial is to learn if the drug semaglutide changes markers of disease risk as it relates to weight in children ages 12-15 years old who are obese (class 2 or 3).
- Conditions
- Obesity and Overweight, Obese Adolescents, Weight Management, Weight Loss
- Trial name
- MODERN (NCT06967389)
- Testing
- Ozempic®
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- John Bauer
Oral Cavity Carcinoma
Behavior Changing Intervention for Smokeless Tobacco and Betel Quid Use in Adolescents
Smokeless tobacco (SLT) is a known risk factor for Oral, Pharyngeal and Esophageal carcinoma. Three-quarters global SLT consumption is among the South Asian Population.
- Trial name
- NCT03488095
- Testing
- BCI for SLT and BQ Use in Adolescents: A CRT
- Where
- Pakistan
- Volunteers
- 2,200 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Cardiac Rhythm Disorder
3T MRI CIED Post-Approval Study
The purpose of this study is to evaluate product performance of Magnetic Resonance (MR) Conditional Cardiac Implantable Electronic Devices (CIED) following 3 tesla (3T) MRI exposure.
- Trial name
- NCT02969395
- Where
- 204 sites in United States, Belgium and 20 more
- Volunteers
- 41 people
- Sponsor
- Medtronic
Diabetes Mellitus, Type 2
Online Program Assisting Lifestyle Changes (Asterix 1.0 & Obelix 2.0)
The purpose of this study is to help Internet users to adopt and maintain a healthy lifestyle, it is imperative to increase self-management competencies to improve healthy eating and regular physical activity.
- Trial name
- OPAL (NCT00986375)
- Testing
- Intervention Group (IG), Active Control Group (ACG)
- Where
- Germany
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Freie Universität Berlin
Depression, Bipolar I Disorder
A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.
Bipolar disorder is a severe chronic mood disorder that affects up to 4% of the adult population and 1.8% of the pediatric population in the United States.
- Trial name
- 3112 Ped BPD (NCT04777357)
- Testing
- Cariprazine
- Where
- 81 sites in United States, Puerto Rico and 1 more
- Volunteers
- 380 people
- Sponsor
- AbbVie
Acute Leukemia
Clinical Study of DC Plus CIK for Patients With Relapse Acute Leukemia After Allo-HSCT
Allogeneic hematopoietic cell transplantation(Allo-HSCT) is currently an effective treatment for Acute leukemia (AL). Relapse after transplantation, being a main obstacle for patient survival, is so far treated by second…
- Trial name
- NCT01956630
- Testing
- Genetically modified DCs plus CIK cells, Donor leukocyte infusions (DLI)
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Fever of Unknown Origin
Causes of FUO in Infants and Children
Definition: fever < 38˚c for which the cause could not be identified, documented by a health care provider after 3w.evaluation as an outpatient [or after 1w. evaluation in the hospital].
- Trial name
- NCT04073108
- Testing
- tuberculin test
- Volunteers
- 50 people
- Sponsor
- Assiut University
Neoplasms, Head and Neck
Change in Symptom Clusters in HNC Patients
Head and neck cancer (HNC) is the sixth most common malignancy worldwide, causing more than 379,000 deaths in 2015 notwithstanding the breakthrough in cancer screening and medical treatment.
- Trial name
- NCT03356093
- Testing
- complete questionnaire
- Volunteers
- 100 people
- Sponsor
- Taipei Medical University
NSTEMI - Non-ST Segment Elevation MI
TIII Over TI in Subjects With Myocardial Infarction
Study was performed to identify ECG criteria for unmasking of subjects with NSTEMI at elevated risk.
- Trial name
- T-infarction (NCT03057093)
- Testing
- Non interventional study
- Volunteers
- 903 people
- Sponsor
- University of Cologne
Birth Outcomes, Stunting
Uganda Birth Cohort Study
The UBC was a USAID-funded longitudinal prospective cohort study of pregnant women (n= 5030) aged 15-49 years from rural North and South-Western regions of Uganda, conducted between 2014 and 2016.
- Conditions
- Birth Outcomes, Stunting, Wasting, Anemia
- Trial name
- UBC (NCT04233944)
- Where
- United States
- Volunteers
- 5,044 people
- Sponsor
- Tufts University
Substance Use Disorders
Effect of Mindfulness-Based Relapse Prevention Program on Readiness for Change and Self-efficacy Among Clients With Substance Use Disorders
The treatment process of substance addiction is applied principally by psychiatrists, psychologists, and psychiatric mental health nurses. In this respect, psychiatric mental health nurses have a crucial role to play.
- Trial name
- NCT05990699
- Testing
- Mindfulness-Based Relapse Prevention program
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Alexandria University
Pancreatic Neoplasms, Cachexia
Strength Training on Pancreatic Cancer
The purpose of this study is to determine whether prednisone, methotrexate, and cyclophosphamide are effective in the treatment of rapidly progressive hearing loss in both ears due to autoimmune inner ear disease (AIED).
- Conditions
- Pancreatic Neoplasms, Cachexia, Myopathy
- Trial name
- STOPC (NCT01395563)
- Testing
- strength training
- Where
- 3 sites in Germany
- Sponsor
- German Cancer Research Center
Diarrhea
Effects of Probiotic in Treatment of Persistent Diarrhea in Children
Persistent diarrhea is a common health problem worldwide, particularly in low-income countries. Approximately 3% to 20% of acute diarrhea episodes in children under 5 years of age become persistent diarrhea.
- Trial name
- NCT05812820
- Testing
- LiveSpo DIA30, LiveSpo CLAUSY, RO
- Where
- Vietnam
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- National Children's Hospital, Vietnam
Physical Inactivity, Environmental Exposure
Reconstructing Schoolyards With Greenery to Increase Schoolchildren's Physical Activity and Mitigate Climate Changes
By reconstructing schoolyards with greenery, physical activity levels among children can be increased at the population level and also mitigate health and environmental risks resulting from rising climate changes in urban areas.
- Conditions
- Physical Inactivity, Environmental Exposure, Mental Health Wellness 1
- Trial name
- NCT05865782
- Testing
- Schoolyard reconstruction
- Where
- Sweden
- Volunteers
- 3,600 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Epilepsy
Dietary Therapy in Children With Refractory Epilepsy
In children aged 1yr -18 years with refractory epilepsy Modified Atkins diet as add on to ongoing AED therapy would not be inferior compared to ketogenic diet ** in terms of seizure reduction from baseline seizure frequency at 6…
- Trial name
- NCT01983163
- Testing
- Ketogenic diet (2.5 to 4:1), Modified Atkin's diet
- Where
- India
- Volunteers
- 30 people
- Sponsor
- All India Institute of Medical Sciences
Acute Upper Respiratory Infection, Fever
Phase 3 Study of Pelubiprofen & Loxoprofen in Patients With Upper Respiratory Tract Infection
Multi-center, Randomized, Double blind, Controlled Parallel-group Comparative Phase 3 Clinical trial to assess the efficacy and safety of Pelubiprofen Compared to Loxoprofen in patients with Acute upper respiratory infection.
- Trial name
- NCT01779271
- Testing
- Pelubiprofen, Loxoprofen
- Where
- South Korea
- Volunteers
- 183 people
- Sponsor
- Daewon Pharmaceutical Co., Ltd.
White Spot Lesions
Effect of Nanohydroxyapatite Paste After Different Pretreatment Techniques on White Spot White Spot Lesions
forty teeth diagnosed with white spot lesions in children aged between 10-14 years old were selected to compare between the effect of using nanohydroxyapatite paste applicatio either alone or preceded by the application of HCl…
- Trial name
- NCT06834464
- Testing
- Nanohydroxyapatite paste, HCl liquid, microabrasion
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Research Centre, Egypt
Fever
The Impact of C-reactive Protein Testing
PRIMARY OBJECTIVE To assess the impact of C-reactive protein (CRP) Point-of-care (POC) testing on health care worker prescribing behaviour in patients presenting to primary healthcare centres with an acute fever or recent history…
- Trial name
- NCT02758821
- Testing
- No CRP will be measured onsite, CRP cut-off of 20mg/L., CRP cut-off of 40mg/L.
- Where
- Thailand
- Volunteers
- 2,410 people
- Sponsor
- University of Oxford
Diabetic Macular Edema
Change Oxygen Consumption Following Intravitreal Treatment of Lucentis (Ranibizumab) in Eyes With Diabetic Macular Edema
Recent reports suggest that anti-VEGF agents (ranibizumab) may suppress the progression of retinal nonperfusion area. This protective effect would cause the increase of the oxygen consumption in the diabetic retina.
- Trial name
- NCT02329132
- Testing
- Ranibizumab
- Where
- Japan
- Volunteers
- 30 people
- Sponsor
- Kagawa University
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