Clinical trials: Multimorbidity
Diet, Food, and Nutrition, Exercise
The NutriNet-Santé Study
The NutriNet-Santé study was set up to investigate nutrition and health relationships. Specifically, it was the first web-based cohort worldwide on such a large scale (n=171 000 as of 2021) focused on the complex link between…
- Conditions
- Diet, Food, and Nutrition, Exercise, Diseases Category, Cohort Studies
- Trial name
- NCT03335644
- Where
- France
- Volunteers
- 170,000 people, healthy volunteers welcome
- Sponsor
- University of Paris 13
Maternal Cardiometabolic Health, Infertility
St Mary's Assisted Reproductive Technology and Cardiometabolic Health: Modifiable Targets for Multimorbidity Prevention (START-HEALThY)
The main causes of death in women are conditions affecting the heart and blood vessels (cardiovascular disease, CVD). Women who have difficulties getting pregnant (infertility) may be at increased risk, but the reasons for this…
- Conditions
- Maternal Cardiometabolic Health, Infertility, Assisted Reproductive Technology, Cardiovascular Health
- Trial name
- START-HEALThY (NCT07173569)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Multimorbidity
Discharge Information and Support for Patients Receiving Outpatient Care in the Emergency Department
The Veterans' Health Administration (VHA) is committed to improving primary care through the implementation of Patient Aligned Care Teams (PACTs).
- Trial name
- DISPO ED (NCT01717976)
- Testing
- DISPO ED
- Where
- United States
- Volunteers
- 513 people
- Sponsor
- VA Office of Research and Development
Polycystic Ovary Syndrome, Weight Gain
Empagliflozin vs Metformin on Metabolic Dysfunction in Polycystic Ovary Syndrome With or Without Comorbidity or Multimorbidity
this is open labelled randomize control trial among women with PCOS. PCOS, an endocrine condition, affects 5%-15% of premenopausal women.
- Conditions
- Polycystic Ovary Syndrome, Weight Gain, HbA1c
- Trial name
- NCT06140108
- Testing
- Empagliflozin 10 MG, MetFORMIN 500 Mg Oral Tablet
- Where
- Pakistan
- Volunteers
- 70 people
- Sponsor
- SINA Health Education and Welfare Trust
Chronic Disease, Integrated Care
Implementation of Community-based Collaborative Management of Complex Chronic Patients
Background/Aims: Large scale adoption of integrated care for chronic patients constitutes a key milestone to accelerate adaptation of current healthcare systems to the evolving needs triggered by population ageing and high…
- Conditions
- Chronic Disease, Integrated Care, Telemedicine
- Trial name
- Nextcare_CCP (NCT02956395)
- Testing
- Integrated care intervention
- Where
- Spain
- Volunteers
- 3,000 people
- Sponsor
- Hospital Clinic of Barcelona
Twins, Metabolic Syndrome
Metabolic Syndrome Among Polish Twins
Over a 5-year follow-up period, we aim to conduct a study among twins aged 15-44 years from the Polish population with the following objectives: 1.
- Trial name
- TWINSPL (NCT07181018)
- Testing
- Trial within cohort (TWIC)
- Where
- Poland
- Volunteers
- 1,500 people
- Sponsor
- Poznan University of Medical Sciences
Frailty, Cardiovascular Diseases
MultiMorbidity Life-Course Approach To Myocardial Health -A Cardiac Sub-Study of the MRC National Survey of Health and Development (NSHD)
Background The life course accumulation of overt and subclinical myocardial dysfunction contributes to older age mortality, frailty, disability and loss of independence.
- Trial name
- MyoFit46 (NCT05455125)
- Testing
- CMR CGI
- Where
- United Kingdom
- Volunteers
- 550 people
- Sponsor
- University College, London
Youth with Multimorbidity or Rare Dieases
Evaluation of the TAC Program
This is a mixed-methods evaluative study examining the effectiveness of the Transition to Adult Care Program at the Hospital for Sick Children (TAC) Program on high-risk youth with medical and psychosocial complexity…
- Trial name
- NCT06583525
- Testing
- Intensive Transition Support
- Where
- Canada
- Volunteers
- 126 people
- Sponsor
- The Hospital for Sick Children
Self-management
Self-management Education in Multi-professional Health Centres
The goal of this observational study is to learn about the best educative and organizational dimensions favouring the development of self-management education in multiprofessional health centres.
- Trial name
- ETHOPEE (NCT05950451)
- Testing
- No intervention
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Rennes University Hospital
Sleep Disordered Breathing (SDB), Sleep Apnea
Sleep Disordered Breathing and Multimorbidity: The Xiangya SDB Cohort Study
Sleep disordered breathing (SDB) is one of the most common sleep disorders, including obstructive sleep apnea (OSA), central sleep apnea (CSA), sleep-related hypoventilation, hypoxemia, etc., with OSA being the most prevalent.
- Conditions
- Sleep Disordered Breathing (SDB), Sleep Apnea, Cardiometabolic Diseases, Multimorbidity
- Trial name
- NCT06755840
- Where
- China
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Xiangya Hospital of Central South University
Diabetes Mellitus, Chronic Kidney Diseases
Integrated, Multidisciplinary, Person-centered Care for Patients With Complex Comorbidities: Heart, Kidney and Diabetes
Patient with complex comorbidities present a growing challenge for health-care providers, that the current system is poorly designed to handle.
- Conditions
- Diabetes Mellitus, Chronic Kidney Diseases, Cardiovascular Diseases, Chronic Disease
- Trial name
- CareHND (NCT03362983)
- Testing
- CareHND
- Where
- Sweden
- Volunteers
- 131 people
- Sponsor
- Danderyd Hospital
Polypharmacy Because of Multimorbidity in Geriatric Nursing Home Residents
Discontinuing Inappropriate Medication in Nursing Home Residents
Nursing home residents are among the frailest patient groups with a high number of co-morbidities and a high use of medicines. Inappropriate polypharmacy (i.e.
- Trial name
- NCT01876095
- Testing
- Multidisciplinary medication review
- Where
- Netherlands
- Volunteers
- 992 people
- Sponsor
- University of Groningen
Multimorbidity, General Practice (GP), Primary Care Settings
Exploring the Multimorbidity Burden in Primary Care in Romania
Multimorbidity, the coexistence of two or more chronic conditions, is a growing challenge in primary care, significantly impacting healthcare systems worldwide.
- Conditions
- Multimorbidity, General Practice (GP), Primary Care Settings, Specialist Referral
- Trial name
- MULTIMORB-PC-R (NCT06876558)
- Where
- Romania
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Internist.Ro
Frailty, Disability
Multidisciplinary Mobile Unit for Preventing Hospitalization of Nursing Home Residents
Elderly patients residing in nursing homes are particularly at risk of experiencing urgent medical problems needing admission to the Emergency Department (ED).
- Conditions
- Frailty, Disability, Multimorbidity, Respiratory Failure
- Trial name
- MMU-1 (NCT04085679)
- Testing
- Multidisciplinary Mobile Unit (MMU)
- Where
- Italy
- Volunteers
- 13 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Parma
Complex and Chronic Pluripathology
Case Management of Complex Pluripathology in Primary Care
Aims To assess the effect of the implementation of the Community Nurse Case Manager (CNCM) in the care of complex and pluripathological chronic patients (CPCP) with dependence, from Primary Care, on functional capacity, cognitive…
- Trial name
- ENGESCC (NCT06155591)
- Testing
- Community Nurse Case Manager (CNCM)
- Volunteers
- 212 people
- Sponsor
- José Ignacio Recio Rodriguez
Multimorbidity, Comorbidity
Use of a Hypercaloric and Hyperprotein Supplement Enriched with Immunonutrients in Multi-pathological Malnourished Patients to Improve the Incidence and Prevalence of Pressure Sores
The goal of this study is to evaluate the efficacy of a hypercaloric, hyperproteic enteral formula enriched with immunonutrients in preventing and treating pressure injuries in hospitalized malnourished patients.
- Conditions
- Multimorbidity, Comorbidity, Malnutrition, Pressure Ulcer Prevention
- Trial name
- NCT06726486
- Testing
- Atémpero, Control (Standard treatment)
- Where
- Spain
- Volunteers
- 69 people
- Sponsor
- University of Cadiz
Multiple Mental Health Conditions, Child Mental Health
Cohort Network for Adolescents and Youth With multipLe Mental Health Conditions
The Cohort Network for Adolescents and Youth With multipLe Mental Health Conditions (CALM) Master Observational Trial is a prospective, longitudinal observational study that seeks to improve clinical care for youth with multiple…
- Conditions
- Multiple Mental Health Conditions, Child Mental Health, Youth Mental Health
- Trial name
- CALM (NCT07699159)
- Where
- 6 sites in Canada
- Volunteers
- 1,620 people
- Sponsor
- Centre for Addiction and Mental Health
Myopia, Mental Health
Intervention for Preventing Myopia and Multimorbidity in Children
This study aims to develop and evaluate a scalable, hybrid intervention model for the co-prevention of myopia, obesity, and mental health issues among children.
- Conditions
- Myopia, Mental Health, Cardiovascular Health Status
- Trial name
- NCT07294222
- Testing
- Standard School Health Education, Multi-component Health Promotion Package
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Fangbiao Tao
Multimorbidity, Comorbidity
A Study on the Effectiveness of Comprehensive Intervention Based on Specialized Physical Education Courses in the Prevention of Comorbidity Among Junior Middle School Students
Junior high school students are in a critical period of physical and mental development, currently facing two major health challenges: first, persistently high rates of myopia with a noticeable trend toward younger onset; second…
- Conditions
- Multimorbidity, Comorbidity, Common Diseases in Children and Adolescents, Myopia
- Trial name
- NCT07237698
- Testing
- The intervention group participated in specialized physical education courses.
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Xiaoyan Wu