Clinical trials: Muscle Weakness Condition
Neuromuscular Diseases
Measuring Physical Activity With ActivPal
This study measures the level of physical activity in participants with neuromuscular disorders. The patient wears a small button like meter on their leg for a period of 1 week every 6 months over a period of 3 years.
- Trial name
- Activpal (NCT06084026)
- Testing
- ActivPal
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Columbia University
Cerebral Palsy
Intensive Somatosensory Camp for Manual Function and Participation in Children With Unilateral Cerebral Palsy
This study will evaluate whether an intensive day camp that combines somatosensory and motor training for the affected upper limb improves hand function and participation in children with unilateral cerebral palsy more than an…
- Trial name
- CAMPUSENS (NCT07487857)
- Testing
- Somatosensory-Motor Intensive Camp, Motor-Only Intensive Camp
- Volunteers
- 26 people
- Sponsor
- University of Castilla-La Mancha
Thymidine Kinase 2 Deficiency
An Open-Label Study of Continuation Treatment With Combination Pyrimidine Nucleosides in Patients With TK2 Deficiency
This is a Phase 2 prospective open-label treatment study of the safety and efficacy of doxecitine and doxribtimine in study participants with thymidine kinase 2 (TK2) deficiency who participated in the retrospective study…
- Trial name
- Continuation (NCT03845712)
- Testing
- doxecitine and doxribtimine
- Where
- 8 sites in United States, Israel and 1 more
- Volunteers
- 47 people
- Sponsor
- UCB BIOSCIENCES, Inc.
Perinatal Stroke, Hemiparesis
Perinatal Arterial Stroke: A Multi-site RCT of Intensive Infant Rehabilitation (I-ACQUIRE)
This is a Phase III clinical trial to compare the efficacy of two dosages of a new infant rehabilitation protocol - I-ACQUIRE - to usual and customary forms of infant rehabilitation in infants who experienced Perinatal Arterial…
- Trial name
- I-ACQUIRE (NCT03910075)
- Testing
- I-ACQUIRE - High Dosage, I-ACQUIRE - Moderate Dosage, Usual & Customary Treatment (U&CT)
- Where
- 15 sites in United States
- Volunteers
- 216 people
- Sponsor
- Virginia Polytechnic Institute and State University
Unilateral Cerebral Palsy
Wereables for Upper Limb Functionality in Hemiparesis
The project is configured as a national interventional study that aims to determine the effectiveness of an intervention strategy using wearable technology, tailored to improve function (WeFun-wearable), on the spontaneous use of…
- Trial name
- WeFun (NCT06872736)
- Testing
- WeFun-wearable activated, WeFun-wearable desactivated
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Universidade da Coruña
Congenital Hemiparesis
Comparing the Location of the Motor Cortex in Children Using Two Methods
Hypothesis: In typically developing children (TDC), use of conventional EEG landmarks to determine the brain area that controls hand function will not differ from TMS-guided determination of individual motor hotspots.
- Trial name
- NCT02015338
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Acquired Brain Injury, Stroke
Feasibility of tDCS as an Adjunct to Outpatient Physiotherapy in Children With ABI
This study will evaluate the feasibility of transcranial direct current stimulation (tDCS) as an adjunct to an outpatient motor skills-based physiotherapy intervention for children and youth with acquired brain injury.
- Conditions
- Acquired Brain Injury, Stroke, Traumatic Brain Injury, Hemiparesis
- Trial name
- NCT05637957
- Testing
- active transcranial direct current stimulation
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Unilateral Vocal Cord Paralysis, Unilateral Vocal Cord Paresis
Recurrent Laryngeal Nerve Monitoring During Pediatric Aerodigestive Tract and Cardiac Surgery
This research studies whether a device used during surgery can help doctors better protect the nerve that moves a child's vocal cords. Damage to this nerve can affect speaking, swallowing, and sometimes breathing.
- Trial name
- NCT07604623
- Testing
- Intraoperative laryngeal nerve monitor
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Alberta
ACL Reconstruction, ACL Surgery
Post Operative Use of Neuromuscular Electrical Stimulation (NMES) Device for ACLR Patients
This study is being conducted to learn about how neuromuscular electrical stimulation (NMES) in addition to standard of care aids in the recovery of muscle strength in patients undergoing ACLR procedure.
- Conditions
- ACL Reconstruction, ACL Surgery, ACL Injury, Electrotherapy
- Trial name
- NCT07171346
- Testing
- Zynex NexWave Electrotherapy Device
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Kansas Medical Center
Postural Imbalance, Muscle Weakness
Effects of Corrective Exercises in Adolescent Fencers
The goal is to learn if a Functional Corrective Training (FCT) exercise program improves posture, core muscle endurance, jumping ability, and reaction time in adolescent fencers.
- Conditions
- Postural Imbalance, Muscle Weakness, Athletic Performance
- Trial name
- FMS exercise (NCT06927778)
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Cerebral Palsy, Hemiplegia
The Effect of Combined Armeospring and CIT on Neuro-motor and Functional Recovery in Children With Unilateral CP
The purpose of this study is to assess the use of a commercially available arm weight supporting training system (Armeo®Spring) in conjunction with Constraint Induced Therapy (CIT) for improving upper extremity function for…
- Conditions
- Cerebral Palsy, Hemiplegia, Upper Extremity Weakness
- Trial name
- NCT02914925
- Testing
- ArmeoSpring/CIT
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- St Mary's Hospital for Children
Urinary Incontinence, Pelvic Floor Muscle Weakness
Dose-response of Physical Exercise on Pelvic Floor Muscle Function in Postmenopausal Women With Urinary Incontinence
Urinary incontinence (UI) symptoms are highly prevalent among women, and menopause is one of the risk factors for UI. During the menopausal transition, not only the hormonal secretion is changed but also the level of physical…
- Trial name
- NCT04351750
- Testing
- general exercise, pelvic floor muscle training
- Where
- Taiwan
- Volunteers
- 47 people
- Sponsor
- National Cheng Kung University
Primary Lateral Sclerosis, Hereditary Spastic Paraplegia
Nuclear Magnetic Spectroscopy Imaging to Evaluate Primary Lateral Sclerosis, Hereditary Spastic Paraplegia and Amyotrophic Lateral Sclerosis
This study will use a magnetic resonance imaging technique called nuclear magnetic spectroscopy (H-MRS) to define the pathology and progression of primary lateral sclerosis, hereditary spastic paraplegia and amyotrophic lateral…
- Conditions
- Primary Lateral Sclerosis, Hereditary Spastic Paraplegia, Amyotrophic Lateral Sclerosis
- Trial name
- NCT00023075
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Hemiparesis, Stroke
Functional Electrical Stimulation for Children With Upper Limb Weakness Post Stroke
A new technology system called MyndMove has been developed by MyndTec Inc. (Missisauga Canada) to administer FES. The purpose of this technology is to improve voluntary upper limb (hand and arm) function (i.e.
- Trial name
- NCT03147794
- Testing
- MyndMove
- Volunteers
- 3 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Children, Cerebral Palsy
Reliability and Validity of Strength Measurements of the Lower Limbs in Children With Bilateral Spastic Cerebral Palsy.
Specific musculo-tendinous adaptations in children with cerebral palsy (CP) have an influence on muscle strength and consequently on functional behavior and participation.
- Conditions
- Children, Cerebral Palsy, Muscle Weakness
- Trial name
- NCT03818152
- Testing
- Functional strength assessment
- Where
- Belgium
- Volunteers
- 24 people
- Sponsor
- University Ghent
Muscle Weakness
Maximal Strength Training in Patients Undergoing Total Hip Arthroplasty
Conventional rehabilitation after total hip arthroplasty (THA) does not seem to restore muscular strength or walking speed. Three-5 years after surgery patients are still not fully rehabilitated.
- Trial name
- NCT02498093
- Testing
- Maximal strength training, conventional rehabilitation
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Norwegian University of Science and Technology
ACL - Anterior Cruciate Ligament Deficiency, Muscle Weakness
Isokinetic Muscular Assessment After ACL Ligamentoplasty: Study of Factors Predictive of Muscle Imbalance.
Despite advances in surgery and rehabilitation, the return to sport after anterior cruciate ligament (ACL) reconstruction surgery remains a major challenge. challenge.
- Trial name
- PREDICT-ACL (NCT04071912)
- Where
- France
- Volunteers
- 113 people
- Sponsor
- University Hospital, Caen
Hemiplegia and Hemiparesis
The Effect of Therapeutic Climbing on Muscle Strength, Tone and Balance in Hemiplegic Children
The goal of this randomised controlled trial is to learn about the effect of therapeutic climbing in hemiplegic children. The main questions it aims to answer are: Does climbing affect muscle strength and tone? What is its…
- Trial name
- NCT05983887
- Testing
- Therapeutic Climbing
- Where
- Greece
- Volunteers
- 12 people
- Sponsor
- Pavlos Kitixis
Cerebral Palsy, Movement Disorder
Rehabilitation Gaming System for Cerebral Palsy
In this study the investigators evaluate the effectivity of Virtual Reality-based rehabilitation protocols for preventing motor deterioration in patients with cerebral palsy.
- Trial name
- NCT02938754
- Testing
- VR-based motor training, Conventional Therapy
- Where
- Spain
- Volunteers
- 14 people
- Sponsor
- Universitat Pompeu Fabra
Hemiparesis, Hemiplegic Cerebral Palsy
The Impact of Robot Assisted Therapy and Metacognitive Skills Training for Children With Hemiparesis
The Occupational Therapy Department at Boston Children's Hospital is teaming up with MGH Institute of Health Professions to explore the benefits of using robot assisted therapy (Amadeo) and a problem solving approach (Active…
- Conditions
- Hemiparesis, Hemiplegic Cerebral Palsy, Hemiparesis;Poststroke/CVA
- Trial name
- NCT04309266
- Testing
- Amadeo by Tyromotion, Active Learning Protocol for Stroke
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Boston Children's Hospital