Clinical trials: Non-invasive Ventilation
Infant, Premature
Automated Oxygen Control in Preterms on Non-invasive Ventilation
This randomised controlled trial aims to investigate the effectiveness of closed-loop automated oxygen control (CLAC) in preterm infants receiving non-invasive respiratory support and determine if it reduces the duration of…
- Conditions
- Infant, Premature, Airway Morbidity
- Trial name
- NCT07622563
- Testing
- Closed loop automated oxygen control
- Where
- United Kingdom
- Volunteers
- 76 people
- Sponsor
- King's College Hospital NHS Trust
Respiratory Insufficiency of Prematurity
Nasal Intermittent Positive Pressure Ventilation in Premature Infants (NIPPV)
The machines and oxygen used to help very premature babies breathe can have side-effects, such as bronchopulmonary dysplasia (BPD).
- Trial name
- NIPPV (NCT00433212)
- Testing
- nCPAP, NIPPV
- Where
- 35 sites in United States, Austria and 8 more
- Volunteers
- 1,011 people
- Sponsor
- McMaster University
Diaphragm Ultrasound, Electrical Cardiometry
Diaphragmatic Ultrasound and Thoracic Fluid Content for Prediction of Non-Invasive Ventilation Failure in Neonates
This research assessed diaphragmatic ultrasound and thoracic fluid content (TFC) as potential early predictive tools for detecting NIV failure in preterm neonates.
- Conditions
- Diaphragm Ultrasound, Electrical Cardiometry, Non Invasive Ventilation (NIV), RDS of Prematurity
- Trial name
- NCT07148102
- Testing
- Diaphragmatic US, EC
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Lamiaa Khaled Zidan
Preterm Birth, Premature Lungs
Effect of Nasal CPAP Versus NIPPV On Diaphragm Electrical Activity (Edi) In VLBW Preterm Infants
Background: In premature babies, many organ systems are not fully grown and developed, including the lungs and respiratory muscles, so they will need breathing support to help them to breathe by preventing their tiny air sacs to…
- Conditions
- Preterm Birth, Premature Lungs, Respiratory Distress Syndrome in Premature Infant
- Trial name
- NCT06295484
- Testing
- Alternating traditional CPAP, NIPPV, and high CPAP
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Sunnybrook Health Sciences Centre
Respiratory Insufficiency
NIV Mask and Headgear Evaluation
Non-invasive ventilation (NIV) is the delivery of breathing support via a facemask. It is used to treat people whose natural breathing is ineffective.
- Trial name
- NIV Masks (NCT07391150)
- Testing
- NIV Mask
- Where
- United Kingdom
- Volunteers
- 195 people
- Sponsor
- Sheffield Children's NHS Foundation Trust
Neonatal Respiratory Distress Syndrome, Prematurity
Breathing Variability and NAVA in Neonates
The current study is a crossover trial, aiming at evaluating the effect of NAVA -NIV compared to Nasal Intermittent Positive Pressure Ventilation (PC-NIV) at the same level of peak inspiratory pressure, in terms of…
- Trial name
- BRAVe NANO (NCT04000568)
- Testing
- Respiratory support: NAVA -NIV and PC-NIV
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Preterm Infants
NHFOV vs. NCPAP as a Primary Treatment to Neonatal Respiratory Distress Syndrome(NRDS)
The investigators compared advantages and disadvantages of two forms of noninvasive respiratory support -noninvasive high-frequency oscillatory ventilation (nHFOV) or nasal continuous positive airway pressure (nCPAP) -as a…
- Trial name
- NCT03099694
- Testing
- noninvasive high-frequency ventilation (nHFOV), nasal continuous positive airway pressure (nCPAP)
- Where
- China
- Volunteers
- 340 people
- Sponsor
- Xingwang Zhu
Bronchopulmonary Dysplasia
Nasal Mask and Prong Use in Non-invasive Ventilation for Newborns
The study aims to investigate efficacy and safety of nasal mask and prongs used in non-invasive ventilation in newborns by using esophageal pressure transducer.
- Trial name
- NIV (NCT01989442)
- Testing
- binasal prongs, nasal mask
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Ankara University
Sleep Disordered Breathing
Contribution of an Educational Game for Continuous Positive Pressure/Non-invasive Ventilation Therapeutic Education in Children
A growing number of children with obstructive sleep apnea syndrome (OSAS) or nocturnal alveolar hypoventilation syndrome are treated with continuous positive airway pressure (CPAP) or nocturnal non-invasive ventilation (NIV)…
- Trial name
- YAPOUNI (NCT04660994)
- Testing
- Educational game
- Where
- France
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Non-invasive Ventilation, Pediatric Pulmonary Disease
High-flow Nasal Cannula Flow Rates, Severe Bronchiolitis
Objective: The investigators aimed to compare the heated humidified high-flow nasal cannula (HHHFNC) flow rate of 1-L/kg/min (1L) with 2-L/kg/min (2L) in patients with severe bronchiolitis presenting to the pediatric emergency…
- Trial name
- NCT03859947
- Testing
- Heated humidified high-flow nasal cannula
- Where
- Turkey (Türkiye)
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Ali Yurtseven
Noninvasive Ventilation, Low Birth Weight
Noninvasive NAVA Versus NIPPV in Low Birthweight Premature Infants
The investigator hypothesizes that in very low birth weight infants who require respiratory support via noninvasive ventilation, that synchronizing the ventilator breath with the baby's breath using neurally adjusted ventilatory…
- Trial name
- NCT03137225
- Testing
- Neurally Adjusted Ventilatory Assist, Nasal Intermittent Positive Pressure Ventilation
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Virginia Commonwealth University
Infant, Premature
Less Invasive Beractant Administration in Preterm Infants
The aim of this study is to assess the efficacy and feasibility of a new less invasive surfactant administration (LISA) technique with a specific designed cannula for surfactant administration using Beractant replacement in…
- Trial name
- NCT02611284
- Testing
- LISA, INSURE
- Volunteers
- 60 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Asthma in Children, Status Asthmaticus
BPAP in Pediatric Asthma Pilot Study
The investigators aim to study the effect and safety of bilevel positive airway pressure (BPAP) in children with moderate to severe asthma exacerbations - by examining the effects of early initiation of BPAP in pediatric patients…
- Trial name
- NCT04656587
- Testing
- Philips Respironics V60 Non-invasive ventilator, BPAP, Standard Therapy
- Sponsor
- Columbia University
Hypercapnic Respiratory Failure
Clinical Trial Assessing Two Protocols to Withdraw Non-invasive Ventilation in Hypercapnic Respiratory Failure
The purpose of the study is to determine the optimal method to withdraw non-invasive ventilation after an episode of hypercapnic respiratory failure.
- Trial name
- NCT00775710
- Testing
- Nocturnal non-invasive ventilation
- Where
- 3 sites in Spain
- Volunteers
- 128 people
- Sponsor
- Hospital Clinic of Barcelona
PreTerm Neonate, Respiratory Distress Syndrome (RDS)
Neonatologist-Performed Lung Ultrasound (NPLUS) to Guide Respiratory Therapy
The goal of this cross-over clinical trial is to evaluate whether Neonatologist-Performed Lung Ultrasound (NPLUS) can be used in preterm babies on non-invasive breathing support to reduce the amount of oxygen they need.
- Trial name
- NCT06901206
- Testing
- Neonatologist performed lung ultrasound
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- Royal Hospital For Women
Respiratory Distress Syndrome
Impact of Synchronized Nasal Intermittent Positive Pressure Ventilation Using NAVA in Preterm Infants With RDS
The nasal CPAP (continuous positive airway pressure), is a technique of noninvasive ventilation commonly used in neonatal intensive care units, and has recently been used in association with nasal intermittent mandatory…
- Trial name
- NCT02030652
- Testing
- Intermittent nasal positive pressure positive ventilation., CPAP
- Where
- Brazil
- Volunteers
- 56 people
- Sponsor
- Hospital Israelita Albert Einstein
Chronic Respiratory Failure, Tracheostomy Complication
Parental Perception of COVID-19 Vaccine in Technology Dependent Patients
This study involves conducting a telephonic or in person survey regarding parental perception and attitudes about vaccinating the respective "technology dependent" child with the COVID 19 vaccination.
- Conditions
- Chronic Respiratory Failure, Tracheostomy Complication, Mechanical Ventilation Complication
- Trial name
- NCT05084976
- Testing
- COVID 19 vaccine counseling
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Northwell Health
Fontan Physiology
Feasibility and Efficacy of Portable Non-invasive Negative Pressure Ventilation in Fontan Patients
The human heart has 4 chambers: 2 collecting chambers (atria) and 2 pumping chambers (ventricles) to allow blood flow within two distinct circuits: "pulmonary" and "systemic".
- Trial name
- FONTAN-CMR (NCT03251742)
- Testing
- Hayek RTX ventilator
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Respiratory Mechanics, Monitoring, Physiologic
Dynamic Non-invasive Monitoring of Inspiratory Effort
This prospective, observational cohort study aims to evaluate whether the dynamic monitoring of a patient's breathing effort can predict successful liberation from invasive mechanical ventilation.
- Conditions
- Respiratory Mechanics, Monitoring, Physiologic, Respiratory Insufficiency Requiring Mechanical Ventilation, Critical Illness
- Trial name
- NCT07839949
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Fundació d'investigació Sanitària de les Illes Balears
Premature Birth
Changes in Respiratory Effort in Preterm Infants
Continuous Positive Airway Pressure (CPAP) is used to treat preterm infants with an immature respiratory center and having respiratory distress. CPAP requires intensive care monitoring and special qualified staff.
- Trial name
- NCT02014493
- Testing
- High Flow Nasal Cannulae (HFNC), Continuous Positive Airway Pressure (CPAP)
- Where
- Norway
- Volunteers
- 21 people
- Sponsor
- St. Olavs Hospital