Clinical trials: Physical Function
Cerebral Palsy
Functional Strength Training and Virtual Reality in Children With CP
Virtual reality (VR) has shown to be effective to improve arm function in children with cerebral palsy (CP). Recently, functional strength training (FST) starts to show to improve arm function in patients with stroke but has not…
- Trial name
- NCT04147468
- Testing
- Virtual Reality, Functional Strength Training
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Georgia State University
Child Behavior, Problem Behavior
Executive Function and Symptom Reduction in Youth Receiving Home-based Treatment With Collaborative Problem Solving
In this project, the investigators will extend prior results of parent-reported executive function growth and symptom reduction in children receiving home-based treatment with the Collaborative Problem Solving treatment approach…
- Conditions
- Child Behavior, Problem Behavior, Executive Dysfunction
- Trial name
- NCT04121650
- Testing
- Collaborative Problem Solving
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Massachusetts General Hospital
X-linked Myotubular Myopathy
Respiratory Muscle Function in Untreated X-Linked Myotubular Myopathy (XLMTM)
This study is a longitudinal study evaluating the severity and progression of respiratory muscle function in patients with X-Linked Myotubular Myopathy (XLMTM) aged 0-14.
- Trial name
- NCT02453152
- Testing
- History and physical, Tidal breathing, Maximal respiratory pressures
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Florida
Pulmonary Arterial Hypertension
The Effects of Drug Candidate CS1 on Lung Structure and Function Utilizing FRI
Explore the impact of drug candidate CS1 on pathological vascular remodeling of small pulmonary arteries in the disease pulmonary arterial hypertension (PAH).
- Trial name
- NCT06907693
- Testing
- CT Pulmonary Angiography Scan
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Prisma Health-Upstate
Obesity, Insulin Resistance
Endothelial Function in Hispanic Children/Adolescents at Risk for Type 2 Diabetes
Type 2 diabetes is now more frequent in children/adolescents, especially in those from minority populations, including Hispanic Americans (HA).
- Trial name
- NCT01926925
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Joslin Diabetes Center
Cystic Fibrosis
The Prevalence and Significance of Gastro-oesophageal Reflux in Cystic Fibrosis Before and After Lung Transplantation
Gastro-oesophageal reflux (GOR) has been found to be prevalent in children with cystic fibrosis (CF)and may further worsen lung damage via reflex bronchospasm or pulmonary aspiration.
- Trial name
- NCT00164021
- Testing
- Physiotherapy, exercise, percutaneous gastrostomy feeds, Anti-reflux pharmacotherapy
- Where
- Australia
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Bayside Health
Hyperkyphosis, Respiratory Failure
Core Stability and Respiratory Parameters in Children With Thoracic Hyperkyphosis
Hyperkyphosis, defined as an excessive curvature of the thoracic spine beyond normal limits, is among the factors that reduce chest wall mobility and lung function.
- Trial name
- NCT06853548
- Testing
- Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people
- Sponsor
- Istinye University
Physiological Changes in Deliberate Apnea
Evaluating the Influence of Apnea on Cardiac Function Using Cardiac Magnetic Resonance Imaging.
Former studies revealed a distinct pattern of changes in circulation during deliberate apnea. Blood pressure rises significantly often accompanied by bradycardia.
- Trial name
- NCT02280226
- Testing
- magnetic resonance imaging (MRI)
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
Chagas Cardiomyopathy
Microvascular Endothelial Function in a Cohort of Patients With the Cardiac Form of Chronic Chagas Disease.
The present study aims to evaluate the microvascular endothelial function of a single centre cohort of patients with the cardiac form of Chagas disease, and to search for associations with clinical and laboratory variables.
- Trial name
- NCT03524768
- Testing
- skin laser speckle contrast imaging and video-capillaroscopy
- Where
- Brazil
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
Spinal Cord Injury Cervical
Noninvasive Spinal Stimulation to Restore Hand Function in Children With Spinal Cord Injury
The main goal of this pilot study is to find the best ways to use transcutaneous spinal cord stimulation (scTS) to improve hand function in children with spinal cord injuries (SCI).
- Trial name
- NCT06489106
- Testing
- Activity based upper extremity training with and without stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Louisville
Cystic Fibrosis
Gut Imaging for Function and Transit in Cystic Fibrosis 3 Junior
Recently trial data has shown that the medicine KaftrioTM (Elexacaftor/ Tezacaftor/ Ivacaftor) improves lung function in children aged 6 to 11 years who have cystic fibrosis (CF).
- Trial name
- GIFT-CFJunior (NCT05699148)
- Testing
- Elexacaftor / Ivacaftor / Tezacaftor
- Where
- United Kingdom
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Nottingham University Hospitals NHS Trust
Limb-girdle Muscular Dystrophy
A Study of the Natural History of Participants With LGMD2E/R4, LGMD2D/R3, LGMD2C/R5, and LGMD2A/R1 ≥ 4 Years of Age, Who Are Managed in Routine Clinical Practice
This study will follow participants who are screened and confirmed with a genetic diagnosis of Limb-girdle muscular dystrophy type 2E (LGMD2E/R4), Limb-girdle muscular dystrophy type 2D (LGMD2D/R3), Limb-girdle muscular dystrophy…
- Trial name
- NCT04475926
- Where
- 26 sites in United States, Belgium and 8 more
- Volunteers
- 205 people
- Sponsor
- Sarepta Therapeutics, Inc.
Cerebral Palsy
Hippotherapy in Children With Cerebral Palsy
The hippotherapy is a complementary therapeutic modality that seeks to promote changes in the functionality of children with cerebral palsy (CP).
- Trial name
- Hippotherapy (NCT03548376)
- Testing
- Hippotherapy
- Volunteers
- 31 people
- Sponsor
- Federal University of Minas Gerais
Mesothelioma; Peritoneum, Pseudomyxoma Peritonei
Thrombin Generation and Platelet Activation in CRS/HIPEC
Cytoreductive surgery (CRS) with hyperthermic intraperitoneal peroperative chemotherapy (HIPEC), indicated for patients with peritoneal metastases from digestive or gynecological malignancies alike, demonstrates a considerable…
- Conditions
- Mesothelioma; Peritoneum, Pseudomyxoma Peritonei, Peritoneal Carcinomatosis
- Trial name
- NCT03034850
- Testing
- CRS/HIPEC
- Volunteers
- 27 people
- Sponsor
- Ziekenhuis Oost-Limburg
Cystic Fibrosis (CF), Chronic Kidney Disease(CKD)
Kidney Function in People With Cystic Fibrosis in the Era of HEMT
The purpose of this study is to find out what causes kidney disease in people with CF. The investigators will study biomarkers in the blood and urine that can either predict who is at risk or detect kidney damage early before it…
- Conditions
- Cystic Fibrosis (CF), Chronic Kidney Disease(CKD), Acute Kidney Injury
- Trial name
- NCT06595420
- Where
- 3 sites in United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Spastic Hemiplegic Cerebral Palsy
Modified Constraint-Induced Movement Therapy in Children With Hemiparetic Cerebral Palsy
Cerebral palsy (CP) is defined as a non-progressive lesion of the developing foetal or infant brain and causes variety of motor, sensory and cognitive impairments.
- Trial name
- NCT04064788
- Testing
- Consecutive Modified Constraint-Induced Movement Therapy, Traditional physiotherapy, Intermittent Modified Constraint-Induced Movement Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people
- Sponsor
- Abant Izzet Baysal University
Parent-Child Relations
ATTACH™ Online Platform: Helping Children Vulnerable to Early Adversity
Addressing the impact of early childhood adversity (e.g., family violence, parental depression, and low income) can promote children's mental health and development, giving children the best start in life and reducing societal…
- Trial name
- ATTACH™ (NCT05994027)
- Testing
- ATTACH™ Online Platform Parenting Program
- Where
- Canada
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Developmental Delay (Disorder)
Creative Music Therapy for Premature Infants
This study investigates whether creative music therapy applied to premature infants will facilitate brain growth and development at term equivalent assessed by magnetic resonance imaging.
- Trial name
- NCT02434224
- Testing
- Music Therapy
- Where
- Switzerland
- Volunteers
- 81 people
- Sponsor
- University of Zurich
Atherosclerosis, Coronary Disease
Study of the Interaction Between the Cells Lining Blood Vessels and Angiotensin-Converting Enzyme
The walls of blood vessels are lined by flat cells that are responsible for releasing substance(s) that control the activity of the blood vessel. These cells are referred to as the endothelium of the blood vessel.
- Trial name
- NCT00001461
- Where
- United States
- Volunteers
- 209 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Gastric Function Disorder
Laparoscopic Management of Gastroesophageal Reflux Disease in Children
gastric functions especially gastric emptying is still debatable after anti reflux surgery in children. this study aims to predict the best procedure associated with good gastric emptying time and gastric functions following anti…
- Trial name
- NCT07708220
- Testing
- fundoplication
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Tanta University
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