Clinical trials: Positive Pressure Ventilation
Premature Birth, Ventilator Lung; Newborn
sNIPPV Versus NIV-NAVA in Extremely Premature Infants
The aim of this study is to demonstrate a significant decrease in asynchrony with NIV-NAVA using the Servo n ventilator (Getinge, Sweden), as compared to abdominal triggered (Graseby capsule) synchronized nasal intermittent…
- Trial name
- EASYNNEO (NCT04068558)
- Testing
- VNI-NAVA/sNIPPV, sNIPPV/VNI-NAVA
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Respiratory Distress Syndrome, Newborn
A Safety and Efficacy Study of Lucinactant for Inhalation in Preterm Neonates 26 to 32 Weeks Gestational Age
This study is to evaluate the safety and efficacy of lucinactant for inhalation in conjunction with nCPAP, in comparison to nCPAP alone, in preterm neonates with RDS, as assessed by the incidence of and time to respiratory…
- Trial name
- NCT04264156
- Testing
- Lucinactant for Inhalation, nCPAP Only
- Where
- 3 sites in Poland
- Volunteers
- 12 people
- Sponsor
- Windtree Therapeutics
Respiratory Distress Syndrome
Comparative Effectiveness Study of Bubble CPAP Devices in the NICU
Multiple different devices are available to provide Bubble CPAP to preterm and newborn infants. The most significant difference between these devices is the size of the bubble produced by the exhalation limb.
- Trial name
- NCT02392806
- Testing
- Bubble CPAP- BabiPlus, Respiralogics, Bubble CPAP- B&B Bubbler, B&B Medical devices
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Marya Strand, MD
Respiratory Insufficiency
High Flow Nasal Cannula Versus Nasal Continuous Positive Airway Pressure
The purpose of this study is to compare two common methods of providing respiratory support: nasal continuous airway pressure and high flow nasal cannula to see what effect it has on babies breathing.
- Trial name
- NCT01531465
- Testing
- Pulmonary Function Testing & esophageal pressure monitoring, Pulmonary function testing and esophageal pressure
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Christiana Care Health Services
Respiratory Insufficiency of Prematurity
Nasal Intermittent Positive Pressure Ventilation in Premature Infants (NIPPV)
The machines and oxygen used to help very premature babies breathe can have side-effects, such as bronchopulmonary dysplasia (BPD).
- Trial name
- NIPPV (NCT00433212)
- Testing
- nCPAP, NIPPV
- Where
- 35 sites in United States, Austria and 8 more
- Volunteers
- 1,011 people
- Sponsor
- McMaster University
Nasal Intermittent Positive Pressure Ventilation, Nasal Continuous Positive Airway Pressure
Nasal Intermittent Positive Pressure Ventilation(NIPPV) vs Continuous Positive Airway Pressure for Respiratory Distress Syndrome
In the past, several studies have compared the effects between nasal intermittent positive pressure ventilation(NIPPV) and nasal continuous positive airway pressure(NCPAP) on the incidence of intubation in preterm infants, and…
- Trial name
- NCT03226977
- Testing
- NIPPV, NCPAP
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Prematurity, BPD - Bronchopulmonary Dysplasia
Feasibility and Impact of Volume Targeted Ventilation in the Delivery Room
Despite significant improvement in preterm infant survival, the incidence of bronchopulmonary dysplasia (BPD) in infants born < 28 weeks gestational age (GA) has been relatively stable at ~40%, with 10,000-15,000 new cases…
- Conditions
- Prematurity, BPD - Bronchopulmonary Dysplasia, Respiratory Distress Syndrome, Newborn
- Trial name
- NCT03938532
- Testing
- Volume Targeted Ventilation (VTV) using the Philips Respironics NM3 monitor, Tidal Volume Measurement using the Philips Respironics NM3 monitor
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Baystate Medical Center
Prematurity, Respiratory Distress Syndrome
CPAP vs.Unsynchronized NIPPV at Equal Mean Airway Pressure
This study seeks to determine if standard continuous positive airway pressure, known as CPAP is as effective as a more complicated approach that generates intermittent increases in airway pressure applied to the nostrils via a…
- Conditions
- Prematurity, Respiratory Distress Syndrome, Apnea of Prematurity
- Trial name
- NICA (NCT03670732)
- Testing
- continuous positive airway pressure, nasal intermittent positive pressure ventilation
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Down Syndrome, Obstructive Sleep Apnea
Positive Airway Pressure (PAP) for Children With Down Syndrome (DS) and Obstructive Sleep Apnea Syndrome (OSAS)
Determine the efficacy of family-informed intervention (INT) vs standard clinical care over a period of twelve months in children with obstructive sleep apnea and Down Syndrome.
- Trial name
- NCT04132999
- Testing
- Family-informed intervention, Standard Clinical Care
- Where
- 3 sites in United States
- Volunteers
- 27 people
- Sponsor
- University of Miami
Obstructive Sleep Apnea (OSA)
CPAP vs High-Flow Nasal Cannula for Treating Sleep Apnea in Children
This study is looking at two different treatments for obstructive sleep apnea (OSA) in children. OSA is a sleep condition where breathing repeatedly stops and starts during sleep, which can affect a child's health, behavior…
- Trial name
- CHOSA (NCT07600333)
- Testing
- High Flow Nasal Cannula, Continuous Positive Airway Pressure
- Where
- Canada
- Volunteers
- 258 people
- Sponsor
- The Hospital for Sick Children
Preterm Birth, Premature Lungs
Effect of Nasal CPAP Versus NIPPV On Diaphragm Electrical Activity (Edi) In VLBW Preterm Infants
Background: In premature babies, many organ systems are not fully grown and developed, including the lungs and respiratory muscles, so they will need breathing support to help them to breathe by preventing their tiny air sacs to…
- Conditions
- Preterm Birth, Premature Lungs, Respiratory Distress Syndrome in Premature Infant
- Trial name
- NCT06295484
- Testing
- Alternating traditional CPAP, NIPPV, and high CPAP
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Sunnybrook Health Sciences Centre
Preterm Birth, Extreme Prematurity
Sustained Aeration of Infant Lungs Trial
This study is a 2-arm randomized, controlled, multi-center clinical trial to determine which of two strategies at birth are best to optimally aerate the lung of preterm infants.
- Trial name
- SAIL (NCT02139800)
- Testing
- Sustained Inflation, Standard of Care
- Where
- 21 sites in United States, Australia and 7 more
- Volunteers
- 460 people
- Sponsor
- University of Pennsylvania
Neonatal Respiratory Distress Syndrome, Prematurity
Breathing Variability and NAVA in Neonates
The current study is a crossover trial, aiming at evaluating the effect of NAVA -NIV compared to Nasal Intermittent Positive Pressure Ventilation (PC-NIV) at the same level of peak inspiratory pressure, in terms of…
- Trial name
- BRAVe NANO (NCT04000568)
- Testing
- Respiratory support: NAVA -NIV and PC-NIV
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Sleep Disordered Breathing
Contribution of an Educational Game for Continuous Positive Pressure/Non-invasive Ventilation Therapeutic Education in Children
A growing number of children with obstructive sleep apnea syndrome (OSAS) or nocturnal alveolar hypoventilation syndrome are treated with continuous positive airway pressure (CPAP) or nocturnal non-invasive ventilation (NIV)…
- Trial name
- YAPOUNI (NCT04660994)
- Testing
- Educational game
- Where
- France
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Newborn Resuscitation
PEEP Resuscitation Trial
Each year, almost 3 million newborn babies die within their first month of life, often as a consequence of labour complications. Approximately 5% of newborns will not start breathing at birth and need immediate help.
- Trial name
- PEEPrest (NCT02971553)
- Testing
- Upright Resuscitator with PEEP, Upright Resuscitator
- Where
- Tanzania
- Volunteers
- 330 people
- Sponsor
- Helse Stavanger HF
Respiratory Distress Syndrome, Preterm Infant
Nasal High Frequency Oscillation Ventilation(NHFOV) for Respiratory Distress Syndrome
In very preterm infants with severe respiratory distress syndrome(RDS), invasive ventilation(IV) , besides nasal continuous positive airway pressure (NCPAP) and early/selective pulmonary surfactant administration, is one key…
- Trial name
- NHFOV (NCT03140891)
- Testing
- NHFOV, NCPAP
- Where
- China
- Volunteers
- 206 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Asthma in Children, Status Asthmaticus
BPAP in Pediatric Asthma Pilot Study
The investigators aim to study the effect and safety of bilevel positive airway pressure (BPAP) in children with moderate to severe asthma exacerbations - by examining the effects of early initiation of BPAP in pediatric patients…
- Trial name
- NCT04656587
- Testing
- Philips Respironics V60 Non-invasive ventilator, BPAP, Standard Therapy
- Sponsor
- Columbia University
Respiratory Distress Syndrome, Newborn, Respiratory Tract Diseases
Nasal HFOV Versus Nasal CPAP to Reduce Post-extubation pCO2
To investigate whether nasal high frequency oscillation ventilation (nHFOV) immediately after extubation reduces the arterial partial pressure of carbon dioxide (paCO2) at 72 hours after extubation in comparison with nasal…
- Trial name
- NCT02340299
- Testing
- nHFOV, nCPAP
- Where
- Germany
- Volunteers
- 6 people
- Sponsor
- Charite University, Berlin, Germany
Infant, Newborn, Infant, Low Birth Weight
Delivery Room CPAP in Extremely Low Birth Weight Infants
This pilot study was designed to determine the feasibility of randomizing extremely low birth weight (ELBW) infants <28 weeks' gestation who required resuscitation to one of two resuscitation methods, either: (a) 100% oxygen by…
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- DR-CPAP (NCT01223274)
- Testing
- CPAP/PEEP, Standard management practices
- Where
- 6 sites in United States
- Volunteers
- 104 people
- Sponsor
- NICHD Neonatal Research Network
Acute Respiratory Distress Syndrome
Surfactant Versus Nasal Continuous Positive Airway Pressure (nCPAP) for Respiratory Distress Syndrome in the Newborn ≥ 35 Weeks of Gestation
Term and near term newborns can present acute respiratory distress syndrome (RDS). Surfactant treatment has been shown effective in reducing mechanical ventilation and oxygen treatment durations in the preterm newborn.
- Trial name
- ASPEN (NCT01306240)
- Testing
- Surfactant instillation, nCPAP
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens