Clinical trials: Randomised Controlled Trial
Dentine Caries
Effectiveness of Single and Dual Silver Fluoride Application
This is a community-based, parallel-group, double-blinded randomised controlled trial aimed at evaluating the effectiveness of single and dual applications of 38% Silver Fluoride (SF) in arresting dentinal caries among Malaysian…
- Trial name
- NCT07658690
- Testing
- 38% Silver Fluoride (Riva Star Aqua)
- Where
- Malaysia
- Volunteers
- 148 people
- Sponsor
- University of Malaya
Procrastination
Randomised Controlled Trial of a Digital Programme for Procrastination in UK University Students
The aim of this study is to evaluate the effect of an 8-week self-directed internet based CBT intervention on various psychological outcomes for young students struggling with procrastination in the UK.
- Trial name
- NCT06157710
- Testing
- Digital intervention through modules
- Where
- United Kingdom
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Bath
Language Development
Evaluating the Effectiveness of the Reader Organisation's Get Into Reading Intervention
The investigators will evaluate the effectiveness of a parent-child shared reading intervention run by The Reader Organisation. The investigators will be asking parents and children across Liverpool to either (i) attend a weekly…
- Trial name
- NCT02659579
- Testing
- The Reader Organisation's Shared Reading Programme, Shared Reading control
- Where
- United Kingdom
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Caroline Rowland
Peer Violence, Depression
Evaluation of Right To Play's Positive Child and Youth Development Program in Middle Schools in Hyderabad, Pakistan
This is a RCT conducted with 1752 children in 40 public middle schools in Hyderabad Pakistan with the goal of evaluating the effectiveness of the international non-governmental organisation Right To Play's Positive Child and…
- Trial name
- NCT03448523
- Testing
- Right To Play's Positive Child and Youth Development program
- Volunteers
- 1,752 people, healthy volunteers welcome
- Sponsor
- Medical Research Council, South Africa
Hookworm Infection
Triple Combinations Against Hookworm Infections in Lao
More than one billion people are infected with soil-transmitted helminths (STH, A. lumbricoides, hookworm or Trichuris trichiura). Preventive chemotherapy - i.e.
- Trial name
- Tricombi (NCT03278431)
- Testing
- Albendazole, Pyrantel Pamoate, Oxantel Pamoate
- Where
- Laos
- Volunteers
- 420 people
- Sponsor
- Swiss Tropical & Public Health Institute
Atrial Fibrillation
The Effect of Arrhythmia Surgery on Quality of Life in Patients With Atrial Fibrillation Undergoing Cardiac Surgery
Atrial fibrillation (AF) is connected with an increased morbidity and mortality. In addition, quality of life is diminished due to palpitations, dyspnea, dizziness and syncope.
- Trial name
- NCT00886080
- Testing
- Pulmonary vein isolation using microwave energy
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- Maastricht University Medical Center
Traumatic Brain Injury
Clinical Randomisation of an Antifibrinolytic in Significant Head Injury
The CRASH-3 trial will provide reliable evidence about the effect of tranexamic acid on mortality and disability in patients with traumatic brain injury.
- Trial name
- CRASH-3 (NCT01402882)
- Testing
- Tranexamic Acid
- Where
- Georgia
- Volunteers
- 12,737 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Skin Cancer, Skin Cancer Prevention
Developing and Testing the Effectiveness of a Skin Cancer Self-Detection Educational Program
Skin cancer is a significant public health concern, even in an Asian society like Singapore where it ranks among the top 10 cancers.
- Conditions
- Skin Cancer, Skin Cancer Prevention, Benign Skin Growth
- Trial name
- NCT07247123
- Testing
- Skin Cancer Self-Detection Educational Program with gain-framing, Skin Cancer Self-Detection Educational Program with loss-framing, Wait-list Control
- Where
- Singapore
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Vascular Access Complication, Device Related Infection
Novel Antimicrobial Dressing in Peripheral Intravenous Catheters (PIVCs)
The goal of this clinical trial is to compare a chlorhexidine impregnated dressing for peripheral intravenous catheters (PIVCs) to the standard dressing currently used in general medical and surgical inpatient wards.
- Conditions
- Vascular Access Complication, Device Related Infection, Device Related Sepsis, Device Site Reactions
- Trial name
- ProP (NCT05741866)
- Testing
- Chlorhexidine gluconate impregnated bordered polyurethane dressing, Standard bordered polyurethane dressing
- Where
- 3 sites in Australia, France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The University of Queensland
Cystic Fibrosis
Outcomes in CF Patients Accessing Their Registry Health Records
A multifactorial, parallel group, randomised control study in cystic fibrosis (CF) patients aged 13-30 years over an 18 month period.
- Trial name
- CFView (NCT03434886)
- Testing
- CFView, CF educational videos
- Volunteers
- 282 people
- Sponsor
- Cystic Fibrosis Registry of Ireland
Pediatric Kidney Disease
Shockwave Lithotripsy (SWL) Versus SWL and Oral Dissolution Therapy (ODT) For Paediatrics Radiolucent Renal Stone
To conduct a RCT comparing SWL versus combined ODT and SWL as non-invasive methods for management of paediatrics radiolucent renal stone.
- Trial name
- NCT05896345
- Testing
- SWL, SWL and ODT
- Where
- Egypt
- Volunteers
- 76 people
- Sponsor
- Mansoura University
Atopic Eczema
Softened Water for Eczema Prevention Pilot Trial
An outcome assessor-blinded pilot randomised controlled trial of an ion-exchange water softener for the prevention of atopic eczema in neonates, with an embedded mechanistic study
- Trial name
- SOFTER (NCT03270566)
- Testing
- Domestic ion-exchange water softener
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- King's College London
Depression
A Mobile Phone Self-Monitoring Tool to Increase Emotional Self-Awareness and Reduce Depression in Young People
The mobiletype program is a mental health assessment and monitoring tool that runs on mobile phones. The program assesses the general mental health of young people in real-time and transmits this data to a website to be reviewed…
- Trial name
- mobiletype (NCT00794222)
- Testing
- Mobile Tracking Young People's Experiences (mobiletype)
- Where
- Australia
- Volunteers
- 118 people
- Sponsor
- Murdoch Childrens Research Institute
Cortical Dysplasia
Evaluating Dietary Intervention Before surgicaL Treatment for Epilepsy
The investigators are undertaking the first European Randomised Controlled Trial (RCT) for epilepsy surgery in children with FCD type II, to prospectively evaluate the role of the KD prior to surgery in improving seizure outcome.
- Trial name
- EDIBLE (NCT02261753)
- Testing
- Classical ketogenic diet
- Where
- 15 sites in United States, Austria and 6 more
- Volunteers
- 3 people
- Sponsor
- University College, London
Attention Deficit Disorder With Hyperactivity
Support for PARents of Children Living With ADHD - a Research Trial
Attention-Deficit/Hyperactivity Disorder (ADHD) is a chronic and pervasive disorder characterised by problems in attention, impulse control and activity regulation that substantially burdens patients, families, and society.
- Trial name
- SPARCLAR (NCT03832270)
- Testing
- Parents InC, Incredible Years
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Glasgow
Enhancing Early Language and Cognitive Development in Toddlers Through a Culturally Adapted Home-based Parent Intervention
Home-Based Language and Cognitive Intervention for Arab Toddlers in Israel
This study evaluates the effectiveness of a culturally adapted, home-based program designed to improve language and cognitive development in Arab toddlers in Israel.
- Trial name
- CAHBI-T (NCT07233525)
- Testing
- Culturally Adapted Parent-Implemented Intervention, Child Health Education Sessions
- Where
- Israel
- Volunteers
- 240 people
- Sponsor
- Hillel Yaffe Medical Center
Dental Caries
European Study on Three Different Approaches to Managing Class 2 Cavities in Primary Teeth
The purpose of this randomized clinical trial is to compare the clinical effectiveness of three treatments involving different caries management strategies (conventional restorations, Hall technique, and Non-Restorative Caries…
- Trial name
- NCT01797458
- Testing
- Hall Technique, Non-Restorative Caries Treatment, Conventional Restoration
- Where
- 3 sites in Germany, Lithuania and 1 more
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Biliary Atresia
Trail to Investigate the Effectiveness of CoSeal in Reducing Adhesions Following the Kasai Hepatoportoenterostomy for Biliary Atresia
The investigators plan to invite all children in the UK with biliary atresia, treated at the three national centres (Birmingham, Kings College and Leeds), over a three year period to take part in a randomised control study.
- Trial name
- CoSRCT (NCT01745991)
- Testing
- CoSeal spray
- Where
- 3 sites in United Kingdom
- Volunteers
- 126 people
- Sponsor
- Naved Alizai
Unmet Fertility Information Needs
Investigating the Efficacy of a Paediatric Fertility Preservation Decision Aid in Parents and Adolescents and Young Adults (CAYA) Cancer Survivors
The current standard of care for paediatric patients with cancer regarding preservation of their fertility (FP) is to provide high-quality information during the clinical consultation process.
- Trial name
- FOCUS (NCT06894810)
- Testing
- Decision-aid
- Where
- Australia
- Volunteers
- 358 people
- Sponsor
- Murdoch Childrens Research Institute
Telerehabilitation, Anterior Cruciate Ligament Injuries
Telerehabilitation for Anterior Cruciate Ligament Reconstruction - TAR Program in Adolescents
Anterior cruciate ligament (ACL) injuries are common in adolescents and its prevalence has increased over the years, especially with more adolescents engaging in physical activities and competitive sports.
- Conditions
- Telerehabilitation, Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament
- Trial name
- TAR (NCT05799235)
- Testing
- Telerehabilitation TAR program using a mobile application, Standard rehabilitation sessions
- Where
- Singapore
- Volunteers
- 40 people
- Sponsor
- KK Women's and Children's Hospital
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