Clinical trials: Randomised Controlled Trial
Congenital Heart Disease, Child Development
A Parent-child Yoga Intervention for Reducing Attention Deficits in Children with Congenital Heart Disease: a Feasibility Study
The proposed study aims to determine the feasibility of the procedures for a future full randomized controlled trial (RCT), which will test the efficacy of a parent-child yoga intervention in reducing attention deficits in…
- Conditions
- Congenital Heart Disease, Child Development, Neurodevelopmental Disorders, Parents
- Trial name
- NCT05997680
- Testing
- Parent-child yoga
- Where
- 2 sites in Canada
- Volunteers
- 24 people
- Sponsor
- Anne Gallagher
Ageism, Job Satisfaction
Reducing Ageism in Organizations: A Study Protocol
Background: This article presents the protocol for a randomised controlled trial designed to develop and evaluate a psychoeducational intervention aimed at reduce ageism in the workplace, will improve attitudes toward older…
- Conditions
- Ageism, Job Satisfaction, Workers
- Trial name
- ageism (NCT07484165)
- Testing
- Psychoeducational Programme, Education Programme
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Malaria, Anaemia
Intermittent Preventive Treatment (IPTp) Versus Rapid Diagnostic Testing (RDT) and Treatment of Malaria in Pregnancy
Among the best practices recommended for malaria control during pregnancy is ensuring effective case management of malaria illness.
- Conditions
- Malaria, Anaemia, Pregnancy
- Trial name
- NCT00432367
- Testing
- Amodiaquine plus artesunate combination; sulphadoxine-pyrimethamine
- Where
- Ghana
- Volunteers
- 3,333 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Pelvic Organ Prolapse
Multi-centre Randomised Controlled Trial of Pelvic Floor Muscle Training for Prolapse
The aim of this study is to determine the effectiveness and cost-effectiveness of pelvic floor muscle training in the management of pelvic organ prolapse in women.
- Trial name
- POPPY (NCT00476892)
- Testing
- Pelvic Floor Muscle Training
- Where
- 28 sites in Australia, Ireland and 2 more
- Volunteers
- 448 people
- Sponsor
- Glasgow Caledonian University
Type 1 Diabetes
Trial of Intranasal Insulin in Children and Young Adults at Risk of Type 1 Diabetes
In people with type 1 diabetes the beta cells of the pancreas no longer make insulin because the body's immune system has attacked and destroyed the beta cells.
- Trial name
- INITII (NCT00336674)
- Testing
- Intranasal insulin
- Where
- 6 sites in Australia, New Zealand
- Volunteers
- 110 people
- Sponsor
- Melbourne Health
Adenosine Deaminase Deficiency, Severe Combined Immunodeficiencies (SCID)
Lentiviral (LV) Gene Therapy for Adenosine Deaminase (ADA) Deficiency
This is a historically controlled, non-randomized Phase I/II clinical trial to assess the safety and efficacy of autologous transplantation of CD34+ hematopoietic stem/progenitor cells (HSPCs), obtained from infants affected by…
- Trial name
- NCT01380990
- Testing
- Infusion of autologous EFS-ADA LV CD34+ cells, Haematopoietic Stem Cell Transplantation (HSCT), Busulfan
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Ulcerative Colitis
Mini-MARVEL - Mitochondrial Antioxidant Therapy in Ulcerative Colitis
Mini-MARVEL study, children and young people with an active flare of UC requiring either the start of or an increase in existing mesalazine therapy will be given either MitoQ or placebo as a daily capsule for 24 weeks in the…
- Trial name
- Mini-MARVEL (NCT05539625)
- Testing
- MitoQ
- Where
- United Kingdom
- Sponsor
- University of Edinburgh
HIV
Phase II Randomised Controlled Trial of Memory Work Therapy at PASADA, Tanzania
Memory Work Therapy (MWT) has been developed to improve psycho-social outcomes for children living with HIV who are orphaned. This phase 2 trial aims to determine whether attending the intervention improves outcomes compared to…
- Trial name
- MWT (NCT02180750)
- Testing
- Memory Work Therapy, Standard care
- Where
- Tanzania
- Volunteers
- 48 people
- Sponsor
- Pastoral Activities and Service for AIDS Dar-Es-Salaam Archdiocese
Biliary Atresia
Trail to Investigate the Effectiveness of CoSeal in Reducing Adhesions Following the Kasai Hepatoportoenterostomy for Biliary Atresia
The investigators plan to invite all children in the UK with biliary atresia, treated at the three national centres (Birmingham, Kings College and Leeds), over a three year period to take part in a randomised control study.
- Trial name
- CoSRCT (NCT01745991)
- Testing
- CoSeal spray
- Where
- 3 sites in United Kingdom
- Volunteers
- 126 people
- Sponsor
- Naved Alizai
Nephrolithiasis, Staghorn Calculus
Impact of Tranexamic Acid Use in Percutaneous Nephrolithotomy
This study is a double blinded randomized controlled trial evaluating the impact of tranexamic acid use on the transfusion rate in patients with complex kidney stones undergoing percutaneous nephrolithotomy.
- Trial name
- NCT02966236
- Testing
- Tranexamic Acid
- Where
- Brazil
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Developmental Language Disorder and Language Impairment, Anxiety Disorders and Symptoms
Reducing Anxiety Problems Among Children Indicated to Have Developmental Language Disorder
This study aims to pilot a world-first intervention, a mental health intervention augmented for children indicated with developmental language disorder (DLD).
- Trial name
- RAP-iDLD (NCT05552365)
- Testing
- Adapted Cognitive Behavioural, Treatment as Usual
- Where
- Singapore
- Volunteers
- 9 people
- Sponsor
- Nanyang Technological University
Pneumonia, Pneumococcal
Immunogenicity and Safety Study of 15-Valent Pneumococcal Conjugate Vaccine in 2-month-old and 3-month-old Healthy Volunteers
The purpose of this study is to evaluate Immunogenicity and safety of 15-Valent Pneumococcal Conjugate Vaccine in healthy volunteers aged 2 and 3 months.
- Trial name
- NCT04357522
- Testing
- 15-Valent Pneumococcal Conjugate Vaccine, 13-Valent Pneumococcal Conjugate Vaccine
- Where
- 3 sites in China
- Volunteers
- 1,950 people, healthy volunteers welcome
- Sponsor
- Beijing Zhifei Lvzhu Biopharmaceutical Co., Ltd
Acute Myocardial Infarction
A Trial of a Home Based Walking Program as an Alternate Program for Non Attenders at Cardiac Rehabilitation
The purpose of this study is to investigate if a home-based walking program is an acceptable alternative for those who choose not to attend formal cardiac rehabilitation programs and if such a program has an effect on coronary…
- Trial name
- CRU-SHAL (NCT00219830)
- Testing
- home-based walking program
- Where
- United Kingdom
- Sponsor
- Queen's University, Belfast
HIV Infections, Tuberculous Meningitis
Immediate Versus Deferred Antiretroviral Therapy for HIV-Associated Tuberculous Meningitis
The optimal time to initiate antiretroviral therapy (ART) in HIV-associated tuberculous meningitis (TBM) unknown. There are concerns that immediate ART may worsen rather than improve outcome, because drug interactiond and…
- Trial name
- NCT00433719
- Testing
- Combivir and efavirenz
- Where
- 2 sites in Vietnam
- Volunteers
- 253 people
- Sponsor
- University of Oxford
Hypoxic-Ischemic Encephalopathy
PAEAN - Erythropoietin for Hypoxic Ischaemic Encephalopathy in Newborns
Double-blind, placebo controlled Phase III trial of erythropoietin for hypoxic ischaemic encephalopathy in infants receiving hypothermia.
- Trial name
- PAEAN (NCT03079167)
- Testing
- Epoetin Alfa, Normal saline
- Where
- 24 sites in Australia, New Zealand and 1 more
- Volunteers
- 313 people
- Sponsor
- University of Sydney
Congenital Heart Disease
Multi-micronutrient Supplementation During Peri-conception and Congenital Heart Disease
The purpose of this study is to determine whether daily oral supplements of vitamin B complex along with folic acid or supplements of iron plus folic acid given to women during peri-conception can reduce the risk of congenital…
- Trial name
- NCT02537392
- Testing
- Vitamin B Complex and Folic Acid, Iron and Folic Acid, Folic Acid
- Where
- China
- Volunteers
- 7,315 people
- Sponsor
- Xi'an Jiaotong University
Back Pain
Injection Treatment of Corticosteroid to Pelvic Ligament Insertions on Women With Longlasting Backpain After Pregnancy
To evaluate the pain relief effect of locally injected corticosteroid treatment in women with long-lasting low back pain beginning in pregnancy.
- Trial name
- NCT00757016
- Testing
- Triamcinolone, Saline solution
- Where
- Sweden
- Volunteers
- 38 people
- Sponsor
- Sundsvall Hospital
Myopia
Low-dose Atropine Eye Drops to Reduce Progression of Myopia in Children in the United Kingdom
Short-sightedness, also called myopia, makes objects in the distance, such as the television, look blurred. This is caused by the eye growing too long, something that usually happens while children are also getting taller.
- Trial name
- CHAMP-UK (NCT03690089)
- Testing
- Atropine Sulfate
- Where
- 4 sites in United Kingdom
- Volunteers
- 289 people, healthy volunteers welcome
- Sponsor
- Belfast Health and Social Care Trust
Allergic Rhinitis, Allergic Rhinoconjunctivitis
Specific Immunotherapy With Mannan-Conjugated Allergoids for HDM-Allergic Rhinitis/Rhinoconjunctivitis. MM09-SIT-063.
The goal of this clinical trial is to learn whether EP-088_MM09 works to treat house dust mite allergy. It will also assess the treatment's safety.
- Conditions
- Allergic Rhinitis, Allergic Rhinoconjunctivitis, Allergic Asthma
- Trial name
- MM09-SIT-063 (NCT07904052)
- Testing
- EP-088_MM09
- Where
- 16 sites in Portugal, Spain
- Volunteers
- 250 people
- Sponsor
- Inmunotek S.L.
Depression
Dance-movement Therapy in the Treatment of Adolescent Depression
The aim of this research is to measure the effectiveness of Dance movement therapy in the treatment of adolescent depression.
- Trial name
- DMT (NCT07293806)
- Testing
- Dance movement therapy
- Where
- 2 sites in Finland
- Volunteers
- 140 people
- Sponsor
- Helsinki University Central Hospital
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