Clinical trials: Spectrum
Anxiety, Autism
Testing a CBT Program for Anxiety in Teenagers With Autism: A Feasibility Study
The objective is to investigate the feasibility of a newly developed manualised group Cognitive Behavioural Therapy (CBT) programme for anxiety in 15 teenagers (aged 13-17 years) with Autism Spectrum Disorder (ASD).
- Trial name
- NCT04838912
- Testing
- Cool Kids (Chilled) Anxiety program adapted to children and youths with autism and anxiety disorders.
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- University of Aarhus
Neuropsychiatric Symptom
Dissecting Immunological and Autoimmune Mechanisms of Neuropsychiatric Diseases
The goal of this observational cohort study is to investigate the role of immune system in neuropsychiatric symptoms (NPS) and to identify immunological biomarkers that may improve the diagnosis, prognosis, and future treatment…
- Trial name
- DIAMOND (NCT07791212)
- Where
- 2 sites in United Kingdom
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- King's College London
Cowden's Disease, Cowden's Syndrome
Double-Blind Trial of Everolimus for Improving Social Abilities in PTEN Germline Mutations
The goal of this study is to examine the safety and treatment effects of everolimus in adults and children with PTEN Hamartoma Tumor Syndrome (PHTS) who experience social difficulties.
- Conditions
- Cowden's Disease, Cowden's Syndrome, Lhermitte-Duclos Disease, Cerebellum Dysplastic Gangliocytoma
- Trial name
- NCT07218575
- Testing
- Everolimus blinded oral capsules
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Boston Children's Hospital
Child Behavior
Parents Resources for Decreasing the Incidence of Change Triggered Temper Outbursts
'PREDICTORS' (Parents Resources for Decreasing the Incidence of Change Triggered Temper Outbursts) aims to evaluate web-based training packages for caregivers of children who show frequent temper outbursts following changes to…
- Trial name
- PREDICTORS (NCT02567357)
- Testing
- Visual Scheduling, signalling change
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Autism Spectrum Disorder
Active Ingredients & Efficacy of Aquatic Therapy for Autistic Children
Accidental drowning is the number one cause of death in children with autism spectrum disorders (ASD) and highlights the critical need for swim lessons and water safety training for this population.
- Trial name
- NCT05524753
- Testing
- AquOTic
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Autism
Expanding Autism Diagnostic Biomarkers to Kenya
The study will use a non-invasive remote eye-tracking system (Eyelink Portable Duo) to acquire a short series of eye-tracking measures.
- Trial name
- KinleyET (NCT06685822)
- Testing
- Eyelink Portable Duo
- Where
- Kenya
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Indiana University
Bladder Injury, Complications; Cesarean Section
Cystoinflation to Prevent Bladder Injury in Obstetrics and Gynaecology Surgery
Part1:The healthy pregnant women with previous operative deliveries admitted for elective C-section will be counselled and conditioned informed consent will be taken to be included in either study group if dense pelvic adhesions…
- Conditions
- Bladder Injury, Complications; Cesarean Section, Adhesions Pelvic
- Trial name
- NCT04302545
- Testing
- Cystoinflation
- Where
- Pakistan
- Volunteers
- 564 people, healthy volunteers welcome
- Sponsor
- Shazia Saaqib
Autism Spectrum Disorder, Social Stories
Effect of Social Stories on Anesthesia Compliance in Children With Autism
Children with Autism Spectrum Disorder (ASD) frequently experience heightened anxiety and reduced cooperation during the perioperative period, which can complicate anesthesia induction and negatively affect procedural safety and…
- Trial name
- NCT07356895
- Testing
- Social Stories Group, Routine Preoperative Preparation Group
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Dental Caries
Prevelance of Dental Caries in Agroup of Egyption Children Using Caries Assessment Spectrum and Treatment
To explore the prevalence of dental caries in Egyptian children aged from 6 to 9 years oldusing CAST index and DMFT index
- Trial name
- NCT04285931
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Cairo University
Transcranial Direct Current Stimulation, Autistic Disorders Spectrum
Transcranial Direct Current Stimulation in Autism Spectrum Disorder
Background: Transcranial Direct Current Stimulation (tDCS) is a form of non-invasive brain stimulation that has aroused increased interests in the past decade.
- Conditions
- Transcranial Direct Current Stimulation, Autistic Disorders Spectrum, Electroencephalography
- Trial name
- NCT03814083
- Testing
- Active-tDCS, Wait-list
- Where
- Hong Kong
- Volunteers
- 105 people
- Sponsor
- The Hong Kong Polytechnic University
Autism Spectrum Disorder
Safety and Tolerability of Cannabidivarin (CBDV) in Children and Young Adults With Autism Spectrum Disorder
To determine the safety and tolerability of GWP42006 (cannabidivarin, CBDV) in children and young adults with autism spectrum disorder (ASD) and to examine the effect of GWP42006 on communication, social interactions, sleep…
- Trial name
- NCT03849456
- Testing
- GWP42006
- Where
- 3 sites in United States
- Volunteers
- 1 people
- Sponsor
- Jazz Pharmaceuticals
Autism, Autism Spectrum Disorder
Exploring Theatrical Expressive Tasks for Children With ASD
Autism Spectrum Disorder (ASD), according to the diagnostic criteria of Diagnostic and Statistical Manual of Mental Disorders- V Edition (DSM-5), is a disorder involving (a) persistent deficits in social communication, social…
- Trial name
- NCT06468072
- Testing
- Expressivity protocol for children with autism, Expressivity protocol for non-autistic children
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Istituto per la Ricerca e l'Innovazione Biomedica
Autism Spectrum Disorder
Efficacy of a Comprehensive School-based Intervention for High-functioning Children With Autism Spectrum Disorder
This study was a 4-year efficacy trial (cluster randomized trial) of a comprehensive school-based intervention (CSBI) for high-functioning elementary students with autism spectrum disorder (HFASD).
- Trial name
- NCT03338530
- Testing
- Comprehensive School-Based Intervention
- Volunteers
- 103 people
- Sponsor
- Canisius College
Schizophrenia
Study to Assess the Safety, Tolerability and Pharmacokinetics of Oral Brexpiprazole (OPC- 34712) in Adolescents With Schizophrenia
The purpose of this study is to assess the safety, tolerability and pharmacokinetics (PK) of oral brexpipirazole in adolescent subjects with schizophrenia or Other Related Psychiatric Disorders.
- Trial name
- NCT02411695
- Testing
- Brexpiprazole (OPC-34712)
- Where
- 10 sites in United States
- Volunteers
- 43 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Cystic Fibrosis (CF), Cystic Fibrosis-related Diabetes
Studying the Presence of CFRD Complications With Thoughtful Recruitment (SPeCTRuM)
This multicenter cross-sectional study will include a diverse population of adolescents and adults with CF. The overall Aim is to describe prevalence of diabetes microvascular complications and macrovascular surrogates in people…
- Conditions
- Cystic Fibrosis (CF), Cystic Fibrosis-related Diabetes, Diabetes, Retinopathy
- Trial name
- SPeCTRuM (NCT06837181)
- Testing
- observational study
- Where
- 18 sites in United States
- Volunteers
- 200 people
- Sponsor
- Jaeb Center for Health Research
Autism Spectrum Disorder, Dental Caries
Using Video Modeled Social Stories to Improve Oral Hygiene in Children With Autism Spectrum Disorder
We hypothesize that oral hygiene habits in children 8-12 years of age can be improved using video format Social Story intervention techniques.
- Trial name
- NCT02003820
- Testing
- video modeled social story
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- Yale University
Autism Spectrum Disorder
Evaluating Bone Marrow Cell Transplant for Treating Cerebral Palsy From Brain Hypoxia
This clinical trial aims to evaluate the effectiveness of autologous bone marrow mononuclear cell transfusion in treating cerebral palsy caused by cerebral hypoxia.
- Trial name
- NCT06629324
- Testing
- Autologous Bone Marrow Mononuclear Cell Transfusion, Rehabilitation
- Where
- 2 sites in Vietnam
- Volunteers
- 58 people
- Sponsor
- Vinmec Research Institute of Stem Cell and Gene Technology
Autism Spectrum Disorder
Intranasal Oxytocin for the Treatment of Children and Adolescents With Autism Spectrum Disorders (ASD)
We are studying an investigational drug called intranasal oxytocin (Syntocinon®). Syntocinon® has been approved by the U.S. Food and Drug Administration for use in helping women breastfeed, but it has not been approved for use in…
- Trial name
- OXY-R (NCT01908205)
- Testing
- Intranasal Oxytocin
- Where
- 2 sites in United States, Canada
- Volunteers
- 60 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Autism Spectrum Disorders
Pivotal Response Treatment for Infants At-Risk for Autism Spectrum Disorder
The purpose of this study aims to investigate the utility of Pivotal Response Treatment (PRT), a behaviorally derived intervention, to improve the quality and frequency of communication and social engagement of toddlers with…
- Trial name
- NCT01691066
- Testing
- Infant Toddler Years PRT
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Yale University
Psychotic Disorders, Schizophrenia
A Comparative Study of New Medications for Psychosis in Adolescents
The overall goal of this study is to determine the efficacy and tolerability of three atypical antipsychotic medications (risperidone, olanzapine, and quetiapine) in the treatment of adolescents with psychosis.
- Conditions
- Psychotic Disorders, Schizophrenia, Schizophreniform Disorders, Schizoaffective Disorders
- Trial name
- NCT00222495
- Testing
- quetiapine, olanzapine, risperidone
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
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